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Gene Expression and Control

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ISBN: 9781789855173 9781789855180 Year: Pages: 200 DOI: 10.5772/intechopen.76958 Language: English
Publisher: IntechOpen
Subject: Genetics
Added to DOAB on : 2019-10-03 07:51:53

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Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss ""Gene Expression and Control.""

Muscular Dystrophies

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ISBN: 9781789238457 9781789238464 9781839622243 Year: Pages: 130 DOI: 10.5772/intechopen.73974 Language: English
Publisher: IntechOpen
Subject: Genetics
Added to DOAB on : 2019-10-03 07:51:53

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Skeletal muscle is a highly plastic organ that is modulated by various pathways controlling protein turnover. Muscle loss is common in muscular dystrophy, in which marked loss of various proteins such as the dystrophin-glycoprotein complex occurs around muscle fibers. This book provides a comprehensive overview of the various muscular dystrophies, including characteristics, diagnosis, and classification. General treatment of drugs (e.g. corticosteroids) and physical therapy for muscular dystrophies are discussed. In addition, current applications for cell and tissue engineering using muscle stem cells or gene therapy are introduced. This book also deals with the recent advances in appropriate models of drug screening using cell cultures or mammalian organs in vitro in this field.

Medical Internet of Things (m-IoT) - Enabling Technologies and Emerging Applications

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ISBN: 9781789850918 9781789850925 Year: Pages: 134 DOI: 10.5772/intechopen.71858 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:52

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The recent developments in biomedical sensors, wireless communication systems, and information networks are transforming the conventional healthcare systems. The transformed healthcare systems are enabling distributed healthcare services to patients who may not be co-located with the healthcare providers, providing early diagnoses, and reducing the cost in the healthcare section. The developments in medical internet of things (m-IoT) would enable a range of applications, including remote health monitoring through medical-grade wearables to provide homecare for elderlies; virtual doctor-patient interaction to have any time and place access to medical professionals; wireless endoscopic examination; and remotely operated robotic surgery to extend the access to highly skilled surgeons. Wireless body area networks (WBAN) are key enablers of these transformations. These networks connect sensors and actuators to external processing units, which could be placed on the surface of the patient's body or implanted inside the body to connect specific sensors and/or actuators inside, on, and around the body to the data collection points. The success of these networks highly relies on the advent of low-power, low-delay, reliable, and low-cost wireless connectivity solutions. This book covers recent developments in wireless healthcare systems to provide an insight to the technological solutions (e.g. for body area channel propagation models, communication techniques, and energy harvesting/transfer) for wireless body area networks, and emerging applications of medical internet of things and wireless healthcare systems.

Endoscopy - Novel Techniques and Recent Advancements

Authors: --- ---
ISBN: 9781789851250 9781789851267 Year: Pages: 150 DOI: 10.5772/intechopen.74359 Language: English
Publisher: IntechOpen
Subject: Performing Arts --- Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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Endoscopic techniques are widely used for screening, diagnostic and therapeutic maneuvers in all groups of patients and for a large spectrum of complaints. The availability of basic iterations of endoscopic techniques made screening programs for various diseases viable in most parts of the world, while the advent of modern techniques opens new perspectives for rapid and correct diagnosis. Going beyond normal human vision, innovative techniques opened the prospect of in-situ pathology. Endoscopic ultrasound has made incredible progress in recent years. Reaching the smaller orifices by endoscopy was a major step forward in the surveillance of previously inaccessible lesions. Investigatory techniques were complemented by advances in therapy, with novel applications in many major areas of medicine.

Poisoning in the Modern World - New Tricks for an Old Dog?

Authors: ---
ISBN: 9781838807856 9781838807863 9781838807870 Year: Pages: 128 DOI: 10.5772/intechopen.73906 Language: English
Publisher: IntechOpen
Subject: Public Health
Added to DOAB on : 2019-10-03 07:51:53

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Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: ""All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy."" This is often condensed to: ""The dose makes the poison."" So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.

Cytotoxicity - Definition, Identification, and Cytotoxic Compounds

Authors: ---
ISBN: 9781789847543 9781789847550 9781839622861 Year: Pages: 118 DOI: 10.5772/intechopen.77899 Language: English
Publisher: IntechOpen
Subject: Public Health
Added to DOAB on : 2019-10-03 07:51:53

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Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.

Digital Transformation and Public Services

Authors: ---
Book Series: Routledge Studies in the European Economy ISBN: 9780367333430 9780429319297 Year: Pages: 378 DOI: 10.4324/9780429319297 Language: English
Publisher: Taylor & Francis
Subject: Political Science
Added to DOAB on : 2019-10-17 11:21:14
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Through a series of studies, the overarching aim of this book is to investigate if and how the digitalization/digital transformation process affects various welfare services provided by the public sector, and the ensuing implications thereof. Ultimately, this book seeks to understand if it is conceivable for digital advancement to result in the creation of private/non-governmental alternatives to welfare services, possibly in a manner that transcends national boundaries. This study also investigates the possible ramifications of technological development for the public sector and the Western welfare society at large.&#xD;&#xD;This book takes its point of departure from the 2016 Organization for Economic Co-operation and Development (OECD) report that targets specific public service areas in which government needs to adopt new strategies not to fall behind. Specifically, this report emphasizes the focus on digitalization of health care/social care, education, and protection services, including the use of assistive technologies referred to as "digital welfare." Hence, this book explores the factors potentially leading to whether state actors could be overrun by other non-governmental actors, disrupting the current status quo of welfare services.&#xD;&#xD;The book seeks to provide an innovative, enriching, and controversial take on society at large and how various aspects of the public sector can be, and are, affected by the ongoing digitalization process in a way that is not covered by extant literature on the market. This book takes its point of departure in Sweden given the fact that Sweden is one of the most digitalized countries in Europe, according to the Digital Economy and Society Index (DESI), making it a pertinent research case. However, as digitalization transcends national borders, large parts of the subject matter take on an international angle. This includes cases from several other countries around Europe as well as the United States.

The Ethics of Vaccination

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ISBN: 9783030020675 Year: DOI: 10.1007/978-3-030-02068-2 Language: English
Publisher: Palgrave Macmillan
Subject: Biology --- Medicine (General) --- Philosophy
Added to DOAB on : 2019-10-19 11:21:22
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This open access book discusses individual, collective, and institutional responsibilities with regard to vaccination from the perspective of philosophy and public health ethics. It addresses the issue of what it means for a collective to be morally responsible for the realisation of herd immunity and what the implications of collective responsibility are for individual and institutional responsibilities. The first chapter introduces some key concepts in the vaccination debate, such as ‘herd immunity’, ‘public goods’, and ‘vaccine refusal’; and explains why failure to vaccinate raises certain ethical issues. The second chapter analyses, from a philosophical perspective, the relationship between individual, collective, and institutional responsibilities with regard to the realisation of herd immunity. The third chapter is about the principle of least restrictive alternative in public health ethics and its implications for vaccination policies. Finally, the fourth chapter presents an ethical argument for unqualified compulsory vaccination, i.e. for compulsory vaccination that does not allow for any conscientious objection. The book would appeal both philosophers interested in public health ethics and the general public interested in the philosophical underpinning of different arguments about our moral obligations with regard to vaccination.

Greek Medical Papyri. Text, Context, Hypertext

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Book Series: Archiv für Papyrusforschung und verwandte Gebiete - Beihefte ISSN: 18689337 ISBN: 9783110536409 Year: Volume: 40 Pages: 389 DOI: 10.1515/9783110536409 Language: English
Publisher: De Gruyter
Added to DOAB on : 2019-11-06 16:06:17

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This volume, authored by outstanding papyrologists and historians of ancient medicine, deals with topics focused on the papyrological evidence of ancient medical texts and contexts. The first part contains some new reflections on important sources such as the Anonymus Londinensis and the Hippocratic corpus, the second part collects papers about the “doctors’ context”, and the final part is focused on the digitisation of the medical papyri.

An Equal Burden

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ISBN: 9780198824169 Year: Pages: 240 DOI: 10.1093/oso/9780198824169.001.0001 Language: English
Publisher: Oxford University Press Grant: Wellcome Trust - 480342
Subject: Medicine (General) --- History
Added to DOAB on : 2019-03-21 11:21:02
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"An Equal Burden forms the first scholarly study of the Army Medical Services in the First World War to focus on the roles and experiences of the men of the ranks of the Royal Army Medical Corps (RAMC). These men, through their work as stretcher bearers and orderlies, provided a range of labour, both physical and emotional, in aid of the sick and wounded. They were not professional medical caregivers, yet were called upon to provide medical care, however rudimentary; they served in uniform, under military discipline, yet were forbidden, as non-combatants, from carrying weapons. Their service as men in wartime, was thus unique. &#xD;&#xD;Structured both chronologically and thematically, this study examines both the work that RAMC rankers undertook and its importance to the running of the chain of medical evacuation. It additionally explores the gendered status of these men within the medical, military and cultural hierarchies of a society engaged in total war, locating their service within the context of that of doctors, female nurses and combatant servicemen. Through close readings of official documents, personal papers, and cultural representations, both verbal and visual, it argues that the ranks of the RAMC formed a space in which non-commissioned servicemen, through their many roles, defined and redefined medical caregiving as men’s work in wartime."&#xD;

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