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Antioxidants and Second Messengers of Free Radicals

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ISBN: 9783038975335 / 9783038975342 Year: Pages: 194 DOI: 10.3390/books978-3-03897-534-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Medicine (General) --- Chemistry (General)
Added to DOAB on : 2019-01-17 09:35:49
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The history of science can teach modern men that our understanding of life is to a great extent based on the accuracy of the analytical methods that we use and, on our readiness to oppose dogmatic opinions, which are based on outdated methods and black/white approaches to the major questions raised by mankind in the past. The recent decades have brought a lot of new insights into the fundamentals of the active principles of reactive oxygen species that are necessary for living cells, but which also cause dangerous pathophysiological processes. Accordingly, although they were previously considered to be the most undesired toxic compounds generated as the final products of the oxidative degradation of lipids, reactive aldehydes are now considered to play important roles both in health and in major diseases. Represented mostly by 4-hydroxynonenal (HNE), a substance discovered only fifty years ago, reactive aldehydes are the focus of research not only because of their toxicity but also because of their positive effects regulating the most important metabolic processes such as growth of living cells or the death of cells. Better understanding the interactions between reactive aldehydes and natural or synthetic antioxidant substances might eventually help us to better monitor, prevent and control modern diseases, thus building pillars for the development of the modern, multidisciplinary life sciences and integrative medicine of the 21st century.

Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions

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ISBN: 9783038979920 / 9783038979937 Year: Pages: 212 DOI: 10.3390/books978-3-03897-993-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Oral health is general health. If the oral cavity is kept healthy, the whole body is always healthy. Bacteria in the oral cavity do not stay in the oral cavity, but rather they travel throughout the body and can induce various diseases. Periodontal pathogens are involved in tooth loss. The number of remaining teeth decreases with age. People with more residual teeth can bite food well and live longer with lower incidence of dementia. There are many viruses in the oral cavity that also cause various diseases. Bacteria and viruses induce and aggravate inflammation, and therefore should be removed from the oral cavity. In the natural world, there are are many as yet undiscovered antiviral, antibacterial and anti-inflammatory substances. These natural substances, as well as chemically modified derivatives, help our oral health and lead us to more fulfilling, high quality lives. This Special Issue, entitled “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”, was written by specialists from a diverse variety of fields. It serves to provide readers with up-to-date information on incidence rates in each age group, etiology and treatment of stomatitis, and to investigate the application of such treatments as oral care and cosmetic materials.

Keywords

metabolomics --- oral cell --- benzaldehyde --- eugenol --- inflammation --- cytotoxicity --- stomatitis --- recurrent aphthous stomatitis --- oral lichen planus --- CCN2 --- glucocorticoids --- alkaloids --- anti-human immunodeficiency virus (HIV) --- antiviral --- natural product --- human virus --- inflammatory disease --- stomatitis --- periodontitis --- anti-osteoclast activity --- cepharanthin --- herbal medicine --- natural product --- arachidonic acid cascade --- allergic rhinitis --- mice --- quercetin --- thioredoxin --- nasal epithelial cell --- production --- increase --- in vitro --- in vivo --- nutritionally variant streptococci --- antimicrobial susceptibilities --- oral microbiota --- infective endocarditis --- kampo formula --- traditional Japanese herbal medicine --- stomatitis --- mucositis --- Hangeshashinto --- polyphenol --- chromone --- lignin-carbohydrate complex --- alkaline extract --- Kampo medicine --- glucosyltransferase --- angiotensin II blocker --- QSAR analysis --- oral diseases --- dental application --- Chinese herbal remedies --- stomatitis --- periodontitis --- Kampo --- traditional medicine --- Jixueteng --- Juzentaihoto --- technical terms --- gargle --- tongue diagnosis --- mastic --- pathogenic factors --- quantitative structure-activity relationship --- machine learning --- random forest --- natural products --- tumour-specificity --- Kampo medicine --- constituent plant extract --- stomatitis --- oral inflammation --- quantitative structure-activity relationship (QSAR) analysis --- metabolomics

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2019 (2)