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Stem Cell and Biologic Scaffold Engineering

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ISBN: 9783039214976 9783039214983 Year: Pages: 110 DOI: 10.3390/books978-3-03921-498-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.

The Long-Term Perspective of Human Impact on Landscape for Environmental Change and Sustainability

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ISBN: 9783039217960 9783039217977 Year: Pages: 258 DOI: 10.3390/books978-3-03921-797-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Environmental Sciences
Added to DOAB on : 2019-12-09 11:49:16
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The research studies included in this Special Issue highlight the fundamental contribution of the knowledge of environmental history to conscious and efficient environment conservation and management. The long-term perspective of the dynamics that govern the human–climate ecosystem is becoming one of the main focuses of interest in biological and earth system sciences. Multidisciplinary bio-geo-archaeo investigations into the underlying processes of human impact on the landscape are crucial to envisage possible future scenarios of biosphere responses to global warming and biodiversity losses. This Special Issue seeks to engage an interdisciplinary dialog on the dynamic interactions between nature and society, focusing on long-term environmental data as an essential tool for better-informed landscape management decisions to achieve an equilibrium between conservation and sustainable resource exploitation.

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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2019 (2)