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Genome Mining and Marine Microbial Natural Products

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ISBN: 9783039280902 9783039280919 Year: Pages: 202 DOI: 10.3390/books978-3-03928-091-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Microbiology --- Biology --- Science (General)
Added to DOAB on : 2020-01-30 16:39:46
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Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.

In-Cell NMR Spectroscopy: Biomolecular Structure and Function

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ISBN: 9783039282548 / 9783039282555 Year: Pages: 152 DOI: 10.3390/books978-3-03928-255-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]

Nutrition and Eye Health

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ISBN: 9783039219902 9783039219919 Year: Pages: 242 DOI: 10.3390/books978-3-03921-991-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2020-01-30 16:39:46
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Blindness and visual impairment impact significantly on an individual’s physical and mental well-being. Loss of vision is a global health problem, with approximately 250 million of the world’s population currently living with vision loss, of which 36 million are classified as blind. Visual impairment is more frequent in the elderly, with cataract and age-related macular degeneration (AMD) accounting for over 50% of cases globally. Oxidative stress has been strongly implicated in the pathogenesis of both conditions, and consequently the role of nutritional factors, in particular carotenoids and micronutrient antioxidants, have been investigated as possible preventative or therapeutic strategies. Dry eye syndrome (DES) is one of the most common ophthalmic conditions in the world. DES occurs where the eye does not produce enough tears and/or the tears evaporate too quicklyleading to discomfort and varying degrees of visual disturbance. There has recently been a great deal of interest in the potential for oral or topical supplementation with essential fatty acids (EFAs), specifically omega-3 and omega-6 fatty acids, as an adjunct to conventional treatments for DES. The objective of this Special Issue on ‘Nutrition and Eye Health’ is to publish papers describing the role of nutrition in maintaining eye health and the use of nutritional interventions to prevent or treat ocular disease. A particular (but not exclusive) emphasis will be on papers (reviews and/or clinical or experimental studies) relating to cataract, AMD and DES.

Keywords

lutein --- RR-zeaxanthin --- mesozeaxanthin (RS zeaxanthin) --- light damage --- photoreceptor degeneration --- oxidative stress --- endoplasmic reticulum stress --- electroretinography --- advanced glycation end products --- chyrsin --- diabetic retinopathy --- endoplasmic reticulum --- retinal pigment epithelium --- visual cycle --- cataract --- phytoconstituents --- lens --- preclinical models --- drug discovery --- age-related macular degeneration --- gut-retina axis --- gut microbiota --- dietary habits --- micronutrients --- fish oil --- omega-3 polyunsaturated fatty acids --- personalised medicine --- Lactobacillus paracasei KW3110 --- retina --- light --- macrophage --- saffron --- Crocus Sativus L. --- crocin --- crocetin --- supplements --- anti-oxidant --- anti-inflammatory --- AMD --- diabetes --- glaucoma --- retina --- oxidative stress --- inflammation --- microvascular lesions --- neoangiogenesis --- polyphenols --- flavonoids --- carotenoids --- saponins --- rosmarinic acid --- sinapic acid --- lenses --- estrogen-deficient rats --- oxidative stress --- reduced glutathione --- omega-3 --- fatty acid --- diet --- dietary assessment --- clinical survey --- eye disease --- dry eye --- age-related macular degeneration --- food frequency questionnaire --- CODS --- clinical practice guidelines --- systematic reviews --- age-related macular degeneration --- nutritional supplements --- diet --- nutrition --- AGREE II --- Cucurbita argyrosperma --- corneal chemical burn --- angiogenesis --- corneal neovascularization (CNV) --- vascular endothelial growth factor (VEGF) --- interleukin-1? (IL-1?) --- cyclooxigenase-2 (COX-2) --- nuclear factor-kappaB (NF-?B) --- dietary antioxidants --- antioxidant supplements --- lens --- cataract --- n/a

Medicinal Plants and Natural Product Research

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ISBN: 9783039281183 9783039281190 Year: Pages: 231 DOI: 10.3390/books978-3-03928-119-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2020-04-07 23:07:08
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The book entitled Medicinal Plants and Natural Product Research describes various aspects of ethnopharmacological uses of medicinal plants; extraction, isolation, and identification of bioactive compounds from medicinal plants; various aspects of biological activity such as antioxidant, antimicrobial, anticancer, immunomodulatory activity, etc., as well as characterization of plant secondary metabolites as active substances from medicinal plants.

Keywords

Chrysanthemum coronarium L. --- aerial parts --- caffeoylquinic acids --- Malian medicinal plants --- Biophytum umbraculum --- Burkea africana --- Lannea velutina --- Terminalia macroptera --- medicinal plants --- traditional knowledge --- Eastern Himalayas --- mountain plants --- ethnobotany --- ethnopharmacology --- bioprospecting --- antibiotic resistance --- antimicrobial --- mechanism of action --- plant metabolite --- saline habitats --- secondary metabolites --- adaptation --- different solvents --- antibiotic resistance --- antimicrobial activity --- cytotoxicity --- ethnobotany --- Eucalyptus --- natural products --- Pseudomonas aeruginosa --- stingless bees --- Tetragonula --- traditional medicine --- basil varieties --- essential oil --- GC-MS --- harvest --- cluster analysis --- antimicrobial --- antioxidants --- medicinal plants --- BHT --- Ficus hirta --- Moraceae --- carboline alkaloids --- sesquiterpenoids --- flavonoids --- antifungal --- phytochemicals --- Nirgundi --- chaste tree --- antibacterial --- free radical --- scavenger --- oxidative stress --- P. alliaceae --- P. niruri --- S. reticulata --- UPLC --- TQ-ESI-MS --- proanthocyanidins --- mass spectrometry --- antioxidant --- cytotoxicity --- Moringa oleifera --- DPPH --- antioxidant activity --- oxidative stress --- sickle cell anemia --- Ophiopogon --- Liriope --- rbcL --- DNA barcoding --- high-resolution melt curve (HRM) analysis --- allergy --- inflammation --- mast cells --- Immulina® --- immunLoges® --- anthracene derivatives --- antimicrobial --- Asphodelus --- ethnomedicine --- skin diseases --- plant-food --- processing --- nutraceuticals --- inflammation --- health --- Arbutus unedo L. --- ?-glucosidase --- catechin --- HPLC --- NMR --- activity --- bioproduct --- Brunfelsia --- Amazonian --- Ecuador --- ethnobotanic --- ayahuasca --- validation --- drug discovery --- scopoletin

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

Authors: --- ---
ISBN: 9783039282883 9783039282890 Year: Pages: 406 DOI: 10.3390/books978-3-03928-289-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Keywords

MC3R --- MC4R --- mixed pharmacology --- tetrapeptides --- melanocortins --- Plk1 --- selectivity --- polo-box domain --- peptide --- triazole --- PKA --- stapled peptide --- PKI --- pseudosubstrate --- kinase inhibitor --- IP20 --- polycationic -amino acids --- small antimicrobial peptides --- sepsis --- peptidomimetics --- VEGF165 --- neuropilin-1 --- molecular dynamics --- structure–activity relationship --- OBOC --- combinatorial chemistry --- opioid --- drug screen --- molecular rotor dye --- high throughput screening --- sensor chip --- peptide --- peptide-drug conjugate --- mixed-mode pharmacology --- GLP-1 --- GnRH --- LHRH --- chemical linker --- cancer --- diabetes --- obesity --- drug discovery --- melanocortin-4 receptor --- obesity --- peptide agonist --- cardiovascular profile --- G?S signaling --- receptor desensitization --- receptor internalization --- peptidomimetics --- azapeptides --- aza-amino acids --- ?-hairpin --- ?-sheet --- programmed cell death ligand protein 1 --- pharmacophore --- peptide --- small molecule --- anticancer peptide --- therapeutic peptides --- support vector machine --- random forest --- machine learning --- classification --- peptides --- endosomolytic --- amphiphilic --- fusogenic --- influenza hemagglutinin --- RBC lysis --- peptide permeability --- stapled peptide --- macrocyclic peptide --- D-amino acid --- helix-breaker --- adaptogenic --- autophagy --- ?-ginkgotide --- cytoprotective --- cysteine-rich peptides --- disulfide-rich scaffold --- hyperdisulfide --- hypoxia --- LIR motif --- ginkgo nuts --- ?-helix mimetics --- bis-benzamide scaffold --- protein–protein interaction --- prostate cancer --- androgen receptor --- coactivator PELP1 --- Ranalexin --- peptide therapeutics --- antibiotics --- configuration --- antimicrobial activity --- cancer vaccine --- synthetic vaccine --- adjuvant --- Toll-like receptor --- Pam2Cys --- N-acetylated Pam2Cys --- bioconjugation --- lipidation --- prostaglandin F2? --- preterm labor --- myometrium contractions --- peptidomimetic --- structure-activity --- opioids --- multifunctional ligands --- peptide design --- free energy calculation --- d-amino acid scan --- alanine scan

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2020 (5)