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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

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ISBN: 9783039282883 9783039282890 Year: Pages: 406 DOI: 10.3390/books978-3-03928-289-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Abstract

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Keywords

MC3R --- MC4R --- mixed pharmacology --- tetrapeptides --- melanocortins --- Plk1 --- selectivity --- polo-box domain --- peptide --- triazole --- PKA --- stapled peptide --- PKI --- pseudosubstrate --- kinase inhibitor --- IP20 --- polycationic -amino acids --- small antimicrobial peptides --- sepsis --- peptidomimetics --- VEGF165 --- neuropilin-1 --- molecular dynamics --- structure–activity relationship --- OBOC --- combinatorial chemistry --- opioid --- drug screen --- molecular rotor dye --- high throughput screening --- sensor chip --- peptide --- peptide-drug conjugate --- mixed-mode pharmacology --- GLP-1 --- GnRH --- LHRH --- chemical linker --- cancer --- diabetes --- obesity --- drug discovery --- melanocortin-4 receptor --- obesity --- peptide agonist --- cardiovascular profile --- G?S signaling --- receptor desensitization --- receptor internalization --- peptidomimetics --- azapeptides --- aza-amino acids --- ?-hairpin --- ?-sheet --- programmed cell death ligand protein 1 --- pharmacophore --- peptide --- small molecule --- anticancer peptide --- therapeutic peptides --- support vector machine --- random forest --- machine learning --- classification --- peptides --- endosomolytic --- amphiphilic --- fusogenic --- influenza hemagglutinin --- RBC lysis --- peptide permeability --- stapled peptide --- macrocyclic peptide --- D-amino acid --- helix-breaker --- adaptogenic --- autophagy --- ?-ginkgotide --- cytoprotective --- cysteine-rich peptides --- disulfide-rich scaffold --- hyperdisulfide --- hypoxia --- LIR motif --- ginkgo nuts --- ?-helix mimetics --- bis-benzamide scaffold --- protein–protein interaction --- prostate cancer --- androgen receptor --- coactivator PELP1 --- Ranalexin --- peptide therapeutics --- antibiotics --- configuration --- antimicrobial activity --- cancer vaccine --- synthetic vaccine --- adjuvant --- Toll-like receptor --- Pam2Cys --- N-acetylated Pam2Cys --- bioconjugation --- lipidation --- prostaglandin F2? --- preterm labor --- myometrium contractions --- peptidomimetic --- structure-activity --- opioids --- multifunctional ligands --- peptide design --- free energy calculation --- d-amino acid scan --- alanine scan

Transmucosal Absorption Enhancers in the Drug Delivery Field

Authors: --- ---
ISBN: 9783039218486 9783039218493 Year: Pages: 406 DOI: 10.3390/books978-3-03921-849-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-01-30 16:39:46
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Abstract

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.

Keywords

absorption enhancers --- sugar-based surfactants --- biocompatibility studies --- transmucosal drug delivery --- intestinal permeation enhancers --- sodium cholate (NaC) --- N-dodecyl-?-D-maltoside (DDM) --- small intestine --- enterocyte --- brush border --- tryptophan --- oral delivery --- insulin --- GLP-1 --- intestinal absorption --- amino acid --- cell-penetrating peptide --- combined microsphere --- chitosan --- cyclodextrin --- nasal delivery --- nose to brain transport --- penetration enhancer --- nasal formulation --- in vivo studies --- nose to brain delivery --- antiepileptic drug --- drug delivery --- block copolymers --- thermogel system --- chitosan derivatives --- amphiphilic polymers --- polymeric micelles --- quaternization --- curcumin --- intestinal delivery --- mucoadhesiveness --- cervicovaginal tumors --- cationic functionalization --- imatinib --- nanocrystals --- in situ hydrogel --- bioenhancer --- cytochrome P450 --- drug absorption enhancer --- efflux --- metabolism --- P-glycoprotein --- pharmacokinetic interaction --- tight junction --- Aloe vera --- gel --- whole leaf --- absorption enhancement --- Caco-2 --- confocal laser scanning microscopy --- F-actin --- FITC-dextran --- tight junctions --- transepithelial electrical resistance --- permeation enhancer --- oral delivery --- formulation --- permeability --- safety --- simulated intestinal fluid --- hydrophobization --- epithelium --- compound 48/80 --- chitosan --- nanoparticles --- mast cell activator --- vaccine adjuvant --- nasal vaccination --- absorption enhancer --- antimicrobial peptide --- Caco-2 --- claudin --- cell-penetrating peptide (CPP) --- drug delivery --- intestinal epithelial cells --- KLAL --- PN159 --- tight junction modulator --- oral macromolecule delivery --- oral peptides --- sodium caprate --- salcaprozate sodium --- epithelial permeability --- epithelial transport --- nasal permeability --- nose-to-brain --- simvastatin --- nanocapsules --- mucoadhesion --- CNS disorders --- chitosan --- nasal --- pulmonary --- drug administration --- absorption enhancers --- nanoparticle --- and liposome --- absorption enhancer --- gemini surfactant --- intestinal absorption --- poorly absorbed drug --- Caco-2 cells --- PTH 1-34 --- teriparatide --- nasal delivery --- pharmacokinetics --- osteoporosis --- man --- sheep --- clinical trial --- preclinical --- Caco-2 --- intestinal absorption --- nanomedicine --- nanoparticle --- oral delivery --- transferrin --- ocular drug delivery --- cornea --- penetration enhancers --- ocular conditions --- ophthalmology --- permeation enhancers --- absorption modifying excipients --- oral delivery --- nasal delivery --- ocular delivery --- vaginal delivery --- transmucosal permeation

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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english (2)


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2020 (2)