Search results: Found 20

Listing 1 - 10 of 20 << page
of 2
>>
Sort by
Diet and Immune Function

Authors: --- ---
ISBN: 9783039216123 / 9783039216130 Year: Pages: 314 DOI: 10.3390/books978-3-03921-613-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Supporting initiation, development and resolution of appropriate immune responses is key to survival. Many nutrients and dietary components have been purported to have a role in supporting optimal immune function. This is vital throughout the life course, from the development and programming of the immune system in early life, to supporting immunity and reducing chronic inflammation in older people. In this special issue of Nutrients, we examine the evidence for the role of diet and dietary components in promoting protective immunity.

Keywords

inflammation --- toll-like receptor 4 --- obesity --- fatty acids --- protein hydrolysate --- bioactive peptide --- immunomodulation --- Toll-like receptor --- functional foods --- zinc --- sepsis --- biomarker --- supplementation --- homeostasis --- human milk oligosaccharides --- intestinal immune system --- microbiota --- fermented milk --- Th1/Th17 response --- inflammatory process --- growth factors --- breast milk --- immunonutrition --- cytokines --- lymphocytes --- selenocysteine --- macrophage --- T cell --- antibody --- inflammation --- cancer --- adults --- age-related immunity --- deficiency --- elderly --- immunosenescence --- infants --- infection --- micronutrients --- older people --- nutrition --- amino acids --- leukocytes --- skeletal muscle --- gut --- liver --- anorexia nervosa --- inflammatory markers --- inflammation --- cytokines --- chemokines --- adhesion molecules --- carbohydrates --- fiber --- food structure --- formulation --- plant --- microbiota --- inflammation --- metabolism --- nutrition guidelines --- vitamin E --- macrophages --- T cells --- dendritic cells --- immunomodulation --- infection --- polyphenols --- immune system --- inflammation --- molecular mechanisms --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) --- arachidonic acid --- mitogen-activated protein Kinase (MAPK) --- cytokines --- oxidative stress --- reactive oxygen species (ROS) --- cyclooxygenase (COX) --- nitric oxide synthase (NOS) --- lipoxygenase (LOX) --- superoxide dismutase (SOD) --- inhibitor of kappa kinase (IKK) --- extra-cellular signal regulated kinases (ERK) --- cancer --- anti-inflammation --- anti-tumorigenic --- chronic inflammatory conditions --- macrophages --- T helper 1 (Th1) --- Th17 --- Treg --- vitamin D --- immune system --- gut microbiota --- autoimmune diseases --- T cells --- weaning --- oligosaccharides --- non-digestible carbohydrates --- metabolites --- gut barrier --- tolerance --- nutrition --- immunity --- macronutrients --- micronutrients --- microbiome --- life course --- probiotic --- prebiotic --- inflammation

Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms

Authors: ---
ISBN: 9783039280445 9783039280452 Year: Pages: 186 DOI: 10.3390/books978-3-03928-045-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
License:

Loading...
Export citation

Choose an application

Abstract

This Special Issue Book ""Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms"" is aimed at collecting literature on the below-mentioned keyword topics, which can significantly increase our basic understanding of marine-derived compounds in cosmeceutical product development and increases the value of marine products at the industrial level.

Biomedical Insights that Inform the Diagnosis of ME/CFS

Authors: ---
ISBN: 9783039283903 9783039283910 Year: Pages: 202 DOI: 10.3390/books978-3-03928-391-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
License:

Loading...
Export citation

Choose an application

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.

Keywords

myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnosis --- symptoms --- muscles --- neurology --- myalgic encephalomyelitis --- chronic fatigue syndrome --- post-exertional malaise --- assessment --- patient-driven questionnaire --- participatory research --- myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) --- energy metabolism --- potential biomarkers --- fatigue syndrome --- chronic --- exercise --- hypoacetylation --- methylhistidine --- histone deacetylation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnostic biomarker --- inflammation and immunity --- metabolism --- mitochondria --- circadian rhythm --- neuro-inflammation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- activin --- pathology --- biomarker --- cytokine --- machine learning --- reference intervals --- myalgic encephalomyelitis --- chronic fatigue syndrome --- ME/CFS --- diagnosis --- metabolism --- mitochondria --- inflammation --- immune system --- signaling --- gut microbiota --- tryptophan metabolism --- indoleamine-2,3-dioxygenase --- bistability --- kynurenine pathway --- substrate inhibition --- myalgic encephalomyelitis --- chronic fatigue syndrome --- mathematical model --- critical point --- immunological --- chronic fatigue syndrome --- myalgic encephalomyelitis --- biomarker --- neuroimmune --- Epstein Barr virus --- hypothalamic–pituitary–adrenal axis --- CFS (Chronic Fatigue Syndrome) --- ME (Myalgic Encephalomyelitis) --- medical retirement --- prognosis --- work rehabilitation --- n/a

Nutrients Intake and Hypertension

Author:
ISBN: 9783039286621 / 9783039286638 Year: Pages: 242 DOI: 10.3390/books978-3-03928-663-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Hypertension is a major health problem worldwide, increasing cardiovascular (CV) risk and mortality. Together with pharmacological treatments, non-pharmacological approaches, such as nutrient intake modifications, play an important role in optimizing treatment. A link has been demonstrated between hypertension and body weight as well as dietary habits. The aim of this Special Issue is to improve the understanding of the relationships between some nutrients and hypertension, and of the effects of different dietary approaches on hypertension regulation from different points of view.

Kidney Inflammation, Injury and Regeneration

Authors: --- ---
ISBN: 9783039285389 / 9783039285396 Year: Pages: 496 DOI: 10.3390/books978-3-03928-539-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Keywords

kidney injury --- alport syndrome --- modifier gene --- nephrin --- podocin --- glomerular basement membrane --- slit diaphragm --- focal segmental glomerulosclerosis --- inflammatory bowel disease (IBD) --- DSS-colitis --- glomerular filtration barrier (GFB) --- type IV collagen --- type I collagen --- type V collagen --- genotype --- IL-18 --- polymorphism --- renal cell carcinoma --- Taiwan --- mesenchymal stem cells --- acute and chronic kidney disease --- exosome --- natural products --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- renal fibrosis --- biomarkers --- therapeutics targets --- rhabdomyolysis --- pigment nephropathy --- haem --- NLRP3 inflammasome --- acute kidney injury --- hypertension --- kidney --- molecular signaling --- hematuria --- inflammation --- oxidative stress --- tubular injury --- AKI --- chronic kidney disease (CKD) --- mesenchymal stromal cells --- extracellular vesicles --- acute kidney injury --- modified-MSCs --- microRNA --- mesenchymal stem cell --- mesodermal stem cell --- renal ischemia-reperfusion --- inflammation --- kidney transplantation --- microRNA --- extracellular vesicles --- exosomes --- B-cell attracting chemokine --- CXCL13 --- kidney transplantation --- allograft rejection --- T cell-mediated rejection --- diabetic nephropathy --- lysophosphatidic acid --- lysophosphatidic acid receptor --- chronic kidney injury --- kidney proximal tubule --- acute kidney failure --- signal transduction --- transcription --- CREB Regulated Transcriptional Coactivators (CRTC) --- cAMP Regulatory Element Binding Protein (CREB) --- Salt Inducible Kinase (SIK) --- Class IIa Histone Deacetylases (HDAC) --- lncRNA --- long non-coding RNA --- miRNA --- kidney --- glomerulus --- podocyte --- acute kidney injury --- AKI --- diabetic nephropathy --- diabetic kidney disease --- diabetic nephropathy --- inflammation --- signaling cascade --- ischemia-reperfusion --- acute kidney injury --- stem cell --- conditioned medium --- inflammation --- apoptosis --- necrosis --- regulated necrosis --- kidney injury --- tubular injury --- glomerular injury --- polyunsaturated fatty acids --- omega-3 fatty acid --- inflammatory maker --- C-reactive protein --- interleukin-6 --- LPS-binding protein --- fibrosis --- pericyte --- myofibroblast --- endotoxemia-induced oliguric kidney injury --- arachidonic acid --- cyclooxygenase --- lipoxygenase --- cytochrome P450 --- kidney inflammation --- therapeutic target --- obese kidney fibrosis --- endotoxemia --- ROS --- cPLA2 and COX-2 --- IgA nephropathy --- KIT assay --- KIT-IgA score --- noninvasive --- diagnostics --- prediction --- diabetic kidney diseases --- xanthine oxidase --- glomerular damage --- acute kidney injury --- chronic kidney disease --- renal progenitors --- polyploidization --- diabetic nephropathy --- diabetes mellitus --- GLP-1 receptor agonists --- SGLT2 inhibitors --- molecular mechanisms --- chemerin --- CmklR1 --- 2-kidney-1-clip --- 2k1c --- Thy1.1 nephritis --- renovascular hypertension --- renal inflammation --- renal injury --- renal fibrosis --- inflammation --- ischemia/reperfusion injury --- Farnesiferol B --- Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) --- G-protein-coupled bile acid receptor (TGR5) --- renal stem cells --- differentiation --- scattered tubular cells --- papilla --- niches --- renal tubular cells --- epithelial cells --- proximal tubule --- cytotoxicity --- injury --- inflammation --- empagliflozin --- dapagliflozin --- kidney --- n/a

Surgery for Spine Disease and Intractable Pain

Author:
ISBN: 9783039284788 9783039284795 Year: Pages: 88 DOI: 10.3390/books978-3-03928-479-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Surgery
Added to DOAB on : 2020-04-07 23:07:09
License:

Novel Aspects of Lipoprotein Metabolism with Focus on Systemic Inflammation

Author:
ISBN: 9783039282142 9783039282159 Year: Pages: 248 DOI: 10.3390/books978-3-03928-215-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
License:

Loading...
Export citation

Choose an application

Abstract

With cardiometabolic diseases still topping the list of mortality causes and in facing the obesity and diabetes epidemic, there remains a great need to better understand the pathophysiological derangements underlying these conditions. During the past years, it has become increasingly appreciated that low grade systemic inflammation is a common hallmark of cardiometabolic disorders—not only concerning diabetes and atherosclerotic cardiovascular disease but also involving non-alcoholic fatty liver disease. Recently developed high-throughput laboratory techniques for lipidomics and metabolomics have enabled researchers to discern novel crosstalk pathways between lipid phenotypes and enhanced chronic inflammation. With this Special Issue of the Journal of Clinical Medicine, entitled “Novel Aspects of Lipoprotein Metabolism with a Focus on Systemic Inflammation”, researchers were invited to submit original papers and reviews on various topics, in particular, at the interface of lipid metabolism and inflammation.

Keywords

carbamoylation --- chronic kidney disease --- lipoproteins --- infrared spectroscopy --- Breast cancer --- cholesterol --- 27-hydroxycholesterol --- HDL --- LDL --- cholesterol-lowering therapies --- biomarker --- anti-apolipoprotein A-1 antibodies --- renal transplant recipient --- HDL function --- prognosis --- cholesterol --- acute coronary syndrome --- biomarkers --- anti-apolipoprotein A-I autoantibodies --- GRACE score --- C-statistics --- adipose tissue --- ANGPTL3 --- ANGPTL4 --- ANGPTL8 --- lipid metabolism --- cholesterol efflux capacity --- coronary artery calcium score --- obesity --- anti-apoA-1 IgG --- autoantibodies --- cardiovascular disease --- C-reactive protein --- HDL --- paraoxonase-1 --- cardiovascular disease --- myocardial infarction --- diabetic cardiomyopathy --- cytokines --- interleukin 1? --- inflammation --- CANTOS --- canakinumab --- retinol binding protein 4 --- retinol --- lipoprotein subfractions --- large VLDL --- small LDL --- Type 2 diabetes mellitus --- metabolic syndrome --- nuclear magnetic resonance spectroscopy --- betaine --- trimethylamine N-oxide related metabolites --- nuclear magnetic resonance spectroscopy --- type 2 diabetes mellitus --- anti-apolipoprotein A-1 IgG --- familial hypercholesterolemia --- cholesterol homeostasis --- foam cells --- miR-33a --- TLR2/4 --- passive diffusion --- microvesicles --- inflammation --- lipoproteins --- LDL cholesterol --- microparticles --- cardiovascular disease --- platelets --- endothelial cells --- leukocytes --- atherothrombosis --- HDL --- lipids --- inflammation --- atherosclerotic cardiovascular disease (ASCVD) --- cardiovascular events --- GlycA --- non-alcoholic fatty liver --- sodium intake --- insulin resistance --- fatty liver index --- hepatic steatosis index --- HOMA-IR --- gut microbiota --- lipoprotein metabolism --- metabolic disorder --- adiponectin --- free thiols --- nuclear magnetic resonance spectroscopy --- phospholipid transfer protein activity --- triglycerides --- type 2 diabetes mellitus --- large very low density lipoproteins --- ANGPTL8 --- visceral adipose tissue (VAT) --- obesity --- endothelial cells

Adipokines 2.0

Author:
ISBN: 9783039285860 / 9783039285877 Year: Pages: 406 DOI: 10.3390/books978-3-03928-587-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2020-06-09 16:38:57
License:

Loading...
Export citation

Choose an application

Abstract

Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.

Keywords

adipokines --- secreted frizzled-related protein 5 --- leptin --- ghrelin --- excessive gestational weight gain --- neonatal anthropometry --- obesity --- proteolysis --- Tango bioassay --- biologic activity --- chemerin receptors --- excessive gestational weight gain --- neonatal anthropometry --- leptin --- ghrelin --- Nonalcoholic fatty liver disease --- fatty liver --- free fatty acids --- label-free proteomic profiling --- adipokine --- obesity --- visceral fat --- sick fat --- annexins --- adipose tissue --- adiponectin --- cholesterol --- glucose homeostasis --- inflammation --- insulin --- lipid metabolism --- obesity --- triglycerides --- adipokine --- chemerin --- leukocyte --- cancer --- adipokines --- PCOS --- polycystic ovary morphology --- follicular fluid --- human granulosa cells --- chemerin --- chemerin receptors --- hypothalamus --- oestrous cycle --- early pregnancy --- pig --- alpha-fetoprotein --- liver steatosis --- hypertension --- adipokines --- SGBS adipocytes --- glucose restriction --- in vitro fat regain --- weight regain --- complement factors --- cathepsins --- extracellular remodeling --- adipokine --- rheumatic diseases --- inflammation --- osteoarthritis --- rheumatoid arthritis --- ovary --- testis --- adipose tissue --- polycystic ovary syndrome --- preeclempsia --- gestational diabetes --- testicular pathologies --- rheumatoid arthritis --- tocilizumab --- lipids --- adipokines --- adiponectin --- resistin --- leptin --- cancer --- obesity --- adipokine --- chemerin --- chemokine-like receptor 1 --- G protein-coupled receptor 1 --- C-C chemokine receptor-like 2 --- critical illness --- sepsis --- adipokines --- biomarker --- prognosis --- ICU --- adipokine --- adipose-brain axis --- brain health --- neurodegeneration --- depression --- energy metabolism --- inflammation --- hypothalamus --- microglia --- adiponectin --- adipokine --- myokine --- fitness --- metabolically healthy obese --- early-life programming --- epicardial adipose tissue (EAT) --- prostaglandin E2 (PGE2) --- EP3 receptor --- EP4 receptor --- exchange protein directly activated by cAMP isoform 2 (EPAC2) --- stimulating growth factor 2 (ST2) --- interleukin(IL)-33 --- Cardiovascular Diseases (CVDs) --- fat mass --- n/a

Iron as Therapeutic Targets in Human Diseases Volume 1

Authors: --- ---
ISBN: 9783039280827 9783039280834 Year: Pages: 472 DOI: 10.3390/books978-3-03928-083-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2020-04-07 23:07:08
License:

Loading...
Export citation

Choose an application

Abstract

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Keywords

cinnamic acid derivatives --- soybean seed ferritin --- iron release --- binding ability --- Fe2+-chelating activity --- reducibility --- adverse event profile --- anaemia --- bioengineering --- labile iron --- intravenous iron --- iron-carbohydrate complex --- iron processing --- iron metabolism --- infection --- innate immunity --- hepcidin --- ferritin --- anemia of inflammation --- pharmaceutical targets --- iron deficiency anemia --- nutrient iron --- oral iron therapy --- FeSO4 --- NaFeEDTA --- non-transferrin-bound iron (NTBI) --- developing countries --- Indonesia --- neurodegeneration --- mitochondria --- therapy --- heme --- haem --- Iron-sulfur --- Friedreich Ataxia --- Oxidative stress --- Iron chelators --- iron deficiency --- anemia --- cancer --- hepcidin --- patient blood management --- malaria --- iron deficiency --- hepcidin --- TNF --- children --- Africa --- Anemia --- iron deficiency --- oral iron salts --- intravenous iron --- Sucrosomial® iron --- M cells --- bioavailability --- tolerability --- efficacy --- iron --- gut microbiota --- iron supplementation --- iron transporters --- mucosal immunity --- SCFA --- intestinal inflammation --- inflammatory bowel disease (IBD) --- colorectal cancer --- oxidative stress --- anaemia --- cardiovascular disease --- chronic kidney disease --- IV iron therapy --- bone homeostasis --- iron overload --- iron deficiency --- osteoclast --- osteoblast --- osteoporosis --- neurodegeneration with brain iron accumulation --- iron chelation therapy --- multifunctional iron chelators --- fluorescent iron chelator --- 3-hydroxy-4-pyridinone --- fluorophore --- rhodamine --- membrane interactions --- bacteria --- antibacterial activity --- histidine --- iron --- anemia --- oxidative stress --- kidney --- chelation --- iron --- retina --- age-related macular degeneration (AMD) --- iron --- lipid --- obesity --- cancer --- neurodegeneration --- iron chelation --- phlebotomy --- NCOA4 --- ferritinophagy --- iron homeostasis --- erythropoiesis --- ferroptosis --- cancer --- Tfr2 --- iron metabolism --- hepcidin --- erythropoiesis --- SNC --- ferritin --- iron mobilization --- chaotropes --- flavin nucleotide --- electron transfer --- kinetics --- ferritin --- iron --- iron delivery --- nanotechnology --- nanocage --- drug delivery --- inflammation --- serum biomarker --- iron metabolism --- hepcidin --- ferroportin --- hemochromatosis --- anemia --- hepcidin --- iron deficiency anemia --- iron dextran --- neonatal period --- pig --- supplementation --- Alzheimer’s disease --- neuroinflammation --- neurodegeneration --- cytokines --- neuroimmune responses --- iron --- genetic hemochromatosis --- non transferrin bound iron --- hepcidin --- ferroportin --- venesections --- Anemia of chronic disease --- anemia of inflammation --- hepcidin --- anti-hepcidin therapy --- iron supplementation --- macrophage --- central nurse macrophage --- red pulp macrophage --- Kupffer cell --- iron metabolism --- erythropoiesis --- erythroblastic islands --- erythrophagocytosis --- inflammation --- iron homeostasis --- lung diseases --- oxygen sensing --- hypoxia --- ferritin --- hereditary hyperferritinemia --- hereditary hypoferritinemia --- iron metabolism --- cataracts syndrome --- neurodegenerative disease --- n/a --- iron --- neurodegeneration --- NBIA --- hepcidin --- iron --- lung --- acute lung injury --- COPD --- lung infection --- cystic fibrosis --- iron --- anaemia --- infection --- malaria --- immunity --- brain development --- growth --- microbiome --- hepcidin --- ferritin --- iron supplementation --- infants --- children --- low and middle income countries --- liver --- iron --- hepcidin --- Mek/Erk --- Hfe --- Bmp/Smad --- iron --- mycobacteria --- immunity --- Alzheimer’s disease --- iron homeostasis --- ferroptosis --- senescence --- chelators --- macrophages --- iron --- metabolism --- inflammation --- iron --- ferritin --- acute kidney injury --- chronic kidney disease --- vascular calcification --- iron --- hepcidin --- ferroportin --- Interleukin-6 --- infection --- rheumatoid arthritis --- iron homeostasis --- iron absorption --- non-haem iron --- flavonoids --- developmental --- iron deficiency anemia --- neonatal --- transferrin receptor --- treatment --- hemochromatosis --- HFE --- natural history --- T lymphocytes --- MHC --- CD8+ T cells --- prevention --- iron homeostasis --- hepcidin --- protein binding --- peritoneal dialysis --- iron --- hepcidin --- iron regulatory proteins --- cardiomyocyte --- chronic heart failure --- pulmonary arterial smooth muscle cells --- pulmonary arterial hypertension --- iron --- brain --- neurophysiology --- cognition --- social behavior --- didox --- iron chelators --- antitumor compound --- iron metabolism --- RRM2 --- SLC40A1 --- ferroportin --- iron overload --- non-HFE --- ferritin --- hemochromatosis --- iron --- chelation --- neurodegenerative diseases --- pituitary --- brain --- hemopexin --- heme homeostasis --- iron homeostasis --- hemolysis --- haptoglobin --- ferroptosis --- inflammation --- biomarker --- heme oxygenase --- liver --- microbiome --- trauma --- hemorrhage --- iron metabolism --- hepcidin --- iron homeostasis --- ferroportin --- n/a

Iron as Therapeutic Targets in Human Diseases Volume 2

Authors: --- ---
ISBN: 9783039281145 9783039281152 Year: Pages: 440 DOI: 10.3390/books978-3-03928-115-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2020-04-07 23:07:08
License:

Loading...
Export citation

Choose an application

Abstract

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Keywords

cinnamic acid derivatives --- soybean seed ferritin --- iron release --- binding ability --- Fe2+-chelating activity --- reducibility --- adverse event profile --- anaemia --- bioengineering --- labile iron --- intravenous iron --- iron-carbohydrate complex --- iron processing --- iron metabolism --- infection --- innate immunity --- hepcidin --- ferritin --- anemia of inflammation --- pharmaceutical targets --- iron deficiency anemia --- nutrient iron --- oral iron therapy --- FeSO4 --- NaFeEDTA --- non-transferrin-bound iron (NTBI) --- developing countries --- Indonesia --- neurodegeneration --- mitochondria --- therapy --- heme --- haem --- Iron-sulfur --- Friedreich Ataxia --- Oxidative stress --- Iron chelators --- iron deficiency --- anemia --- cancer --- hepcidin --- patient blood management --- malaria --- iron deficiency --- hepcidin --- TNF --- children --- Africa --- Anemia --- iron deficiency --- oral iron salts --- intravenous iron --- Sucrosomial® iron --- M cells --- bioavailability --- tolerability --- efficacy --- iron --- gut microbiota --- iron supplementation --- iron transporters --- mucosal immunity --- SCFA --- intestinal inflammation --- inflammatory bowel disease (IBD) --- colorectal cancer --- oxidative stress --- anaemia --- cardiovascular disease --- chronic kidney disease --- IV iron therapy --- bone homeostasis --- iron overload --- iron deficiency --- osteoclast --- osteoblast --- osteoporosis --- neurodegeneration with brain iron accumulation --- iron chelation therapy --- multifunctional iron chelators --- fluorescent iron chelator --- 3-hydroxy-4-pyridinone --- fluorophore --- rhodamine --- membrane interactions --- bacteria --- antibacterial activity --- histidine --- iron --- anemia --- oxidative stress --- kidney --- chelation --- iron --- retina --- age-related macular degeneration (AMD) --- iron --- lipid --- obesity --- cancer --- neurodegeneration --- iron chelation --- phlebotomy --- NCOA4 --- ferritinophagy --- iron homeostasis --- erythropoiesis --- ferroptosis --- cancer --- Tfr2 --- iron metabolism --- hepcidin --- erythropoiesis --- SNC --- ferritin --- iron mobilization --- chaotropes --- flavin nucleotide --- electron transfer --- kinetics --- ferritin --- iron --- iron delivery --- nanotechnology --- nanocage --- drug delivery --- inflammation --- serum biomarker --- iron metabolism --- hepcidin --- ferroportin --- hemochromatosis --- anemia --- hepcidin --- iron deficiency anemia --- iron dextran --- neonatal period --- pig --- supplementation --- Alzheimer’s disease --- neuroinflammation --- neurodegeneration --- cytokines --- neuroimmune responses --- iron --- genetic hemochromatosis --- non transferrin bound iron --- hepcidin --- ferroportin --- venesections --- Anemia of chronic disease --- anemia of inflammation --- hepcidin --- anti-hepcidin therapy --- iron supplementation --- macrophage --- central nurse macrophage --- red pulp macrophage --- Kupffer cell --- iron metabolism --- erythropoiesis --- erythroblastic islands --- erythrophagocytosis --- inflammation --- iron homeostasis --- lung diseases --- oxygen sensing --- hypoxia --- ferritin --- hereditary hyperferritinemia --- hereditary hypoferritinemia --- iron metabolism --- cataracts syndrome --- neurodegenerative disease --- n/a --- iron --- neurodegeneration --- NBIA --- hepcidin --- iron --- lung --- acute lung injury --- COPD --- lung infection --- cystic fibrosis --- iron --- anaemia --- infection --- malaria --- immunity --- brain development --- growth --- microbiome --- hepcidin --- ferritin --- iron supplementation --- infants --- children --- low and middle income countries --- liver --- iron --- hepcidin --- Mek/Erk --- Hfe --- Bmp/Smad --- iron --- mycobacteria --- immunity --- Alzheimer’s disease --- iron homeostasis --- ferroptosis --- senescence --- chelators --- macrophages --- iron --- metabolism --- inflammation --- iron --- ferritin --- acute kidney injury --- chronic kidney disease --- vascular calcification --- iron --- hepcidin --- ferroportin --- Interleukin-6 --- infection --- rheumatoid arthritis --- iron homeostasis --- iron absorption --- non-haem iron --- flavonoids --- developmental --- iron deficiency anemia --- neonatal --- transferrin receptor --- treatment --- hemochromatosis --- HFE --- natural history --- T lymphocytes --- MHC --- CD8+ T cells --- prevention --- iron homeostasis --- hepcidin --- protein binding --- peritoneal dialysis --- iron --- hepcidin --- iron regulatory proteins --- cardiomyocyte --- chronic heart failure --- pulmonary arterial smooth muscle cells --- pulmonary arterial hypertension --- iron --- brain --- neurophysiology --- cognition --- social behavior --- didox --- iron chelators --- antitumor compound --- iron metabolism --- RRM2 --- SLC40A1 --- ferroportin --- iron overload --- non-HFE --- ferritin --- hemochromatosis --- iron --- chelation --- neurodegenerative diseases --- pituitary --- brain --- hemopexin --- heme homeostasis --- iron homeostasis --- hemolysis --- haptoglobin --- ferroptosis --- inflammation --- biomarker --- heme oxygenase --- liver --- microbiome --- trauma --- hemorrhage --- iron metabolism --- hepcidin --- iron homeostasis --- ferroportin --- n/a

Listing 1 - 10 of 20 << page
of 2
>>
Sort by
Narrow your search

Publisher

MDPI - Multidisciplinary Digital Publishing Institute (20)


License

CC by-nc-nd (20)


Language

eng (10)

english (10)


Year
From To Submit

2020 (20)