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This Special Issue focuses on the synthesis and characterization of hydrogels specifically used as carriers of biological molecules for pharmaceutical and biomedical employments. Pharmaceutical applications of hydrophilic materials has emerged as one of the most significant trends in the area of nanotechnology. To propose some of the latest findings in this field, each contribution involves an in-depth analysis including different starting materials and their physico-chemical and biological properties with the aim of synthetizing high-performing devices for specific use. In this context, intelligent polymeric devices able to be morphologically modified in response to an internal or external stimulus, such as pH or temperature, have been actively pursued. In general, hydrophilic polymeric materials lead to high in vitro and/or in vivo therapeutic efficacy, with programmed site-specific feature showing remarkable potential for targeted therapy. This Special Issue serves to highlight and capture the contemporary progress in this field. Relevant resources and people to approach - American Association Pharmaceutical Scientists (AAPS): web: www.aaps.org; email: (marketing division): Marketing@aaps.org; (mmeting division): Meetings@aaps.org - International Association for Pharmaceutical Technology (APV): web: apv-mainz.de; email (managing director):

pellets 1 --- pellet diameter 2 --- crystallinity 3 --- sphericity 4 --- fast release 5 --- extended release 6 --- elastin-like polypeptide (ELPs) --- contact lens --- lacritin --- protein therapeutics --- drug delivery --- controlled release --- nanoporous silicon --- ?CD polymer --- caffeic acid --- pinocembrin --- polyphenols --- HUVECs --- polymer carriers --- drug delivery --- conjugates --- self-assemblies --- star polymers --- graft polymers --- poly(ionic liquid)s --- retinol --- “click” chemistry --- alkyne–azide reaction --- ATRP --- graft copolymers --- amphiphilic copolymers --- micellar carriers --- sustained release --- wound healing --- crosslinking --- allantoin --- equilibrium swelling ratio --- accumulative release --- thermogravimetric analysis --- lutein --- nanofibers --- polyvinyl alcohol --- sodium alginate --- injectable hydrogels --- drug delivery --- anticancer activity --- natural polymers --- synthetic polymers --- stimuli-responsive materials --- silk fibroin --- drug delivery --- gene delivery --- controlled release --- bioconjugation --- n/a

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The aim of this book is to provide an analysis of the main characteristics and applications of hydrogels. Hydrogels are frequently used for manufacturing contact lenses, hygiene products, tissue engineering scaffolds, drug delivery systems, and wound dressings. These materials are useful in everyday life, so publicizing them in both academic and pharmaceutical fields is essential.

drug delivery --- microemulsion --- contact lenses --- cationic surfactant --- controlled release --- hydrogels --- oxidized inulin --- periodate oxidation --- colon targeting --- hyaluronic acid --- hydrogel --- cancer --- drug delivery --- click chemistry --- biomaterial --- allotransplantation --- hydrogels --- sustained delivery --- tacrolimus --- gel --- sustained release --- carbamazepine --- epilepsy --- pediatric --- zein/poly 4-mercaptophenyl methacrylate-carbon nano-onions hydrogels --- acoustic cavitation method --- pH-responsive drug release --- cytocompatibility --- thermosensitive hydrogels --- mucoadhesive chitosan multifunctional derivatives --- mucoadhesive nanoparticles --- ocular cancer --- microrheology --- ocular delivery --- trimethyl chitosan --- progesterone --- brain --- hydrogel nanoparticles --- poloxamer --- hydrogels --- micelle --- thermosensitive --- biomedical --- copolymer --- n/a

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Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy, which reflects current developments in the area of intrinsically biocompatible polymer systems. Polymeric biomaterials are presently used as, for example, long-term implantable medical devices, degradable implantable systems, transient invasive intravascular devices, and, recently, as tissue engineering scaffolds. This Special Issue welcomes full papers and short communications highlighting the aspects of the current trends in the area of intrinsically biocompatible polymer systems.

antimicrobial peptides --- biodegradable polymers --- biocompatible polymers --- drug delivery systems --- controlled release --- citropin --- temporin --- ionic liquids --- chitooligosaccharide --- polyurethane --- biodegradability --- physicochemical properties --- hemocompatibility --- biological activity --- crosslinking --- drug delivery --- cosmetic --- food-supplement --- functionalization --- hyaluronan applications --- hyaluronan derivatives --- hyaluronan synthases --- hyaluronic acid --- hyaluronidases --- physico-chemical properties --- cyclohexanone --- ?-butyrolactone --- chloroform --- extraction --- polyhydroxyalkanoates --- PHB --- electrospraying --- biodegradable nano/microparticles --- drug delivery --- septic arthritis --- release characteristics --- biopolymers --- silk fibroin --- konjac glucomannan --- porous beads --- scaffolds --- tissue engineering --- microcarriers --- Poly (l-lactic) acid --- Chitosan --- nanohydroxyapatite --- osteoblasts --- ion-releasing materials --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- enzymatic polymerization --- chemical polymerization --- poly(benzyl malate) --- biocompatible nanoparticles --- cell uptake --- cytotoxicity --- HepaRG cells --- human macrophages --- star polymers --- solution behavior --- ATRP --- SPION --- contrast agent --- MRI --- cancer diagnosis --- folate receptor --- pluronic F127 --- polylactide --- hydrolytic degradation --- mechanical properties --- PEEK copolymer synthesis --- PEEK composite --- Spine cage application --- In vitro biosafety --- degradation --- saliva --- mechanical properties --- molecular weight --- thermal properties --- activation energy of thermal decomposition --- anterior cruciate ligament reconstruction --- bone tunnel enlargement --- X-ray microtomography --- polylactide --- n/a

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Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

electrospinning --- gentamicin sulfate --- polylactide-co-polycaprolactone --- drug release kinetics --- tissue engineering --- growth factor --- diabetic --- wound healing --- nanocomposite --- electrospinning --- coaxial spinning --- core-sheath nanofibers --- biomedical --- drug delivery --- electrospinning --- scale-up --- processability --- biopharmaceuticals --- oral dosage form --- grinding --- aceclofenac --- nanofiber --- electrospinning --- scanning electron microscopy --- fourier transform infrared spectroscopy --- differential scanning calorimetry --- nanotechnology --- biotechnology --- probiotics --- Lactobacillus --- Lactococcus --- electrospinning --- nanofibers --- drying --- local delivery --- viability --- antibacterial activity --- bacterial bioreporters --- drug release --- electrospinning --- microfibers --- nanofibers --- UV imaging --- wetting --- in situ drug release --- nanofibers --- electrospinning --- poorly water-soluble drug --- piroxicam --- hydroxypropyl methyl cellulose --- polydextrose --- scanning white light interferometry --- nanotechnology --- nanofibers --- traditional electrospinning --- ultrasound-enhanced electrospinning --- drug delivery system --- haemanthamine --- plant-origin alkaloid --- electrospinning --- amphiphilic nanofibers --- self-assembled liposomes --- physical solid-state properties --- drug release --- electrospinning --- PCL --- gelatin --- clove essential oil --- antibacterial --- biocompatibility --- artificial red blood cells --- electrospinning and electrospray --- pectin --- oligochitosan --- hydrogel --- microcapsules --- electrospinning --- wound dressings --- solvent casting --- 3D printing --- polymeric carrier --- n/a

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The present book covers all research areas related to magnetic nanoparticles, magnetic nanorods, and other magnetic nanospecies, their preparation, characterization, and various applications, specifically emphasizing biomedical applications. The chapters written by the leading experts cover different subareas of the science and technology related to various magnetic nanospecies—providing broad coverage of this multifaceted area and its applications. The different topics addressed in this book will be of great interest to the interdisciplinary community active in the area of nanoscience and nanotechnology. It is hoped that this collection and its various chapters will be important and beneficial for researchers and students working in various areas related to bionanotechnology, materials science, biosensor applications, medicine, and many others. Furthermore, this book is aimed at attracting young scientists and introducing them to this field, in addition to providing newcomers with an enormous collection of literature references.

cellulase immobilization --- magnetic nanoparticles --- stability --- functionalized nanoparticles --- green chemistry --- magnetic nanoparticles --- enzyme immobilization --- controlled drug delivery --- supporting materials --- iron oxide nanoclusters --- superparticles --- magnetically responsive photonic crystals --- collective behaviors --- magnetic separation --- bioimaging --- magnetic Janus particles --- (bio)sensing --- static --- self-propelled --- magnetic nanoparticles --- iron oxide --- pharmaceutics --- magnetism --- therapy --- development --- nanotechnology --- magnetic nanoparticles (MNPs) --- cancer biomarkers --- MNPs synthesis --- MNPs functionalization --- sensors --- cancer detection --- cancer treatment --- cancer screening --- magnetic/targeted drug delivery --- optical sensor --- magnetic nanoparticle --- imaging --- surface plasmon resonance --- surface-enhanced Raman spectroscopy --- fluorescence spectroscopy --- near infrared spectroscopy --- extracellular vesicles --- superparamagnetic iron oxide nanoparticles --- magnetic resonance imaging (MRI) --- magnetic nanoparticles --- magnetic nanowires --- magnetic nanotubes --- core-shell composition --- biosensors --- Magnetic bead --- marine toxin --- toxin capture --- toxin detection --- antibody --- aptamer --- immunoassay --- immunosensor --- electrochemical biosensor --- magnetic nanoparticles --- surface functionalization --- immobilization support --- separation probe --- analytical platform --- food safety --- magnetic particles --- sensor --- biomarkers --- cells/cancer cells --- food analytes --- pathogens --- pharmaceuticals --- real sample matrices --- optical --- electrochemical --- surface sensitive methods --- NiCu magnetic nanoparticles --- physical and chemical methods --- surface modification --- biomedicine --- magnetic hyperthermia --- curie temperature --- magnetic hyperthermia --- cancer --- nanoparticles --- magnetic relaxation --- magnetic anisotropy --- heat generation --- multifunctional nanoparticles --- graphene oxide --- photothermal therapy --- magnetic nanoparticle systems --- bio-ferrofluids --- nanomedicine --- single core --- multi-core --- synthesis --- functional coating --- physical-chemical properties --- structural characterization --- magnetorheology --- magnetic nanoparticles --- nanocarriers --- controlled drug delivery --- high-resolution medical imaging --- cancer biomarkers --- circulating cancer cells --- fluorescent probes --- magnetite --- superparamagnetism --- biodetection --- magnetofection --- imaging --- therapy --- tissue engineering --- n/a