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International Cooperation for Enhancing Nuclear Safety, Security, Safeguards and Non-proliferation

Authors: --- --- ---
Book Series: Springer Proceedings in Physics ISBN: 9783030429133 Year: Pages: 222 DOI: 10.1007/978-3-030-42913-3 Language: English
Publisher: Springer Nature
Subject: Mathematics --- Agriculture (General) --- Political Science --- Science (General)
Added to DOAB on : 2020-05-14 09:27:41
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This open access book examines key aspects of international cooperation to enhance nuclear safety, security, safeguards, and nonproliferation, thereby assisting in development and maintenance of the verification regime and fostering progress toward a nuclear weapon-free world. Current challenges are discussed and attempts made to identify possible solutions and future improvements, considering scientific developments that have the potential to increase the effectiveness of implementation of international regimes, particularly in critical areas, technology foresight, and the ongoing evaluation of current capabilities.

Audacious Education Purposes

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ISBN: 9783030418823 Year: Pages: 250 DOI: 10.1007/978-3-030-41882-3 Language: English
Publisher: Springer Nature
Subject: Education
Added to DOAB on : 2020-05-14 09:29:31
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This open access book offers a comparative study of eight ambitious national reforms that sought to create opportunities for students to gain the necessary breath of skills to thrive in a rapidly changing world. It examines how national governments transform education systems to provide students opportunities to develop such skills. It analyses comprehensive education reforms in Brazil, Finland, Japan, Mexico, Peru, Poland, Portugal and Russia and yields original and important insights on the process of educational change. The analysis of these 21st century skills reforms shows that reformers followed approaches which are based on the five perspectives: cultural, psychological, professional, institutional and political. Most reforms relied on institutional and political perspectives. They highlight the systemic nature of the process of educational change, and the need for alignment and coherence among the various elements of the system in order. They underscore the importance of addressing the interests of various stakeholders of the education system in obtaining the necessary impetus to initiate and sustain change. In contrast, as the book shows, the use of a cultural and psychological frame proved rarer, missing important opportunities to draw on systematic analysis of emerging demands for schools and on cognitive science to inform the changes in the organization of instruction. Drawing on a rich array of sources and evidence the book provides a careful account of how education reform works in practice.

Understanding Game-based Approaches for Improving Sustainable Water Governance: The Potential of Serious Games to Solve Water Problems

Authors: --- --- --- --- et al.
ISBN: 9783039287628 / 9783039287635 Year: Pages: 272 DOI: 10.3390/books978-3-03928-763-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2020-06-09 16:38:57
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The sustainable governance of water resources relies on processes of multi-stakeholder collaborations and interactions that facilitate knowledge co-creation and social learning. Governance systems are often fragmented, forming a barrier to adequately addressing the myriad of challenges affecting water resources, including climate change, increased urbanized populations, and pollution. Transitions towards sustainable water governance will likely require innovative learning partnerships between public, private, and civil society stakeholders. It is essential that such partnerships involve vertical and horizontal communication of ideas and knowledge, and an enabling and democratic environment characterized by informal and open discourse. There is increasing interest in learning-based transitions. Thus far, much scholarly thinking and, to a lesser degree, empirical research has gone into understanding the potential impact of social learning on multi-stakeholder settings. The question of whether such learning can be supported by forms of serious gaming has hardly been asked. This Special Issue critically explores the potential of serious games to support multi-stakeholder social learning and collaborations in the context of water governance. Serious games may involve simulations of real-world events and processes and are challenge players to solve contemporary societal problems; they, therefore, have a purpose beyond entertainment. They offer a largely untapped potential to support social learning and collaboration by facilitating access to and the exchange of knowledge and information, enhancing stakeholder interactions, empowering a wider audience to participate in decision making, and providing opportunities to test and analyze the outcomes of policies and management solutions. Little is known about how game-based approaches can be used in the context of collaborative water governance to maximize their potential for social learning. While several studies have reported examples of serious games, there is comparably less research about how to assess the impacts of serious games on social learning and transformative change.

Keywords

simulations --- serious games --- Q-method --- integrated water resources management --- policy analysis --- nexus --- participatory modelling --- serious game --- system dynamics --- water-food-land-energy-climate --- active learning --- drinking water --- role-play --- stakeholder collaboration --- Water Safety Plan --- water supply --- serious games --- social simulation --- social learning --- relational practices --- river basin management --- water governance --- multi-party collaboration --- stakeholders --- experimental social research --- Maritime Spatial Planning (MSP) --- stakeholder participation --- serious game --- Blue Growth --- Good Environmental Status --- serious games (SGs) --- water management --- value change --- transcendental values --- social equity --- sustainability --- Schwartz’s Value Survey (SVS) --- Integrated Water Resource Management (IWRM) --- psychosocial perspectives --- decision-making processes --- assessment --- educational videogames --- online games --- water --- ecology education --- drinking water management --- peri-urban --- institutions --- gaming-simulation --- groundwater --- capacity building --- serious games --- planning support systems --- knowledge co-creation --- sustainability --- maritime spatial planning --- serious gaming --- flood --- urban --- rural --- infrastructure --- decision making --- serious games --- role-playing games --- learning-based intervention --- transformative change --- social learning --- aquaculture --- Mekong Delta --- mangrove --- gamification --- serious games --- water governance --- stakeholder participation --- sustainability --- game-based learning --- integrated water resource management (IWRM) --- natural resource management --- simulation --- serious game --- social learning --- stakeholder collaboration --- sustainability --- water governance

Health and Wellbeing in Sexual Orientation and Gender Identity

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ISBN: 9783039283682 / 9783039283699 Year: Pages: 228 DOI: 10.3390/books978-3-03928-369-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Social Sciences --- Sociology
Added to DOAB on : 2020-06-09 16:38:57
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This is a collection of published papers from a variety of authors from around the world on the topic of the health and wellbeing of minority sexual orientation and gender identity populations. Some of the included papers focused on health inequality and inequity and some focussed on healthcare delivery. Many showed how health inequities in LGBT+ groups of people were found across a wide variety of political environments and health and wellbeing topics and frequently inadequate healthcare delivery. The increasing interest in research in this area, which has been neglected in the past, shows its growing importance.

Keywords

women’s health --- sexual identity --- chronic health conditions --- Chinese gay men --- interpersonal sensitivity --- loneliness --- influencing factors --- LGBT --- gay --- lesbian --- transgender --- undergraduate medical education --- decolonizing the curriculum --- medical education --- curriculum development --- sexually transmitted diseases --- risk factors --- sexual and gender minorities --- sexual minority women --- SMW --- lesbian --- bisexual --- trans --- health inequalities --- heterosexism --- adolescents --- romantic attraction --- same-gender attraction --- both-gender attraction --- sexual minority youth --- substance use --- alcohol consumption --- drunkenness --- tobacco --- cannabis --- HBSC --- age --- gender --- same-sex marriage --- sexual orientation --- suicidality --- diversity --- gender --- health care system --- homosexuality --- LGBTI --- gay men --- content analysis --- behavioral characteristics --- GSN apps --- Blued --- LGBT --- wellbeing --- Ottawa Charter --- recognition --- Theory of Recognition --- mental health --- social inclusion and sense of community --- social participation --- community participation --- social connectedness --- community connectedness --- bullying --- sexual minority --- sexual orientation --- gender role nonconformity --- family support --- lesbian --- bisexual --- gay --- transgender --- education --- systematic review --- assessment as learning --- medical student --- game-based teaching --- gender competency --- LGBT+ friendly healthcare

Renal Cell Carcinoma

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ISBN: 9783039286386 / 9783039286393 Year: Pages: 500 DOI: 10.3390/books978-3-03928-639-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2020-06-09 16:38:57
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Renal cancer is a health problem of major concern worldwide. Although tyrosine kinase inhibitors and immune check-point blockade treatments, alone or in combination, are giving promising results, failures are quite frequent due to intratumor heterogeneity and to the acquisition of drug resistance. The spectrum of renal cell carcinoma subtypes is wide. Up to 70–80% of renal tumors are clear cell renal cell carcinomas, a clinically aggressive tumor subtype linked to VHL gene inactivation. Next in frequency, the papillary renal cell carcinoma category encompasses an intricate puzzle of classic and newly described entities with poorly defined limits, some of them pending definite clarification. Likewise, the chromophobe–oncocytoma duality, the so-called hybrid tumors and oncocytic neoplasms, remain to be well profiled. Finally, a growing list of very uncommon renal tumors linked to specific molecular signatures fulfill the current portrait of renal cell neoplasia. This Special Issue of Cancers regards RCC from very different perspectives, from the intimate basic mechanisms governing this disease to the clinical practice principles of their diagnoses and treatments. The interested reader will have the opportunity to contact with some of the most recent findings and will be updated with excellent reviews.

Keywords

ghrelin --- aurora A --- MMP10 --- invasion --- sarcomatoid --- RCC --- immunotherapy --- checkpoint inhibitors --- survival --- PD-L1 --- chronic kidney disease --- nephrectomy --- overall survival --- recurrence free survival --- renal cell carcinoma --- statins --- uric acid --- intratumour heterogeneity --- metastatic ccRCC --- copy number alteration --- mutation --- gene expression --- MiT family translocation renal cell carcinoma --- Xp11 translocation renal cell carcinoma --- t(6 --- 11) translocation renal cell carcinoma --- FISH --- TFE3 --- TFEB --- TFEB-amplified renal cell carcinoma --- renal cell carcinoma --- immune checkpoint inhibitors --- tyrosine kinase inhibitors --- efficacy --- toxicity --- cytoreductive nephrectomy --- Papillary renal cell carcinoma (pRCC) --- proteome profiling --- metabolome profiling --- glutathione metabolism --- metabolic reprogramming --- IL4R? --- IL13R?1 --- renal cell carcinoma --- JAK2 --- FOXO3 --- clear cell renal cell carcinoma --- identification of circular RNAs --- experimental validation of circular RNA --- diagnostic and prognostic markers --- circular RNAs in a clinico-genomic predictive model --- cancer-specific survival --- recurrence-free survival --- overall survival --- chromophobe renal cell carcinoma --- pale cell --- eosinophilic variant --- chromosomal loss --- copy number analysis --- renal cell carcinoma --- clear cell renal cell carcinoma --- AMP-activated protein kinases --- immunohistochemistry --- prognosis --- SMAD proteins --- transforming growth factor beta --- renal cell cancer --- microRNA --- metabolome --- proliferation --- PPP --- pentose phosphate pathway --- TCA cycle --- miR-155-5p --- miR-146a-5p --- TCGA --- renal cell carcinoma --- metastasis --- MTA2 --- MMP-9 --- miR-133b --- kidney cancer --- immunotherapy --- renal cell --- inflammation markers --- programmed death-ligand 1 --- immune checkpoint inhibitors --- prognostic factors --- predictive factors --- glutathione transferase omega 1 --- glutathione transferase omega 2 --- polymorphism --- PI3K/Akt/mTOR --- Raf/MEK/ERK --- IL-1? --- pro-IL-1? --- gene signature --- renal cancer --- survival prediction --- polybromo-1 --- PBRM1 --- renal cell carcinoma --- biomarker --- prognosis --- predictive role --- collecting duct carcinoma --- RNA sequencing --- solute carrier proteins --- kidney --- renal cell carcinoma --- molecular genetic features --- practical approach --- review --- renal cell carcinoma --- sarcomatoid --- immunotherapy --- renal cell carcinoma --- checkpoint inhibitors --- VEGF inhibitors --- mTOR inhibitors --- kidney --- emerging entity --- new entity --- oncocytic renal tumor --- unclassified renal cell carcinoma --- unclassified renal tumor --- anaplastic lymphoma kinase rearrangement --- ALK --- ESC --- HOT --- LOT --- drug sensitivity --- immune infiltration --- renal cancer --- targeted therapy --- tumor slice culture --- clear cell Renal Cell Carcinoma --- urine --- glycoproteomics --- N-glycomapping --- label-free --- glycomarkers --- everolimus --- EVI1 --- genetic association --- mTOR --- clear cell renal cell carcinoma --- curcumin --- renal cell cancer --- tumor adhesion --- tumor migration --- integrins --- NK cells --- kidney cancer --- renal cell carcinoma --- IL-2 --- cancer immunotherapy --- tumor microenvironment --- von Hippel–Lindau --- EMT like --- hyperosmolality --- chromophobe renal cell carcinoma --- copy number loss --- CDKN1A expression --- patient survival --- prognosis --- n/a

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eng (3)

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2020 (5)