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Evidence-based Positron Emission Tomography

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ISBN: 9783030477011 Year: Pages: 143 DOI: 10.1007/978-3-030-47701-1 Language: English
Publisher: Springer Nature
Subject: Medicine (General)
Added to DOAB on : 2020-07-15 23:58:54
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This open access book summarizes the findings of recent evidence-based articles (meta-analyses) on the use of positron emission tomography (PET) for various clinical indications. It is divided into five main sections, starting with an introduction to PET and meta-analysis. In turn, the second part addresses evidence-based PET in oncology, providing a broad overview of its use for different types of tumours. The remaining sections are focused on the use of PET in cardiology, in infectious and inflammatory diseases, and in neurology, respectively. Given its scope and the wealth of information it provides, the book will be an invaluable tool for clinicians with various specialties, as well as international scientific societies interested to the recent evidence-based data about PET.

Biomedical Insights that Inform the Diagnosis of ME/CFS

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ISBN: 9783039283903 9783039283910 Year: Pages: 202 DOI: 10.3390/books978-3-03928-391-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Therapeutics --- Medicine (General)
Added to DOAB on : 2020-04-07 23:07:09
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.

Keywords

myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnosis --- symptoms --- muscles --- neurology --- myalgic encephalomyelitis --- chronic fatigue syndrome --- post-exertional malaise --- assessment --- patient-driven questionnaire --- participatory research --- myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) --- energy metabolism --- potential biomarkers --- fatigue syndrome --- chronic --- exercise --- hypoacetylation --- methylhistidine --- histone deacetylation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- diagnostic biomarker --- inflammation and immunity --- metabolism --- mitochondria --- circadian rhythm --- neuro-inflammation --- myalgic encephalomyelitis --- chronic fatigue syndrome --- activin --- pathology --- biomarker --- cytokine --- machine learning --- reference intervals --- myalgic encephalomyelitis --- chronic fatigue syndrome --- ME/CFS --- diagnosis --- metabolism --- mitochondria --- inflammation --- immune system --- signaling --- gut microbiota --- tryptophan metabolism --- indoleamine-2,3-dioxygenase --- bistability --- kynurenine pathway --- substrate inhibition --- myalgic encephalomyelitis --- chronic fatigue syndrome --- mathematical model --- critical point --- immunological --- chronic fatigue syndrome --- myalgic encephalomyelitis --- biomarker --- neuroimmune --- Epstein Barr virus --- hypothalamic–pituitary–adrenal axis --- CFS (Chronic Fatigue Syndrome) --- ME (Myalgic Encephalomyelitis) --- medical retirement --- prognosis --- work rehabilitation --- n/a

Chronic Rhinosinusitis and Concomitant Medical Disorders

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ISBN: 9783039288113 / 9783039288120 Year: Pages: 88 DOI: 10.3390/books978-3-03928-812-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Surgery
Added to DOAB on : 2020-06-09 16:38:57
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It is with great pleasure that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the medical comorbidities that contribute to chronic rhinosinusitis, and, conversely, how our interventions as otolaryngologists can impact those systemic conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify the patients’ response to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease. A clear understanding of the nuances that distinguish these unique and challenging disorders is critical for the practicing otolaryngologist. Equally important, however, is a clear understanding of the powerful benefits that our interventions as otolaryngologists can have for our patients’ rhinologic and systemic health. Knowing that our rhinologic interventions might spare an asthma patient a trip to an emergency room or reduce lung infections in a cystic fibrosis patient makes this a very exciting time to be a rhinologist. We hope you enjoy this Special Issue of Medical Sciences.

Nonparametric Bayesian Learning for Collaborative Robot Multimodal Introspection

Authors: --- --- --- --- et al.
ISBN: 9789811562631 Year: Pages: 137 DOI: 10.1007/978-981-15-6263-1 Language: English
Publisher: Springer Nature
Subject: Agriculture (General) --- Mathematics --- Computer Science
Added to DOAB on : 2020-09-01 00:02:34
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This open access book focuses on robot introspection, which has a direct impact on physical human–robot interaction and long-term autonomy, and which can benefit from autonomous anomaly monitoring and diagnosis, as well as anomaly recovery strategies. In robotics, the ability to reason, solve their own anomalies and proactively enrich owned knowledge is a direct way to improve autonomous behaviors. To this end, the authors start by considering the underlying pattern of multimodal observation during robot manipulation, which can effectively be modeled as a parametric hidden Markov model (HMM). They then adopt a nonparametric Bayesian approach in defining a prior using the hierarchical Dirichlet process (HDP) on the standard HMM parameters, known as the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM). The HDP-HMM can examine an HMM with an unbounded number of possible states and allows flexibility in the complexity of the learned model and the development of reliable and scalable variational inference methods. This book is a valuable reference resource for researchers and designers in the field of robot learning and multimodal perception, as well as for senior undergraduate and graduate university students.

Carbohydrates 2018

Authors: ---
ISBN: 9783039283163 9783039283170 Year: Pages: 172 DOI: 10.3390/books978-3-03928-317-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2020-04-07 23:07:09
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This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Agroforestry Systems: The Role of Trees in Ecosystem Services—A Special Issue in Collaboration with the 4th World Congress on Agroforestry

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ISBN: 9783039281640 / 9783039281657 Year: Pages: 184 DOI: 10.3390/books978-3-03928-165-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Agriculture (General)
Added to DOAB on : 2020-06-09 16:38:57
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Planting trees in the agricultural landscape, in the form of establishing agroforestry systems, has a significant role to play in potentially improving ecosystem services, such as increased biodiversity, reduced soil erosion, increased soil carbon storage, improved food security and nutrition, and reduced greenhouse gas emissions. While the role of trees in agroforestry systems in improving ecosystem services has been researched, studies in new systems/regions and new agroforestry system designs are still emerging. This Special Issue includes selected papers presented at the 4th World Congress on Agroforestry, Montpellier, France 20–22 May 2019, and other volunteer papers. The scope of articles includes all aspects of agroforestry systems.

Cow's Milk and Allergy

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ISBN: 9783039280285 9783039280292 Year: Pages: 232 DOI: 10.3390/books978-3-03928-029-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Nutrition and Food Sciences --- Biology --- Science (General)
Added to DOAB on : 2020-01-30 16:39:46
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The purpose of this Special Issue “Cow’s Milk and Allergy” is to provide an overview of the association of cow’s milk with allergy. This topic has two quite different faces. On the one hand, we are all aware of the importance of cow’s milk allergy in early life. What is less known is that the consumption of raw, unprocessed milk is associated with a lower incidence of asthma and rhinitis. This Special Issue takes a closer look at all of these aspects of cow’s milk and allergy and focus on the following questions:

Keywords

allergic march --- cow’s milk allergy --- genome-wide association --- polygenic risk score --- food allergy --- cow’s milk --- camel milk --- infant formula --- animal models --- raw milk --- allergy --- asthma --- protection --- cow’s milk allergy --- casein --- cell-mediated reactions --- delayed-type hypersensitivity --- extracellular vesicles --- miRNA-150 --- cow’s milk allergy --- epidemiology --- natural history --- prevalence --- Cow’s milk allergy (CMA), anaphylaxis --- sensitization pattern --- cow’s milk allergens --- CAP-FEIA (Fluorescence Enzyme Immunoassay) --- multiplex dot test --- basophil activation test (BAT), human breast milk --- cow’s milk allergy --- immune system --- dietary intervention --- bioactive peptides --- gut microbiota --- prebiotics --- probiotics --- aggregation --- allergenicity --- ?-lactoglobulin --- CML --- glycation --- sRAGE --- IgE binding --- partial hydrolysate --- cow’s milk protein allergy --- hydrolysate --- infant feeding --- Middle-East --- step-down --- infant allergy --- cow’s milk allergy --- cow’s milk allergens --- diagnosis of cow’s milk allergy --- molecular diagnosis --- treatment of cow’s milk allergy --- prevention of cow’s milk allergy --- alkaline phosphatase --- allergic diseases --- food allergy --- immune regulation --- milk processing --- raw cow’s milk --- milk allergen --- baked milk --- cow’s milk --- allergenicity modulation --- proteomics --- epigenetics --- farming effect --- food allergy --- histone acetylation --- milk processing --- raw milk --- cow’s milk allergy --- milk --- hydrolysate --- asthma --- processing --- tolerance --- allergy --- cow’s milk --- formula --- therapy --- immune cells --- Immunoglubuline E

Intrinsically Biocompatible Polymer Systems

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ISBN: 9783039284207 9783039284214 Year: Pages: 270 DOI: 10.3390/books978-3-03928-421-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Materials
Added to DOAB on : 2020-04-07 23:07:09
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Biocompatibility refers to the ability of a biomaterial to perform its desired function with respect to a medical therapy, without eliciting any undesirable local or systemic effects in the recipient or beneficiary of that therapy, but generating the most appropriate beneficial cellular or tissue response in that specific situation, and optimizing the clinically relevant performance of that therapy, which reflects current developments in the area of intrinsically biocompatible polymer systems. Polymeric biomaterials are presently used as, for example, long-term implantable medical devices, degradable implantable systems, transient invasive intravascular devices, and, recently, as tissue engineering scaffolds. This Special Issue welcomes full papers and short communications highlighting the aspects of the current trends in the area of intrinsically biocompatible polymer systems.

Keywords

antimicrobial peptides --- biodegradable polymers --- biocompatible polymers --- drug delivery systems --- controlled release --- citropin --- temporin --- ionic liquids --- chitooligosaccharide --- polyurethane --- biodegradability --- physicochemical properties --- hemocompatibility --- biological activity --- crosslinking --- drug delivery --- cosmetic --- food-supplement --- functionalization --- hyaluronan applications --- hyaluronan derivatives --- hyaluronan synthases --- hyaluronic acid --- hyaluronidases --- physico-chemical properties --- cyclohexanone --- ?-butyrolactone --- chloroform --- extraction --- polyhydroxyalkanoates --- PHB --- electrospraying --- biodegradable nano/microparticles --- drug delivery --- septic arthritis --- release characteristics --- biopolymers --- silk fibroin --- konjac glucomannan --- porous beads --- scaffolds --- tissue engineering --- microcarriers --- Poly (l-lactic) acid --- Chitosan --- nanohydroxyapatite --- osteoblasts --- ion-releasing materials --- shrinkage stress --- water sorption --- hydroscopic expansion --- photoelastic investigation --- enzymatic polymerization --- chemical polymerization --- poly(benzyl malate) --- biocompatible nanoparticles --- cell uptake --- cytotoxicity --- HepaRG cells --- human macrophages --- star polymers --- solution behavior --- ATRP --- SPION --- contrast agent --- MRI --- cancer diagnosis --- folate receptor --- pluronic F127 --- polylactide --- hydrolytic degradation --- mechanical properties --- PEEK copolymer synthesis --- PEEK composite --- Spine cage application --- In vitro biosafety --- degradation --- saliva --- mechanical properties --- molecular weight --- thermal properties --- activation energy of thermal decomposition --- anterior cruciate ligament reconstruction --- bone tunnel enlargement --- X-ray microtomography --- polylactide --- n/a

Microwave Imaging and Electromagnetic Inverse Scattering Problems

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ISBN: 9783039219506 / 9783039219513 Year: Pages: 170 DOI: 10.3390/books978-3-03921-951-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Microwave imaging techniques allow for the development of systems that are able to inspect, identify, and characterize in a noninvasive fashion under different scenarios, ranging from biomedical to subsurface diagnostics as well as from surveillance and security applications to nondestructive evaluation. Such great opportunities, though, are actually severely limited by difficulties arising from the solution of the underlying inverse scattering problem. As a result, ongoing research efforts in this area are devoted to developing inversion strategies and experimental apparatus so that they are as reliable and accurate as possible with respect to reconstruction capabilities and resolution performance, respectively. The intent of this Special Issue is to present the experiences of leading scientists in the electromagnetic inverse scattering community, as well as to serve as an assessment tool for people who are new to the area of microwave imaging and electromagnetic inverse scattering problems.

Ultrasonic Guided Waves

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ISBN: 9783039282982 9783039282999 Year: Pages: 376 DOI: 10.3390/books978-3-03928-299-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-04-07 23:07:09
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The propagation of ultrasonic guided waves in solids is an important area of scientific inquiry, primarily due to their practical applications for nondestructive characterization of materials, such as nondestructive inspection, quality assurance testing, structural health monitoring, and providing a material state awareness. This Special Issue of Applied Sciences covers all aspects of ultrasonic guided waves (e.g., phased array transducers, meta-materials to control wave propagation characteristics, scattering, attenuation, and signal processing techniques) from the perspective of modeling, simulation, laboratory experiments, or field testing. In order to fully utilize ultrasonic guided waves for these applications, it is necessary to have a firm grasp of their requisite characteristics, which include that they are multimodal, dispersive, and are comprised of unique displacement profiles through the thickness of the waveguide.

Keywords

electromagnetic wave --- group velocity --- time-frequency domain reflectometry --- dispersive medium --- ultrasonic guided wave --- nondestructive testing --- square steel bar --- non-detection zone --- surface flaw --- Rayleigh wave --- scattering --- modified BEM --- reconstruction --- adhesive joint --- single lap joint --- non-destructive testing --- damage identification --- Lamb waves --- scanning laser vibrometry --- signal processing --- ultrasonic guided waves --- axial transmission --- ultrasonic guided waves --- fiber optics --- fiber Bragg grating --- nondestructive testing --- structural health monitoring --- pipe inspection --- partial wave method --- slowness curves --- lamb wave --- stoneley wave --- mode sorting --- acoustic leakage --- rayleigh wave --- surface waves --- elastodynamics --- guided waves --- lamb wave --- dispersion curves --- phase velocity --- group velocity --- signal processing --- SH0 mode --- circumferential scanning --- synthetic aperture focusing --- exploding reflector model --- Lamb wave --- local wavenumber --- air-coupled transducer --- wavenumber domain filtering --- hybrid and non-contact system --- signal processing --- SNR --- split-spectrum processing --- ultrasonic guided waves --- signal processing --- defect detection --- spatial domain --- array analysis --- pipeline inspection --- ultrasonic guided waves (UGWs) --- metamaterial --- resonator --- low-frequency --- lamb wave --- adaptive filtering --- leaky normalized mean square --- ultrasonic guided waves --- pipeline inspection --- SNR enhancement --- signal processing --- guided wave --- multi-wire cable --- wave structure --- contact acoustic nonlinearity --- energy transfer --- rail --- ultrasonic guided wave --- semi-analytical finite element --- single mode extraction algorithm --- defect location --- signal processing --- defect detection --- torsional wave --- power spectrum --- sliding window --- pipeline inspection --- ultrasonic guided-waves (UGWs) --- magnetostrictive patch transducer --- shear mode --- soft magnetic patch --- dynamic magnetic field optimization --- signal strength enhancement --- acoustic emission --- nondestructive testing --- leakage location --- fault diagnosis --- n/a --- lamb waves --- composite --- ultrasonic testing --- numerical modelling --- pressure vessels

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2020 (18)