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Small scale mechanical deformations have gained a significant interest over the past few decades, driven by the advances in integrated circuits and microelectromechanical systems. One of the most powerful and versatile characterization methods is the nanoindentation technique. The capabilities of these depth-sensing instruments have been improved considerably. They can perform experiments in vacuum and at high temperatures, such as in-situ SEM and TEM nanoindenters. This allows researchers to visualize mechanical deformations and dislocations motion in real time. Time-dependent behavior of soft materials has also been studied in recent research works. This Special Issue on ""Small Scale Deformation using Advanced Nanoindentation Techniques""; will provide a forum for researchers from the academic and industrial communities to present advances in the field of small scale contact mechanics. Materials of interest include metals, glass, and ceramics. Manuscripts related to deformations of biomaterials and biological related specimens are also welcome. Topics of interest include, but are not limited to:
multiscale --- quasicontinuum method --- surface pit defect --- size effect --- tantalum --- mammalian cells --- morphology --- biomaterials --- nanoscale --- Bi2Se3 thin films --- nanoindentation --- hardness --- pop-in --- nanoindentation --- constitutive model --- rate factor --- dimensionless analysis --- solder --- InP(100) single crystal --- Pop-in --- nanoindentation --- transmission electron microscopy --- fracture toughness --- cement paste --- miniaturized cantilever beam --- micromechanics --- fatigue --- nanoindenter --- nanoindentation --- reduced activation ferritic martensitic (RAFM) steels --- helium irradiation --- irradiation hardening --- nuclear fusion structural materials --- metallic glass --- nanoindentation --- creep --- strain rate sensitivity --- shear transformation zone --- nanoindentation --- mechanical properties --- soft biomaterials --- viscoelasticity --- atomic force microscopy (AFM) --- TSV --- nanoindentation --- FIB --- micro-cantilever beam --- mixed-mode --- fracture --- nickel --- nanoindentation --- hardness --- brittleness and ductility --- hydrogen embrittlement --- n/a
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This Special Issue examines state-of-the-art in-cell NMR spectroscopy as it relates to biological systems of increasing complexity. The compendia of research and recent innovations from prominent laboratories in the field of solid state and solution in-cell NMR spectroscopy, metabolomics and technology development are presented. The work establishes in-cell NMR spectroscopy as the premier method for determining the structures and interaction capabilities of biological molecules at high resolution within the delicately intricate interior of living cells, and the means of utilizing cells as living laboratories to directly assess the effects of exogenous and endogenous stimuli on cell physiology.]
whole cell NMR --- magic-angle spinning --- 2D INADEQUATE --- crystalline and amorphous starch --- in-cell NMR --- Tau --- MARK2 phosphorylation --- mammalian cells --- in-cell NMR --- protein structure --- protein dynamics --- drug discovery --- target engagement --- protein modification --- antimicrobial peptide --- live cell --- solid-state NMR --- DNA --- lipid membrane --- protein NMR --- in-cell NMR --- in-situ NMR --- DNP --- review --- in-cell NMR --- time-resolved NMR --- post-translational modifications --- structure function --- intrinsically disordered proteins --- Ribosome --- mRNA --- rRNA --- Thioredoxin --- Adenylate kinase --- Thymidylate synthase --- Dihydrofolate reductase --- cross-correlated relaxation --- protein interactions --- protein structure-function --- enzyme activity --- enzyme kinetics --- NMR spectroscopy --- protein structure determination 1 --- non-uniform sampling 2 --- spectrum reconstruction 3 --- structural calculation 4 --- paramagnetic effects
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