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Schizophrenia: A Consequence of Gene-Environment Interactions?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195312 Year: Pages: 126 DOI: 10.3389/978-2-88919-531-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2015-12-10 11:59:06
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Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems.

Sub-cellular Proteomics

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193028 Year: Pages: 254 DOI: 10.3389/978-2-88919-302-8 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2016-02-05 17:24:33
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Whilst significant advances have been made in whole organismal proteomics approaches, many researchers still rely on combinations of tissue selection and subcellular prefractionation methods to reduce the complexity of protein extracts from plants prior to proteomic analysis. Often this will allow identification of many lower abundance proteins of the target proteome and it may involve the selection of specific organs, cell types or the isolation of specific subcellular components. These subcellular proteomes provide insight into functions following various treatments and also contribute to the wider understanding of the entire organismal proteome by cataloguing a series of sub-proteome contents. The aim of this Research Topic is to bring together knowledge of sub cellular components in different plant species to provide a basis for accelerated research. It aims to provide a mini-review for each proposed section that summarizes the current understanding of a particular proteome, with the anticipation that every 5 - 10 years we can update these definitive publications.

The Standard Theory of Particle Physics:Essays to Celebrate CERN's 60th Anniversary

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Book Series: Advanced Series on Directions in High Energy Physics ISSN: 17931339 ISBN: 9789814733519 Year: Volume: 26 Pages: 484 DOI: 10.1142/9878 Language: English
Publisher: World Scientific Publishing Co.
Subject: Physics (General)
Added to DOAB on : 2016-09-06 09:30:00
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The book gives a quite complete and up-to-date picture of the Standard Theory with an historical perspective, with a collection of articles written by some of the protagonists of present particle physics. The theoretical developments are described together with the most up-to-date experimental tests, including the discovery of the Higgs Boson and the measurement of its mass as well as the most precise measurements of the top mass, giving the reader a complete description of our present understanding of particle physics.

A Unifying Theory of Evolution Generated by Means of Information Modelling

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Book Series: Studies in Health Technology and Informatics ISSN: 09269630 18798365 ISBN: 9781614996873 9781614996880 Year: Volume: 230 Pages: 236 DOI: 10.3233/978-1-61499-688-0-i Language: English
Publisher: IOS Press
Subject: Biology --- Genetics
Added to DOAB on : 2017-02-08 13:32:57
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"Stringent ways of thinking, ‘conceptual frameworks’, are necessary in science. The drawback is that the associated assumptions, concepts, rules and practice may become so deeply entrenched that they turn into tacit knowledge and hence give rise to constraints in scientific thought and practice – that is, a new kind of plethora that seriously blinds and thereby hampers scientific progress. This book, 'A Unifying Theory of Evolution Generated by Means of Information Modelling', presents a methodology for describing complex knowledge domains. It applies a template information model based on a dynamic structure of interrelated functions, called the Mereon Matrix. Application of this template model to the field of evolutionary theories enabled the unification of the sometimes chaotic and competing field of evolutionary theories, large and small, seamlessly in a shared framework. The author has Masters degrees in both biochemistry and computer science, as well as a European Doctorate and PhD in health informatics and has spent 35 years in full-time research. It is her particular combination of professional experience and expertise together with the template information model which has enabled her to write this book.Whilst primarily aimed at a scientific audience, and evolutionary biologists in particular, the book will be of interest to all those looking for new approaches to exploring and explaining phenomena in nature, and because the text is largely non-technical in nature, much of the content will also be accessible to a wider readership."

Non-Extensive Entropy Econometrics for Low Frequency Series. National Accounts-Based Inverse Problems

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ISBN: 9783110550443 9783110550764 Year: Pages: 218 DOI: 10.1515/9783110550443 Language: English
Publisher: De Gruyter
Subject: Economics
Added to DOAB on : 2017-08-10 13:47:31
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Non-extensive Entropy Econometrics for Low Frequency Series provides a new and robust power-law-based, non-extensive entropy econometrics approach to the economic modelling of ill-behaved inverse problems. Particular attention is paid to national account-based general equilibrium models known for their relative complexity.In theoretical terms, the approach generalizes Gibbs-Shannon-Golan entropy models, which are useful for describing ergodic phenomena. In essence, this entropy econometrics approach constitutes a junction of two distinct concepts: Jayne’s maximum entropy principle and the Bayesian generalized method of moments. Rival econometric techniques are not conceptually adapted to solving complex inverse problems or are seriously limited when it comes to practical implementation. Recent literature showed that amplitude and frequency of macroeconomic fluctuations do not substantially diverge from many other extreme events, natural or human-related, once they are explained in the same time (or space) scale. Non-extensive entropy is a precious device for econometric modelling even in the case of low frequency series, since outputs evolving within the Gaussian attractor correspond to the Tsallis entropy limiting case of Tsallis q-parameter around unity. This book introduces a sub-discipline called Non-extensive Entropy Econometrics or, using a recent expression, Superstar Generalised Econometrics. It demonstrates, using national accounts-based models, that this approach facilitates solving nonlinear, complex inverse problems, previously considered intractable, such as the constant elasticity of substitution class of functions. This new proposed approach could extend the frontier of theoretical and applied econometrics.

Charophytes: Evolutionary Ancestors of Plants and Emerging Models for Plant Research

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451647 Year: Pages: 150 DOI: 10.3389/978-2-88945-164-7 Language: English
Publisher: Frontiers Media SA
Subject: Botany --- Science (General)
Added to DOAB on : 2017-08-28 14:01:09
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The charophytes are the group of green algae that are anestral and most closely related to land plants. Today, these organisms are not only important in evoutionary studies but have become outstanding model organisms for plant research.

Empirical modelling of translation and interpreting

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Book Series: Translation and Multilingual Natural Language Processing ISBN: 9783961100248 9783961100255 Year: Pages: 522 DOI: 10.5281/zenodo.1089335 Language: English
Publisher: Language Science Press
Subject: Linguistics
Added to DOAB on : 2018-01-13 11:01:52
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"Empirical research is carried out in a cyclic way: approaching a research area bottom-up, data lead to interpretations and ideally to the abstraction of laws, on the basis of which a theory can be derived. Deductive research is based on a theory, on the basis of which hypotheses can be formulated and tested against the background of empirical data. Looking at the state-of-the-art in translation studies, either theories as well as models are designed or empirical data are collected and interpreted. However, the final step is still lacking: so far, empirical data has not lead to the formulation of theories or models, whereas existing theories and models have not yet been comprehensively tested with empirical methods. This publication addresses these issues from several perspectives: multi-method product- as well as process-based research may gain insights into translation as well as interpreting phenomena. These phenomena may include cognitive and organizational processes, procedures and strategies, competence and performance, translation properties and universals, etc. Empirical findings about the deeper structures of translation and interpreting will reduce the gap between translation and interpreting practice and model and theory building. Furthermore, the availability of more large-scale empirical testing triggers the development of models and theories concerning translation and interpreting phenomena and behavior based on quantifiable, replicable and transparent data."

Hvorfor vokser steder?

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ISBN: 9788202549893 Year: Pages: 217 DOI: 10.23865/noasp.32 Language: Uncoded
Publisher: Cappelen Damm Akademisk/NOASP (Nordic Open Access Scholarly Publishing)
Subject: Sociology --- History --- Migration
Added to DOAB on : 2018-03-22 11:01:57
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"Why do some places grow while others are shrinking? What are the most important driving forces behind increases in the number of inhabitants and jobs? How can places affect their own growth? This book is written for those who want to understand how structural forces affect the development of their locale and how one can create growth through increased attractiveness. Most Norwegian municipalities, cities, regions and counties try to stimulate growth and development in their localities. They want growth in the population and more jobs. This book describes the main features of regional development in Norway since 2000. Telemark Research Institute has proposed a new model, the attractiveness model, to explain the growth and development of places. This book explains how this model works, how it is constructed and how it can be used to understand the forces behind regional development."

Hillslope and Watershed Hydrology

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ISBN: 9783038429517 9783038429524 Year: Pages: 246 DOI: 10.3390/books978-3-03842-952-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences
Added to DOAB on : 2018-09-14 11:41:26
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Watershed hydrology is driven by climate forcing, near ground surface characteristics, and human activities, addressing a wide spectrum of environmental and water resource problems regarding both scientific-driven questions and practical engineering issues. This book collates watershed problems and solutions from around the world covering diverse climate types. These cases show complex interactions between hydrological processes and environmental conditions and scientific methods for understanding the hydrological regime and management of human activities. This book can be used as a state-of-the-art resource for academic researchers and water resource professionals, and will also appeal to students, scholars, and general readers interested in watershed models, water management, environmental management, climate change impact assessment, or ecohydrologic interactions.

Sustainable Governance in Northeast Asia: Challenges for Innovation Frontier

Authors: --- ---
ISBN: 9783038971535 9783038971542 Year: Pages: 274 DOI: 10.3390/books978-3-03897-154-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Business and Management --- Social Sciences
Added to DOAB on : 2018-09-21 12:02:45
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This special edition is based on the annual conference of Sustainable Asia Conference (http://abf.inha.ac.kr/). The purpose of the conference is to work together for our future challenges. Every year more than 50 papers are presented in the conference and published in the special edition of Sustainability. Your participation on the next SAC conference shall greatly enhance our research human network. Once a friend, forever friend, it is our slogan for the conference.

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