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Pattern recognition receptors and cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196746 Year: Pages: 201 DOI: 10.3389/978-2-88919-674-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-08-16 10:34:25
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The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.

Computer and Information Sciences: 31st International Symposium, ISCIS 2016, Kraków, Poland, October 27–28, 2016, Proceedings

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Book Series: Communications in Computer and Information Science ISSN: 1865-0929 ISBN: 9783319472164 9783319472171 Year: Volume: 659 Pages: 278 DOI: 10.1007/978-3-319-47217-1 Language: English
Publisher: Springer Nature
Subject: Business and Management --- Transportation --- Manufactures --- Biotechnology --- Therapeutics --- Electrical and Nuclear Engineering
Added to DOAB on : 2017-03-08 12:46:55
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This book constitutes the refereed proceedings of the 31st International Symposium on Computer and Information Sciences, ISCIS 2016, held in Krakow, Poland, in October 2016.The 29 revised full papers presented were carefully reviewed and selected from 65 submissions. The papers are organized in topical sections on smart algorithms; data classification and processing; stochastic modelling; performance evaluation; queuing systems; wireless networks and security; image processing and computer vision.

Marine Glycobiology, Glycomics and Lectins

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ISBN: 9783039218202 9783039218219 Year: Pages: 176 DOI: 10.3390/books978-3-03921-821-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-12-09 16:39:37
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Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences.This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.

Selected Papers from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP)

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ISBN: 9783039210404 9783039210411 Year: Pages: 194 DOI: 10.3390/books978-3-03921-041-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This Special Issue contains a series of excellent research works on telecommunications and signal processing, selected from the 2018 41st International Conference on Telecommunications and Signal Processing (TSP) which was held on July 4–6, 2018, in Athens, Greece. The conference was organized in cooperation with the IEEE Region 8 (Europe, Middle East, and Africa), IEEE Greece Section, IEEE Czechoslovakia Section, and IEEE Czechoslovakia Section SP/CAS/COM Joint Chapter by seventeen universities from the Czech Republic, Hungary, Turkey, Taiwan, Japan, Slovak Republic, Spain, Bulgaria, France, Slovenia, Croatia, and Poland, for academics, researchers, and developers, and serves as a premier international forum for the annual exchange and promotion of the latest advances in telecommunication technology and signal processing. The aim of the conference is to bring together both novice and experienced scientists, developers, and specialists, to meet new colleagues, collect new ideas, and establish new cooperation between research groups from universities, research centers, and private sectors worldwide. This collection of 10 papers is highly recommended for researchers, and believed to be interesting, inspiring, and motivating for readers in their further research.

Cyberpunk in a Transnational Context

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ISBN: 9783039214211 9783039214228 Year: Pages: 122 DOI: 10.3390/books978-3-03921-422-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Arts in general --- Performing Arts
Added to DOAB on : 2019-12-09 11:49:15
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Mike Mosher’s “Some Aspects of Californian Cyberpunk” vividly reminds us of the influence of West Coast counterculture on cyberpunks, with special emphasis on 1960s theoretical gurus such as Timothy Leary and Marshall McLuhan, who explored the frontiers of inner space as well as the global village. Frenchy Lunning’s “Cyberpunk Redux: Dérives in the Rich Sight of Post-Anthropocentric Visuality” examines how the heritage of Ridley Scott’s techno-noir film

Earth Observation, Remote Sensing and Geoscientific Ground Investigations for Archaeological and Heritage Research

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ISBN: 9783039211937 9783039211944 Year: Pages: 304 DOI: 10.3390/books978-3-03921-194-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General)
Added to DOAB on : 2019-08-28 11:21:27
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This book collects 15 papers written by renowned scholars from across the globe that showcase the forefront research in Earth observation (EO), remote sensing (RS), and geoscientific ground investigations to study archaeological records and cultural heritage.Archaeologists, anthropologists, geographers, remote sensing, and archaeometry experts share their methodologies relying on a wealth of techniques and data including, but not limited to: very high resolution satellite images from optical and radar space-borne sensors, air-borne surveys, geographic information systems (GIS), archaeological fieldwork, and historical maps.A couple of the contributions highlight the value of noninvasive and nondestructive laboratory analyses (e.g., neutron diffraction) to reconstruct ancient manufacturing technologies, and of geological ground investigations to corroborate hypotheses of historical events that shaped cultural landscapes.Case studies encompass famous UNESCO World Heritage Sites (e.g., the Nasca Lines in Peru), remote and yet-to-discover archaeological areas in tropical forests in central America, European countries, south Asian changing landscapes, and environments which are arid nowadays but were probably full of woody vegetation in the past.Finally, the reader can learn about the state-of-the-art of education initiatives to train site managers in the use of space technologies in support of their activities, and can understand the legal aspects involved in the application of EO and RS to address current challenges of African heritage preservation.

Keywords

analytic hierarchy process (AHP) --- archaeology --- predictive model --- tumuli --- remote sensing --- multi-criteria --- Saharan Morocco --- airborne laser scanning --- orthophotographs --- archaeological survey --- field reconnaissance --- Arran --- national archaeological mapping programme --- synthetic aperture radar --- subsurface imaging --- microwave penetration --- archaeology --- arid environments --- remote sensing --- Oman --- e-learning --- Earth observation --- education --- capacity development --- cultural and natural heritage --- UNESCO --- photogrammetry --- RPAS --- UAV --- Peru --- geoglyph Pista --- mapping --- drones --- remote sensing --- free satellite imagery --- GoogleEarth --- Bing Maps --- archaeological fieldwork --- arid environments --- basalt desert --- landscape accessibility --- Harra --- Jordan --- archaeological landscapes --- settlements --- historical maps --- Survey of India --- Archaeological Survey of India --- heritage --- colonial studies --- remote sensing --- historical landscapes --- landscape archaeology --- settlements --- colonial studies --- river morphology --- Indus --- floods --- remote sensing --- satellite --- Sentinel-2 --- surface survey --- Roman archaeology --- Sumerian pottery --- neutron techniques --- neutron diffraction --- chemometric analysis --- Mega El Niño --- pampa of Nazca --- Cuenca Pisco --- Rio Grande de Nazca --- grain-size --- volcaniclastic layer --- stratigraphy --- petrography --- Lidar --- GIS --- Mesoamerica --- Archaeology --- Caves --- Landscape --- Ritual --- Visualization --- Maya --- Belize --- Sacred --- automated detection --- OBIA --- LiDAR --- Difference Map --- field monument --- Burial Mound --- Motte-and-Bailey castle --- Ridge and Furrow --- space law --- disaster and conservation management --- Geographic Information System (GIS) --- international boundaries --- Africa --- Cameroon-Nigeria Mixed Commission --- satellite imagery --- Boundary Demarcation --- international law --- relict boundaries --- Earth Observation --- remote sensing --- optical --- SAR --- drone --- airborne LiDAR --- GIS --- OBIA --- neutron diffraction --- archaeological prospection --- pattern recognition --- archaeometry --- geological mapping

Nanoelectronic Materials, Devices and Modeling

Authors: ---
ISBN: 9783039212255 9783039212262 Year: Pages: 242 DOI: 10.3390/books978-3-03921-226-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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As CMOS scaling is approaching the fundamental physical limits, a wide range of new nanoelectronic materials and devices have been proposed and explored to extend and/or replace the current electronic devices and circuits so as to maintain progress with respect to speed and integration density. The major limitations, including low carrier mobility, degraded subthreshold slope, and heat dissipation, have become more challenging to address as the size of silicon-based metal oxide semiconductor field effect transistors (MOSFETs) has decreased to nanometers, while device integration density has increased. This book aims to present technical approaches that address the need for new nanoelectronic materials and devices. The focus is on new concepts and knowledge in nanoscience and nanotechnology for applications in logic, memory, sensors, photonics, and renewable energy. This research on nanoelectronic materials and devices will be instructive in finding solutions to address the challenges of current electronics in switching speed, power consumption, and heat dissipation and will be of great interest to academic society and the industry.

Keywords

UAV --- vision localization --- hierarchical --- landing --- information integration --- memristor --- synaptic device --- spike-timing-dependent plasticity --- neuromorphic computation --- memristive device --- ZnO films --- conditioned reflex --- quantum dot --- sample grating --- cross-gain modulation --- bistability --- distributed Bragg --- semiconductor optical amplifier --- topological insulator --- field-effect transistor --- nanostructure synthesis --- optoelectronic devices --- topological magnetoelectric effect --- drain-induced barrier lowering (DIBL) --- gate-induced drain leakage (GIDL) --- silicon on insulator (SOI) --- graphene --- supercapacitor --- energy storage --- ionic liquid --- UV irradiation --- luminescent centres --- bismuth ions --- two-photon process --- oscillatory neural networks --- pattern recognition --- higher order synchronization --- thermal coupling --- vanadium dioxide --- band-to-band tunneling --- L-shaped tunnel field-effect-transistor --- double-gate tunnel field-effect-transistor --- corner-effect --- AlGaN/GaN --- high-electron mobility transistor (HEMTs) --- p-GaN --- enhancement-mode --- 2DEG density --- InAlN/GaN heterostructure --- polarization effect --- quantum mechanical --- gallium nitride --- MISHEMT --- dielectric layer --- interface traps --- current collapse --- PECVD --- gate-induced drain leakage (GIDL) --- drain-induced barrier lowering (DIBL) --- recessed channel array transistor (RCAT) --- on-current (Ion) --- off-current (Ioff) --- subthreshold slope (SS) --- threshold voltage (VTH) --- saddle FinFET (S-FinFET) --- potential drop width (PDW) --- shallow trench isolation (STI) --- source/drain (S/D) --- conductivity --- 2D material --- Green’s function --- reflection transmision method --- variational form --- dual-switching transistor --- third harmonic tuning --- low voltage --- high efficiency --- CMOS power amplifier IC --- insulator–metal transition (IMT) --- charge injection --- Mott transition --- conductive atomic force microscopy (cAFM) --- gate field effect --- atomic layer deposition (ALD) --- zinc oxide --- silicon --- ZnO/Si --- electron affinity --- bandgap tuning --- conduction band offset --- heterojunction --- solar cells --- PC1D --- vertical field-effect transistor (VFET) --- back current blocking layer (BCBL) --- gallium nitride (GaN) --- normally off power devices --- n/a

Non-destructive Testing of Materials in Civil Engineering

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ISBN: 9783039216901 9783039216918 Year: Pages: 448 DOI: 10.3390/books978-3-03921-691-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:16
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This book was proposed and organized as a means to present recent developments in the field of nondestructive testing of materials in civil engineering. For this reason, the articles highlighted in this editorial relate to different aspects of nondestructive testing of different materials in civil engineering—from building materials to building structures. The current trend in the development of nondestructive testing of materials in civil engineering is mainly concerned with the detection of flaws and defects in concrete elements and structures, and acoustic methods predominate in this field. As in medicine, the trend is towards designing test equipment that allows one to obtain a picture of the inside of the tested element and materials. From this point of view, interesting results with significance for building practices have been obtained

Keywords

non-destructive testing --- masonry structures --- strengthening --- ultrasonic tomography --- adhesion assessment --- autoclaved aerated concrete (AAC) --- compressive strength --- shape and size of specimen --- moisture of AAC --- ultrasonic testing --- gantry crane --- RMF technique --- civil engineering --- fibre-cement boards --- non-destructive testing --- acoustic emission --- degree of degradation --- thermovision --- active thermography --- thermal contrast --- defect detection --- location of inclusions --- non-destructive testing --- materials research --- building partition --- cement-based composites --- fiber cement boards --- durability --- ultrasound measurements --- spun concrete --- micro-computed tomography --- nanoindentation --- deconvolution --- mathematical morphology --- non-destructive evaluation --- structural damage --- natural frequency --- singular value truncation --- multiple feedbacks --- data noise --- NDT methods --- rebar location --- eddy-current method --- GPR method --- concrete --- concrete mix design --- concrete strength prediction --- data mining --- machine learning --- timber structures --- non-destructive methods --- ultrasonic wave --- stress wave --- drilling resistance --- X-ray micro-computed tomography --- waste brick dust --- adsorption --- lead --- cesium --- surface complexation --- precipitation --- solid-state NMR spectroscopy --- Lamb waves --- scanning laser vibrometry --- adhesive joints --- non-destructive testing --- damage detection --- excitation frequency --- nondestructive testing --- thermography --- monitoring of structures --- reinforced concrete chimney --- corrosion processes --- service life of a structure --- viscoelastic parameters --- creep test --- fatigue tests --- asphalt mixtures --- Burgers model --- four point bending beam --- pattern recognition --- acoustic emission --- Structural Health Monitoring --- brittle fracture --- diagnostics --- non-destructive testing --- reinforced concrete grandstand stadium --- vibration analysis --- crowd-induced excitation --- structural tuning --- concrete slabs and floorings --- horizontal casting --- compressive strength --- ultrasonic tests --- fibre-cement boards --- non-destructive testing --- acoustic emission --- artificial neural networks --- SEM --- non-destructive method --- damage --- mercury intrusion porosimetry --- X-ray computed tomography --- acoustic emission AE --- acoustic spectrum --- quasi brittle cement composites --- destruction process --- resistance measurement --- wood moisture sensing --- non-destructive testing --- moisture safety --- cellulose fibre cement boards --- microstructure --- nanoindentation --- SEM-EDS analysis --- temperature --- concrete elements --- concrete strength --- reinforced concrete tanks --- concrete corrosion --- sulphate corrosion --- ultrasound tests --- rebound hammer --- SilverSchmidt --- concrete --- compressive strength --- non-destructive testing --- non-destructive testing --- diagnostic --- acoustic methods --- ultrasound --- building materials --- defects

Plant Proteomic Research 2.0

Author:
ISBN: 9783039210626 9783039210633 Year: Pages: 594 DOI: 10.3390/books978-3-03921-063-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2019-06-26 08:44:07
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Advancements in high-throughput “Omics” techniques have revolutionized plant molecular biology research. Proteomics offers one of the best options for the functional analysis of translated regions of the genome, generating a wealth of detailed information regarding the intrinsic mechanisms of plant stress responses. Various proteomic approaches are being exploited extensively for elucidating master regulator proteins which play key roles in stress perception and signaling, and these approaches largely involve gel-based and gel-free techniques, including both label-based and label-free protein quantification. Furthermore, post-translational modifications, subcellular localization, and protein–protein interactions provide deeper insight into protein molecular function. Their diverse applications contribute to the revelation of new insights into plant molecular responses to various biotic and abiotic stressors.

Keywords

Phalaenopsis --- petal --- pollination --- senescence --- 2-DE --- ROS --- Medicago sativa --- leaf cell wall proteome --- cadmium --- quantitative proteomics --- 2D DIGE --- chloroplast --- elevated CO2 --- heat stress --- nucleotide pyrophosphatase/phosphodiesterase --- (phospho)-proteomics --- photosynthesis --- protein phosphorylation --- 14-3-3 proteins --- Oryza sativa L. --- starch --- sucrose --- N utilization efficiency --- proteomics --- 2D --- protein phosphatase --- rice isogenic line --- SnRK1 --- 14-3-3 --- lettuce --- bolting --- proteome --- high temperature --- iTRAQ --- proteome profiling --- iTRAQ --- differentially abundant proteins (DAPs) --- drought stress --- physiological responses --- Zea mays L. --- GS3 --- ? subunit --- heterotrimeric G protein --- mass spectrometric analysis --- RGG3 --- rice --- western blotting --- Dn1-1 --- ?-subunit --- heterotrimeric G protein --- mass spectrometry analysis --- RGG4 --- rice --- western blotting --- Clematis terniflora DC. --- polyphenol oxidase --- virus induced gene silencing --- photosynthesis --- glycolysis --- Camellia sinensis --- chlorotic mutation --- chlorophyll deficiency --- weakening of carbon metabolism --- iTRAQ --- proteomics --- degradome --- wheat --- cultivar --- protease --- papain-like cysteine protease (PLCP) --- subtilase --- metacaspase --- caspase-like --- wheat leaf rust --- Puccinia recondita --- Stagonospora nodorum --- iTRAQ --- proteomics --- somatic embryogenesis --- pyruvate biosynthesis --- Zea mays --- chlorophylls --- LC-MS-based proteomics --- pea (Pisum sativum L.) --- proteome functional annotation --- proteome map --- seeds --- seed proteomics --- late blight disease --- potato proteomics --- Phytophthora infestans --- Sarpo Mira --- early and late disease stages --- Simmondsia chinensis --- cold stress --- proteomics --- leaf --- iTRAQ --- Ricinus communis L. --- cold stress --- seed imbibition --- iTRAQ --- proteomics --- Morus --- organ --- gel-free/label-free proteomics --- flavonoid --- antioxidant activity --- phosphoproteome --- barley --- seed dormancy --- germination --- imbibition --- after-ripening --- sugarcane --- Sporisorium scitamineum --- smut --- proteomics --- RT-qPCR --- ISR --- holm oak --- Quercus ilex --- 2-DE proteomics --- shotgun proteomics --- non-orthodox seed --- population variability --- stresses responses --- ammonium --- Arabidopsis thaliana --- carbon metabolism --- nitrogen metabolism --- nitrate --- proteomics --- root --- secondary metabolism --- proteomics --- wheat --- silver nanoparticles --- plant pathogenesis responses --- data-independent acquisition --- quantitative proteomics --- Pseudomonas syringae --- sweet potato plants infected by SPFMV --- SPV2 and SPVG --- sweet potato plants non-infected by SPFMV --- SPV2 and SPVG --- co-infection --- transcriptome profiling --- gene ontology --- pathway analysis --- lesion mimic mutant --- leaf spot --- phenylpropanoid biosynthesis --- proteomics --- isobaric tags for relative and absolute quantitation (iTRAQ) --- rice --- affinity chromatography --- ergosterol --- fungal perception --- innate immunity --- pattern recognition receptors --- plasma membrane --- proteomics --- proteomics --- maize --- plant-derived smoke --- shoot --- Solanum tuberosum --- patatin --- seed storage proteins --- vegetative storage proteins --- tuber phosphoproteome --- targeted two-dimensional electrophoresis --- B. acuminata petals --- MALDI-TOF/TOF --- GC-TOF-MS --- qRT-PCR --- differential proteins --- n/a

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