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Muscle Cell and Tissue - Current Status of Research Field

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ISBN: 9781789840056 9781789840063 Year: Pages: 370 DOI: 10.5772/intechopen.71591 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:52

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In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.

Biomaterial-supported Tissue Reconstruction or Regeneration

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ISBN: 9781838803773 9781838803780 9781838804336 Year: Pages: 162 DOI: 10.5772/intechopen.77756 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:53

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This book is a collection of chapters from different biomaterial experts, including their design, new insights into the molecular basis of their interaction with the organism, and their successful application. The chapters have been organized to illustrate different aspects of multidisciplinary biomaterial science. Thus, this book should give readers a view into the different biomaterial disciplines and methodologies that are needed for specific clinical applications.

Cartilage Tissue Engineering and Regeneration Techniques

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ISBN: 9781789238495 9781789238501 9781838807818 Year: Pages: 158 DOI: 10.5772/intechopen.77717 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 07:51:53

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Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Tissue Engineering

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ISBN: 9789533070797 Year: Pages: 536 DOI: 10.5772/189 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 09:47:08

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The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues that closely match the patient’s needs can be reconstructed from readily available biopsies and subsequently be implanted with minimal or no immunogenicity. This eventually conquers several limitations encountered in tissue transplantation approaches. This book serves as a good starting point for anyone interested in the application of Tissue Engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications.

Applied Tissue Engineering

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ISBN: 9789533076898 Year: Pages: 98 DOI: 10.5772/2630 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 09:47:08

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Tissue engineering, which aims at regenerating new tissues, as well as substituting lost organs by making use of autogenic or allogenic cells in combination with biomaterials, is an emerging biomedical engineering field. There are several driving forces that presently make tissue engineering very challenging and important: 1) the limitations in biological functions of current artificial tissues and organs made from man-made materials alone, 2) the shortage of donor tissue and organs for organs transplantation, 3) recent remarkable advances in regeneration mechanisms made by molecular biologists, as well as 4) achievements in modern biotechnology for large-scale tissue culture and growth factor production. This book was edited by collecting all the achievement performed in the laboratory of oral and maxillofacial surgery and it brings together the specific experiences of the scientific community in these experiences of our scientific community in this field as well as the clinical experiences of the most renowned experts in the fields from all over Nagoya University. The editors are especially proud of bringing together the leading biologists and material scientists together with dentist, plastic surgeons, cardiovascular surgery and doctors of all specialties from all department of the medical school of Nagoya University. Taken together, this unique collection of world-wide expert achievement and experiences represents the current spectrum of possibilities in tissue engineered substitution.

New Trends in Tissue Engineering and Regenerative Medicine - Official Book of the Japanese Society for Regenerative Medicine

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ISBN: 9789535117247 9789535142317 Year: Pages: 132 DOI: 10.5772/58896 Language: English
Publisher: IntechOpen
Subject: Medicine (General)
Added to DOAB on : 2019-10-03 09:47:09

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This book is an edited collection of all the achievements of the main members of the Dental Division of the Japanese Society for Regenerative Medicine, which derives from the Japanese Forum for Regenerative Dentistry established in 2003. Scientific meetings held by these organizations gleaned specific experiences of the academic community as well as clinical experiences of the most renowned experts in the field of dentistry. The editors are especially proud of bringing together leading biologists and dentists of all specialties. This unique collection of reports on the achievements and experiences of experts from all over the world represents the current spectrum of possibilities in tissue engineering of substitutes not only in dentistry but also in medicine.

This book has been produced and distributed with the support from The Japanese Society for Regenerative Medicine.

Dilated Cardiomyopathy

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ISBN: 9783030138646 Year: Pages: 241 DOI: 10.1007/978-3-030-13864-6 Language: English
Publisher: Springer Nature
Subject: Medicine (General) --- Biology
Added to DOAB on : 2020-02-05 11:21:10
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This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Adult neurogenesis twenty years later: physiological function versus brain repair

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194940 Year: Pages: 120 DOI: 10.3389/978-2-88919-494-0 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2015-11-16 15:44:59
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The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.

Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197774 Year: Pages: 102 DOI: 10.3389/978-2-88919-777-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Somatic stem cells reside in definite compartments, known as “niches”, within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organ, including brain and heart. The adult bone marrow, in particular, houses a complex multifunctional niche comprising hemopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), that intensely interact. HSCs represent the common precursors of all mature blood cells. MSCs are instead able to differentiate along multiple mesodermal lineages and are believed to represent the key somatic stem cell within the skeletogenic niche, being conceptually able to produce any tissue included within a mature skeletal segment (bone, cartilage, blood vessels, adipose tissue, and supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal lineages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors’ lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreaking research achievements in the field of regenerative medicine, along with the pressing need for effective innovative tools for the treatment of neurodegeneration and neurologic disorders, have been forcing experimental clinical applications, which, despite their scientific weakness, have recently stimulated the public opinion. Based on this contemporary background, this Research Topic wish to provide an in-depth revision of the state of the art on relevant scientific milestones addressing the differences and possible interconnections and overlaps, between the osteogenic and the neurogenic niches. Dissertations on both basic research and clinical aspects, along with ethical and regulatory issues on the use of somatic stem cells for in vivo transplantation, have been covered.

Bioethics Across the Globe

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ISBN: 9789811535727 Year: Pages: 146 DOI: 10.1007/978-981-15-3572-7 Language: English
Publisher: Springer Nature
Subject: Biology
Added to DOAB on : 2020-06-16 23:58:49
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This open access book addresses a variety of issues relating to bioethics, in order to initiate cross-cultural dialogue. Beginning with the history, it introduces various views on bioethics, based on specific experiences from Japan. It describes how Japan has been confronted with Western bioethics and the ethical issues new to this modern age, and how it has found its foothold as it decides where it stands on these issues. In the last chapter, the author proposes discarding the overarching term ‘Global Bioethics’ in favor of the new term, ‘Bioethics Across the Globe (BAG)’, which carries a more universal connotation. This book serves as an excellent tool to help readers understand a different culture and to initiate deep and genuine global dialogue that incorporates local and global thinking on bioethics. Bioethics Across the Globe is a valuable resource for researchers in the field of bioethics/medical ethics interested in adopting cross-cultural approaches, as well as graduate and undergraduate students of healthcare and philosophy.

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