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Data-Based Radiation Oncology - Design of Clinical Trials

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454389 Year: Pages: 109 DOI: 10.3389/978-2-88945-438-9 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-11-16 17:17:57
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In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients?Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable.In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management.

Berufliche Bildung in Deutschland

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Book Series: Reihe Materialien zur Berufs- und Arbeitspädagogik der Projektgruppe Vergleichende Berufspädagogik ISBN: 9783866442580 Year: Volume: 14 Pages: 558 DOI: 10.26530/OAPEN_422394 Language: German
Publisher: KIT Scientific Publishing
Subject: Political Science --- Education
Added to DOAB on : 2012-07-29 10:36:06
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Informative Psychometric Filters

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ISBN: 9781920942663 Year: Pages: 310 DOI: 10.26530/OAPEN_459293 Language: English
Publisher: ANU Press
Subject: Psychology
Added to DOAB on : 2014-01-27 08:26:29
License: ANU Press

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Psychometrics; Psychological tests; Human being; Case study; Classification; Reliability

El estudiante liberal: sociología y vida de la comunidad escolar universitaria de Valencia (1875-1939)

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Book Series: Historia de las Universidades ISSN: 18860710 ISBN: 9788498497014 Year: Volume: 17 Pages: 326 Language: Spanish
Publisher: Universidad Carlos III de Madrid. Figuerola Institute of Social Science History
Subject: History
Added to DOAB on : 2014-07-04 11:55:10
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Con la Restauración Borbónica quedaba consolidado el sistema político que iba a marcar las siguientes décadas de la historia española. Lo conocemos como el Estado liberal, y abarcaba todas las esferas de la sociedad, entre ellas la educación superior. Se completaba la creación de una universidad liberal acorde al nuevo modelo, en la que habitaba un nuevo tipo estudiantil, un estudiante liberal. Queremos saber quién integraba este grupo, cuál era su origen y composición y cómo evolucionó. Nos interesa ver cómo afrontaba sus años académicos, en los que se relacionaba con los espacios físicos, la legislación o el profesorado de esta nueva universidad. Aspiramos a entender cómo vivía el día a día de su condición estudiantil, así dentro de las facultades como en la ciudad que les acogía, y a acercarnos a su mentalidad a través de las manifestaciones que como corporación realizaba. Nos centramos para ello en una universidad intermedia, la de Valencia, lo bastante reducida como para ser abarcable, pero suficientemente importante como para ser en gran medida representativa de la generalidad. En suma, se trata de dibujar el nuevo tipo estudiantil, con sus cambios y sus permanencias, conectado con el sistema liberal del que era a la vez resultado y miembro, entre los años que separaron los golpes de Estado de 1875 y de 1936.

Chapter: 'Does Taking a MOOC as a Complement for Remedial Courses Have an Effect on My Learning Outcomes? A Pilot Study on Calculus' from book: Adaptive and Adaptable Learning: 11th European Conference on Technology Enhanced Learning, EC-TEL 2016, Lyon, France, September 13-16, 2016, Proceedings (Book chapter)

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Book Series: Lecture Notes in Computer Science ISSN: 0302-9743 / 1611-3349 ISBN: 9783319451527 9783319451534 Year: Pages: 12 DOI: 10.1007/978-3-319-45153-4_17 Language: English
Publisher: Springer
Subject: Education
Added to DOAB on : 2017-11-27 16:03:42
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This paper presents the results of a pilot study about students’ adoption and learning outcomes of 4 MOOCs proposed as a complementary resource for traditional remedial courses on calculus. While the MOOCs were not mandatory, traditional remedial courses were required for those freshmen failing a diagnostic exam. The effects on 589 freshmen students were investigated. The data analysis shows that up to 16 % of the students were active in the MOOCs under study, mostly during the days before taking the diagnostic exam that preceded the traditional face-to-face remedial courses. Trace data about learner actions within the platform were collected as well as the students’ scores. According to a statistical comparison of the students’ exam scores and their interaction behavior with the MOOCs, we observe that active students had more chances of passing the diagnostic exam and skipping the required remedial courses. However, we found no significant differences on the remedial course exam scores between the students that were active in the MOOCs and those that were not. These findings suggest that MOOCs are a good solution to strengthening skills and reviewing concepts, but that more guidance is needed when used as a complement to traditional f2f courses.

Born in 1953

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ISBN: 9789176350843 9789176350874 9789176350850 9789176350867 Year: Pages: 284 DOI: 10.16993/bav Language: English
Publisher: Stockholm University Press
Subject: Philosophy --- Social Sciences
Added to DOAB on : 2019-01-15 13:33:11
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"At the beginning of the 1960s, Swedish researchers started a sociological study of all children born in Stockholm in 1953, Project Metropolitan. This book describes the project’s at times dramatic history, where issues of personal integrity and the role of social sciences were heavily debated. These discussions were fueled by the rapid and far-reaching digitalization in society at large and also within social sciences. As such, Project Metropolitan came to symbolize the benefits and potential risks related to an expanding body of research based on large groups of individuals and multiple register data sources.&#xD;At the outset, the project’s founders sought to answer the following question: “Why do some get on better in life than others?” One of the main aims of the project was to study the long-term impact of conditions in childhood. The book therefore also includes an updated presentation of the main findings, as they have been conveyed in over 160 publications to date. These publications cover a wide array of topics and phenomena such as social mobility and education, substance abuse and crime, health and ill-health, peer influences and family relations, and adult lives of adopted children.&#xD;Today Project Metropolitan is known as the “Stockholm Birth Cohort Multigenerational Study (SBC Multigen)” and is still in full vigor. From its original group of 15,000 children, the study has become multi-generational by adding data about their parents, siblings, children, nieces and nephews. As they approach their late 60s, it will also be possible to follow these “children” into retirement and old-age.&#xD;In the concluding chapter the author discusses some of the challenges contemporary social research is facing. What are the current threats to academic freedom and what opportunities do the unique data registers in countries like Sweden provide?"&#xD;

Keywords

Sociology --- Cohort study --- Longitudinal --- Sweden --- Post-war --- Welfare

Wiki Writing: Collaborative Learning in the College Classroom

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ISBN: 9780472116713 9780472024513 Year: Language: English
Publisher: University of Michigan Press
Subject: Languages and Literatures
Added to DOAB on : 2012-04-06 14:29:55
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When most people think of wikis, the first—and usually the only—thing that comes to mind is Wikipedia. The editors of Wiki Writing: Collaborative Learning in the College Classroom, Robert E. Cummings and Matt Barton, have assembled a collection of essays that challenges this common misconception, providing an engaging and helpful array of perspectives on the many pressing theoretical and practical issues that wikis raise. Written in an engaging and accessible manner that will appeal to specialists and novices alike, Wiki Writing draws on a wealth of practical classroom experiences with wikis to offer a series of richly detailed and concrete suggestions to help educators realize the potential of these new writing environments.

Collaborative approaches to the digital in English Studies

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ISBN: 9780874218879 087421887X Year: Language: English
Publisher: Utah State University Press/ Computers and Composition Digital Press
Subject: Languages and Literatures --- Technology (General)
Added to DOAB on : 2012-06-10 22:32:13

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As a field concerned with the production, consumption, and analysis of texts, English studies is also necessarily and uniquely tied to the technologies that support those activities. As those technologies evolve, the field evolves new research and teaching practices and new ways of using and thinking about digital tools. No longer the sole purview of a handful of specialists, digital texts (multimedia, Web content, digitized material, etc.), tools (software and hardware), and user practices (how readers and writers interact with, read, compose, analyze, share, and remix digital texts) pervade the field, from literary studies to writing studies and beyond. Although many English studies professionals have assimilated, investigated, and experimented with digital tools and associated practices on their own, such work is often facilitated by strategic collaborations. In fact, as this collection’s chapters demonstrate, forming collaborative partnerships is often the most productive way—if not the only way—to address research, professionalization, teaching, program development, and other challenges that arise as the field responds to digitality.Collaborative Approaches to the Digital in English Studies joins the ongoing conversation about collaborative work in the humanities. Instead of focusing exclusively on the digital humanities or emphasizing only the large-scale computational analysis or archival projects typical of that field of study, the collection focuses on a variety of projects led by or involving English studies professionals in particular. In doing so, the collection demonstrates growing interest in and diverse application of collaborative methods within the field and provides examples of the exigencies that have prompted a move away from the stereotypical lone-scholar model of scholarly work toward collaborative endeavors.The first aim of the collection is to present readers with compelling examples of how English studies professionals are employing collaborative approaches to the digital, thereby providing an up-to-date perspective on the nature of the work colleagues are doing as they come together around technology-related research and teaching questions. The second aim is to provide readers with concepts and models they can use in their own work as educators, researchers, and administrators.With chapters by Joyce Neff, Liza Potts, and Carl Whithaus; Lisa Spiro, Laura McGrath; Jim Ridolfo, Martine Courant Rife, Kendall Leon, Amy Diehl, Jeff Grabill, Douglas Walls, and Stacey Pigg; Sean McCarthy and Lauren Mitchell Nahas; Matt Barton and Kevin Moberly; Magnus Gustafsson, Donna Reiss, Art Young, and Linda Bradley; Caroline Cason Barratt, Jill Parrott, and Erin Presley; Monica Bulger, Jessica Murphy, Jeff Scheible, and Elizabeth Lagresa; Alan Liu; and Jentery Sayers.

Technological ecologies & sustainability

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ISBN: 9780874217490 0874217490 Year: Language: English
Publisher: Utah State University Press/ Computers and Composition Digital Press
Subject: Technology (General) --- Languages and Literatures
Added to DOAB on : 2012-06-10 22:15:08

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Together, computerized writing environments (e.g., physical spaces, hardware, software, and networks) and the humans who use and support such technologies comprise complex ecologies of interaction. As with any ecology, a human-computer techno-ecological system needs to be planned, fostered, designed, sustained, and assessed to create a vibrant culture of support at the individual, programmatic, institutional, and even national and international level. Local and larger infrastructures of composing are critical to digital writing practices and processes. In academia, specifically, all writing is increasingly computer-mediated; all writing is digital.Unfortunately, at far too many institutions, it is difficult to sustain ecologies of digital writing. How then to best plan, foster, design, sustain, and assess the complex ecologies framing the study and practice of digital writing that we do (or hope to do) as teachers, scholars, learners, and writers?The audience for this collection is teachers, scholars, administrators, and graduate students working in fields of composition studies, computers and writing, technical/professional communication, literature, education, and English education. We all face the same dilemma: More and more of our work and instruction takes place in electronic environments, but budget constraints and assessment mandates loom, and often our positions within or institutions prohibit us from active participation in central computing endeavors. This necessarily multivocal collection refines our discussions of the many components of sustainability, providing contextual, situated, and flexible modes and methods for theorizing, building, assessing, and sustaining digital writing ecologies.Section I: Sustaining instructors, students, and classroom practices. Introduction to section I / Heidi McKee --Political economy and sustaining the unstable : new faculty and research in English studies / Kelli Cargile Cook, Ryan (Rylish) M. Moeller, and Cheryl E. Ball --A portable ecology : supporting new media writing and laptop-ready pedagogy / Kristie S. Fleckenstein, Fred Johnson, and Jackie Grutsch McKinney --Stifling innovation : the impact of resource-poor techno-ecologies on student technology use / Anthony T. Atkins and Colleen A. Reilly --Video for the rest of us? Toward sustainable processes for incorporating video into multimedia composition / Peter J. Fadde and Patricia Sullivan --Portfolios, circulation, ecology, and the development of literacy / Kathleen Blake Yancey --Section II: Sustaining writing programs. Introduction to section II / Danielle Nicole DeVoss --The administrator as technorhetorician : sustainable technological ecologies in academic programs / Michael Day --Sustainability and digital technology : program analysis via a "three-legged" framework / Patricia Ericsson --The hybrid academy : building and sustaining a technological culture of use / Beth L. Brunk-Chavez and Shawn J. Miller --Using the LEED evaluation tool to assess the sustainability of first-year computers and writing programs / Kip Strasma --Digital studio as method : collaboratively migrating theses and dissertations into the technological ecology of English studies / Jude Edminster, Andrew Mara, and Kristine Blair --Section III: Sustaining writing center, research centers, and community programs. Introduction to section III / Dickie Selfe --Sustaining a research center : building the research and outreach profile for a writing program / James E. Porter --Sustaining community and technological ecologies : what writing centers can teach us / Jeanne R. Smith and Jay D. Sloan --Sustaining (and growing) a pedagogical writing environment : an activity theory analysis / Mike Palmquist, Kate Kiefer, and Jill Salahub --Genre-informed implementation analysis : an approach for assessing the sustainability of new textual practices / Lisa Dush --Section IV: Sustaining scholarship and the environment. Introduction to section IV / Danielle Nicole DeVoss --Sustainable digital ecologies and considered limits / Lisa Lebduska --Old world successes and new world challenges : reducing the computer waste stream in America / Shawn Apostel and Kristi Apostel --Sustaining scholarly efforts : the challenge of digital media / Cynthia L. Selfe, Gail E. Hawisher, and Patrick W. Berry --Afterword : sustainable writing programs : a continuing agenda / Charlie Moran --Author biographies and photos.

The Foundation of Precision Medicine: Integration of Electronic Health Records with Nenomics Through Basic, Clinical, and Translational Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198726 Year: Pages: 194 DOI: 10.3389/978-2-88919-872-6 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.

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