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Coarse-grained molecular dynamics and continuum models for the transport of protein molecules

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Book Series: Premio Tesi di Dottorato ISSN: 26128020 ISBN: 9788866556947 Year: Volume: 44 Pages: 134 DOI: 10.36253/978-88-6655-694-7
Publisher: Firenze University Press
Subject: Biology --- Organic Chemistry
Added to DOAB on : 2020-11-10 16:26:00
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The present work makes use of coarse-grained molecular dynamics simulations and continuum models to investigate the behavior of biomolecules in experiments such as mechanical pulling and driven transport across nanopores. The approach reproduces the wide phenomenology of experiments and allows one to maintain the main features of the transport by modeling the process as a 1D dynamics in a suited potential of the mean force. The standard 1D continuum view is enriched by proposing a model for the description of the shape of isolated molecules based on a tensorial representation and Cauchy-Born rule. Results indicate limitations for unconstrained dynamics and appropriateness for driven ones.

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Plasticity of GABAergic synapses

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197323 Year: Pages: 175 DOI: 10.3389/978-2-88919-732-3 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression.

La metodologia Sei Sigma nei servizi

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Book Series: Studi e saggi ISSN: 27045919 ISBN: 8884534860 Year: Volume: 45 Pages: 210 DOI: 10.26530/OAPEN_356379 Language: Italian
Publisher: Firenze University Press
Subject: Business and Management --- Economics
Added to DOAB on : 2011-11-04 00:00:00
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This book explains how the methodological approach of the Six Sigma can be used to provide an effective solution to one of the most widespread problems faced by Small and Medium Enterprises: the frequent undercapitalisation linked to short-term investments often funded by bank loans. The Six Sigma method enables the problem to be tackled by studying, in an analytical and statistical manner, both the payments that the enterprises are to receive and the possible conditions of the funding, proposing solutions to optimise these processes and improve the financial performance of the SMEs. Hence the book is offered as both a methodological analysis and as an operative tool for the sphere of enterprise.

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