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Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196845 Year: Pages: 248 DOI: 10.3389/978-2-88919-684-5 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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Abstract

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.

Dietary Protein and Muscle in Aging People

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ISBN: 9783038974574 / 9783038974581 Year: Pages: 160 DOI: 10.3390/books978-3-03897-458-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Nutrition and Food Sciences
Added to DOAB on : 2019-02-14 10:56:39
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Abstract

This Special Issue of Nutrients, entitled “Dietary Proteins and Muscle in Aging People”, welcomes the submission of manuscripts either reporting original research or reviewing the scientific literature. Manuscripts should focus on the mechanisms linking dietary protein with muscle quality and quantity. Articles presenting results from clinical trials testing protein interventions on muscle mass and function are welcome. The Special Issue aims at including articles spanning different disciplines to explore the topic of interest. Reports from basic to clinical and population research are suitable. Articles adopting a longitudinal approach or reporting data from life-long interventions/observations in the exploration of the theme will be given special consideration.Potential topics include, but are not limited to:•Description of patterns of dietary protein consumption across life•Influence of dietary protein intake on the functional status of older people•Preclinical and clinical studies describing the mechanisms through which protein intake modifies muscle mass and function•Protein/amino acid supplementation interventions against sarcopenia, cachexia, or disease conditions associated with muscle wasting in old age•Disease-specific alterations modifying the effects of dietary protein intake on skeletal muscles•Effects of the interactions of dietary protein intake and gut microbiota on skeletal muscles]

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