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Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194582 Year: Pages: 158 DOI: 10.3389/978-2-88919-458-2 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Medicine (General)
Added to DOAB on : 2016-02-05 17:24:33
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Abstract

This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.

Keywords

DNA Methylation --- Histones --- miRNA --- stress --- Fear --- PTSD

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