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The Foundation of Precision Medicine: Integration of Electronic Health Records with Nenomics Through Basic, Clinical, and Translational Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198726 Year: Pages: 194 DOI: 10.3389/978-2-88919-872-6 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.

Biocomputing 2019:Proceedings of the Pacific Symposium:Pacific Symposium on Biocomputing 2019

Authors: --- --- --- --- et al.
ISBN: 9789813279827 Year: Pages: 472 DOI: 10.1142/11263 Language: English
Publisher: World Scientific Publishing Co.
Added to DOAB on : 2019-01-23 03:26:21
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The Pacific Symposium on Biocomputing (PSB) 2019 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2019 will be held on January 3 – 7, 2019 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2019 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Biocomputing 2020:Proceedings of the Pacific Symposium

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ISBN: 9789811215636 Year: Pages: 764 DOI: 10.1142/11698 Language: English
Publisher: World Scientific Publishing Co.
Added to DOAB on : 2019-12-10 07:38:37
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The Pacific Symposium on Biocomputing (PSB) 2020 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2020 will be held on January 3 –7, 2020 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2020 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Biocomputing 2016:Proceedings of the Pacific Symposium

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ISBN: 9789814749411 Year: Pages: 604 DOI: 10.1142/9930 Language: English
Publisher: World Scientific Publishing Co.
Subject: Biology
Added to DOAB on : 2016-01-19 03:27:59
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The Pacific Symposium on Biocomputing (PSB) 2016 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2016 will be held on January 4 – 8, 2016 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2016 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field. Contents: Cancer Panomics: Computational Methods and Infrastructure for Integrative Analysis of Cancer High-Throughput "Omics" Data; Computational Approaches to Drug Repurposing and Pharmacology; Detecting and Characterizing Pleiotropy: New Methods for Uncovering the Connection Between the Complexity of Genomic Architecture and Multiple Phenotypes; Personalized Medicine: From Genotypes and Molecular Phenotypes Towards Therapy; Text and Data Mining for Biomedical Discovery. Readership: Academia and industry in the fields of biocomputing, bioinformatics and computational biology.

Biocomputing 2015:Proceedings of the Pacific Symposium

Authors: --- --- --- --- et al.
ISBN: 9789814644730 Year: Pages: 516 DOI: 10.1142/9455 Language: English
Publisher: World Scientific Publishing Co.
Subject: Biology
Added to DOAB on : 2016-01-19 03:42:23
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The Pacific Symposium on Biocomputing (PSB) 2015 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2015 will be held from January 4 – 8, 2015 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2015 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field. Contents:Cancer Panomics: Computational Methods and Infrastructure for Integrative Analysis of Cancer High-Throughput "OMICS" Data; Cancer Pathways: Automatic Extraction, Representation, and Reasoning in the "Big Data" ERA; Characterizing the Importance of Environmental Exposures, Interactions Between the Environment and Genetic Architecture, and Genetic Interactions: New Methods for Understanding the Etiology of Complex Traits and Disease; Crowdsourcing and Mining Crowd Data; Personalized Medicine: From Genotypes, Molecular Phenotypes and the Quantified Self, Towards Improved Medicine; Readership: Academia and industry in the fields of biocomputing, bioinformatics and computational biology.

Biocomputing 2014:Proceedings of the Pacific Symposium

Authors: --- --- --- --- et al.
ISBN: 9789814583220 Year: Pages: 436 DOI: 10.1142/9078 Language: English
Publisher: World Scientific Publishing Co.
Subject: Biology
Added to DOAB on : 2016-01-19 03:46:40
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The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 – 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.Contents:Cancer Panomics: Computational Methods and Infrastructure for Integrative Analysis of Cancer High-Throughput “Omics” DataComputational Approaches to Drug Repurposing and PharmacologyDetecting and Characterizing Pleiotropy: New Methods for Uncovering the Connection Between the Complexity of Genomic Architecture and Multiple PhenotypesPersonalized Medicine: From Genotypes and Molecular Phenotypes Towards TherapyText and Data Mining for Biomedical DiscoveryWorkshopsReadership: Academia and industry in the fields of biocomputing, bioinformatics and computational biology.

Biocomputing 2017:Proceedings of the Pacific Symposium

Authors: --- --- --- --- et al.
ISBN: 9789813207813 Year: Pages: 668 DOI: 10.1142/10388 Language: English
Publisher: World Scientific Publishing Co.
Subject: Biology
Added to DOAB on : 2016-12-02 03:01:48
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The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 – 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

Biocomputing 2018:Proceedings of the Pacific Symposium

Authors: --- --- --- --- et al.
ISBN: 9789813235533 Year: Pages: 500 DOI: 10.1142/10864 Language: English
Publisher: World Scientific Publishing Co.
Added to DOAB on : 2017-11-20 08:35:10
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The Pacific Symposium on Biocomputing (PSB) 2018 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2018 will be held on January 3 – 7, 2018 in Kohala Coast, Hawaii. PSB 2018 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

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