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Current Challenges in Modeling Cellular Metabolism

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197545 Year: Pages: 115 DOI: 10.3389/978-2-88919-754-5 Language: English
Publisher: Frontiers Media SA
Subject: Biology --- Science (General) --- Biotechnology --- General and Civil Engineering
Added to DOAB on : 2016-04-07 11:22:02
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Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to such systems. The recent advances in genome sequencing techniques have facilitated the reconstruction of genome-scale metabolic networks for a wide variety of organisms from microbes to human cells. These models have been successfully used in multiple biotechnological applications. Despite these advancements, modeling cellular metabolism still presents many challenges. The aim of this Research Topic is not only to expose and consolidate the state-of-the-art in metabolic modeling approaches, but also to push this frontier beyond the current edge through the introduction of innovative solutions. The articles presented in this e-book address some of the main challenges in the field, including the integration of different modeling formalisms, the integration of heterogeneous data sources into metabolic models, explicit representation of other biological processes during phenotype simulation, and standardization efforts in the representation of metabolic models and simulation results.

Indonesia in a Reforming World Economy: Effects on Agriculture, Trade and the Environment

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ISBN: 9780980623871 Year: Pages: 266 DOI: 10.1017/UPO9780980623871 Language: English
Publisher: University of Adelaide Press
Subject: Economics
Added to DOAB on : 2012-05-14 08:42:51
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In the mid-1990s a joint research project was established between CASER (Bogor), CIES (Adelaide), CSIS ( Jakarta) and RSPAS (at ANU, Canberra) to examine interactions between agriculture, trade and the environment in Indonesia. Funded by the Australian Centre for International Agricultural Research (ACIAR Project No. 9449), the specific objective of the project was to assess the production, consumption, trade, income distributional, regional, environmental, and welfare eff ects in Indonesia of structural and policy changes at home and abroad. Particular attention was to be paid to those structural and policy changes that could aff ect Indonesia’s agricultural sector over the next 5-10 years.

The implications of national and global economic growth, of regional and multilateral trade liberalisation initiatives, and of Indonesia’s ongoing unilateral policy reforms were the initial focus of the study. However, with the onslaught of the financial crisis that began in the latter part of 1997, the project leaders added that issue to the research agenda.

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