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AR Signaling in Human Malignancies: Prostate Cancer and Beyond

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ISBN: 9783038427407 9783038427391 Year: Pages: 244 DOI: 10.3390/books978-3-03842-739-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2018-02-16 08:45:39
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The notion that androgens and androgen receptor (AR) signaling are the hallmarks of prostate cancer oncogenesis and disease progression is generally well accepted. What is more poorly understood is the role of AR signaling in other human malignancies. This Special Issue of Cancers initially reviews the role of AR in advanced prostate cancer, and then explores the potential importance of AR signaling in other epithelial malignancies. The first few articles focus on the use of novel AR-targeting therapies in castration-resistant prostate cancer and the mechanisms of resistance to novel antiandrogens, and they also outline the interaction between AR and other cellular pathways, including PI3 kinase signaling, transcriptional regulation, angiogenesis, stromal factors, Wnt signaling, and epigenetic regulation in prostate cancer. The next several articles review the possible role of androgens and AR signaling in breast cancer, bladder cancer, salivary gland cancer, and hepatocellular carcinoma, as well as the potential treatment implications of using antiandrogen therapies in these non-prostatic malignancies.

Spatial Audio

Authors: ---
ISBN: 9783038425854 9783038425861 Year: Pages: VIII, 206 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2017-12-06 12:39:21
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This special issue compiles some of the latest state-of-the-art research works in the area of spatial audio and it serves as a good reference for both undergraduate and postgraduate students, and to researchers working in this exciting area of spatial audio.

Digital Entrepreneurship

Authors: --- --- --- --- et al.
Book Series: Future of Business and Finance ISBN: 9783030539146 Year: Pages: 327 DOI: 10.1007/978-3-030-53914-6 Language: English
Publisher: Springer Nature
Subject: Business and Management
Added to DOAB on : 2020-12-16 00:03:30
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This open access book explores the global challenges and experiences related to digital entrepreneurial activities, using carefully selected examples from leading companies and economies that shape world business today and tomorrow. Digital entrepreneurship and the companies steering it have an enormous global impact; they promise to transform the business world and change the way we communicate with each other. These companies use digitalization and artificial intelligence to enhance the quality of decisions and augment their business and customer operations. This book demonstrates how cloud services are continuing to evolve; how cryptocurrencies are traded in the banking industry; how platforms are created to commercialize business, and how, taken together, these developments provide new opportunities in the digitalized era. Further, it discusses a wide range of digital factors changing the way businesses operate, including artificial intelligence, chatbots, voice search, augmented and virtual reality, as well as cyber threats and data privacy management. “Digitalization mirrors the Industrial Revolution’s impact. This book provides a complement of perspectives on the opportunities emanating from such a deep seated change in our economy. It is a comprehensive collection of thought leadership mapped into a very useful framework. Scholars, digital entrepreneurs and practitioners will benefit from this timely work.” Gina O’Connor, Professor of Innovation Management at Babson College, USA “This book defines and delineates the requirements for companies to enable their businesses to succeed in a post-COVID19 world. This book deftly examines how to accomplish and achieve digital entrepreneurship by leveraging cloud computing, AI, IoT and other critical technologies. This is truly a unique “must-read” book because it goes beyond theory and provides practical examples.” Charlie Isaacs, CTO of Customer Connection at Salesforce.com, USA "This book provides digital entrepreneurs useful guidance identifying, validating and building their venture. The international authors developed new perspectives on digital entrepreneurship that can support to create impact ventures.” Felix Staeritz, CEO FoundersLane, Member of the World Economic Forum Digital Leaders Board and bestselling author of FightBack, Germany

Spectral Line Shapes in Astrophysics and Related Topics

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ISBN: 9783039281688 9783039281695 Year: Pages: 268 DOI: 10.3390/books978-3-03928-169-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Physics (General) --- Astronomy (General)
Added to DOAB on : 2020-04-07 23:07:08
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Spectral lines, widths, and shapes are powerful tools for emitting/absorbing gas diagnostics in different astrophysical objects (from the solar system to the most distant objects in the universe—quasars). On the other hand, experimental and theoretical investigations of laboratory plasma have been applied in spectroscopic astrophysical research, especially in research on atomic data needed for line shape calculations. Data on spectral lines and their profiles are also important for diagnostics, analysis, and the modelling of fusion plasma, laser-produced plasma, laser design and development, and various plasmas in industry and technology, like light sources based on plasmas or the welding and piercing of metals by laser-produced plasma. The papers from this book can be divided into four groups: 1. stark broadening data for astrophysical and laboratory plasma investigations; 2. applications of spectral lines for astrophysical and laboratory plasma research; 3. spectral line phenomena in extragalactic objects, and 4. laboratory astrophysics results for spectra investigation. The reviews and research papers, representing new research on the topics presented in this book, are of interest for specialists and PhD students. We hope that the present book will be useful and interesting for scientists interested in the investigation of spectral line shapes and will contribute to the education of young researchers and PhD students.

Keywords

stark broadening --- atomic data --- subdwarfs B stars --- Ar II --- stark broadening --- atomic data --- atomic processes --- line profiles --- Ar VII --- stark broadening --- line profiles --- atomic data --- Na IV --- atomic/molecular data --- radiative and collisional processes --- stars --- stark broadening --- impact approximation --- numerical simulation --- ionization processes --- emission line formation --- atomic spectroscopy --- supermassive black holes --- emission line profiles --- quasars --- line shape --- wave collapse --- electric field solitons --- plasma turbulence --- line shapes --- stark broadening --- neutral broadening --- corona discharge --- line shapes --- Stark broadening --- Zeeman effect --- tokamaks --- white dwarfs --- active galaxies --- BL Lacertae objects --- AO 0235+164 --- photometry --- polarimetry --- plasma spectroscopy --- microwave discharges --- gas temperature --- stark broadening parameters --- atomic emission spectroscopy --- laboratory plasma --- spectra --- line profiles --- astrophysical plasmas --- inner plasma electrostatic screening --- different charged ions --- stars --- galaxies: active --- galaxies: nuclei --- line: profiles --- quasars: emission lines --- catalogs --- surveys --- line shapes --- Stark broadening --- Zeeman effect --- white dwarfs --- QSO samples --- QSO selection --- medium-band photometry --- electron scattering --- cross sections --- Rosetta mission --- atomic and molecular databases --- Stark broadening --- line profiles --- atomic data --- spectroscopy --- alkali atoms --- astrophysics --- atomic processes --- molecular processes --- radiative transfer --- absorption quasi-molecular bands --- sun:atmosphere --- sun:photosphere --- stars:atmospheres --- white dwarfs --- atomic processes --- radiative transfer --- Sun: atmosphere --- Sun: photosphere --- stars: atmospheres --- white dwarfs --- Stark effect --- electron broadening --- Lienard-Wiechert --- retarded interaction --- relativistic collision operator --- Stark broadening --- line profiles --- atomic data --- plasmas --- Maxwell --- Juttner-Maxwell --- relativistic --- Doppler effect --- asymmetry --- Stark broadening --- Ar VII line profiles --- stars --- white dwarfs --- atomic data --- scattering

Molecular Modeling in Drug Design

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ISBN: 9783038976141 Year: Pages: 220 DOI: 10.3390/books978-3-03897-615-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General) --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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This book is a printed edition of the Special Issue Molecular Modeling in Drug Design that was published in Molecules

Keywords

hyperlipidemia --- squalene synthase (SQS) --- molecular modeling --- drug discovery --- Traditional Chinese Medicine --- molecular dynamics simulation --- biophenols --- natural compounds --- amyloid fibrils --- Alzheimer’s disease --- ligand–protofiber interactions --- adhesion --- FimH --- rational drug design --- molecular dynamics --- molecular docking --- ligand binding --- EphA2-ephrin A1 --- PPI inhibition --- interaction energy --- in silico screening --- adenosine --- boron cluster --- adenosine receptors --- AR ligands --- aggregation --- promiscuous mechanism --- human ecto-5?-nucleotidase --- virtual screening --- enzymatic assays --- turbidimetry --- dynamic light scattering --- docking --- solvent effect --- binding affinity --- scoring function --- molecular dynamics --- target-focused pharmacophore modeling --- density-based clustering --- structure-based drug design --- AutoGrid --- grid maps --- probe energies --- method development --- steered molecular dynamics --- all-atom molecular dynamics simulation --- resultant dipole moment --- mechanical stability --- protein-peptide interactions --- molecular dynamics --- proteins --- molecular recognition --- protein protein interactions --- artificial intelligence --- deep learning --- neural networks --- property prediction --- quantitative structure-activity relationship (QSAR) --- quantitative structure-property prediction (QSPR) --- de novo design --- adenosine receptor --- metadynamics --- extracellular loops --- allosterism --- molecular dynamics --- cosolvent molecular dynamics --- drug design --- fragment screening --- docking

Mineralogy and Geochemistry of Gems

Authors: --- --- ---
ISBN: 9783039280766 9783039280773 Year: Pages: 528 DOI: 10.3390/books978-3-03928-077-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Geology --- Earth Sciences
Added to DOAB on : 2020-04-07 23:07:09
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Gems have been used in the manufacture of jewellery and as ornaments since antiquity. Considering gems, recent statistics have shown that about 15 billion Euros are annually at stake. Nowadays, gemmology, i.e., the study of gem materials, is one of the most expanding fields in the earth sciences, positioned between academia and industry. As an applied science, in gemmology, the instruments used should be non- or microdestructive, and their cost should be reasonable both in terms of equipment and time consumption. Gemmology can also be used contribute to the development of pure science and in some cases, destructive techniques may have to be used. Taking into account the fact that gems are albeit rarely available for scientific research, this compilation of 20 articles by around 100 researchers from over 30 different institutions situated in 20 countries from around the globe, presented in the Special Issue entitled “Mineralogy and Geochemistry of Gems”, offers very good examples on the application of various methods for their study which will hopefully contribute to our better understanding of gem formation in general and will enhance scientific debates attracting more scientists from various disciplines to get involved in this field.

Keywords

danburite --- trace elements --- REE --- femtosecond LA-ICP-MS --- CHNS elemental analyzer --- pegmatites --- skarn --- gemstones --- placer --- heavy and light minerals --- landforms --- climate --- geodynamic setting --- green quartz --- prase --- amethyst --- color --- amphibole --- actinolite --- skarn --- Serifos --- Greece --- zircon --- xenocryst --- alkali basalt --- Ratanakiri Volcanic Province --- trace elements --- O-isotopes and Hf-isotopes --- U-Pb --- (U-Th)/He --- granitic pegmatite --- gem-quality tourmaline --- Adamello Massif --- Central Alps --- Italy --- ruby --- Mogok --- Mong Hsu --- New South Wales --- trace elements --- LA-ICP-MS analysis --- inclusions --- U–Pb age-dating --- genetic diversity --- geographic typing --- corundum --- blue sapphire --- meta-ultramafic rocks --- LA-ICP-MS --- Rb-Sr and Sm-Nd isotopy --- Ilmenogorsky complex --- Ural Mountains --- metasomatism --- corundum megacrysts --- ruby --- sapphire --- plumasite --- metamorphic-metasomatic origin --- Greece --- zircon megacrysts --- placer deposits --- rare earth elements (REE) --- carbonatite-dominant melts --- Central Highlands --- Vietnam --- hyperspectral photoluminescence imaging --- LA-ICP-MS --- rubies --- corundum --- in-situ oxygen isotopes --- Paranesti Greece --- Nestos Shear Zone --- Secondary ion mass spectrometry (SIMS) --- emerald deposits --- classification --- typology --- metamorphism --- magmatism --- sedimentary --- alkaline metasomatism --- fluids --- stable and radiogenic isotopes --- genetic models --- exploration --- andradite --- demantoid --- gemstone --- Raman spectroscopy --- UV-Vis-NIR spectroscopy --- X-ray fluorescence spectroscopy --- gem-quality --- garnet --- gem-bearing pegmatite --- fluid inclusions --- P-T-X equilibria --- spodumene --- Ar/Ar dating --- blue sapphire --- anorthosites --- kyshtymites --- sapphire geochemistry --- Ilmenogorsky-Vishnevogorsky complex --- in situ LA-ICP-MS U-Pb zircon dating --- kyanite --- Mn-rich silicates --- Rhodope --- Thassos --- amphibolite facies --- metasomatism --- opal --- hyalite --- silica --- X-ray diffraction --- Raman --- Infrared --- 29Si nuclear magnetic resonance --- SEM --- provenance --- pearls --- freshwater --- saltwater --- LA-ICP-MS --- X-ray luminescence --- sapphires --- corundum --- in situ oxygen isotopes --- Orosmayo Argentina --- lamprophyre --- secondary ion mass spectrometry (SIMS) --- carbonatite --- gemstones --- corundum --- beryl --- jadeitite --- garnet --- quartz varieties --- Greece --- emeralds --- LA-ICP-MS --- UV-Vis-NIR --- FTIR --- Raman --- PL --- n/a

Circulating Tumor Cells: Finding Rare Events for A Huge Knowledge of Cancer Dissemination

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ISBN: 9783039286980 / 9783039286997 Year: Pages: 366 DOI: 10.3390/books978-3-03928-699-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2020-06-09 16:38:57
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The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.

Keywords

circulating tumor cells --- circulating tumor DNA --- liquid biopsy --- metastatic colorectal cancer --- FOLFIRINOX --- circulating tumor cells --- CTC --- liquid biopsy --- CTM --- CTMat --- CTC biology --- CTC capture technology --- metastasis --- circulating tumor cells (CTCs) --- hepatocellular carcinoma (HCC) --- castration resistant prostate cancer (CRPC) --- epithelial-to-mesenchymal transition (EMT) --- fibronectin --- integrin B1 --- SLUG --- major histocompatibility complex class I (MHCI) --- immunomodulation --- bone marrow --- melanoma --- disseminated tumor cells --- solid cancers --- single-cell analysis --- enrichment and detection technologies --- flow cytometry --- tumor stem cells --- HMB-45 --- CD133 --- locally advanced rectal cancer --- circulating tumor cells --- RAD23B --- thymidylate synthase --- chemoradioresistance --- liquid biopsy --- circulating tumor cells --- epithelial–mesenchymal transition --- stem cells --- early breast cancer --- prostate cancer (PCa) --- circulating tumor cells (CTC) --- liquid biopsy --- circulating tumor cells --- metastasis --- xenograft models --- breast cancer --- prostate cancer --- CTC --- AR --- AR-V7 --- ctRNA --- exosome --- circulating tumor cells --- hematological cells --- neutrophils --- platelets --- liquid biopsy --- circulating tumor cells --- melanoma --- liquid biopsy --- EPISPOT --- CellSearch® --- liquid biopsy --- CTCs --- immune checkpoint inhibitors --- PD-L1 expression --- NSCLC --- small-cell lung carcinoma --- circulating tumor cells --- microfluidics --- gene expression analysis --- synaptophysin --- chromogranin A --- rovalpituzumab tesirine --- leukocyte-derived extracellular vesicles --- immunofluorescence imaging --- EpCAM enrichment --- CellSearch --- EasyCount slides --- ACCEPT --- CTC --- heterogeneity --- liquid biopsy --- liquid surgery --- clinical utility --- circulating tumor cells (CTCs) --- glioma --- biomarker --- rVAR2 --- malaria --- enrichment and detection technologies --- prostate cancer --- biomarkers --- circulating tumor cells --- androgen receptor --- ARV7 --- abiraterone --- enzalutamide --- metastasis --- tumor-initiating cells (TICs) --- circulating tumor cells (CTCs) --- CTC-derived xenografts --- CTC-derived ex vivo models --- cerebrospinal liquid biopsy --- in vivo flow cytometry --- tumor biomarkers --- circulating tumor cells --- ctDNA --- miRNA --- exosomes --- emboli --- targeted therapy --- circulating tumor cells --- tumor cell dissemination --- immune system --- microbiome --- circulating tumor cells (CTCs) --- clinical trials --- breast cancer --- CTC-based treatment decisions --- circulating tumour cells --- colorectal cancer --- colorectal surgery --- microsatellite instability --- microfluidics --- immunophenotyping --- fish --- liquid biopsy --- circulating leukemia cells --- circulating plasma cells --- n/a

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