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Aging Gracefully in the Renaissance - Stories of Later Life from Petrarch to Montaigne

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Book Series: Medieval and Renaissance Authors and Texts ISBN: 9789004255722 9789004254664 Year: Volume: 11 Pages: 192 DOI: 10.1163/9789004255722 Language: English
Publisher: Brill Grant: Knowledge Unlatched
Subject: Languages and Literatures
Added to DOAB on : 2014-05-09 16:28:21
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Cynthia Skenazi explores in this book a shift in attitudes towards aging and provides a historical perspective on a crucial problem of our time. In Aging Gracefully in the Renaissance: Stories of Later Life from Petrarch to Montaigne Cynthia Skenazi explores a shift in attitudes towards aging and provides a historical perspective on a crucial problem of our time.&#xD;From the late fourteenth to the end of the sixteenth centuries, the elderly subject became a point of new social, medical, political, and literary attention on both sides of the Alps. A movement of secularization tended to dissociate old age from the Christian preparation for death, re-orienting the concept of aging around pragmatic matters such as health care, intergenerational relationships, and accrued insights one might wish to pass along. Such changes were accompanied by an increasing number of personal accounts of later life.&#xD;&#xD;This title was made Open Access by libraries from around the world through Knowledge Unlatched.

Keywords

literature --- history --- aging

Ageing in Europe. Supporting Policies for an Inclusive Society

Authors: --- --- --- --- et al.
ISBN: 9783110444414 9783110437041 Year: Pages: xii, 380 DOI: 10.1515/9783110444414 Language: English
Publisher: De Gruyter
Subject: Economics --- Social Sciences
Added to DOAB on : 2016-01-05 13:11:32
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SHARE is an international survey designed to answer the societal challenges that face us due to rapid population ageing. How do we Europeans age? How will we do economically, socially and healthwise? How are these domains interrelated? The authors of this multidisciplinary book have taken a further big step towards answering these questions based on the recent SHARE data in order to support policies for an inclusive society.

Papers of the Conference on Genetics of Aging and Longevity 2012

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193530 Year: Pages: 140 DOI: 10.3389/978-2-88919-353-0 Language: English
Publisher: Frontiers Media SA
Subject: Genetics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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The 2nd International Conference "Genetics of aging and longevity" took place 22-25 April, 2012 in the main building of Russian Academy of Sciences, Moscow, Russia. Top gerontologists and geneticists from 25 countries around the world discussed the current problems in many areas related to the genetics of longevity and mechanisms of aging. This Research Topic is aimed to provide a collection of articles based on the talks, reports and experimental outcomes related to the topics of the conference: "Epigenetic Changes Associated with Longevity", "Hormones and Aging", "Proximal and Cellular Mechanisms of Aging", "Nutrient Signaling, Stress Resistance and Longevity", "Identifying Longevity Genes by Mutational, QTL and Association Mapping", "Fundamental Biological Processes Central to Aging", "Interventions to Extend Lifespan and Promote Healthy Aging", "Longevity: Meta-Analysis and Informatics Approaches". Participants of the Conference submitted 20 papers belonging to Original Research Papers, Review Articles (Including Mini Reviews), Opinion and Perspective Papers. All of the submitted manuscripts were peer-reviewed by excellent Frontiers Review Editors and prepared for publication by highly efficient Frontiers team, and it is a pleasure to thank them all for their work and dedication.

DNA helicases: expression, functions and clinical implications

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195756 Year: Pages: 78 DOI: 10.3389/978-2-88919-575-6 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2015-10-30 16:33:44
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Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.

Keywords

Aging --- Cancer --- DNA Repair --- helicases --- Telomere

Freiwilliges Engagement in Deutschland: Der Deutsche Freiwilligensurvey 2014

Authors: --- ---
Book Series: Empirische Studien zum bürgerschaftlichen Engagement ISBN: 9783658126438 9783658126445 Year: Pages: 643 DOI: 10.1007/978-3-658-12644-5 Language: German
Publisher: Springer
Subject: Zoology --- Law
Added to DOAB on : 2017-03-09 11:31:34
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Die Herausgeber/innen arbeiten am Deutschen Zentrum für Altersfragen (DZA), einem auf dem Gebiet der sozial- und verhaltenswissenschaftlichen Gerontologie tätigen wissenschaftlichen Forschungsinstitut.Dr. Julia Simonson ist Soziologin, Leiterin des Arbeitsbereichs Forschung und stellvertretende Institutsleiterin.

Brain Networks in Aging: Reorganization and Modulation by Interventions

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454167 Year: Pages: 170 DOI: 10.3389/978-2-88945-416-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2018-11-16 17:17:57
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Old adults undertake multiple reduced cognitive abilities in aging, which are accompanied with specific brain reorganization in forms of regional brain activity and brain tissues, inter-region connectivity, and topology of whole brain networks in both function and structure. The plasticity changes of brain activities in old adults are explained by the mechanisms of compensation and dedifferentiation. For example, older adults have been observed to have greater, usually bilateral, prefrontal activities during memory tasks compared to the typical unilateral prefrontal activities in younger adults, which was explained as a compensation for the reduced brain activities in visual processing cortices. Dedifferentiation is another mechanism to explain that old adults are with much less selective and less distinct activity in task-relevant brain regions compared with younger adults. A larger number of studies have examined the plasticity changes of brain from the perspective of regional brain activities. However, studies on only regional brain activities cannot fully elucidate the neural mechanisms of reduced cognitive abilities in aging, as multiple regions are integrated together to achieve advanced cognitive function in human brain. In recent years, brain connectivity/network, which targets how brain regions are integrated, have drawn increasing attention in neuroscience with the development of neuroimaging techniques and graph theoretical analysis. Connectivity quantifies functional association or neural fibers between two regions that may be spatially far separated, and graph theoretical analysis of brain network examines the complex interactions among multiple regions from the perspective of topology. Studies showed that compared to younger adults, older adults had altered strength of task-relevant functional connectivity between specific brain regions in cognitive tasks, and the alternation of connectivity are correlated to behavior performance. For example, older adults had weaker functional connectivity between the premotor cortex and a region in the left dorsolateral prefrontal cortex in a working memory task. Interventions like cognitive training and neuro-modulation (e.g., transcranial magnetic stimulation) have been shown to be promising in regaining or retaining the decreasing cognitive abilities in aging. However, only few neuroimaging studies have examined the influence of interventions to old adult’s brain activity, connectivity, and cognitive performance. This Research Topic calls for contributions on brain network of subjects in normal aging or with age-related diseases like mild cognitive impairment and Alzheimer’s disease. The studies are expected to be based on neuroimaging techniques including but not limited to functional magnetic resonance imaging, Electroencephalography, and diffusion tensor imaging, and contributions on the influence of interventions to brain networks in aging are highly encouraged. All these studies would enrich our understanding of neural mechanisms underlying aging, and offer new insights for developing possible interventions to retain cognitive abilities in aging subjects.

New Boundaries Between Aging, Cognition, and Emotions

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456659 Year: Pages: 150 DOI: 10.3389/978-2-88945-665-9 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2019-01-23 14:53:43
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Numerous studies have reported age-related differences for emotional information. For example, when, compared to younger adults, older adults reveal a relative preference in attention and memory for positive over negative information. One explanation places emphasis on an emotion processing preference in older adults that reflects their socioemotional self-relevant goals.Based on evidence from behavioral and neuroscientific research, researchers have realized that it is necessary to propose a new conceptual framework to describe the relationship between cognition and emotion.Given the growing body of research focused on the interaction between emotions and cognition, our purpose is to provide a picture of the state of the art of the interaction between aging, cognition and emotions.

Perception of Beauty

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ISBN: 9789535135814 9789535135821 Year: Pages: 234 DOI: 10.5772/66021 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:50

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The authors in this book ask us to consider whether the perception of beauty has been defined by our genetics and culture over the years - has it grown and changed? Do certain neural connections define our emotional reactions to beauty? Does beauty follow any rules or laws? Can the aspiration toward beauty be detrimental? Can we divorce ourselves from dictates and sink into a mindful connection with our internal beauty? Can we move from the superficial where ""beauty is only skin deep"" to an intense appreciation of beauty in all of its variations. The Perception of Beauty will lead to a deeper understanding and contemplation of nature, art, and the world around us.

Gerontology

Authors: --- ---
ISBN: 9781789232523 9781789232530 Year: Pages: 276 DOI: 10.5772/intechopen.69934 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

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Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Geriatrics Health

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ISBN: 9781789237603 9781789237610 Year: Pages: 76 DOI: 10.5772/intechopen.72140 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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Aging is characterized by functional decline in every organ due to several cellular, biological, and physiological changes over time. Molecular and cellular damages are gradually decreasing in the physical and mental capacities of the human body. Health results have shown that lifespan has dramatically increased during the twenty-first century. Increasing elderly population naturally deals with many health problems leading to a rise in health expenditure and labor loss. The good news is that the clinical trials in gene therapy have almost stopped and/or reversed human aging. Regenerative medicine can repair and reverse aging in all body cells. Thus, the body's own repair mechanisms may struggle with aging and age-related diseases. Research is promising and suggests that human aging will be eradicated on earth.

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