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Progress in Physical activity and Exercise and Affective and Anxiety Disorders: Translational Studies, Perspectives and Future Directions

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194711 Year: Pages: 78 DOI: 10.3389/978-2-88919-471-1 Language: English
Publisher: Frontiers Media SA
Subject: Psychiatry --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:33
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Abstract

Physical activity and exercise were receiving a great attention as a strategy of prevention and treatment of affective and some anxiety disorders. Many studies have showed the efficacy of exercise in major depression and at depressed episode of bipolar patients, as well as, some authors shows the benefits of exercise in some anxiety disorders like Generalized Anxiety Disorder and Panic. Despite their efficacy, little is known concerning the main mechanisms related to the antidepressant and anxiolytic effects of exercise. Several studies in an animal model using Neurotrophic Factors, Oxidative Stress, Immunologic response and other biological markers reveal promising results. However, few studies were conducted in clinical samples. Additional to the antidepressant and anxiolytic effects, exercise appears improve QoL in major depressed, bipolar and anxiety patients. Theoretically, this increase may be associated with cognitive improvements, improvements at sleep quality, physical functioning, as well as other psychological issues as self-esteem, self-concept, and general well-being. The propose of this topic is to address the novelty and most recent research, related to antidepressant and anxiolytic effects of physical activity and exercise in patients with affective and anxiety disorders, as well as the issues associated with QoL improvement.The topic is looking for: – Clinical trials using exercise and physical activity as a treatment affective and anxiety disorders. – Studies investigating the optimal prescription factors (dose, volume, intensity, setting, frequency) associated with antidepressant and anxiolytic effects of physical activity and exercise for affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning the mechanisms of antidepressant and anxiolytic effects of physical activity and exercise in affective and anxiety disorder patients. – Original studies, comprehensive reviews, hypothesis and opinions concerning other benefits of physical activity and exercise like : cognition, weight gain prevention and QoL in affective and anxiety disorder patients. – Translational research. – Studies of cost-efficacy analysis

Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196432 Year: Pages: 112 DOI: 10.3389/978-2-88919-643-2 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-08-16 10:34:25
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Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field.

Emotional Modulation of the Synapse

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889196067 Year: Pages: 135 DOI: 10.3389/978-2-88919-606-7 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2016-08-16 10:34:25
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Highly emotional events tend to be well remembered. The adaptive value in this is clear – those events that have a bearing on survival should be stored for future use as long-term memories whereas memories of inconsequential events would not as likely contribute to future survival. Enduring changes in the structure and function of synapses, neural circuitry, and ultimately behavior, can be modulated by highly aversive or rewarding experiences. In the last decade, the convergence of cellular, molecular, and systems neuroscience has produced new insights into the biological mechanisms that determine whether a memory will be stored for the long-term or lost forever. This Research Topic brings together leading experts, who work at multiple levels of analysis, to reveal recent discoveries and concepts regarding the synaptic mechanisms of consolidation and extinction of emotionally arousing memories.

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