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Advances in Mechanisms of Renal Fibrosis

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454990 Year: Pages: 84 DOI: 10.3389/978-2-88945-499-0 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
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Abstract

Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.

Keywords

BMP7 --- fibroblast --- HDAC --- HIPK2 --- JNK --- miRNA --- non-classical RAS --- Smad --- TGF-beta

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