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Global Burden and Challenges of Melioidosis

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ISBN: 9783038977421 Year: Pages: 272 DOI: 10.3390/books978-3-03897-743-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Internal medicine --- Medicine (General)
Added to DOAB on : 2019-04-05 10:34:31
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Abstract

This book is the definitive reference regarding the global status of melioidosis in 2018. Melioidosis is one of the most neglected tropical diseases (NTDs), so much so that it is not even included in the WHO list of NTDs. Yet modeling suggests that it kills more people worldwide every year than diseases that are much better known, such as leptospirosis and dengue. The reasons for this under-recognition are numerous, including the fact that it mainly affects the disadvantaged rural poor in areas that are poorly supplied with the diagnostic capability to make the diagnosis. In 22 separate articles, expert authors from around the world have summarized what is known about the burden of the disease in humans and animals and the presence of the causative bacterium in the environment in their countries or regions. They have also identified the main obstacles and challenges to establishing the true burden, and to ensure that patients receive accurate diagnosis and optimal care for this all too frequently fatal disease. Rather than focusing on the theoretical risk of the use of Burkholderia pseudomallei as a biological weapon, this book highlights its importance as a clear and present danger to global public health.

Keywords

melioidosis --- Burkholderia pseudomallei --- epidemiology --- diagnosis --- treatment --- melioidosis --- Burkholderia pseudomallei --- Laos --- Lao PDR --- melioidosis --- Sri Lanka --- epidemiology --- Burkholderia pseudomallei --- melioidosis --- Cambodia --- epidemiology --- Burkholderia pseudomallei --- melioidosis --- Mexico --- Central America --- Caribbean --- epidemiology --- awareness --- melioidosis --- Burkholderia pseudomallei --- Malaysia --- epidemiology --- bacteriology --- melioidosis --- Burkholderia pseudomallei --- transmission modes --- melioidosis --- Australia --- tropical medicine --- melioidosis --- Burkholderia pseudomallei --- Myanmar --- Melioidosis --- Burkholderia pseudomallei --- western Indian Ocean --- diagnosis --- MLST --- Madagascar --- Mauritius --- Réunion --- Seychelles --- melioidosis --- B. pseudomallei --- Singapore --- clinical --- veterinary --- environmental --- Burkholderia pseudomallei --- melioidosis --- Indonesia --- Papua New Guinea --- Oceania --- melioidosis --- Burkholderia pseudomallei --- melioidosis --- Thailand --- mortality --- diagnosis --- surveillance --- awareness --- treatment --- prevention --- melioidosis --- Burkholderia pseudomallei --- Vietnam --- public awareness --- animal --- environment --- melioidosis --- Burkholderia --- Bangladesh --- Burkholderia pseudomallei --- India --- melioidosis --- South Asia --- melioidosis --- Burkholderia pseudomallei --- South America --- melioidosis --- Africa --- Middle East --- Burkholderia pseudomallei --- genomics --- public awareness --- environment --- melioidosis --- Burkholderia pseudomallei --- Hong Kong --- melioidosis --- Philippines --- Burkholderia pseudomallei --- melioidosis --- Burkholderia pseudomallei --- epidemiology --- China

Enzyme-Mediated Stereoselective Synthesis

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ISBN: 9783039219360 9783039219377 Year: Pages: 116 DOI: 10.3390/books978-3-03921-937-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Inorganic Chemistry
Added to DOAB on : 2020-01-07 09:08:26
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This book is a collection of studies focused on the exploitation of enzyme stereoselectivity for the synthesis of relevant chemicals, such as innovative materials, chiral building blocks, natural products, and flavor and fragrance compounds. Different catalytic approaches are reported. The first study describes a resolution-based process for the stereoselective synthesis of the enantiomeric forms of the flavor compound linaloyl oxide, whereas other enantiomeric enriched aroma compounds were obtained through a novel microbial approach based on solid-state fermentation. Two relevant works exploit the potential of the biocatalyzed reduction reactions. The first of these contributions describes the enantioselective synthesis of ?-nitroalcohols by enzyme-mediated reduction of ?-nitroketones, whereas a second contribution reports the preparation of chiral 1,4-diaryl-1,4-diols through ADH-catalyzed bioreduction of the corresponding diketones. Concerning enantioenriched alcohol derivatives, natural hydroxy fatty acids are prepared by means of the biocatalytic hydration reaction of natural fatty acids using the probiotic bacterium Lactobacillus rhamnosus as a whole-cell biocatalyst. Further studies describe the use of modified pullulan polysaccharide for lipase immobilization and the recent advances in synthetic applications of ?-transaminases for the production of chiral amines.

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MDPI - Multidisciplinary Digital Publishing Institute (2)


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CC by-nc-nd (2)


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english (2)


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2019 (2)