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Interaction Between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199136 Year: Pages: 218 DOI: 10.3389/978-2-88919-913-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-01-19 14:05:46
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Abstract

The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat with cell surface CD44, in contrast to the interaction of short tissue HA (less than 3000 kDa) with the mouse CD44, makes the difference. More specifically, this communication shows that the interaction of short HA with fibroblasts’ CD44 imposes on them susceptibility for malignant transformation, whereas the corresponding interaction with long HA imposes on the fibroblasts a resistance to malignant transformation. The article does not explain the mechanism that underlines these findings. However, the articles, that will be published in the proposed Research Topic in the Inflammation section of Frontiers in Immunology, can bridge not only this gap, but also may explain why interaction between short HA and cell surface CD44 (or RHAMM, an additional HA receptor) enhances the development of inflammatory and malignant diseases. Furthermore, the articles included in the proposed Frontiers Research Topic will show that cancer cells and inflammatory cells share several properties related to the interaction between short HA and cell surface CD44 and/or RHAMM. These shared properties include: 1. Support of cell migration, which allows tumor metastasis and accumulation of inflammatory cells at the inflammation site; 2. Delivery of intracellular signaling, which leads to cell survival of either cancer cells or inflammatory cells; 3. Delivery of intracellular signaling, which activates cell replication and population expansion of either cancer cells or inflammatory cells; and 4. Binding of growth factors to cell surface CD44 of cancer cells or inflammatory cells (i.e., the growth factors) and their presentation to cells with cognate receptors (endothelial cells, fibroblasts), leading to pro-malignant or pro-inflammatory activities. Going back to the naked mole rat story, we may conclude from the proposed articles of this Frontiers Research Topic that the long HA, which displays anti-malignant effect, interferes with the above described pro-malignant potential of the short HA (perhaps by competing on the same CD44 receptor). Extrapolating this concept to Inflammation, the same mechanism (competition?) may be valid for inflammatory (and autoimmune) activities. If this is the case, long HA may be used for therapy of both malignant and inflammatory diseases. Moreover, targeting the interaction between short HA and CD44 (e.g. by anti-CD44 blocking antibodies) may display also a therapeutic effect on both malignant and inflammatory diseases, an issue that encourages not only fruitful exchange of views, but also practical experimental collaboration.

Polymer Clay Nano-composites

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ISBN: 9783039216529 9783039216536 Year: Pages: 246 DOI: 10.3390/books978-3-03921-653-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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This Special Issue focuses on the current state-of-the-art of “Polymer Clay Nano-Composites” for biomedical, anticorrosion, antibacterial, and other applications. Clay–polymer composite nanomaterials represent an emerging area of research. Loading polymers with clay particles essentially enhances the composite strength features. Of particular interest are different nano-assembly methods, such as silane mono and multilayers, polyelectrolyte layer-by-layer assembly, and others. An important development was reached for tubular and fibrous clay nanoparticles, such as halloysite, sepiolite, and imogolite. Polymer clay nanoparticles can be prepared as sheets with 1-nm thickness and width of a few hundred nm (e.g., kaolin and montmorillonite). Fibrous clays significantly reinforce the nano-composites in the assembly with biopolymers and other green polymers, leading to functional hybrid bio nano-composites. The scope of this Special Issue comprehensively includes the synthesis and characterization of polymer clay nano-composites used for several applications, including nano-clay polymer composites and hybrid nano-assemblies.

Keywords

polyimide --- graphene oxide --- composite --- mechanical properties --- indentation recovery --- AFM --- carbon fibers --- surface grafting --- halloysite nanotubes --- polymer composites --- interface --- fish gelatin --- halloysite nanotubes --- glycerol --- mechanical properties --- water resistance --- LAP --- hyaluronic acid --- doxorubicin --- CD44 receptor targeted --- sacrificial bond --- ionic network --- organic montmorillonite --- 1,2-polybutadiene --- in-situ intercalation --- clay–polymer nanocomposites --- atrazine --- radical polymerization --- hexadecyltrimethylammonium bromide --- phenyltrimethylammonium chloride --- FTIR --- TGA --- adsorption --- dental resins --- nanocomposite materials --- organically modified clays --- montmorillonite --- intercalation --- nanotechnology --- ammonium persulfate --- fuzzy optimization --- N,N?-methylenebisacrylamide --- Pareto set --- polyacrylic acid --- swelling capacity --- variable cost --- polyethylene oxide --- montmorillonite clays --- Pd catalysis --- catalytic composite --- positron annihilation --- doubly functionalized montmorillonite --- polystyrene --- soap-free emulsion polymerization --- thermal stability --- tribological property --- organo-clays --- polyamines --- clay-amine interaction mechanisms --- structure effects --- la uptake and release --- layered silicate --- sericite --- CTAB --- intercalation stability --- nanocomposites --- gelation kinetics --- sol–gel transition --- water shutoff --- silica sol --- cellulose nanofibrils --- halloysite nanotubes --- supercritical CO2 --- polystyrene foam --- blowing agent --- in situ polymerization --- attapulgite/polypyrrole nanocomposite --- halloysite nanotubes --- polysaccharide --- interfacial interactions --- reinforcing --- adsorption --- dispersion --- coatings --- whey protein isolate --- nanocomposites --- nanoclay, barrier --- morphology --- n/a

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