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Multiscale Modeling of the Ventricles: From Cellular Electrophysiology to Body Surface Electrocardiograms

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Book Series: Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ISSN: 18645933 ISBN: 9783866447141 Year: Volume: 13 Pages: XIII, 248 p. DOI: 10.5445/KSP/1000023886 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
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This work is focused on different aspects within the loop of multiscale modeling:On the cellular level, effects of adrenergic regulation and the Long-QT syndrome have been investigated.On the organ level, a model for the excitation conduction system was developed and the role of electrophysiological heterogeneities was analyzed.On the torso level a dynamic model of a deforming heart was created and the effects of tissue conductivities on the solution of the forward problem were evaluated.

The Role of the Clinical Cardiac Electrophysiologist in the Management of Congestive Heart Failure

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ISBN: 9789535129479 9789535129486 Year: Pages: 168 DOI: 10.5772/63292 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 07:51:49

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The world of clinical cardiac electrophysiology continues to evolve with newer and more advanced technologies to better serve our patients. In this book, titled The Role of the Clinical Cardiac Electrophysiologist in the Management of Congestive Heart Failure, authors from around the world have contributed their thoughts. Various chapters describing the use of biventricular pacing devices (CRT) in the management of patients suffering from systolic heart failure are included, with a chapter dedicated to management of CRT. A chapter describing the role of CRT in patients with Chagas disease is included. Authors describe the newer pharmaceuticals in the management of this disease and the role of catheter ablation in the management of atrial fibrillation and other arrhythmias. These topics are of great interest to clinicians at the various levels of training, and I believe this textbook gives a flavor of the expanding role of the electrophysiologist in the management of an ever-expanding patient population.

Interpreting Cardiac Electrograms - From Skin to Endocardium

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ISBN: 9789535135715 9789535135722 Year: Pages: 194 DOI: 10.5772/65202 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 07:51:50

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This is a reference book aimed at cardiologists, electrophysiologists and fellows in training. It presents an expansive review of cardiac electrogram interpretation in a collation of manuscripts that represent clinical studies, relevant anecdotal cases and basic science chapters evaluating cardiac signal processing pertaining to persistent atrial fibrillation. A diagnostic approach to arrhythmias using a standard ECG, the signal average ECG and fetal ECG is highlighted. Intracardiac ICD electrograms are also explored in terms of trouble shooting and device programming.

Cardiac Arrhythmias

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ISBN: 9781789233025 9781789233032 Year: Pages: 204 DOI: 10.5772/intechopen.71212 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 07:51:51

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This book is a comprehensive and practical updated review about the various aspects of cardiac arrhythmias. It covers a variety of aspects of both atrial and nonatrial arrhythmias, including genetics, clinical aspects, ECG manifestations, and practical approaches to complex cardiac arrhythmia management - office, hospital, intensive care unit, electrophysiology laboratory, and operating room. This book also presents comprehensive ECG reviews of cardiac arrhythmias like atrial flutter, Brugada pattern, Breijo ECG pattern, and PVCs. Practical aspects of preventing and managing arrhythmias - central venous catheter-induced, atrial flutter, and drug-induced cardiac arrhythmias - are described. Experts have demonstrated the approach for mapping and ablation of complex arrhythmias like atrial flutter, idiopathic ventricular tachycardia, and Brugada syndrome.

Cardiotoxicity

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ISBN: 9781789842371 9781789842388 Year: Pages: 162 DOI: 10.5772/intechopen.75370 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 07:51:52

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Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

Cardiac Pacing and Monitoring - New Methods, Modern Devices

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ISBN: 9781838801793 9781838801809 Year: Pages: 104 DOI: 10.5772/intechopen.73811 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 07:51:53

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Different artificial tools, such as heart-pacing devices, wearable and implantable monitors, engineered heart valves and stents, and many other cardiac devices, are in use in medical practice. Recent developments in the methods of cardiac pacing along with appropriate selection of equipment are the purpose of this book. Implantable heart rate management devices and wearable cardiac monitors are discussed. Indications for using specific types of cardiac pacemakers, cardiac resynchronization therapy devices, and implantable cardioverter defibrillators (ICDs) are of interest and their contraindications are considered. Special attention is paid to using leadless devices. The subcutaneous ICD obviates the need for transvenous leads and leadless pacemakers are entirely implantable into the right ventricle. Finally, applications of user-friendly wearable devices for the detection of atrial arrhythmia are debated.

Cholesterol Lowering Therapies and Drugs

Authors: ---
ISBN: 9789535127345 9789535127352 9789535141662 Year: Pages: 186 DOI: 10.5772/61647 Language: English
Publisher: IntechOpen
Subject: Cardiovascular
Added to DOAB on : 2019-10-03 09:47:10

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Using natural products and developing pharmaceutical drugs are emerging topics to reduce blood cholesterol levels for preventing heart disease and stroke. Covering recent progresses in cholesterol-lowering drugs and therapy, this book describes the natural and pharmaceutical products that are in clinical uses to lower cholesterol and lipids and compares these drugs in responses to different diseases such as homozygous familial hypercholesterolemia, atherosclerosis, cardiovascular disease, and cancer. The relationship between ethnicity and cholesterol-lowering drug responses is also reviewed. Each chapter is a building block for the book, but each individual chapter is also a complete subject package for the readers. Researchers from basic and clinic science interested in lipid and cholesterol metabolism, regulation, and lowering will find this book very useful. Features: - Up-to-date information of the molecular mechanisms of cholesterol lowering, the drugs from natural and pharmaceutical products, and their associated therapeutic strategies in human diseases. - Discussion of the pathogenesis of several human diseases, which are associated with high cholesterol levels and evaluation of the results of different cholesterol-lowering drug treatment in these diseases. - Discussion of the combinations of cancer chemotherapy and cholesterol lowering in potential cancer treatment and cancer prevention by cholesterol-lowering drugs. - Critical analysis of the effect of ethnicity on responses to cholesterol-lowering drug therapy leading to rational dose adjustment of cholesterol-lowering drugs for different people use.

Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455393 Year: Pages: 385 DOI: 10.3389/978-2-88945-539-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Physiology
Added to DOAB on : 2019-01-23 14:53:42
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Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs.This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

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