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General Anesthesia: From Theory to Experiments

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197491 Year: Pages: 138 DOI: 10.3389/978-2-88919-749-1 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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General anesthesia is a standard medical procedure in today's hospital practice. Although in most cases the administration of anesthetics does not affect severely the patients health, side effects of anesthesia are well-known, such as nausea or cognitive impairment. Moreover 1-2 out of 1000 patients under surgery report a partial wake up from anesthesia during the operation. The reason for such a partial lack of control of depth of anesthesia is that medical procedures are highly optimized based on experience but the neural dynamics during general anesthesia is far from being understood. One reason for this lack of understanding is both the complex neural interactions of neurons on different spatial and temporal scales and the poorly understood action of anesthetics on neural populations. For instance, anesthetic agents act on synaptic receptors on a microscopic scale essentially evoking a macroscopic change of population activity, such as Local Field Potentials, EEG/MEG or resulting change of cerebral blood flow. This population effect then triggers the loss of consciousness in patients. This Research Topic aims to address recent theoretical and experimental advances in the field. The theoretical and experimental studies represent a good overview over the current state of research in the field and provides a deeper insight into the underlying neural mechanisms. Each article in the issue focusses on a specific current research topic in general anesthesia research and several articles introduce to the topic in a pedagogical way. The issue covers various types of anaesthesia and the most important topics in the field, such as (but not limited to) recent advances in theoretical models and states of consciousness reflected in experimental data, the connectivity changes observed during anesthesia or effects of specific drugs on brain activity. The introduction style of the papers facilitates the reader to understand the background of the research aspect and even allows readers not familiar with general anesthesia research to enter the research domain. Hence the Research Topic aims to provide on one hand an overview of the current state of the art and on the other hand a good starting point for new researchers in the field.

Development and Application of Optical Coherence Tomography (Oct)

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ISBN: 9783038427445 9783038427438 Year: Pages: 212 DOI: 10.3390/books978-3-03842-743-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering
Added to DOAB on : 2018-02-16 08:34:07
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This special feature issue has been initiated to celebrate the 25th anniversary of Optical Coherence Tomography (OCT). In OCT, broad bandwidth light is used in order to produce cross sectional images of turbid and translucent samples with high axial resolution (in the order of a few µm). The imaging speed of OCT can be as high as several millions of depth scans (A-scans) per second which allows for various applications in different fields. This special feature issue consists of three overview papers covering OCT angiography, polarization-sensitive OCT and dental applications of OCT. Additional applications and the latest developments in OCT are covered in nine research papers. The latest developments presented in this issue include magnetomotive OCT, resonant Doppler OCT, full field OCT, new segmentation algorithms and depth range extension. Applications of OCT are widely spread and range from quality control in tooth prostheses and coating thickness measurements in the automotive industry to the assessment of degradation of coatings and alveolar dynamics.

Text - Verstehen. Grammatik und darüber hinaus

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Book Series: Jahrbuch des Instituts für Deutsche Sprache ISSN: 0537-7900 ISBN: 9783110199963 Year: Volume: 2005 Pages: 430 DOI: 10.1515/9783110199963 Language: German
Publisher: De Gruyter
Subject: Linguistics
Added to DOAB on : 2018-11-14 18:42:56

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This volume examines the question: What happens when texts are comprehended? Written by academics from a variety of countries renowned in the field, the nineteen principal essays investigate the grammatical, psychological, cultural, and didactic aspects of reading comprehension. Overall, the result is an extensive, intelligible synopsis of reading comprehension research.

Speckle Reduction in Projection Systems

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ISBN: 9783866444188 Year: Pages: XIV, 153 p. DOI: 10.5445/KSP/1000012434 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Technology (General)
Added to DOAB on : 2019-07-30 20:01:59
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A speckle pattern is a quasi-random interference pattern which typically emerges when lasers are used as illumination sources in projection applications and which severely degrades the image quality. Since in most projection applications high speckle disturbance is not tolerable, speckle reduction is a major issue. This work gives an introduction into the theoretical description of speckle and investigates different practical methods for speckle reduction in laser projection systems.

Identifying the Epileptic Network

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192960 Year: Pages: 126 DOI: 10.3389/978-2-88919-296-0 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:07
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An important area of current research in epilepsy focuses on identifying the specific regions within the brain that are affected in individuals with recurring seizures. The epileptogenic process may result not only in pathology in focal cortical regions, but abnormalities in subcortical structures, such as thalamus and basal ganglia, and in intercortical and intracortical connecting white matter pathways. Novel methods of treating refractory epilepsy are urgently needed. The goal of identifying for each affected individual the specific brain regions that are involved offers the promise that novel methods of treatment will one day be developed that specifically target those abnormal regions. Researchers from disparate fields are required to develop and advance this area of research, and this current topic proposes to place a spotlight on the “state of the art” of methods to identify the abnormal networks. Recent work covering a wide variety of disciplines and technologies, including dense array electroencephalography (dEEG), novel methods of analyses of both the interictal dEEG and intracranial EEG (icEEG), magnetoencephalography (MEG), high-resolution magnetic resonance imaging (MRI), functional MRI (fMRI), simultaneous fMRI-EEG, fMRI connectivity measures, simultaneous dEEG-icEEG, and techniques to coregister patient-specific MRI (including white matter pathways) and dEEG, are all examples of areas of research that have contributed to a greater understanding of potential epileptogenic regions. We asked for individuals with expertise in an area of research that expands an understanding of identifying epileptic networks to contribute to this research topic.

New perspectives on cohesion and coherence

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Book Series: Translation and Multilingual Natural Language Processing ISBN: 9783946234722 9783946234845 Year: Pages: 157 DOI: 10.5281/zenodo.814452 Language: English
Publisher: Language Science Press
Subject: Linguistics
Added to DOAB on : 2017-06-29 11:01:39
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"The contributions to this volume investigate relations of cohesion and coherence as well as instantiations of discourse phenomena and their interaction with information structure in multilingual contexts. Some contributions concentrate on procedures to analyze cohesion and coherence from a corpus-linguistic perspective. Others have a particular focus on textual cohesion in parallel corpora that include both originals and translated texts. Additionally, the papers in the volume discuss the nature of cohesion and coherence with implications for human and machine translation. The contributors are experts on discourse phenomena and textuality who address these issues from an empirical perspective. The chapters in this volume are grounded in the latest research making this book useful to both experts of discourse studies and computational linguistics, as well as advanced students with an interest in these disciplines. We hope that this volume will serve as a catalyst to other researchers and will facilitate further advances in the development of cost-effective annotation procedures, the application of statistical techniques for the analysis of linguistic phenomena and the elaboration of new methods for data interpretation in multilingual corpus linguistics and machine translation."

Pathophysiology and Imaging Diagnosis of Demyelinating Disorders

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ISBN: 9783038429432 9783038429449 Year: Pages: X, 168 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Neurology
Added to DOAB on : 2018-06-27 15:51:32
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Demyelinating disorders are chronic autoimmune disorders characterized by inflammation, demyelination, axonal degeneration, and neuronal loss. They have complex pathophysiology and diverse clinical presentations. The etiology of these disorders lies in the interaction between genetic and environmental factors. Due to the complexity in pathophysiology and presentation, diagnosis and treatment can be challenging. Advanced technology, including modern imaging techniques, as well as optical coherence tomography (OCT), enrich our understanding of the disease process, improve diagnostic accuracy, and may guide treatment decisions.

The chronic challenge - new vistas on long-term multisite contacts to the central nervous system

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195084 Year: Pages: 161 DOI: 10.3389/978-2-88919-508-4 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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Have you ever heard of a Hype-Cycle? It is a description that was put forward by an IT consultancy firm to describe certain phenomena that happen within the life cycle of new technology products. As Fenn and Raskino stated in their book (Fenn and Raskino 2008), a novel technology - a - “Technology Trigger” - gives rise to a steep increase in interest, leading to the “Peak of Inflated Expectations”. Following an accumulation of more detailed knowledge on the technology and its short-comings, the stake holders may need to traverse a “Trough of Disillusionment”, which is followed by a shallower “Slope of Enlightenment”, before finally reaching the “Plateau of Productivity”. In spite of the limitations and criticisms levied on this over-simplified description of a technology’s life-cycle, it is nonetheless able to describe well the situation we are all experiencing within the brain-machine-interfacing community. Our technology trigger was the development of batch-processed multisite neuronal interfaces based on silicon during the 1980s and 1990s (Sangler and Wise 1990, Campbell, Jones et al. 1991, Wise and Najafi 1991, Rousche and Normann 1992, Nordhausen, Maynard et al. 1996). This gave rise to a seemingly exponential growth of knowledge within the neurosciences, leading to the expectation of thought-controlled devices and prostheses for handicapped people in the very near future (Chapin, Moxon et al. 1999, Wessberg, Stambaugh et al. 2000, Chapin and Moxon 2001, Serruya, Hatsopoulos et al. 2002). Unfortunately, whereas significant steps towards artificial robotic limbs could have been implemented during the last decade (Johannes, Bigelow et al. 2011, Oung, Pohl et al. 2012, Belter, Segil et al. 2013), direct invasive intracortical interfacing was not quite able to keep up with these expectations. Insofar, we are currently facing the challenging, but tedious walk through the Trough of Disillusionment. Undoubtedly, more than two decades of intense research on brain-machine-interfaces (BMI’s) have produced a tremendous wealth of information towards the ultimate goal: a clinically useful cortical prosthesis. Unfortunately even today - after huge fiscal efforts - the goal seems almost to be as far away as it was when it was originally put forward. At the very least, we have to state that one of the main challenges towards a clinical useful BMI has not been sufficiently answered yet: regarding the long term – or even truly chronic – stability of the neural cortical interface, as well as the signals it has to provide over a significant fraction of a human’s lifespan. Even the recently demonstrated advances in BMI’s in both humans and non-human primates have to deal with a severe decay of spiking activity that occurs over weeks and months (Chestek, Gilja et al. 2011, Hochberg, Bacher et al. 2012, Collinger, Kryger et al. 2014, Nuyujukian, Kao et al. 2014, Stavisky, Kao et al. 2014, Wodlinger, Downey et al. 2014) and resolve to simplified features to keep a brain-derived communication channel open (Christie, Tat et al. 2014).

Events, States and Times. An essay on narrative discourse in English

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ISBN: 9783110485912 9783110486452 Year: Pages: x, 176 DOI: 10.1515/9783110485912 Language: English
Publisher: De Gruyter
Subject: Linguistics
Added to DOAB on : 2017-01-18 15:26:23
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This monograph investigates the temporal interpretation of narrative discourse in two parts. The theme of the first part is narrative progression. It begins with a case study of the adverb ‘now’ and its interaction with the meaning of tense. The case study motivates an ontological distinction between events, states and times and proposes that ‘now’ seeks a prominent state that holds throughout the time described by the tense. Building on prior research, prominence is shown to be influenced by principles of discourse coherence and two coherence principles, NARRATION and RESULT, are given a formally explicit characterization. The key innovation is a new method for testing the definitional adequacy of NARRATION and RESULT, namely by an abductive argument. This contribution opens a new way of thinking about how eventive and stative descriptions contribute to the perceived narrative progression in a discourse.

Optical Coherence Tomography guided Laser-Cochleostomy

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ISBN: 9783731503026 Year: Pages: VII, 180 p. DOI: 10.5445/KSP/1000044633 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:01:59
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Despite the high precision of laser, it remains challenging to control the laser-bone ablation without injuring the underlying critical structures. Providing an axial resolution on micrometre scale, OCT is a promising candidate for imaging microstructures beneath the bone surface and monitoring the ablation process. In this work, a bridge connecting these two technologies is established. A closed-loop control of laser-bone ablation under the monitoring with OCT has been successfully realised.

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