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Computational Modelling of the Steps Involved in Photodynamic Therapy (Book chapter)

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ISBN: 9789535104469 Year: DOI: 10.5772/37654 Language: English
Publisher: IntechOpen Grant: FP7 Ideas: European Research Council - 258990
Subject: Science (General)
Added to DOAB on : 2019-01-17 11:47:59
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Photodynamic therapy (PDT) is a branch of phototherapy that has seen a surge of interest in the last few decades, due to its potential in the treatment of various cancers, infections and heart disease.(Bonnett, 2000) This chapter aims to give an overview of the various photochemical steps involved in PDT as a cancer therapy, and in particular the challenges and insight gained from their theoretical description. After a brief review of PDT in general, in a biological and chemical context, the photochemical steps involved will be discussed, detailing the computational techniques required to model these chemical pathways theoretically. We will detail the methodologies that can currently be applied, as well as their limitations of use at present, and areas requiring further development.

How Humans Recognize Objects: Segmentation, Categorization and Individual Identification

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199402 Year: Pages: 265 DOI: 10.3389/978-2-88919-940-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Psychology
Added to DOAB on : 2016-01-19 14:05:46
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Human beings experience a world of objects: bounded entities that occupy space and persist through time. Our actions are directed toward objects, and our language describes objects. We categorize objects into kinds that have different typical properties and behaviors. We regard some kinds of objects – each other, for example – as animate agents capable of independent experience and action, while we regard other kinds of objects as inert. We re-identify objects, immediately and without conscious deliberation, after days or even years of non-observation, and often following changes in the features, locations, or contexts of the objects being re-identified. Comparative, developmental and adult observations using a variety of approaches and methods have yielded a detailed understanding of object detection and recognition by the visual system and an advancing understanding of haptic and auditory information processing. Many fundamental questions, however, remain unanswered. What, for example, physically constitutes an “object”? How do specific, classically-characterizable object boundaries emerge from the physical dynamics described by quantum theory, and can this emergence process be described independently of any assumptions regarding the perceptual capabilities of observers? How are visual motion and feature information combined to create object information? How are the object trajectories that indicate persistence to human observers implemented, and how are these trajectory representations bound to feature representations? How, for example, are point-light walkers recognized as single objects? How are conflicts between trajectory-driven and feature-driven identifications of objects resolved, for example in multiple-object tracking situations? Are there separate “what” and “where” processing streams for haptic and auditory perception? Are there haptic and/or auditory equivalents of the visual object file? Are there equivalents of the visual object token? How are object-identification conflicts between different perceptual systems resolved? Is the common assumption that “persistent object” is a fundamental innate category justified? How does the ability to identify and categorize objects relate to the ability to name and describe them using language? How are features that an individual object had in the past but does not have currently represented? How are categorical constraints on how objects move or act represented, and how do such constraints influence categorization and the re-identification of individuals? How do human beings re-identify objects, including each other, as persistent individuals across changes in location, context and features, even after gaps in observation lasting months or years? How do human capabilities for object categorization and re-identification over time relate to those of other species, and how do human infants develop these capabilities? What can modeling approaches such as cognitive robotics tell us about the answers to these questions? Primary research reports, reviews, and hypothesis and theory papers addressing questions relevant to the understanding of perceptual object segmentation, categorization and individual identification at any scale and from any experimental or modeling perspective are solicited for this Research Topic. Papers that review particular sets of issues from multiple disciplinary perspectives or that advance integrative hypotheses or models that take data from multiple experimental approaches into account are especially encouraged.

Ventricular Mechanics in Congenital Heart Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452644 Year: Pages: 120 DOI: 10.3389/978-2-88945-264-4 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Pediatrics
Added to DOAB on : 2018-02-27 16:16:44
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Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.

Neutrosophic Multi-Criteria Decision Making

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ISBN: 9783038972884 9783038972891 Year: Pages: 206 DOI: 10.3390/books978-3-03897-289-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Mathematics --- Physics (General)
Added to DOAB on : 2018-10-12 10:17:26
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Neutrosophic logic and set are gaining significant attention in solving many real-life problems that involve uncertainty, impreciseness, vagueness, incompleteness, inconsistency, and indeterminacy. A number of new neutrosophic theories have been proposed and have been applied in Multi-Criteria Decision-Making, computational intelligence, multiple-attribute decision-making, image processing, medical diagnosis, fault diagnosis, optimization design, and so on. Neutrosophic logic, set, probability, statistics, etc., are, respectively, generalizations of fuzzy and intuitionistic fuzzy logic and set, classical and imprecise probability, classical statistics and so on.This Special Issue gathers 11 original research papers that report on the state of the art and recent advancements in Multi-Criteria Decision-Making using neutrosophic environment in computing, artificial intelligence, big and small data mining, group decision-making problems, pattern recognition, information processing, image processing, and many other practical achievements.

Biomaterials for Bone Tissue Engineering

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ISBN: 9783039289653 / 9783039289660 Year: Pages: 244 DOI: 10.3390/books978-3-03928-966-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Bone tissue engineering aims to develop artificial bone substitutes that partially or totally restore the natural regeneration capability of bone tissue lost under circumstances of injury, significant defects, or diseases such as osteoporosis. In this context, biomaterials are the keystone of the methodology. Biomaterials for bone tissue engineering have evolved from biocompatible materials that mimic the physical and chemical environment of bone tissue to a new generation of materials that actively interacts with the physiological environment, accelerating bone tissue growth. Mathematical modelling and simulation are important tools in the overall methodology. This book presents an overview of the current investigations and recent contributions in the field of bone tissue engineering. It includes several successful examples of multidisciplinary collaboration in this transversal area of research. The book is intended for students, researchers, and professionals of a number of disciplines, such as engineering, mathematics, physics, chemistry, biomedicine, biology, and veterinary. The book is composed of an editorial section and 16 original research papers authored by leading researchers of this discipline from different laboratories across the world

Keywords

Pelvis --- Bone tumor --- 3D-printed implant --- Fixation design --- von Mises stress --- dental implants --- osseointegration --- resonance frequency analysis --- biomaterials --- titanium --- powder metallurgy --- loose sintering --- finite element method --- mechanical behaviour --- bone tissue regeneration --- computed tomography --- Xenografts --- stem cell --- cartilage --- finite element --- finite-element simulation --- electric stimulation --- bone regeneration --- computational modelling --- electrically active implants --- bioelectromagnetism --- critical size defect --- maxillofacial --- minipig --- oxygen delivery --- optimization --- mass transfer --- transport --- bone tissue engineering --- computational fluid dynamics --- Lattice Boltzmann method --- scaffold design --- culturing protocol --- Lagrangian scalar tracking --- cortical bone --- damage --- finite elements --- numerical results --- adipogenesis --- bone marrow --- MSCs --- prediction marker --- bone tissue --- elastoplasticity --- finite element method --- fracture risk --- osteoporosis --- trabeculae --- trabecular bone score --- vertebra --- biomechanics --- finite element modelling --- pelvis --- bone adaptation --- musculoskeletal modelling --- bone tissue engineering --- biomaterials --- computational mechanobiology --- numerical methods in bioengineering --- Ti6Al4V scaffolds --- triply periodic minimal surfaces --- selective laser melting --- additive manufacturing --- biomaterial applications --- finite element analysis --- spark plasma sintering --- wollastonite --- human dental pulp stem cells --- substrate-mediated electrical stimulation --- direct current electric field --- osteo-differentiation --- bone morphogenesis proteins --- cortical bone --- digital image correlation --- multiscale analysis --- micromechanics --- computational mechanics --- cone beam computed tomography --- automatic segmentation --- sliding window --- 3D virtual surgical plan --- Otsu’s method --- n/a

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