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Neuronal Polarity: Establishment and Maintenance

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889455171 Year: Pages: 172 DOI: 10.3389/978-2-88945-517-1 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Neurology
Added to DOAB on : 2019-01-23 14:53:42
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The term polarity in a biological context is used to describe an asymmetry in morphology and distribution of molecules. In neurons, their complex shape with typically one axon and several dendrites reflects this asymmetry. Although neurons assume many different shapes and sizes they always maintain these two domains, which are essential for neuronal function. In the most simple view, neurons use their axon to transmit signals over long distances due to its capacity to extend to enormous lengths. Dendrites, on the other hand, are shorter and receive and integrate signals from different locations. The selection of the site where the axon and dendrites initially emerge during embryonic development is a tightly regulated event, eventually important for the correct formation of neuronal circuits, and disturbances of these processes can have pathological consequences due to circuit malformation. An important question is which mechanisms neurons utilize to specify the sites where axonal and dendrite outgrowth occurs and how their identities are maintained during and after development. The formation of these functionally diverse domains is the result of polarized differences of membrane and protein delivery, mitochondria transport, actin dynamics and microtubule stability. However how and in which temporal order all those events which coordinate the selection and maintenance of axons and dendrites is still under investigation. This selection of articles shall highlight new findings, which help to unravel all molecular and cellular events important for neuronal polarity establishment and maintenance.

Dendritic spines: From shape to function

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197668 Year: Pages: 235 DOI: 10.3389/978-2-88919-766-8 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked.

Quantitative analysis of neuroanatomy

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197965 Year: Pages: 244 DOI: 10.3389/978-2-88919-796-5 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2016-04-07 11:22:02
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The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.

Neuroproteomics

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ISBN: 9783039281060 9783039281077 Year: Pages: 318 DOI: 10.3390/books978-3-03928-107-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2020-04-07 23:07:08
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The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.

Keywords

proteomics --- basal ganglia --- synapses --- synapse specificity --- neuronal circuits --- axons --- dendrites --- neurodegeneration --- synapse --- postsynaptic --- proteome --- mass spectrometry --- protein interaction networks --- connectome --- neurodegeneration --- Alzheimer’s disease --- cerebrospinal fluid --- plasma --- serum --- proteomics --- biomarkers --- LC-MS/MS --- cocaine --- addiction --- cytokine --- neuroimmune --- ventral tegmental area --- peptidylglycine ?-amidating monooxygenase --- cilia --- mating --- signal peptide --- prohormone convertase --- carboxypeptidase --- matrix metalloproteinase --- subtilisin --- pherophorin --- morphine --- opioid receptors --- conformational antibody --- analgesia --- GPCR signaling --- phosphorylation --- AMPA receptor complex --- transmembrane AMPA receptor regulatory protein --- synaptic plasticity --- adolescence --- corticosterone --- proteomics --- yohimbine --- progressive ratio --- reinstatement --- ethanol --- nicotinic receptor --- CaMKII --- PKA --- quantitative phosphoproteomics --- mouse --- phosphorylation --- nicotine --- proteomics --- proteome --- mass spectrometry --- Alzheimer’s disease --- protein aggregation --- laser capture microdissection --- splicing --- U1 snRNP --- synapse --- synaptic cleft --- trans-synaptic adhesion --- proximity labeling --- SynCAM --- Cadm --- Receptor-type tyrosine-protein phosphatase zeta --- R-PTP-zeta --- Ptprz1 --- neuroproteome --- drug abuse --- neuropeptidomics --- phosphorylation --- interactome --- cell type --- neuroscience --- proteomics --- mass spectrometry --- neuron --- proximity labeling --- affinity chromatography --- neuroproteomics --- biotinylation --- amphetamine --- spinophilin --- protein phosphatase-1 --- dopamine --- striatum --- mass spectroscopy --- bioinformatics --- FGF14 --- voltage gated channels --- schizophrenia --- autism --- Alzheimer’s Disease --- sex-specific differences --- synaptic plasticity --- cognitive impairment --- excitatory/inhibitory tone --- n/a --- postsynaptic density --- PSD --- parallel reaction monitoring --- PRM --- targeted proteomics --- data-independent acquisition --- DIA --- quantitative mass spectrometry --- n/a

Additive Manufacturing: Alloy Design and Process Innovations

Authors: ---
ISBN: 9783039283521 / 9783039283538 Year: Pages: 372 DOI: 10.3390/books978-3-03928-353-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
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Additive manufacturing (AM) is one of the manufacturing processes that warrants the attention of industrialists, researchers and scientists, because of its ability to produce materials with a complex shape without theoretical restrictions and with added functionalities. There are several advantages to employing additive manufacturing as the primary additive manufacturing process. However, there exist several challenges that need to be addressed systematically. A couple such issues are alloy design and process development. Traditionally alloys designed for conventional cast/powder metallurgical processes were fabricated using advanced AM processes. This is the wrong approach considering that the alloys should be coined based on the process characteristics and meta-stable nature of the process. Hence, we must focus on alloy design and development for AM that suits the AM processes. The AM processes, however, improve almost every day, either in terms of processing capabilities or processing conditions. Hence, the processing part warrants a section that is devoted to these advancements and innovations. Accordingly, the present Special Issue (book) focuses on two aspects of alloy development and process innovations. Here, 45 articles are presented covering different AM processes including selective laser melting, electron beam melting, laser cladding, direct metal laser sintering, ultrasonic consolidation, wire arc additive manufacturing, and hybrid manufacturing. I believe that this Special Issue bears is vital to the field of AM and will be a valuable addition.

Keywords

concrete --- slag --- valorization --- cement --- circular economy --- wire feeding additive manufacturing --- wire lateral feeding --- macro defects --- side spatters --- selective laser melting --- numerical analysis --- thermal behaviour --- AlSi10Mg alloy --- design --- disc brake --- 3D metal printing --- direct metal laser sintering --- thermal stress analysis --- radial grooves --- nickel alloys --- Hastelloy X alloy --- additive manufacturing --- microstructure --- scanning electron microscopy (SEM) --- laser powder bed fusion (LPBF) --- selective laser melting --- titanium alloy --- heat treatment --- microstructure --- microhardness measurement --- arc additive manufacturing --- Al–5Si alloy --- pulse frequency --- arc current --- microstructure --- porosity --- 2219 aluminum alloy --- constitutive model --- microstructural evolution --- continuous dynamic recrystallization --- hot deformation --- selective laser melting --- amorphous alloy --- finite element analysis --- residual stress --- 2219 aluminum alloy --- intermediate thermo-mechanical treatment --- storage energy --- CuAl2 phase --- grain refinement --- selective laser melting --- GH4169 --- temperature and stress fields --- simulation --- model --- selective laser melting --- divisional scanning --- residual stress --- deformation --- thermal conductivity --- tensile strength --- inoculation --- gray cast iron --- additive manufacturing --- selective laser melting --- AlSi10Mg --- Al6061 --- SLM process parameters --- performance characteristics --- AlSi10Mg --- multi-laser manufacturing --- selective laser melting --- microstructure --- mechanical property --- additive manufacturing --- metal powders --- powder flowability --- powder properties --- aluminum --- water absorption --- laser cladding deposition --- 12CrNi2 alloy steel powder --- substrate preheating --- microstructure and properties --- residual stress --- ultrafast laser --- femtosecond --- ablation --- scanning --- additive surface structuring --- hydrophobicity --- parts design --- additive manufacturing --- fused filament fabrication --- fatigue --- Taguchi --- ABS --- additive manufacturing --- selective laser melting --- AlSi10Mg --- Al6061 --- SLM process parameters --- quality of the as-built parts --- aluminum alloys --- selective laser melting (SLM) --- mechanical properties --- selective laser melting --- H13 tool steel --- process parameters --- scanning strategy --- support strategy --- porosity reduction --- selective laser melting --- Ti6Al4V alloy --- martensitic transformation --- texture evolution --- mechanical properties --- M300 mold steel --- elastic abrasive --- PSO-BP neural network algorithm --- parameter optimization --- WxNbMoTa --- refractory high-entropy alloy --- laser cladding deposition --- rapid solidification --- bulk metallic glasses --- selective laser melting --- Cu50Zr43Al7 --- mechanical properties --- Ti-6Al-4V --- wear --- additive manufacturing --- properties --- in-process temperature in MPBAM --- analytical modeling --- high computational efficiency --- molten pool evolution --- laser power absorption --- latent heat --- scanning strategy --- powder packing --- graphene nano-sheets (GNSs) --- epoxy solder --- intermetallic compound (IMC) --- laser powder bed fusion --- additive manufacturing --- aluminum --- composition --- mechanical properties --- localized inductive heating --- hot stamping steel blanks --- tailored properties --- magnetizer --- selective laser melting --- AlSi10Mg alloy --- dynamic properties --- impact --- crystallographic texture --- Additive manufacturing --- selective laser melting --- volumetric heat source --- thermal capillary effects --- melt pool size --- selective laser melting --- Inconel 718 --- crystallographic texture --- subgranular dendrites --- epitaxial growth --- 3D printing --- continuous carbon fiber --- thermosetting epoxy resin --- mechanical properties --- Powder bed --- fatigue --- Hot Isostatic Pressure --- Electron Beam Melting --- stability lobe diagram --- milling --- process-damping --- dynamic characteristics --- thin-walled weak rigidity parts --- Al–Si --- selective laser melting (SLM) --- microstructure --- mechanical properties --- selective laser melting --- microstructure --- defects --- Inconel 718 --- laser energy density --- selective laser melting --- molten pool dynamic behavior --- equivalent processing model --- workpiece scale --- nickel-based superalloy --- numerical simulation --- metallic glasses --- composite materials --- interfaces --- additive manufacturing --- ultrasonic bonding --- 3D printing --- Al–Mg–Si alloy --- quenching rate --- microstructures --- mechanical properties --- paint bake-hardening --- precipitates --- additive manufacturing --- powder bed fusion --- selective laser melting --- regular mixing --- ball milling --- flowability --- Ti-6Al-4V --- microstructure --- element segregation --- laves phase --- vanadium --- laser cladding --- arc additive manufacture --- Al–Mg alloy --- Mg content --- microstructure --- mechanical properties --- n/a

Additive Manufacturing: Alloy Design and Process Innovations

Authors: ---
ISBN: 9783039284146 / 9783039284153 Year: Pages: 352 DOI: 10.3390/books978-3-03928-415-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2020-06-09 16:38:57
License:

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Abstract

Additive manufacturing (AM) is one of the manufacturing processes that warrants the attention of industrialists, researchers and scientists, because of its ability to produce materials with a complex shape without theoretical restrictions and with added functionalities. There are several advantages to employing additive manufacturing as the primary additive manufacturing process. However, there exist several challenges that need to be addressed systematically. A couple such issues are alloy design and process development. Traditionally alloys designed for conventional cast/powder metallurgical processes were fabricated using advanced AM processes. This is the wrong approach considering that the alloys should be coined based on the process characteristics and meta-stable nature of the process. Hence, we must focus on alloy design and development for AM that suits the AM processes. The AM processes, however, improve almost every day, either in terms of processing capabilities or processing conditions. Hence, the processing part warrants a section that is devoted to these advancements and innovations. Accordingly, the present Special Issue (book) focuses on two aspects of alloy development and process innovations. Here, 45 articles are presented covering different AM processes including selective laser melting, electron beam melting, laser cladding, direct metal laser sintering, ultrasonic consolidation, wire arc additive manufacturing, and hybrid manufacturing. I believe that this Special Issue bears is vital to the field of AM and will be a valuable addition.

Keywords

concrete --- slag --- valorization --- cement --- circular economy --- wire feeding additive manufacturing --- wire lateral feeding --- macro defects --- side spatters --- selective laser melting --- numerical analysis --- thermal behaviour --- AlSi10Mg alloy --- design --- disc brake --- 3D metal printing --- direct metal laser sintering --- thermal stress analysis --- radial grooves --- nickel alloys --- Hastelloy X alloy --- additive manufacturing --- microstructure --- scanning electron microscopy (SEM) --- laser powder bed fusion (LPBF) --- selective laser melting --- titanium alloy --- heat treatment --- microstructure --- microhardness measurement --- arc additive manufacturing --- Al–5Si alloy --- pulse frequency --- arc current --- microstructure --- porosity --- 2219 aluminum alloy --- constitutive model --- microstructural evolution --- continuous dynamic recrystallization --- hot deformation --- selective laser melting --- amorphous alloy --- finite element analysis --- residual stress --- 2219 aluminum alloy --- intermediate thermo-mechanical treatment --- storage energy --- CuAl2 phase --- grain refinement --- selective laser melting --- GH4169 --- temperature and stress fields --- simulation --- model --- selective laser melting --- divisional scanning --- residual stress --- deformation --- thermal conductivity --- tensile strength --- inoculation --- gray cast iron --- additive manufacturing --- selective laser melting --- AlSi10Mg --- Al6061 --- SLM process parameters --- performance characteristics --- AlSi10Mg --- multi-laser manufacturing --- selective laser melting --- microstructure --- mechanical property --- additive manufacturing --- metal powders --- powder flowability --- powder properties --- aluminum --- water absorption --- laser cladding deposition --- 12CrNi2 alloy steel powder --- substrate preheating --- microstructure and properties --- residual stress --- ultrafast laser --- femtosecond --- ablation --- scanning --- additive surface structuring --- hydrophobicity --- parts design --- additive manufacturing --- fused filament fabrication --- fatigue --- Taguchi --- ABS --- additive manufacturing --- selective laser melting --- AlSi10Mg --- Al6061 --- SLM process parameters --- quality of the as-built parts --- aluminum alloys --- selective laser melting (SLM) --- mechanical properties --- selective laser melting --- H13 tool steel --- process parameters --- scanning strategy --- support strategy --- porosity reduction --- selective laser melting --- Ti6Al4V alloy --- martensitic transformation --- texture evolution --- mechanical properties --- M300 mold steel --- elastic abrasive --- PSO-BP neural network algorithm --- parameter optimization --- WxNbMoTa --- refractory high-entropy alloy --- laser cladding deposition --- rapid solidification --- bulk metallic glasses --- selective laser melting --- Cu50Zr43Al7 --- mechanical properties --- Ti-6Al-4V --- wear --- additive manufacturing --- properties --- in-process temperature in MPBAM --- analytical modeling --- high computational efficiency --- molten pool evolution --- laser power absorption --- latent heat --- scanning strategy --- powder packing --- graphene nano-sheets (GNSs) --- epoxy solder --- intermetallic compound (IMC) --- laser powder bed fusion --- additive manufacturing --- aluminum --- composition --- mechanical properties --- localized inductive heating --- hot stamping steel blanks --- tailored properties --- magnetizer --- selective laser melting --- AlSi10Mg alloy --- dynamic properties --- impact --- crystallographic texture --- Additive manufacturing --- selective laser melting --- volumetric heat source --- thermal capillary effects --- melt pool size --- selective laser melting --- Inconel 718 --- crystallographic texture --- subgranular dendrites --- epitaxial growth --- 3D printing --- continuous carbon fiber --- thermosetting epoxy resin --- mechanical properties --- Powder bed --- fatigue --- Hot Isostatic Pressure --- Electron Beam Melting --- stability lobe diagram --- milling --- process-damping --- dynamic characteristics --- thin-walled weak rigidity parts --- Al–Si --- selective laser melting (SLM) --- microstructure --- mechanical properties --- selective laser melting --- microstructure --- defects --- Inconel 718 --- laser energy density --- selective laser melting --- molten pool dynamic behavior --- equivalent processing model --- workpiece scale --- nickel-based superalloy --- numerical simulation --- metallic glasses --- composite materials --- interfaces --- additive manufacturing --- ultrasonic bonding --- 3D printing --- Al–Mg–Si alloy --- quenching rate --- microstructures --- mechanical properties --- paint bake-hardening --- precipitates --- additive manufacturing --- powder bed fusion --- selective laser melting --- regular mixing --- ball milling --- flowability --- Ti-6Al-4V --- microstructure --- element segregation --- laves phase --- vanadium --- laser cladding --- arc additive manufacture --- Al–Mg alloy --- Mg content --- microstructure --- mechanical properties --- n/a

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