Search results: Found 24

Listing 1 - 10 of 24 << page
of 3
>>
Sort by
Stem Cells in Neuroendocrinology

Authors: ---
Book Series: Research and Perspectives in Endocrine Interactions ISSN: 1861-2253 ISBN: 9783319416021 9783319416038 Year: Pages: 156 DOI: 10.1007/978-3-319-41603-8 Language: English
Publisher: Springer
Subject: Internal medicine
Added to DOAB on : 2016-12-20 11:36:46
License:

Loading...
Export citation

Choose an application

Abstract

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.

Major Topics in Type 1 Diabetes

Author:
ISBN: 9789535122043 9789535142140 Year: Pages: 182 DOI: 10.5772/59335 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

Type 1 diabetes (TD1) is one of the most common endocrine disorders in children and can occur at any age. Incidences of T1D have steadily increased worldwide, and it is largely considered an autoimmune disorder resulting from the specific destruction of pancreatic beta-cells producing insulin. However, T1D pathophysiology is still not completely understood, and although insulin and other therapies ameliorate the manifestations of the disease, no cure is currently available. This book has been written by widely acknowledged experts, with each chapter providing unique information on emerging aspects of T1D. Because a large body of information has been available regarding T1D, this book highlights lesser explored topics linked to the subject using important and recent knowledge that presages directions for further research. Current possibilities to forestall diabetic complications are also explored.

Adiposity - Omics and Molecular Understanding

Author:
ISBN: 9789535129974 9789535129981 Year: Pages: 296 DOI: 10.5772/67422 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:49

Loading...
Export citation

Choose an application

Abstract

This book is the second in a series of two, featuring the Adiposity - Omics and Molecular Understanding, serving as an introduction to modern views on how the adipocytes are reciprocally interacting with organ systems in order to explain the biology of the body's fat cells and how they are integrated with other organ systems, like muscle cells and the liver, in order to control the lipid metabolism in our bodies, to finally preserve a positive balance between white and brown/beige adipocyte tissues (WAT and BAT). The understanding of the ""omics"" of obesity will therefore enable clinicians and researchers to better pursue the untoward incidents of metabolic deviations from a defined and health-bringing homeostasis, with fully responding WAT and BAT, being able to preserve a healthy balance between fat-producing and fat-metabolizing tissues for the benefit of the host, and thus longevity (optimal health with healthy, well-functioning organ systems) throughout a lifetime.

Thyroid Disorders

Author:
ISBN: 9781789857856 9781789857863 Year: Pages: 80 DOI: 10.5772/intechopen.72980 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:53

Loading...
Export citation

Choose an application

Abstract

This is a small book containing various aspects of thyroid gland disorders. Congenital hypothyroidism chapter emphasizes early diagnosis in prevention of irreparable damage to growth and brain of infants. Role of nuclear medicine in diagnosis and treatment is outlined. Last few chapters deal with congenital hypothyroidism, thyroid carcinoma, its diagnosis, treatment and preservation of posterior parathyroid gland during thyroid surgery. The purpose of the book is to disseminate knowledge on thyroid diseases. It will be a good reference book both for students of medicine and general practitioners.

Endocrinologie et communications cellulaires

Authors: ---
ISBN: 2868834760 Year: Pages: 584 DOI: 10.26530/OAPEN_519667 Language: French
Publisher: EDP SCIENCES
Subject: Medicine (General)
Added to DOAB on : 2015-02-10 11:01:11
License:

Loading...
Export citation

Choose an application

Abstract

Cellular communication, endocrinology

The role of the immune system in the pathogenesis of diabetic complications

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193523 Year: Pages: 95 DOI: 10.3389/978-2-88919-352-3 Language: English
Publisher: Frontiers Media SA
Subject: Nutrition and Food Sciences --- Neurology --- Science (General) --- Public Health --- Internal medicine --- Medicine (General)
Added to DOAB on : 2016-03-10 08:14:32
License:

Loading...
Export citation

Choose an application

Abstract

The main causes of morbidity and mortality in diabetes are macrovasular and microvascular complications, including atherosclerosis, nephropathy, and retinopathy. As the definition of atherosclerosis as a chronic, smoldering, inflammatory disease has gained general acceptance, the attention of researchers has focused on the triggers of chronic vascular inflammation. The oxidation and other forms of modification of lipids and lipoproteins have emerged as a major pathogenic factor in atherosclerosis, with a significant interaction with the immune system. Modified lipoproteins by themselves are proinflammatory through the activation of the innate immune system as a consequence of the interaction with scavenger receptors and/or toll-like receptors expressed by a variety of cell types, including phagocytic cells and dendritic cells. A variety of modified forms of LDL (mLDL), including oxidized, malondialdehyde-modified, and Advanced Glycation End-product-modified LDL induce autoimmune responses in humans. Those modifications seem enhanced in diabetes, and the progression of atherosclerosis is accelerated in diabetic patients. The immune response to all forms of mLDL results in both activation of T cells in the arterial wall and in an autoimmune response characterized by the formation of IgG antibodies. Both arms of the immune response are believed to play a role in vascular inflammation. While the cell response is likely to activate resident macrophages, the humoral immune response results in the production of IgG antibodies that bind to specific epitopes in modified forms of LDL, generate immune complexes both intra- and extravascularly, and those complexes are able to activate the classical pathway of the complement system as well as phagocytic cells via Fc? receptors. In vitro studies suggest that the pro-inflammatory activity of immune complexes containing mLDL is several-fold higher than that of the modified LDL molecules by themselves. Clinical studies have provided significant support to the pathogenic role of immune complexes containing modified LDL in the development of atherosclerotic complications in patients with both type 1 and type 2 diabetes. At the same time, there is increasing evidence that the formation of immune complexes containing modified forms of LDL may also be involved in the pathogenesis of diabetic nephropathy and retinopathy. These are areas in which more research is needed to fully understand the pathogenic mechanisms activated by those immune complexes. Of interest is the fact that animal models have suggested the possibility of modifying the adaptive humoral immune response in ways that would result in slowing down, and perhaps prevent, the atherosclerotic process. This possibility is sufficiently alluring as to justify increased research efforts, both in animal models (including diabetic animals) and translational clinical studies. The manipulation of the T regulatory population is another area of potential translational impact, which has hardly been explored. Indeed at this point of time, what seems to be a high priority is an increased and open interchange of information among investigators, trying to reach a better general understanding and integration of knowledge generated from a variety of approaches and perspectives. This Research Topic provided an optimal platform for this open interchange of information. We encouraged interested scientists to submit mini-reviews, methods papers, review articles, perspectives and original research articles covering this topic in all its diversity to facilitate the communication of perspectives and new information between scientists interested in understanding the multiple implications of the involvement of the immune system in the pathogenesis of diabetic complications.

Diabetes and Its Complications

Author:
ISBN: 9781789230345 9781789230352 Year: Pages: 212 DOI: 10.5772/intechopen.68331 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

Loading...
Export citation

Choose an application

Abstract

Diabetes is a complex, progressive disease, which is accompanied by several complications. It is listed among the most common endocrine disorders and a global metabolic epidemic disease. This book focuses on the recent progress in diabetes research worldwide. It has been written by extensively acknowledged experts, with each chapter providing a unique data on developing features of diabetes. It covers the interactions between diabetes and several disorders. Also, it suggests some treatments for this disease offering us hope in prevention and successful improvement.

Sex Hormones in Neurodegenerative Processes and Diseases

Author:
ISBN: 9781789230147 9781789230154 Year: Pages: 358 DOI: 10.5772/66585 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

Loading...
Export citation

Choose an application

Abstract

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Corticosteroids

Author:
ISBN: 9781789231847 9781789231854 Year: Pages: 220 DOI: 10.5772/intechopen.68270 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

Loading...
Export citation

Choose an application

Abstract

Corticosteroids are mainly used to reduce inflammation and suppress the immune system. Corticosteroids will only be prescribed if the potential benefits of treatment outweigh the risks. They will also be prescribed at the lowest effective dose for the shortest possible time. This book will strive to highlight the importance of corticosteroids, to focus on minimizing side effects, to monitor and sensitize the population on the potential adverse effects of misuse, to provide additional knowledge about the design and development of new drug delivery systems loaded with corticosteroids potentially useful in the treatment of chronic inflammatory-based diseases, and to reduce inflammation and affect the immune system. The major objective of this book will be to present the information in a lucid, condensed, and cohesive form and to specially cater to the needs of readers in medicine and pharmacy.

Adipose Tissue

Author:
ISBN: 9781789232288 9781789232295 Year: Pages: 278 DOI: 10.5772/intechopen.71377 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:51

Loading...
Export citation

Choose an application

Abstract

Adipose tissue is a specialized connective tissue which, depending on type, plays different and significant roles in the human body: protects against environmental factors, stores lipids and triacylglycerol, synthesizes fatty acids and is involved in the process of thermogenesis. It is also a major secretory organ and highly active metabolic tissue. It secretes, for example, cholesterol, retinol, steroid hormones, prostaglandins and proteins known as ""adipokines"". Some of these molecules may be associated with pathologies such as obesity and insulin resistance. In humans, there are two main sites of adipose tissue accumulation: visceral and subcutaneous. Obesity is a worldwide health problem. This book also discusses a series of up-to-date topics about this pathology.

Listing 1 - 10 of 24 << page
of 3
>>
Sort by
Narrow your search

Publisher

IntechOpen (20)

Springer (2)

EDP SCIENCES (1)

Frontiers Media SA (1)


License

unknown (20)

CC by (2)

CC by-nc (2)


Language

english (23)

french (1)


Year
From To Submit

2019 (8)

2018 (7)

2017 (3)

2016 (2)

2015 (1)

2014 (1)

2012 (1)

2001 (1)