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New Concepts in Inflammatory Bowel Disease

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ISBN: 9789535138457 9789535138464 9789535140627 Year: Pages: 108 DOI: 10.5772/intechopen.68662 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:51

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Abstract

Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract of unknown origin, which includes Crohn's disease, ulcerative colitis, and inflammatory bowel disease of unclassified type. It is associated with different intestinal and extraintestinal manifestations like different neurological and psychiatric disorders. Histology is an important tool in the diagnosis and prognosis of inflammatory bowel disease and has an increasing part in patients' management. The objective of treatment is to make and keep long-lasting remission by immunosuppressive treatment like corticosteroids, thiopurines, and monoclonal antibodies directed against tumor necrosis factor alpha. Therapeutic drug monitoring of thiopurines by measuring levels of their metabolites has been proposed as a potentially effective tool in optimizing therapy in inflammatory bowel disease. Diets and their components influence microbiota of the intestine, function of the epithelial barrier, immune response, and other factors that have an important role in development and treatment of inflammation in the gut mucosa.

Metagenomics for Gut Microbes

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ISBN: 9781789231106 9781789231113 Year: Pages: 114 DOI: 10.5772/intechopen.68370 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:51

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This book focuses on metagenomics for gut microbiomes. The host is deprived of various benefits derived from the numerous gut microbes for food metabolism and health. However, polysaccharides such as cellulose, xylans, resistant starch, and inulin that are found in vegetables in our diet are digested by certain species that colonize the intestines. In contrast, metagenomic studies that reiterate microbiome intrinsic factors from particular communities and lifestyles and are extremely important for bacterial communities traveling over a long distance have entered a new era. Predominantly to understand the behavior of organisms and their action in a host, next-generation sequencing will provide a new insight into analyzing the livestock industry, agriculture, and human health risks and will consider for future development novel therapies for various diseases through identification of advanced tools. Hence, the book will give more precise information on the role of gut microbiomes in the host.

Current Issues in the Diagnostics and Treatment of Acute Appendicitis

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ISBN: 9781789232967 9781789232974 Year: Pages: 100 DOI: 10.5772/intechopen.70917 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:51

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The book Current Issues in the Diagnostics and Treatment of Acute Appendicitis is devoted to the actual and in some cases controversial and unresolved problems associated with acute appendicitis, as well as peculiarities of its clinical picture, diagnosis, and treatment in children. The materials of the book will be of interest to anyone who considers emergency abdominal surgery their specialty.

Gastroesophageal Reflux Disease - Theory and Research

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ISBN: 9781789844801 9781789844818 Year: Pages: 74 DOI: 10.5772/intechopen.73897 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:53

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Gastroesophageal reflux disease (GERD) is a very common, global clinical problem. It affects any age group, both males and females, and is seen mainly in developed countries, especially among obese individuals. GERD needs to be treated to prevent nuisance symptoms and long-term complications. The book deals with the diagnosis of GERD, including clinical presentations and diagnostic investigations, and describes the different available conservative, medical, surgical and endoscopic treatments. The book also covers gastroesophageal disease in children, its presentation and treatment. It also deals with the refractory type of gastroesophageal disease including different theories. It is very useful for gastroenterologists and upper gastrointestinal surgeons.

Constipation

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ISBN: 9781838818722 9781838818739 9781838818746 Year: Pages: 118 DOI: 10.5772/intechopen.73896 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:53

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Constipation is a problem with multifactorial origin that affects both children and adults. It is a difficult problem to treat because there is no clear diagnostic criteria and there are only limited therapeutic options. This book presents information on constipation, including pathology, diagnosis, imaging, nutrition, and management, among other topics. It is written for physicians and interested readers alike.

Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection

Authors: ---
ISBN: 9789535144434 9789535122517 Year: Pages: 366 DOI: 10.5772/60095 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:49

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The book on Membrane-bound Atp-dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection deals with various aspects of peptic ulcer disease, like clinical pharmacology, nutrition, molecular biochemical pharmacology as well as clinical aspects, and especially with the evaluation of certain biochemical mechanisms in human gastric mucosa and in animal gastric tissues obtained from different ulcer models. This book can be useful to physiologists; biochemists; pharmacologists, particularly molecular and biochemical pharmacologists; internists; gastroenterologists; biologists; surgeons and pharmacists.

New Insights into Inflammatory Bowel Disease

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ISBN: 9789535127543 9789535127550 9789535141679 Year: Pages: 264 DOI: 10.5772/61540 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:49

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The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.

Irritable Bowel Syndrome - Novel Concepts for Research and Treatment

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ISBN: 9789535128274 9789535128281 9789535141402 Year: Pages: 96 DOI: 10.5772/62930 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:49

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This book provides comprehensive and up-to-date insights into emerging trends in research and treatment of irritable bowel syndrome (IBS). Key features include pathogenesis, existing and new therapies, as well as nonpharmacological approach in management of IBS. The authors are known experts who contributed significantly for a better understanding of the etiology of IBS as one of the most commonly diagnosed functional disorders. This book provides a state-of-the-art review of different aspects of IBS and is recommended to healthcare providers, clinical scientists, general practitioners, students, and patients.

Updates in Gallbladder Diseases

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ISBN: 9789535130871 9789535130888 Year: Pages: 150 DOI: 10.5772/65176 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:50

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The basic researches and clinical studies on gallbladder diseases continue to advance at a rapid pace. The chapters in this book were written by recognized medical experts and researchers from North America, Europe, Asia, and Africa and aim to provide the state-of-the-art reviews on the current knowledge and advances in research and management of gallbladder diseases. This book includes the most recent advances in that field, particularly, the immunogenetic basis of cholecystitis, noncoding RNAs in gallbladder cancer, the diagnostic pitfalls and timing of management of acute cholecystitis, the incidental gallbladder cancer, the surgical management of gallbladder cancer, laparoscopic cholecystectomy in special conditions, and robot-assisted cholecystectomy.

Challenges in Pancreatic Pathology

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ISBN: 9789535131151 9789535131168 Year: Pages: 242 DOI: 10.5772/62754 Language: English
Publisher: IntechOpen
Subject: Gastroenterology
Added to DOAB on : 2019-10-03 07:51:50

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The assessment of the pancreas is a challenging problem because it has a profound location and it often presents difficulties in diagnosis and treatment. Despite many efforts in dealing with pancreatic diseases, the pathogenesis is not completely understood, the symptoms and imaging methods are unspecific, and the treatment possibilities are sometimes very limited. The major purpose of this book is to offer the reader a better understanding of the challenging aspects in pancreatic pathology, starting with anatomy and following with different pancreatic pathology. More space is allotted to pancreatic cancer, including surgical procedures, and to the management of the cystic lesions of the pancreas. This book is meant to provide a thorough guide for the best approaches in some of the difficult problems in pancreatology.

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