Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Carbohydrate metabolism is a fundamental aspect of health and a crucial function in a variety of species, including humans. A primary disfunction in major global diseases, such as cardiovascular disease and diabetes, is dysregulation of thecarbohydrate metabolism. Furthermore, certain disease outcomes may be impacted by the amount and type of dietary carbohydrates consumed. Finally, carbohydrate obtainability is essential for optimal performance and endurance during sporting events. This book collates articles that either describe original research, or review the scientific literature on the topic of carbohydrate metabolism in health and disease. .

Carbohydrates --- Metabolic syndrome --- Glucose --- Exercise --- Sports Nutrition --- Sugars --- Fructose --- Insulin

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The field of autonomic neuroscience research concentrates on those neural pathways and processes that ultimately modulate parasympathetic and sympathetic output to alter peripheral organ function. In the following ebook, laboratories from across the field have contributed reviews and original research to summarize current views on the role of the brain in tuning peripheral organ performance to regulate body temperature, glucose homeostasis and blood pressure.

Thermogenesis --- Glucose --- TRPV Cation Channels --- Hypoglycemia --- vagal afferents --- Nucleus Accumbens --- Sympathetic Nervous System --- Parasympathetic Nervous System --- Leptin --- Hypertension

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

We welcome the submission of manuscripts, either describing original research, or reviewing scientific literature. Manuscripts should focus on well-defined topics, not previously reported extensively in the literature, such as (without being limited to): functional aspects of fructose and glucose metabolism health effects of chronic fructose and glucose consumption molecular and mechanistic insights of hexoses-induced metabolic adaptations sugars, sweet taste receptors and brain responses intervention studies in humansPapers covering species comparisons of nutrition/metabolism or evolutionary perspectives, or effects of fructose and glucose in specific physiological conditions (physical activity, pregnancy, growth, etc.) or special tissues (testis, placenta) are welcome.

hepatic glucose production --- insulin resistance --- dyslipidemia --- cardiovascular risk factors --- food intake control --- obesity --- energy efficiency --- added sugars

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In 2011, carbohydrates provided 63% of the dietary energy intake to the world’s population. Historically, carbohydrate-rich diets have been associated with good health and longevity but there has been a move away from traditional carbohydrate-rich diets, with refined carbohydrate taking much criticism for contributing to non-communicable disease. The aim of this Special Issue is to discuss the appropriate use of environmentally sustainable carbohydrate-rich foods in the modern diet in developing and developed countries in the context of prevention and treatment of non-communicable disease.

low-carbohydrate diet --- type 2 diabetes mellitus --- observational study --- fructose --- glycaemia --- insulinaemia --- preload --- kiwifruit --- fruit --- diabetes --- ethnicity --- knowledge --- discussion groups --- qualitative --- Japanese diet --- dietary pattern --- intestinal biota --- prebiotics --- rice consumption --- body weight --- carbohydrates --- glycemic index --- glycemic load --- glycemic response --- satiety --- type 2 diabetes --- chronic disease risk --- satiety --- sugars --- sucrose --- isomaltulose --- glycemia --- kiwifruit --- carbohydrate exchanges --- glycaemic response --- glycaemic glucose equivalents --- vitamin C --- carbohydrate --- satiety --- mixed meal --- potato --- pasta --- rice --- postprandial --- glycaemia --- activity --- exercise --- timing --- potato --- obesity --- satiety --- T2DM --- CVD --- nutrition --- resistant starch --- fibre

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.

acute myeloid leukemia --- metabolism --- mTOR --- PI3K --- phosphorylation --- epithelial to mesenchymal transition --- mTOR inhibitor --- pulmonary fibrosis --- transcriptomics --- miRNome --- everolimus --- mTOR --- thyroid cancer --- sodium iodide symporter (NIS)/SLC5A5 --- dopamine receptor --- autophagy --- AKT --- mTOR --- AMPK --- mTOR --- Medulloblastoma --- MBSCs --- mTOR --- T-cell acute lymphoblastic leukemia --- targeted therapy --- combination therapy --- mTOR --- metabolic diseases --- glucose and lipid metabolism --- anesthesia --- neurotoxicity --- synapse --- mTOR --- neurodevelopment --- mTOR --- rapamycin --- autophagy --- protein aggregation --- methamphetamine --- schizophrenia --- tumour cachexia --- mTOR --- signalling --- metabolism --- proteolysis --- lipolysis --- mTOR --- mTORC1 --- mTORC2 --- rapamycin --- rapalogues --- rapalogs --- mTOR inhibitors --- senescence --- ageing --- aging --- cancer --- neurodegeneration --- immunosenescence --- senolytics --- biomarkers --- leukemia --- cell signaling --- metabolism --- apoptosis --- miRNA --- mTOR inhibitors --- mTOR --- tumor microenvironment --- angiogenesis --- immunotherapy --- fluid shear stress --- melatonin --- chloral hydrate --- nocodazole --- MC3T3-E1 cells --- primary cilia --- mTOR complex --- metabolic reprogramming --- cancer --- microenvironment --- nutrient sensor --- oral cavity squamous cell carcinoma (OSCC) --- NVP-BEZ235 --- mTOR --- p70S6K --- mTOR --- advanced biliary tract cancers --- mTOR --- NGS --- illumina --- IonTorrent --- eIFs --- mTOR --- autophagy --- Parkinson’s disease --- mTOR --- PI3K --- cancer --- inhibitor --- therapy --- mTOR --- laminopathies --- lamin A/C --- Emery-Dreifuss muscular dystrophy (EDMD) --- Hutchinson-Gilford progeria syndrome (HGPS) --- autophagy --- cellular signaling --- metabolism --- bone remodeling --- ageing --- mTOR --- fructose --- glucose --- liver --- lipid metabolism --- gluconeogenesis --- Alzheimer’s disease --- autophagy --- mTOR signal pathway --- physical activity --- microRNA --- mTOR --- spermatogenesis --- male fertility --- Sertoli cells --- n/a