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Influenza Virus Vaccines and Immunotherapies

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889198115 Year: Pages: 185 DOI: 10.3389/978-2-88919-811-5 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-01-19 14:05:46
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Influenza virus infections lead to thousands of deaths worldwide annually and billions of dollars economic burden. Despite continuing advances in our understanding of the immune evasion mechanism, the disease remains one of the foremost threat for human being. Traditional vaccines (attenuated and inactivated) mainly provide protection by inducing virus neutralizing antibodies, targeting ever changing surface antigens: Haemagultinin (HA) and Neuraminidase (NA). Due to genetic shift and immune selection pressure, prevalence of circulating influenza virus subtypes changes every year. Therefore, mismatch between circulating strain and vaccine strain can critically affect the success rate of these conventional flu vaccines, and requires continuous monitoring of circulating influenza virus subtypes and change in the vaccine formulations accordingly. The collective limitations of existing flu vaccines urgently call for the development of a novel universal vaccines that might provide the required protective immunity to a range of influenza virus subtypes. New approaches are being investigated mainly targeting conserved regions of flu proteins. Some of these approaches include universally conserved epitopes of HA, nucleoprotein (NP), capsid protein (M1) and ion channel protein (M2) that induced strong immune responses in animal models. Some attention and progress appears to be focused on vaccines based on the M2 ectodomain (M2e) employing a variety of constructs, adjuvants and delivery systems, including M2e-hepatitis B core antigen, flagellin constructs, and virus-like particles (VLP). Animal studies with these M2e candidate vaccines demonstrated that these vaccine candidates can prevent severe illness and death but not infection, which may pose difficulties in both the evaluation of clinical efficacy and approval by the regulatory authorities. VLP vaccines appear to be promising, but still are mostly limited to animal studies. The discovery and development of new and improved vaccines have been greatly facilitated by the application of new technologies. The use of nucleic acid-based vaccines, to combine the benefits of in-situ expression of antigens with the safety of inactivated and subunit vaccines, has been a key advancement. Upon their discovery more than 20 years ago, nucleic acid vaccines promised to be a safe and effective mean to mimic immunization with a live organism vaccine, particularly for induction of T cell immunity. In addition, the manufacturing of nucleic acid-based vaccines offered the potential to be relatively simple, inexpensive and generic. Reverse Vaccinology and in-silico designing of vaccines are very innovative approaches and being considered as future of vaccines. Furthermore, various immuno-therapeutic agents also being developed to treat and minimize immuno-pathological damage in patients suffering from life threatening complications. For the treatment of such pathological conditions, various novel approaches such as administration of immune suppressive cytokines, blocking co-stimulatory signals or activating co-inhibitory signal of T cell activation, are being tested both in lab and clinics. The Research Topic on influenza virus vaccine and therapeutics will give an insight in to the current status and future scope of these new innovative approaches and technologies. Moreover, these new methods will also serve as a reference tool for the development of future vaccines against several other pathogens.

Why vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199662 Year: Pages: 157 DOI: 10.3389/978-2-88919-966-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology --- Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-01-19 14:05:46
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Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens.

Keywords

Vaccine --- Infectious Disease --- HIV --- HCV --- Malaria --- influenza --- immunology --- Genetics

How aging affects T lymphocyte-mediated immunity

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194186 Year: Pages: 77 DOI: 10.3389/978-2-88919-418-6 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2015-12-10 11:59:06
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Increasing age has been associated with an insufficient protection following vaccination and an increased incidence and severity of infectious diseases. The predicted acceleration of global population aging will accentuate the need to understand the mechanisms that drive the age-related decline of the immune system and to, eventually, identify strategies to lower the burden of infectious diseases in elderly people. One type of immune cell appears to be most dramatically affected by the aging process: T lymphocytes. Age-related changes of the bone marrow and the thymus microenvironment lead to a decreased thymic output of functional, naïve T lymphocytes. As T lymphocytes are key players of the adaptive immune system, this research topic will summarize our current understanding on how aging affects the microenvironmental niches and molecular networks that are important for the generation, survival and function of naïve, memory and effector T lymphocytes. This research topic will also address the impact of aging on the different T lymphocyte lineages, such as regulatory T cells and Th17 cells and how age-related changes of the microenvironment affect organ- and tissue-resident memory T lymphocytes. Eventually, the identification of a set of markers for immunosenescence would facilitate the design and application of more specific therapies and improved vaccines and vaccination strategies for elderly people, thereby increasing life and health span.

Dual-Use Life Science Research and Biosecurity in the 21st Century: Social, Technical, Policy, and Ethical Challenges

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195688 Year: Pages: 95 DOI: 10.3389/978-2-88919-568-8 Language: English
Publisher: Frontiers Media SA
Subject: Public Health --- Medicine (General)
Added to DOAB on : 2016-02-05 17:24:33
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In September 2011, scientists announced new experimental findings that would not only threaten the conduct and publication of influenza research, but would have significant policy and intelligence implications. The findings presented a modified variant of the H5N1 avian influenza virus (hereafter referred to as the H5N1 virus) that was transmissible via aerosol between ferrets. These results suggested a worrisome possibility: the existence of a new airborne and highly lethal H5N1 virus that could cause a deadly global pandemic. In response, a series of international discussions on the nature of dual-use life science arose. These discussions addressed the complex social, technical, political, security, and ethical issues related to dual-use research. This Research Topic will be devoted to contributions that explore this matrix of issues from a variety of case study and international perspectives.

Remote Sensing and Geospatial Technologies in Public Health

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ISBN: 9783038971726 9783038971733 Year: Pages: 244 DOI: 10.3390/books978-3-03897-173-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Environmental Sciences
Added to DOAB on : 2018-09-21 11:22:29
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This book demonstrates the utilization of remote sensing and geospatial technologies for a wide range of public health studies.Although remote sensing and geospatial technologies have been successfully applied for more than 50 years, continuous advancements are essential to better understand the complex environment around us that impacts our health and well-being.Thankfully, the availability of spatial analytical tools and necessary data have enabled us to reveal multifaceted, obscured spatial relationships that would have been unexplored otherwise. Now, we are able to make more precise and effective public health-related decisions. However, without a proper understanding of the methodologies, applying these tools may result in inaccurate findings for decision-making.With 15 selected papers, this book covers diverse topics and discusses different methodologies that are fundamentals for spatial analysis in public health. Readers will have an opportunity to experience the advancements in spatial tools, data, and methodologies that are applicable to public health investigations.This book, Remote Sensing and Geospatial Technologies in Public Health, is expected to encourage academicians and professionals to further advance their knowledge in this sub-discipline.

Human Mobility, Spatiotemporal Context, and Environmental Health: Recent Advances in Approaches and Methods

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ISBN: 9783039211838 / 9783039211845 Year: Pages: 382 DOI: 10.3390/books978-3-03921-184-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-08-28 11:21:27
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Environmental health researchers have long used concepts like the neighborhood effect to assessing people’s exposure to environmental influences and the associated health impact. However, these are static notions that ignore people’s daily mobility at various spatial and temporal scales (e.g., daily travel, migratory movements, and movements over the life course) and the influence of neighborhood contexts outside their residential neighborhoods. Recent studies have started to incorporate human mobility, non-residential neighborhoods, and the temporality of exposures through collecting and using data from GPS, accelerometers, mobile phones, various types of sensors, and social media. Innovative approaches and methods have been developed. This Special Issue aims to showcase studies that use new approaches, methods, and data to examine the role of human mobility and non-residential contexts on human health behaviors and outcomes. It includes 21 articles that cover a wide range of topics, including individual exposure to air pollution, exposure and access to green spaces, spatial access to healthcare services, environmental influences on physical activity, food environmental and diet behavior, exposure to noise and its impact on mental health, and broader methodological issues such as the uncertain geographic context problem (UGCoP) and the neighborhood effect averaging problem (NEAP). This collection will be a valuable reference for scholars and students interested in recent advances in the concepts and methods in environmental health and health geography.

Keywords

obesity --- built environment --- activity space --- regression analysis --- UGCoP --- foodscape exposure --- activity space --- commuting route --- space-time kernel density estimation --- time-weighted exposure --- Beijing --- cycling for transportation --- bike paths --- train stations --- subway stations --- adults --- Brazil --- fuel consumption --- emissions estimation --- GPS trace --- big data --- air pollution exposure --- human mobility --- mobile phone data --- dynamic assessment --- GIS --- GPS --- activity space --- environmental exposure --- the uncertain geographic context problem --- noise pollution --- mental disorders --- built environment --- multilevel model --- China --- PM concentrations --- crop residue burning --- correlation analysis --- interannual and seasonal variations --- China --- the neighborhood effect averaging problem (NEAP) --- human mobility --- environmental exposure --- the uncertain geographic context problem --- UGCoP --- car ownership --- car use --- built environment --- spatial autocorrelation --- multilevel Bayesian model --- geographical accessibility --- Healthcare services --- GIS --- E2SFCA --- CHAS --- Singapore --- environmental health --- food environment --- environmental context cube --- environmental context exposure index --- the uncertain geographic context problem (UGCoP) --- GPS --- GIS --- healthcare accessibility --- catchment areas --- access probability --- taxi GPS trajectories --- E2SFCA --- greenspace exposure --- health --- human mobility --- physical activity --- structural equation modeling --- Guangzhou --- healthcare accessibility --- population demand --- geographic impedance --- the elderly --- urban planning --- 3SFCA --- real-time traffic --- crowdedness --- well-being experience --- long-distance walking --- collective leisure activity --- walking event --- urban leisure --- missing data --- spatial data --- imputation --- geographic imputation --- activity space --- ecological momentary assessment --- EMA --- walking --- active travel --- ageing --- physical environment --- personal projects --- activity space --- Public Participatory GIS (PPGIS) --- spatial accessibility --- multimodal network --- primary healthcare --- China --- 2009 influenza A(H1N1) pandemic --- transport modes --- rail travel --- spatial spread --- quantile regression --- green space --- road traffic accidents --- cognitive aging --- activity space --- life-course perspectives --- environmental exposures

Molecular Computing and Bioinformatics

Authors: --- ---
ISBN: 9783039211951 / 9783039211968 Year: Pages: 390 DOI: 10.3390/books978-3-03921-196-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Biotechnology
Added to DOAB on : 2019-08-28 11:21:27
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This text will provide the most recent knowledge and advances in the area of molecular computing and bioinformatics. Molecular computing and bioinformatics have a close relationship, paying attention to the same object but working towards different orientations. The articles will range from topics such as DNA computing and membrane computing to specific biomedical applications, including drug R&D and disease analysis.

Keywords

prostate cancer --- Mycoplasma hominis --- endoplasmic reticulum --- systems biology --- protein targeting --- biomedical text mining --- big data --- Tianhe-2 --- parallel computing --- load balancing --- bacterial computing --- bacteria and plasmid system --- Turing universality --- recursively enumerable function --- miRNA biogenesis --- structural patterns --- DCL1 --- protein–protein interaction (PPI) --- clustering --- protein complex --- penalized matrix decomposition --- avian influenza virus --- interspecies transmission --- amino acid mutation --- machine learning --- Bayesian causal model --- causal direction learning --- K2 --- brain storm optimization --- line graph --- Cartesian product graph --- join graph --- atom-bond connectivity index --- geometric arithmetic index --- P-glycoprotein --- efflux ratio --- in silico --- machine learning --- hierarchical support vector regression --- absorption --- distribution --- metabolism --- excretion --- toxicity --- image encryption --- chaotic map --- DNA coding --- Hamming distance --- Stenotrophomonas maltophilia --- iron acquisition systems --- iron-depleted --- RAST server --- NanoString Technologies --- siderophores --- gene fusion data --- gene susceptibility prioritization --- evaluating driver partner --- gene networks --- drug-target interaction prediction --- machine learning --- drug discovery --- microRNA --- environmental factor --- structure information --- similarity network --- bioinformatics --- identification of Chinese herbal medicines --- biochip technology --- DNA barcoding technology --- DNA strand displacement --- cascade --- 8-bit adder/subtractor --- domain label --- Alzheimer’s disease --- gene coding protein --- sequence information --- support vector machine --- classification --- adverse drug reaction prediction --- heterogeneous information network embedding --- stacking denoising auto-encoder --- meta-path-based proximity --- Panax ginseng --- oligopeptide transporter --- flowering plant --- phylogeny --- transcription factor --- multiple interaction networks --- function prediction --- multinetwork integration --- low-dimensional representation --- dihydrouridine --- nucleotide physicochemical property --- pseudo dinucleotide composition --- RNA secondary structure --- ensemble classifier --- diabetes mellitus --- hypoxia-inducible factor-1? --- angiogenesis --- bone formation --- osteogenesis --- protein transduction domain --- membrane computing --- edge detection --- enzymatic numerical P system --- resolution free --- molecular computing --- molecular learning --- DNA computing --- self-organizing systems --- pattern classification --- machine learning --- laccase --- Brassica napus --- lignification --- stress --- molecular computing --- bioinformatics --- machine learning --- protein --- DNA --- RNA --- drug --- bio-inspired

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