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Anhand der Entwicklung eines automatisierten Systems für die bidirektionale Kapillarelektrophorese (CE) im Chipformat wird der Einsatz der hauptsächlich in der Laboranalytik eingesetzten Chip-CE für den Bereich der kontinuierlichen Prozessanalytik gezeigt. Die Nutzung der Chip-CE sowie die simultane Analys von Kat- und Anionen führen zu einer deutlichen Verringerung herkömmlicher Analysezeiten. Die abschließende Messung gasförmiger und flüssiger Proben zeigt die Leistungsfähigkeit des Systems.
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Microfluidics has developed rapidly over the past three decades. Relentless diagnostic, medical and chemical applications have been demonstrated in various applications, plateforms and tools. Have microfluidics realized its full potential? Or is it only a leveraging academic tool? In this Special Issue, we focus on both insights and advancements in microfluidics. We invite emerging investigators and pioneers to contribute commentaries, perspectives and insightful reviews on related topics. The various insights from esteemed colleagues will be collated. We will also discuss technological breakthrough of original works in both short communications and full papers. The main idea is to stimulate the community and to provide an unique collection of insightful papers. We will also cover various topics ranging from 3D printing, paper-based microfludics to conventional polymer-based microfluidics which contributes to the technological advancements.
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In dieser Arbeit wird eine Plattform für einwegtaugliche photonische Systeme auf Polymerbasis vorgestellt, in die sowohl organische Halbleiterlaser als auch optofluidische Laser integriert sind. Lab-on-Chip Systeme mit integrierten organischen Halbleiterlasern, Wellenleitern und Mikrofluidikkanälen werden realisiert und mit integrierten Lasern Fluoreszenz angeregt. Auf den Chips wird eine Funktionalisierung aufgebracht und es werden Wellenleitergitterkoppler aus Phospholipiden untersucht.
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Diese Arbeit befasst sich mit neuen Aspekten der Nutzung der Klasse der organischen Halbleiterbauelemente. Es wird dabei insbesondere die Integration organischer Bauelemente in mikrooptische Systeme untersucht. Dabei stehen sowohl das Design, die Herstellung und die Charakterisierung als auch die Anwendung dieser Bauelemente in der Datenübertragung und Sensorik im Vordergrund.
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This work presents the application of organic semiconductor distributed feedback laser as free-space excitation source in Raman spectroscopy. Surface-enhanced Raman scattering effect is exploited to improve the detection sensitivity. The SERS conditionis achiedved by using substrates consisting of gold-coated polymeric nanopillar arrays. The organic-laser-excited SERS measurements are applied to verify the concentration variation of biomolecule adenosine in aqueous solutions.
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The Prototype Laboratory initiated and maintained by the Chair of Product Development at the Faculty of Architecture, TU Delft, has set an example in architectural education for hands-on ‘learning-by-making’ for students. According to the authors of this book, in the current curriculums time spent on practical work is not rewarded and students are educated in an abstract concept of architecture, not getting a proper feeling for materialization. A semester of designing, engineering, producing and building a prototype with their own hands after their own design often gives students a boost in their education. The Delft Prototype laboratory was the base of around 1,000 students, now professionals. Some architect’s offices make prototypes regularly as their designs are quite experimental and require more insight for the designing architect, before the realization of his building. Prototypes of technical components are often developed parallel to the building process.The Prototype Laboratory at the Faculty of Architecture was supervised for almost 18 years by Peter van Swieten. He describes his experiences in this book, in collaboration with the initiator, professor Mick Eekhout. Marcel Bilow took over the Bucky Lab, as it is called, from 2012 onwards.
Prototype Laboratory --- TU Delft --- product development --- Bucky Lab --- design and build
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A growing number of new and established organizations are addressing social ills through innovative and profitable organization. In that regard, we seek to understand how a deeper understanding of social innovation can be achieved by a more sophisticated discussion of organizational form. In this chapter we ask, ‘Which organizational designs and practices can meet both financial and social objectives?’ and ‘How can organizations use those practices to profitably address social ills such as poverty, social inequity, climate change, and educational failure?’ This chapter draws on novel data, practitioners’ experiences, and dozens of interviews to highlight the organizational design and innovation behavior that further the profitable pursuit of social innovation. We focus on benefit corporations or B-corporations as an organizational design that simultaneously delivers business and social impact. We then identify and analyze behaviors within established companies that support social innovation. B-corporations currently exist in 50 countries. They are certified and have their social and environmental impact formally tracked and publicly reported by B-Lab. B-Lab is a non-profit organization that serves and inspires the global movement of ‘B-corporations’ with the aim of building a global community, promoting mission alignment, and helping social innovators ‘measure what matters in the business’. B-Lab’s main instrument is the B-Lab Impact Assessment, which determines the outcome of B-Lab certification. Legal benefit corporations (currently only in the US) may choose to be certified as ‘B-corporations’ as well, though there is no strict requirement to do so. Here, we report on stylized findings from the data.
triple bottom line --- B-corporation --- B-Lab --- organizational form --- social impact --- environmental impact --- legal form
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Biosensors are devices that utilize biological recognition elements to selectively detect and analyze specific biological and chemical analyte substances. In this work a technology platform for label-free optical biosensors based on surface-functionalized photonic crystal slabs is proposed. Using this technology platform, low-cost solutions for three biotechnical questions are presented.
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A new immobilization method for the localized adsorption of proteins on thermoplastic surfaces is introduced. Artificial three-phase interfaces were realized by surface structuring to control the wetting behavior which lead to a preferred adsorption in these modified areas. Additionally, different fabrication methods were analyzed to determine mass fabrication capabilities. These fabrication methods also allowed the production of fully structured microchannels to tune the fluids behavior within.
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