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Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday

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ISBN: 9783038974161 / 9783038974178 Year: Pages: 256 DOI: 10.3390/books978-3-03897-417-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Biochemistry
Added to DOAB on : 2019-06-26 08:44:06
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Abstract

Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

Keywords

Zingiber officinale --- gingerols --- cytotoxic activity --- oleanolic acid --- high-fat high-carbohydrate diet --- pre-diabetes --- glucose homeostasis --- insulin resistance --- atherosclerosis --- ROS --- HUVECs --- LOX-1 --- alkaloid --- granatane --- N-methylcadaverine --- N-methylpiperidine. reductive deamination --- Mucorales --- Rhizopus arrhizus --- sterol pattern --- antifungal effectivity --- gas chromatography-mass spectrometry (GC-MS) --- posaconazole --- sterol biosynthesis --- sterol 14?-demethylase --- sterol C24-methyltransferase --- mechanism-based inactivators --- antifungals --- azoles --- antiparasitic drugs --- human African trypanosomiasis --- Chagas disease --- synthesis --- squalene cyclase --- cycloartenol synthase --- triterpene --- fern --- Polystichum --- terpene --- isoprenoid --- divalent metal co-factor ligation --- antioxidant --- cholesterol --- degeneration --- oxysterol --- retina --- Smith-Lemli-Opitz syndrome --- algal sterols --- ergosterol biosynthesis --- infectious disease --- lipidomics --- oxyphytosterol --- pharmacognosy --- phytosterol --- sterolomics --- lupeol --- keratinocytes --- fibroblasts --- wound healing --- cell migration --- UV-radiation --- ZnO --- toxicity --- sterol content --- cholesterol --- leishmania --- solanaceae --- withanolides --- aurelianolides --- phytosterols --- mesocarp --- oilseed --- maturity --- pod-blast --- ?-tocopherol --- oil bodies --- campesterol --- stigmasterol --- ?-sitosterol --- sterol --- C4-demethylation complex (C4DMC) --- 4-methylsterol --- hormone --- steroid --- development --- genetic disease --- bile alcohol --- cholestanoic acid --- oxysterol --- sterolomics --- enzyme-assisted derivatization --- electrospray ionization-mass spectrometry --- Girard reagent --- n/a

Lignans

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ISBN: 9783038979081 / 9783038979098 Year: Pages: 384 DOI: 10.3390/books978-3-03897-909-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General) --- Organic Chemistry
Added to DOAB on : 2019-06-26 10:09:00
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Abstract

Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

Keywords

lignans --- chemometrics --- neolignans --- flavonolignans --- chemical space --- drug-like --- Lespedeza cuneata --- lignan glycoside --- flavonoid glycoside --- cytotoxicity --- adipocyte and osteoblast differentiation --- Bursera --- Burseraceae --- lignans --- lignan --- molecular dynamics --- intermolecular interactions --- graph theory --- lignans --- heilaohu --- tujia ethnomedicine --- chemical characterization --- cytotoxicity --- antioxidant --- cultivar --- environment --- flax --- flavonol --- genetic --- hydroxycinnamic acid --- lignan --- seed --- aryldihydronaphthalene lignan --- arylnaphthalene lignan --- oxidation --- synthesis --- lignans --- dibenzyl butyrolactones --- anti-proliferative --- acyl-Claisen --- stereoselective synthesis --- Schisandra rubriflora --- Schisandra chinensis --- red-flowered Chinese magnolia vine --- Chinese magnolia vine --- lignans --- phytochemical analysis --- UHPLC-MS/MS --- anti-inflammatory activity --- LOX --- COX --- sPLA2 --- lignans --- neolignans --- Lauraceae --- chemical components --- chemical structures --- dietary lignans --- national databases --- food groups --- dietary intake --- harmonized databases --- lignans --- in silico studies --- podophyllotoxin --- antibacterial activity --- acetylcholinesterase inhibitors --- antioxidant activity --- cytotoxicity --- natural products --- total synthesis --- lignan --- Bursera fagaroides --- podophyllotoxin-type lignans --- cell cycle --- cell migration --- epiboly --- microtubules --- F-actin --- cancer --- lignans --- animal health --- cattle --- enterolignan --- human health --- pharmacokinetic --- ruminant --- secoisolariciresinol diglucoside --- Lignan --- bitterness --- taste-active compound --- quantification --- oak ageing --- lignans --- norlignans --- 9-norlignans --- semisynthesis --- hydroxymatairesinol --- bioactivity --- lignans --- oxidation --- lignans --- diet --- antioxidants --- health promotion --- chronic diseases --- Schisandrae Chinensis Fructus --- wild --- cultivated --- multiple bioactive components --- simultaneous quantitation

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eng (2)


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2019 (2)