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Marine Anti-inflammatory Agents

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ISBN: 9783039215720 / 9783039215737 Year: Pages: 248 DOI: 10.3390/books978-3-03921-573-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-12-09 11:49:16
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Abstract

Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges.

Keywords

THP-1 macrophages --- anti-inflammatory --- TLR4 --- NF-?B --- MAPK --- SPR analysis --- glycolipids --- MGDG --- skin --- inflammation --- epidermal hyperplasia --- microalgae --- Isochrysis galbana --- Frondanol --- Cucumaria frondosa --- DSS colitis --- colon inflammation --- zoantharia --- Tropical Eastern Pacific --- Zoanthus pulchellus --- zoanthamine --- inflammation --- fucoxanthin --- inflammation --- epidermal hyperplasia --- UVB --- photoprotection --- 6-bromoindole --- Geodia barretti --- anti-inflammatory activity --- dendritic cells --- T cell differentiation --- poor blood circulation --- Ecklonia cava --- phlorotannins --- pyrogallol-phloroglucinol-6,6-bieckol --- functional ingredients --- endothelial cell death --- vascular smooth muscle cell proliferation and migration --- inflammation --- anti-inflammatory --- bioactive molecules --- microalgae --- polysaccharides --- carotenoids --- polyunsaturated fatty acids --- fucoxanthin --- ultraviolet B --- denervation --- seafood waste --- polyunsaturated fatty acid --- NO inhibition --- fish oil --- marine nutraceuticals --- fish oil --- omega-3 --- eicosapentaenoic acid --- docosahexaenoic acid --- inflammation --- eicosanoid --- cytokine --- surgery --- critical illness --- parenteral nutrition --- signal transducer and activator of transcription 3 (STAT3) --- matrix metalloproteinases-9 (MMP-9) --- interleukin (IL) --- lipopolysaccharide (LPS) --- acute sickness behavior --- acute lung injury (ALI) --- prostaglandins --- clavulones --- punaglandins --- thromboxane --- inflammation --- marine vertebrates --- marine invertebrates --- diatoms --- macroalgae --- fucoxanthin --- rosmarinic acid --- NRLP3 --- inflammasome --- anti-oxidative --- anti-inflammatory --- photo-protection --- UVB

Protective and Detrimental Role of Heme Oxygenase-1

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ISBN: 9783039218066 / 9783039218073 Year: Pages: 220 DOI: 10.3390/books978-3-03921-807-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
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Abstract

The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.

Keywords

ferroptosis --- heme oxygenase-1 --- iron --- reactive oxygen species --- glutathione --- chemotherapy --- paracetamol --- Myristica fragrans kernels --- heme oxygenase 1 --- liver --- glucocorticoid receptor --- GR --- heme oxygenase 1 --- HO-1 --- prostate cancer --- ANTIGEN presenting cell --- tolerance --- Tet-ON system --- antigen presentation --- analgesia --- carbon monoxide --- heme oxygenase 1 --- inflammatory pain --- locus coeruleus --- nitric oxide --- bilirubin --- Gunn rats --- hyperbilirubinemia --- inflammation --- LPS --- NF-?B --- caloric restriction --- Sirtuin 1 --- Heme Oxygenase-1 --- PGC-1? --- cardiomyopathy --- diabetes mellitus --- Type 1 diabetes mellitus (T1D) --- Pancreatic oxidative damage --- Heme oxygenase-1 (HO-1) inducers --- Caffeic acid phenethyl ester (CAPE) --- Reactive oxygen species (ROS) --- Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) --- Inducible nitric oxide synthase (iNOS) --- Gamma-Glutamyl-Cysteine Ligase (GGCL) --- prostate cancer --- heme oxygenase --- metformin --- apoptosis --- ER stress --- HO-1 activity inhibitor --- carbon monoxide --- lung preservation --- ischemia–reperfusion injury --- high-pressure gas --- Colon cancer --- Betula etnensis Raf. --- oxidative stress --- heme oxigenase-1 --- ferroptosis --- thiol groups --- angiotensin II --- mineralocorticoid receptor --- heme oxygenase 1 --- sirtuin 1 --- adipocytes --- oxidative stress --- heme oxygenase-1 --- atherosclerosis --- coronary artery disease --- peripheral artery disease --- carotid plaque --- heme oxygenase --- endoplasmic reticulum stress --- hemoglobin --- heme --- n/a

Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential

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ISBN: 9783039215324 / 9783039215331 Year: Pages: 442 DOI: 10.3390/books978-3-03921-533-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:16
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This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, andTherapeutic Potential"" includes up-to-date information regarding bioactivepeptides isolated from marine organisms. Marine peptides have been found invarious phyla, and their numbers have grown in recent years. These peptidesare diverse in structure and possess broad-spectrum activities that have greatpotential for medical applications. Various marine peptides are evolutionaryancient molecular factors of innate immunity that play a key role in host defense.A plethora of biological activities, including antibacterial, antifungal, antiviral,anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., makemarine peptides an attractive molecular basis for drug design. This Special IssueBook presents new results in the isolation, structural elucidation, functionalcharacterization, and therapeutic potential evaluation of peptides found inmarine organisms. Chemical synthesis and biotechnological production of marinepeptides and their mimetics is also a focus of this Special Issue Book.

Keywords

sea cucumber --- ACE-inhibitory peptide --- molecular docking --- structure-activity relationship --- plastein reaction --- Gracilariopsis lemaneiformis --- ACE-inhibitory activity --- peptide --- molecular docking --- SHRs --- prostate cancer --- Anthopleura anjunae oligopeptide --- DU-145 cells --- PI3K/AKT/mTOR signaling pathway --- cod skin --- NA-inhibitory peptide --- influenza virus --- neuraminidase --- molecular docking --- adsorption --- host defense peptide --- antimicrobial peptide --- anti-LPS factor --- host?microbe relationship --- functional diversity --- invertebrate immunity --- crustacean --- antimicrobial activity --- antimicrobial peptide --- polychaeta --- innate immunity --- BRICHOS domain --- recombinant peptide --- ?-helix --- Rana-box --- nuclear magnetic resonance (NMR) --- antimicrobial peptide --- cytotoxicity --- ?-hairpin --- polyphemusins --- tachyplesins --- cell death --- signaling pathways --- Neptunea arthritica cumingii --- multi-functional peptides --- antioxidant activity --- ACE-inhibitory activity --- anti-diabetic activity --- Arenicola marina --- antimicrobial peptides --- arenicin --- complement --- C3a --- acid-sensing ion channel --- animal models --- pain relief --- toxin --- Ugr 9-1 --- APETx2 --- hairtail (Trichiurus japonicas) --- muscle --- peptide --- antioxidant activity --- half-fin anchovy hydrolysates --- Maillard reaction products --- antibacterial peptide --- identification --- self-production of hydrogen peroxide --- membrane damage --- Perinereis aibuhitensis --- decapeptide --- lung cancer --- cell proliferation --- apoptosis --- conotoxins --- conopeptides --- computational studies --- molecular dynamics --- machine learning --- docking --- review --- drug design --- ion channels --- Conus --- conotoxin --- transcriptome sequencing --- phylogeny --- venom duct --- abalone --- peptide --- vasculogenic mimicry --- metastasis --- MMPs --- HIF-1? --- dexamethasone --- myotube atrophy --- protein synthesis --- proteolytic system --- Pyropia yezoensis peptide --- PYP15 --- QAGLSPVR --- antihypertensive effect --- Caco-2 cell monolayer --- transport routes --- oyster zinc-binding peptide --- peptide-zinc complex --- caco-2 cells --- intestinal absorption --- zinc bioavailability --- Chlorella pyrenoidosa protein hydrolysate (CPPH) --- Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) --- calcium absorption --- gene expression --- gut microbiota --- cone snails --- conotoxins --- ion channels --- function --- structure --- marine peptides --- arenicin-1 --- molecular symmetry --- structure–activity relationship --- antibacterial --- cytotoxic --- chemical synthesis --- molecular dynamics --- tilapia --- HUVEC --- angiotensin II --- NF-?B --- Nrf2 --- endothelial dysfunction --- conotoxin --- cone snail --- Conus --- Conus ateralbus --- Kalloconus --- n/a

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MDPI - Multidisciplinary Digital Publishing Institute (3)


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CC by-nc-nd (3)


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eng (3)


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2019 (3)