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Fungal Infections in Immunocompromised Hosts

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ISBN: 9783038977162 Year: Pages: 212 DOI: 10.3390/books978-3-03897-717-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Microbiology --- Biology --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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Abstract

This book is a printed edition of the Special Issue Fungal Infections in Immunocompromised Hosts that was published in JoF

Keywords

Candida auris --- Aspergillus fumigatus --- antifungal resistance --- multidrug resistance --- mechanisms of antifungal resistance --- liver disease --- hepatic impairment --- invasive fungal infection --- antifungal agent --- antifungal drug --- toxicity --- Immunotherapy --- invasive aspergillosis --- Aspergillus fumigatus --- fungal infections --- innate immunity --- adaptive immunity --- cell therapy --- cytokine therapy --- taxonomy --- fungal nomenclature --- phylogenetics --- species complex --- invasive fungal infections --- mycoses --- immune reconstitution inflammatory syndrome --- fungal immunity --- prognostic risk model --- prediction models --- risk score --- invasive mold disease --- hematological malignancy --- risk assessment --- antifungal stewardship --- paracoccidioidomycosis --- HIV --- cancer --- lymphoma --- kidney transplant --- TNF inhibitors --- literature review --- MALDI-ToF MS --- yeast --- fungus --- AIDS --- IRIS --- cat-transmitted sporotrichosis --- immunocompromised hosts --- mycoses of implantation --- sporotrichosis --- Sporothrix brasiliensis --- Sporothrix schenckii --- subcutaneous mycoses --- invasive fungal infection --- non-culture-based diagnostics --- aspergillosis --- candidiasis --- Aspergillus PCR --- galactomannan --- lateral flow --- beta-d-glucan --- T2 Candida --- candidemia --- Candida meningoencephalitis --- (1?3)-?-d-glucan --- T2Candida --- PCR --- liposomal amphotericin B --- micafungin --- anidulafungin --- Aspergillus --- anti-fungal agents --- hematological malignancies

TRP Channels in Health and Disease

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ISBN: 9783039210824 9783039210831 Year: Pages: 266 DOI: 10.3390/books978-3-03921-083-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 08:44:07
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Abstract

Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.

Keywords

ion channel --- TRPC --- small molecules --- calcium --- chemical probes --- TRPV1 --- TRPV2 --- TRPV3 --- TRPV4 --- mucosal epithelium --- ulcerative colitis --- inflammatory bowel disease --- TRPM4 channel --- cardiovascular system --- physiology --- pathophysiology --- TRPC6 --- elementary immunology --- inflammation --- calcium --- sodium --- neutrophils --- lymphocytes --- endothelium --- platelets --- human medulla oblongata --- cuneate nucleus --- dorsal column nuclei --- TRPV1 --- calcitonin gene-related peptide --- substance P --- TRP channels --- calcium signaling --- salivary glands --- xerostomia --- radiation --- inflammation --- transient receptor potential channels --- TRPC3 pharmacology --- channel structure --- lipid mediators --- photochromic ligands --- transient receptor potential --- TRPC3 --- mGluR1 --- GABAB --- EPSC --- Purkinje cell --- cerebellum --- toxicology --- TRP channels --- organ toxicity --- chemicals --- pollutants --- chemosensor --- TRPM7 --- kinase --- inflammation --- lymphocytes --- calcium signalling --- SMAD --- TH17 --- hypersensitivity --- regulatory T cells --- thrombosis --- graft versus host disease --- 2D gel electrophoresis --- AP18 --- HEK293 --- HSP70 --- MALDI-TOF MS(/MS) --- nanoHPLC-ESI MS/MS --- proteomics --- sulfur mustard --- TRPA1 --- TRPC channels --- diacylglycerol --- TRPC4 --- TRPC5 --- NHERF --- TRP channel --- TRPY1 --- Saccharomyces cerevisiae --- calcium --- manganese --- oxidative stress --- ion channels --- overproduction --- production platform --- protein purification --- Saccharomyces cerevisiae --- sensors --- transient receptor potential (TRP) channels --- yeast --- adipose tissue --- bioavailable --- menthol --- topical --- TRPM8 --- n/a

Lipopolysaccharides (LPSs)

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ISBN: 9783039282562 9783039282579 Year: Pages: 390 DOI: 10.3390/books978-3-03928-257-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2020-04-07 23:07:08
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Abstract

The cytoplasm of Gram-negative bacteria is bound by three layers: an inner membrane, a layer of peptidoglycan, and an outer membrane. The outer membrane is an asymmetric lipidic bilayer, with phospholipids on its inner surface and lipopolysaccharides (LPSs) on the outside, with the latter being the major component of the outer leaflet and covering nearly three-quarters of the total outer cell surface. All LPSs possess the same general chemical architecture independently of bacterial activity (pathogenic, symbiotic, commensal), ecological niche (human, animal, soil, plant, water), or growth conditions. Endotoxins are large amphiphilic molecules consisting of a hydrophilic polysaccharide component and a covalently bound hydrophobic and highly conserved lipid component, termed lipid A (the endotoxin subunit). The polysaccharide component can be divided into two subdomains: the internal and conserved core region as well as the more external and highly variable O-specific chain, also referred to as the O-antigen due to its immunogenic properties. LPSs are endotoxins, one of the most potent class of activators of the mammalian immune system; they can be released from cell surfaces of bacteria during multiplication, lysis, and death. LPS can act through its biological center (lipid A component) on various cell types, of which macrophages and monocytes are the most important.

Keywords

aspirin --- hepcidin --- P65 (nuclear factor-?B) --- IL-6/JAK2/STAT3 pathway --- lipopolysaccharide (LPS) --- nitric oxide (NO) --- iron regulatory protein 1 (IRP1) --- Megalobrama amblycephala --- lipopolysaccharide induced TNF? factor --- lipopolysaccharide stimulation --- innate immune --- Aeromonas --- genomics --- inner core oligosaccharide --- outer core oligosaccharide --- lipopolysaccharide --- lipopolysaccharide --- Erwinia amylovora --- NMR --- ESI FT-ICR --- structural determination --- Bordetellae --- Bordetella holmesii --- endotoxin --- lipid A --- structure --- mass spectrometry --- genomic --- Edwardsiella tarda --- core oligosaccharide --- MALDI-TOF MS --- ESI MSn --- NMR --- genomic --- LPS tolerance --- hypothalamic inflammation --- insulin resistance --- pJNK --- fibroblast --- keratocyte --- cornea --- lipopolysaccharide --- bacteria --- chemokine --- adhesion molecule --- collagen --- tear fluid --- serum resistance --- complement --- Salmonella --- lipopolysaccharide --- sialic acid --- reptile-associated salmonellosis --- sepsis --- time response --- inflammation --- oxidative stress --- endotoxaemia --- mouse --- rat --- lipopolysaccharide --- double-stranded RNA --- epithelial cell --- dendritic cell --- allergic respiratory disorder --- hygiene hypothesis --- rhinovirus --- respiratory syncytial virus --- toll-like receptor --- LPS --- lipopolysaccharide --- heptosyltransferase --- protein dynamics --- glycosyltransferase --- GT-B --- inhibitor design --- lipopolysaccharide --- Coxiella burnetii --- Q fever --- phagosome --- virenose --- Plesiomonas shigelloides --- O-antigen --- lipopolysaccharide --- O-acetylation --- d-galactan I --- HR-MAS --- NMR spectroscopy --- endotoxin --- lipopolysaccharide --- Low Endotoxin Recovery --- phase transitions --- polysorbate --- LPS aggregates --- Small Angle X-ray Scattering --- MAT --- LAL and LER --- anti-conjugate serum --- core oligosaccharide --- lipopolysaccharide --- NMR spectroscopy --- ESI MS --- Proteus penneri

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english (3)


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