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LC-MS/MS Method for Mycotoxin Analysis

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ISBN: 9783038426066 9783038426073 Year: Pages: VIII, 186 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Chemistry (General)
Added to DOAB on : 2017-12-22 11:28:33
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Mycotoxins are secondary metabolites produced by some species of filamentous fungi belonging to Fusarium, Aspergillus, Penicillium, Claviceps and Alternaria genera. The biochemical significance of mycotoxins in fungal metabolism has not always been fully clarified; however, the main concern for mycotoxins is driven by the deleterious effects they can exert on human and animal health. Structurally, the mycotoxins currently known belong to heterogeneous chemical classes, therefore the toxic effects they can induce are highly diverse (e.g., cancerogenic and immunosuppressive effects). The main route of human exposure to mycotoxins is by intake of contaminated food, either directly from contaminated agricultural products, or indirectly from residues and metabolites present in foods of animal origin. Immunochemical methods are generally used for the fast screening of mycotoxin presence; however, for confirmation purposes, analytical methods based on high-performance liquid chromatography (LC) are preferred, especially when coupled with tandem mass spectrometry (MS/MS), which allows the determination of multiclass mycotoxins in a single analysis. Moreover, the technical innovations available in LC-MS/MS instrumentation are prompting its application to the monitoring of contaminants in food and feed. The aim of this paper collection, constituted by ten research articles and one review, is to provide the reader with an overview on the novelties and capabilities in LC-MS/MS-based multi-mycotoxin methods, also including the investigation of emerging and modified mycotoxins.

Forty Years of Heel Prick Screening in the Netherlands

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ISBN: 9783038421894 9783038421900 Year: Pages: 114 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Added to DOAB on : 2016-06-01 16:35:30
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This book aims to provide an overview of developments in the heel prick screening programme in the Netherlands in which similarities with the situation elsewhere in the world, where relevant, will be mentioned. In the Netherlands, the preparations for the national screening programme started in 1964. The formal launch of the programme was on September 1, 1974. In 2014, therefore this programme had existed 40 years. The book is structured as follows. Chapter 1 describes how the programme began with one disease and over the years has continued to expand to currently covering 19 disorders. Chapter 2 focuses on the organisation of the screening programme and the agencies that have been involved over the years. Chapter 3 is intended to provide a global view of the programme in its current form. Chapter 4 describes how neonatal screening programmes elsewhere in the world developed and outline their main differences with the Dutch programme. Finally, Chapter 5 contains the summary and conclusions. This chosen structure leads to some aspects being mentioned more than once. The book is intended for a broad audience that is interested in policy making on heel prick screening; hence, scientific depth is limited. Where possible and useful, references to the scientific literature have been included but completeness has not been pursued. The main sources were the archives of the National Steering Committees for Phenylketonuria and Congenital Hypothyroidism (LBCs), supplemented with interviews with the persons listed in Annex 1 and, if available, their personal archives. This is a translation of the book “Veertig Jaar Hielprikscreening in Nederland”, that was published by Prelum Publishers, Houten, the Netherlands with ISBN 978-90-8562-133-1 © 2014 Prelum, Houten; RIVM, Bilthoven; Vumc, Amsterdam.

Drug Metabolism, Pharmacokinetics and Bioanalysis

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ISBN: 9783038979166 / 9783038979173 Year: Pages: 230 DOI: 10.3390/books978-3-03897-917-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 08:44:06
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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.

Keywords

procainamide --- N-acetylprocainamide --- ultra-high-pressure liquid chromatography --- rat --- plasma --- pharmacokinetics --- adalimumab --- immunoprecipitation --- liquid chromatography-quadrupole TOF MS --- bioanalysis --- GB3 --- Fabry disease --- LC-QTOF-MS/MS --- B6 --- 129-Glatm1Kul/J --- cytochrome P450 --- drug interaction --- liquid chromatography-tandem mass spectrometry --- organic anion transporting polypeptide --- pharmacokinetics --- Korean red ginseng extract --- metformin --- diabetes --- drug interaction --- pharmacokinetics --- efficacy --- ethyl glucuronide --- hair --- HPLC-MS/MS --- AUDIT score --- alcohol addiction --- eurycomanone --- Eurycoma longifolia --- bioavailability --- pharmacokinetic --- anthraquinone --- glycoside --- aglycone --- LC-MS/MS --- plasma --- protein precipitation --- loxoprofen --- CYP --- UGT --- human liver microsomes --- LC-HR/MS --- mematine --- drug interaction --- liquid chromatography-tandem mass spectrometry --- pharmacokinetics --- biopharmaceuticals --- drying technology --- protein stability --- bioavailability --- pharmacokinetics --- DA-9805 --- saikosaponin a --- paeonol --- imperatorin --- pharmacokinetics --- brain distribution --- Osthenol --- CYP --- UGT --- human liver microsomes --- glucuronidation --- Stauntonia hexaphylla leaf extract --- YRA-1909 --- pharmacokinetics --- chlorogenic acid --- neochlorogenic acid --- cryptochlorogenic acid --- caffeic acid --- caffeic acid O-glucuronides --- LC-MS/MS --- aceclofenac --- diclofenac --- esomeprazole --- pharmacokinetics --- gastric ulcer --- acetyl tributyl citrate --- pharmaceutical excipient --- pharmacokinetics --- metabolic stability --- plasma

TRP Channels in Health and Disease

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ISBN: 9783039210824 / 9783039210831 Year: Pages: 266 DOI: 10.3390/books978-3-03921-083-1 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-06-26 08:44:07
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Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.

Keywords

ion channel --- TRPC --- small molecules --- calcium --- chemical probes --- TRPV1 --- TRPV2 --- TRPV3 --- TRPV4 --- mucosal epithelium --- ulcerative colitis --- inflammatory bowel disease --- TRPM4 channel --- cardiovascular system --- physiology --- pathophysiology --- TRPC6 --- elementary immunology --- inflammation --- calcium --- sodium --- neutrophils --- lymphocytes --- endothelium --- platelets --- human medulla oblongata --- cuneate nucleus --- dorsal column nuclei --- TRPV1 --- calcitonin gene-related peptide --- substance P --- TRP channels --- calcium signaling --- salivary glands --- xerostomia --- radiation --- inflammation --- transient receptor potential channels --- TRPC3 pharmacology --- channel structure --- lipid mediators --- photochromic ligands --- transient receptor potential --- TRPC3 --- mGluR1 --- GABAB --- EPSC --- Purkinje cell --- cerebellum --- toxicology --- TRP channels --- organ toxicity --- chemicals --- pollutants --- chemosensor --- TRPM7 --- kinase --- inflammation --- lymphocytes --- calcium signalling --- SMAD --- TH17 --- hypersensitivity --- regulatory T cells --- thrombosis --- graft versus host disease --- 2D gel electrophoresis --- AP18 --- HEK293 --- HSP70 --- MALDI-TOF MS(/MS) --- nanoHPLC-ESI MS/MS --- proteomics --- sulfur mustard --- TRPA1 --- TRPC channels --- diacylglycerol --- TRPC4 --- TRPC5 --- NHERF --- TRP channel --- TRPY1 --- Saccharomyces cerevisiae --- calcium --- manganese --- oxidative stress --- ion channels --- overproduction --- production platform --- protein purification --- Saccharomyces cerevisiae --- sensors --- transient receptor potential (TRP) channels --- yeast --- adipose tissue --- bioavailable --- menthol --- topical --- TRPM8 --- n/a

Solid Phase Extraction: State of the Art and Future Perspectives

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ISBN: 9783039211586 / 9783039211593 Year: Pages: 176 DOI: 10.3390/books978-3-03921-159-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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This book is a collection of 13 innovative papers describing the state of the art and the future perspectives in solid-phase extraction covering several analytical fields prior to the use of gas or liquid chromatographic analysis. New sorptive materials are presented including carbon nanohorn suprastructures on paper support, melamine sponge functionalized with urea–formaldehyde co-oligomers, chiral metal–organic frameworks, UiO-66-based metal–organic frameworks, and fabric phase sorptive media for various applications. Solid-phase extraction can be applied in several formats aside from the conventional cartridges or mini-column approach, e.g., online solid-phase extraction, dispersive solid-phase microextraction, and in-syringe micro-solid-phase extraction can be very helpful for analyte pre-concentration and sample clean-up. Polycyclic musks in aqueous samples, 8-Nitroguanine in DNA by chemical derivatization antibacterial diterpenes from the roots of salvia prattii, perfluoroalkyl substances (PFASs) in aater samples by bamboo charcoal-based SPE, parabens in environmental water samples, benzotriazoles as environmental pollutants, organochlorine pesticide residues in various fruit juices and water samples and synthetic peptide purification are among the applications cited in this collection. All these outstanding contributions highlight the necessity of this analytical step, present the advantages and disadvantages of each method and focus on the green analytical chemistry guidelines that have to be fulfilled in current analytical practices.

Qualitative and Quantitative Analysis of Bioactive Natural Products 2018

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ISBN: 9783038977889 Year: Pages: 374 DOI: 10.3390/books978-3-03897-789-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology --- Science (General)
Added to DOAB on : 2019-04-05 10:34:31
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Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives.Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today.This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.

Keywords

Talaromyces pinophilus --- talarodiolide --- macrodiolides --- GC/MS --- secondary metabolites --- anthocyanins --- red cabbage --- recycling preparative high performance liquid chromatography --- stability --- UHPLC-MS/MS --- decursin --- decursinol angelate --- nodakenin --- decursinol --- Ginkgo biloba Extract (GBE) --- chromatogram-bioactivity correlation --- bioactive compounds --- endothelial function --- wine --- volatile compounds --- terrain conditions --- odor-activity values --- SPME-GC/MS --- Bolbostemma paniculatum --- identification --- LTQ-Orbitrap --- UPLC --- multivariate statistical analysis --- cannabidiol --- CBD oil --- terpenes --- hemp seed oil --- GC-MS --- HPLC-Q-Exactive-Orbitrap-MS --- Rossa da inverno sel. Rojo Duro onion cultivar --- geographical origin --- amino acids content --- HPLC analysis --- statistical evaluations --- food traceability --- aleuritolic acid --- autophagy --- apoptosis --- HPLC --- Curcuma longa --- turmeric --- curcuminoids --- turmerone --- quantification --- Quercus acuta leaf --- antioxidant --- antibacterial activity --- Staphylococcus aureus --- Erigeron breviscapus extract --- UPLC-ESI-MS/MS --- cerebral ischemia reperfusion injury --- scutellarin --- scutellarein --- HPLC --- Podospermum --- Scorzonera --- triterpenes --- ginseng berry extract --- ginsenosides --- stereoselective and simultaneous analysis --- pharmacokinetics --- oral administration --- saffron --- crocins --- UHPLC analysis --- separation optimisation --- artificial neural network --- response surface methodology --- bioactive natural compounds --- secondary metabolites --- Alzheimer’s disease --- Olea europaea L. --- liquid chromatography --- gas chromatography --- mass spectrometry --- secondary metabolites --- olive leaves --- Moroccan region --- phenolic compounds --- liquid chromatography-mass spectrometry --- chemometrics --- metabolic profiling --- Sorbus --- fruit powders --- phenolic compounds --- carotenoids --- sugars --- organic acids --- chili --- capsaicinoids --- phenolics --- free radical-scavenging --- geographical variation --- 1-triacontanol --- HPLC-ELSD --- biostimulant --- method validation --- Myristica fragrans --- nutmeg --- essential oil --- ionic liquids --- hydrodistillation --- MODDE experimental design --- rice --- phenolic compounds --- phenolic acids --- flavonoids --- anthocyanins --- proanthocyanidins --- antioxidant activity --- extraction --- HPLC methods --- phenolic compounds --- Spondias spp. --- UPLC-MS --- antioxidant capacity --- Iris lactea Pall. var. chinensis (Fisch.) Koidz. --- HPLC-Q-TOF-MS/MS --- qualitative analysis --- quantitative analysis --- C-glycosylflavone --- traditional Chinese medicine decoction --- quality evaluation --- UPLC-QTOF-MS --- UFLC-QQQ-MS --- ShenFu prescription decoction

Isolation and Structure Elucidation of Bioactive Compounds (Dedicated to the memory of the late Professor Charles D. Hufford)

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ISBN: 9783038977803 9783038977810 Year: Pages: 276 DOI: 10.3390/books978-3-03897-781-0 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-04-25 16:37:17
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We are very pleased to introduce the Book Version of our Special Issue in Molecules dedicated to the memory of the late Professor Dr. Charles D. Hufford. The issue has been a huge success, with 22 full-length peer-reviewed papers and a tribute by Professor Alice M.Clark. Authors, reviewers, and collaborators from many countries across the worldhave contributed to this endeavour, and we are truly grateful to all. This Special Issue isrepresentative of the broad impact that &ldquo;Charlie&rdquo; had on the field of bioactive naturalproducts. This Special Issue comprises papers from Professor Hufford&rsquo;s former students,colleagues, and collaborators throughout the world who have utilized a wide array ofstate-of-the-art techniques to examine diverse natural sources to isolate and identify avariety of natural products with a wide spectrum of biological activities, including somenew microbial transformations and insights into bioactive molecules. Many new bioactive compounds are described and reported here for the first time. Bioactivities reportedinclude cytotoxicity, antimicrobial activity, anti-inflammatory activity, antileishmanialactivity, antitrypanosomal activity, antimalarial activity, analgesic activity, and beneficialliver activities, just to name a few. This Special Issue will undoubtedly have a lasting impact on the field of bioactive natural products, as exemplified by the career of Dr. Hufford.Lastly, without the timely and outstanding contributions from all of you, this Special Issue would not have been possible. We thank you all very much for your contributions and your time devoted to this Special Issue in memory of a special person. Finally, we express ourgratitude and thanks to the journal Molecules and their excellent team of expert reviewers for giving us the support and opportunity to make this Special Issue a huge success!

Keywords

fusidic acid --- Cunninghamella echinulata --- C-26-oxidation --- C-27-oxidation --- Morus alba L. --- aldose reductase inhibitor --- neuroprotective agent --- natural products --- Mitracarpus scaber Zucc. --- pentalogin --- anti-inflammatory --- MS/MS --- Il-8 --- Crinum amabile --- augustine N-oxide --- buphanisine N-oxide --- biological activities --- Cryptococcus neoformans --- cryptococcosis --- HepG2 --- Prosopis glandulosa --- prosopilosidine --- amphotericin B --- fluconazole --- resveratrol --- dietary supplement --- gastro-resistant --- microparticles --- obesity --- HPLC --- Jatropha pelargoniifolia --- alkaloids --- flavonoids --- coumarinolignans --- diterpenes --- anti-inflammatory --- analgesic --- antipyretic --- Cochlospermum vitifolium --- Cochlospermaceae --- flavonoids --- lignans --- aromatic compounds --- carotenoids --- sterols --- liver activity --- Arthrinium sp. --- chromone --- polyketide --- antioxidant activity --- Rubiaceae --- jenipapo --- HPLC-ESI-IT-MS/MS --- flavonoids glycosides --- Baccharis --- antimalarial activity --- antitrypanosomal activity --- insecticidal activity --- GC/MS --- DNA barcoding --- microscopy --- antibacterial --- channel catfish --- columnaris disease --- Flavobacterium columnare --- stilbenes --- muscadine --- pyranoanthocyanin --- anti-leishmanial activity --- Leishmania donovani --- maleimides --- cytotoxicity --- SAR --- phlorogluciniol --- acylphloroglucinol --- anti-inflammatory --- iNOS --- NF-?B --- endophytic fungi --- sesterterpene --- cytotoxic activity --- pancreatic cancer --- Stevia rebaudiana --- diterpene glycosides --- rebaudioside A isomers --- 13(S)-hydroxyatisenoic acid derivative --- iso-stevioside X-ray structure --- Litsea cubeba --- cytotoxicity --- isolation and elucidation --- lignans --- antimicrobial resistance --- multi-drug resistant (MDR) --- methicillin resistant Staphylococcus aureus (MRSA) --- Zingiber monatnum --- terpenes --- (E)-8(17),12-labdadiene-15,16-dial --- zerumbol --- microbial transformation --- hop prenylflavanone --- isoxanthohumol --- cardiomyogenesis --- factor VII --- factor X --- inflammation --- thrombosis --- vasculogenesis --- herbal medicine --- n/a --- Nemania --- Xylariaceae --- Torreya taxifolia --- plant pathogenic and endophytic fungi --- cytochalasins --- malaria --- cytotoxicity --- phytotoxicity --- acacetin 7-methyl ether --- acacetin --- monoamine oxidase-A --- monoamine oxidase-B --- molecular docking --- molecular dynamics --- neurological disorder --- Turnera diffusa

Mass Spectrometric Proteomics

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ISBN: 9783038978268 9783038978275 Year: Pages: 192 DOI: 10.3390/books978-3-03897-827-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-04-25 16:37:17
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As suggested by the title of this Special Issue, liquid chromatography-mass spectrometry plays a pivotal role in the field of proteomics. Indeed, the research and review articles&nbsp; published in the Issue clearly evidence how the data produced by this sophisticated methodology may promote impressive advancements in this area. From among the topics discussed in the Issue, a few point to the development of&nbsp; new procedures for the&nbsp; optimization of the experimental conditions that should be applied&nbsp; for the identification of proteins present in complex mixtures.&nbsp; Other applications&nbsp; described in these articles show&nbsp; the huge potential of&nbsp; these strategies in the protein profiling of organs and&nbsp; range from&nbsp; to the study of post-translational tissue modifications to the investigation of the molecular mechanisms behind human disorders and the identification of potential biomarkers of these diseases.

Biological Potential and Medical Use of Secondary Metabolites

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ISBN: 9783039211876 / 9783039211883 Year: Pages: 284 DOI: 10.3390/books978-3-03921-188-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Chemistry (General)
Added to DOAB on : 2019-08-28 11:21:27
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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

Keywords

Juniperus --- secondary metabolites --- diterpenes --- flavonoids --- lignans --- cytotoxic --- antitumor --- antibacterial --- amentoflavone --- deoxypodophyllotoxin --- frankincense --- Boswellia --- cembranoids --- cneorubenoids --- boswellic acids --- molecular docking --- Scabiosa --- flavonoids --- iridoids --- pentacyclic triterpenoids --- antioxidant --- anti-inflammatory --- antibacterial --- anticancer --- Cordyceps militaris --- xanthine oxidase --- antioxidant --- antibacterial --- cordycepin --- GC-MS --- Artemisia species --- Artemisia vachanica --- artemisinin --- HPLC-PAD --- Tajikistan --- Malus x domestica --- Tuscany --- ancient varieties --- nutraceutics --- antioxidants --- polyphenols --- sugars --- pectin --- defensins --- secondary metabolites --- plant defense --- antimicrobial and anticancer activity --- medicine --- innate immunity --- cannabis --- cannabinoids --- therapeutics --- toxicology --- analytical determination --- legalization --- natural products --- biosynthetic gene clusters --- secondary metabolites --- antiSMASH --- Mitragyna speciosa --- kratom --- secondary metabolites --- therapeutic uses --- toxicology --- analysis --- Maytenus chiapensis --- Celastraceae --- quinonemethide triterpenoids --- pristimerin --- tingenone --- HPLC-PDA --- Ocimum sanctum --- Lamiaceae --- (-)-rabdosiin --- cytotoxic activity --- triterpenoids --- phenolic derivatives --- nanoemulsion --- essential oils --- vector control --- infectious diseases --- TCM --- phytochemistry --- LC-MS/MS --- antioxidant activity --- ABTS --- DPPH --- FRAP --- ascorbic acid --- EGCG --- total phenolics --- antimicrobial activity --- sargaquinoic acid --- sarganaphthoquinoic acid --- antiplasmodial --- malaria --- PPAR-? --- sargahydroquinoic acid --- sarganaphthoquinoic acid --- sargachromenoic acid --- inflammation --- bowel diseases --- secondary metabolites --- biological activities --- medicinal applications --- plants --- seaweeds

Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis

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ISBN: 9783039210848 / 9783039210855 Year: Pages: 308 DOI: 10.3390/books978-3-03921-085-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- Chemical Engineering
Added to DOAB on : 2019-06-26 08:44:06
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The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical methods using hyphenated instrument configurations to support the optimization of the whole process and the scale-up possibility

Keywords

branched-chain keto acids --- serum --- muscle --- HPLC-Q-TOF/MS --- wood --- odor --- volatile organic compounds --- gas chromatography-olfactometry --- Wuyi Rock tea --- quality --- UPLC-QTOF MS --- UPLC-QqQ MS --- metabolite profiling --- metabolomics --- cluster analysis --- cultivars --- Lycium ruthenicun --- flavonoid --- ruthenicunoid A --- SIRT1 --- Asphodeline lutea --- HPLC-PDA --- heavy metals --- tyrosinase --- diabetes --- neurodegenerative disease --- color analysis --- pigments --- MAE --- HPLC-PDA --- SFE --- Thymus algeriensis --- rare earth elements --- flow injection --- inductively coupled plasma-mass spectrometry --- seawater --- Hericium erinaceuns mycelium --- high-speed counter-current chromatography (HSCCC) --- genistein --- daidzein --- Fe3O4 --- modification --- alginate --- alkaloid --- ultrasound assisted extraction --- gelatin --- actinidin --- bovine hide --- physicochemical properties --- gel strength --- Semen Cuscutae --- ultra-high-performance liquid chromatography coupled to electrospray ionization mass spectrometry --- chlorogenic acids --- flavonoids --- steamed Panax notoginseng --- saponins --- extraction --- optimization --- antioxidant activity --- response surface methodology --- hematopoiesis --- microwave processing --- response surface methodology --- minor ginsenosides --- blood-enriching activity --- hemostatic activity --- ionic liquids --- sample preparation --- microextraction --- solid-phase microextraction --- dispersive liquid-liquid microextraction --- single-drop microextraction --- stir bar sorptive extraction --- stir cake sorptive extraction --- rosuvastatin --- metformin --- HILIC --- LC-MS --- therapeutic drug monitoring --- oolong tea --- Tieguanyin tea cultivar --- metabolite profiling --- UPLC-QTOF MS --- metabolomics --- Ajuga genevensis --- near-infrared spectroscopy --- dry extract --- fluid bed process --- microNIR --- in-line monitoring --- total polyphenolic content --- antioxidant --- flavonoids --- mouse melanoma B16 cells --- Panax notoginseng --- surfactant --- n/a --- ultra-high-performance liquid chromatography tandem mass spectrometry --- GHB --- GHB glucuronide --- nails --- endogenous values --- walnut septum --- polyphenols --- phytosterols --- HPLC-MS/MS --- Ultra-Turrax extraction --- biological activity --- antioxidant activity --- experimental design --- optimization --- phytochemicals

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