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Immunoglobulin therapy in the 21st century: the dark side of the moon

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889197033 Year: Pages: 124 DOI: 10.3389/978-2-88919-703-3 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Allergy and Immunology
Added to DOAB on : 2016-08-16 10:34:25
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In the early decades since the introduction in the early '80s of immunoglobulin therapy many studies tried to identify which clinical indications might benefit from the therapy, which treatment’s schedules are effective and safe. It is universally accepted that immunoglobulin therapy is a life-saving treatment in patients with PID. The rise of new indications for further different clinical conditions resulted in a steady increase in demand for immunoglobulins. Currently the consumption of immunoglobulin for PID represents a small fraction of the market. In the recent past we have been observing:1) An increase in the demand for plasma and in the consequent need to increase the number of donors;2) Changes in methods to improve IgG recovery and to increase productivity as a response to growing clinical demand;3) Introduction of immunoglobulin treatments with higher concentration;4) Changes in the timing of administration with an increase in the rate of infusion;5) Introduction of immunoglobulin treatment administered subcutaneously mainly confined initially to patients with PID and later extended to other clinical indications which often require higher volumes of infusion. Doctors following patients with PID were initially alarmed only to a possible risk of shortage. More relevant and less discussed appear the possible consequences of:1) the risk of an improper transfer of information on treatments from a clinical indication to another. In particular, the idea of a mere replacement function in patients with PID might possibly be borrowed from the model of other clinical conditions requiring a replacement such as haemophilia. In PID, immunoglobulin treatment instead is obviously replacing a missing feature. However, other immune alterations are responsible for the large number of PID-associated diseases including inflammatory manifestations and tumors, common causes of morbidity and mortality. The immunomodulatory effects of immunoglobulin administered at replacement dosages on multiple cells and immune system functions are still largely to be checked in in vitro studies and in vivo.2) the changes in the immunoglobulin production and schedules of administration. These should have been assessed in studies of drug surveillance, necessary in order to evaluate on large numbers of what it is initially reported on patients enrolled in the pivotal clinical trials, usually in the absence of most of the main disease-associated clinical conditions affecting pharmacokinetics, efficacy and tolerability. Severe side effects are now more frequently reported. This requires surveillance studies in order to verify the tolerability. Nowadays, personalized health research presents methodologic challenges, since emphasis is placed on the individual response rather than on the population. Even within a universally accepted indication, such as in PID, the identification of prognostic markers should guide the therapeutic intervention.3) the risk of a decrease in the surveillance and monitoring of PID-associated clinical conditions. In fact, self- administration of immunoglobulins administered subcutaneously increased the independence of a number of patients. On the other hand, it led to the reduction in the number of contacts between specialized centers and patients who often require a close monitoring of disease-associated conditions. A wide debate between experts is necessary to afford the new challenge on immunoglobulin usage.

Protecting the Body in War and Combat

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ISBN: 9783700177418 Year: Pages: 381 Seiten Language: English
Publisher: Verlag der Österreichischen Akademie der Wissenschaften Grant: Austrian Science Fund - PUB 337
Added to DOAB on : 2018-02-23 11:02:20
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This monograph provides an overview of all metal body armour from the European Bronze Age from a typo-chronological perspective but also in focusing on the manufacture and usage of such armour. This was enabled through the re-evaluation of central and eastern European finds in particular and their material analyses. The research history, distribution and chronology, as well as manufacture and use of helmets, greaves and cuirasses is discussed.

Sugar, Steam and Steel: The Industrial Project in Colonial Java, 1830-1850

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ISBN: 9781922064998 Year: Pages: 322 DOI: 10.20851/steam-and-steel Language: English
Publisher: University of Adelaide Press
Subject: History --- Migration
Added to DOAB on : 2014-12-19 00:53:15
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Sugar, Steam and Steel is about cane sugar and the transformation of an Indonesian island into the ‘Oriental Cuba’ during the middle decades of the nineteenth century. Between the 1830s and the 1880s, sweetener manufacture in Dutch-controlled Java — the crown jewel of the erstwhile Netherlands Indies — drew decisively away in matters of technology and sugar science from other Asian centres of production which had once equaled or, more often, surpassed it in terms of both output and know-how. Along with its larger and altogether more famous Caribbean counterpart, Java’s industry came to occupy a position at the apex of the trade in what had become by this date a key global commodity.

Flexible Electronics: Fabrication and Ubiquitous Integration

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ISBN: 9783038978282 / 9783038978299 Year: Pages: 160 DOI: 10.3390/books978-3-03897-829-9 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Electrical and Nuclear Engineering
Added to DOAB on : 2019-06-26 08:44:06
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Flexible Electronics platforms are increasingly used in the fields of sensors, displays, and energy conversion with the ultimate goal of facilitating their ubiquitous integration in our daily lives. Some of the key advantages associated with flexible electronic platforms are: bendability, lightweight, elastic, conformally shaped, nonbreakable, roll-to-roll manufacturable, and large-area. To realize their full potential, however, it is necessary to develop new methods for the fabrication of multifunctional flexible electronics at a reduced cost and with an increased resistance to mechanical fatigue. Accordingly, this Special Issue seeks to showcase short communications, research papers, and review articles that focus on novel methodological development for the fabrication, and integration of flexible electronics in healthcare, environmental monitoring, displays and human-machine interactivity, robotics, communication and wireless networks, and energy conversion, management, and storage.

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