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Alzheimer's Disease Pathogenesis - Core Concepts, Shifting Paradigms and Therapeutic Targets

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ISBN: 9789533076904 Year: Pages: 704 DOI: 10.5772/951 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:48

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Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

A Comprehensive Book on Autism Spectrum Disorders

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ISBN: 9789533074948 Year: Pages: 490 DOI: 10.5772/975 Language: English
Publisher: IntechOpen
Subject: Psychiatry
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The aim of the book is to serve for clinical, practical, basic and scholarly practices. In twentyfive chapters it covers the most important topics related to Autism Spectrum Disorders in the efficient way and aims to be useful for health professionals in training or clinicians seeking an update. Different people with autism can have very different symptoms. Autism is considered to be a ""spectrum"" disorder, a group of disorders with similar features. Some people may experience merely mild disturbances, while the others have very serious symptoms. This book is aimed to be used as a textbook for child and adolescent psychiatry fellowship training and will serve as a reference for practicing psychologists, child and adolescent psychiatrists, general psychiatrists, pediatricians, child neurologists, nurses, social workers and family physicians. A free access to the full-text electronic version of the book via Intech reading platform at http://www.intechweb.org is a great bonus.

Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring

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ISBN: 9789533074856 Year: Pages: 572 DOI: 10.5772/1252 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:48

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Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring focuses on biological mechanisms, prevention, neuroprotection and even monitoring of disease progression. This book emphasizes the general biological processes of neurodegeneration in different neurodegenerative diseases. Although the primary etiology for different neurodegenerative diseases is different, there is a high level of similarity in the disease processes. The first three sections introduce how toxic proteins, intracellular calcium and oxidative stress affect different biological signaling pathways or molecular machineries to inform neurons to undergo degeneration. A section discusses how neighboring glial cells modulate or promote neurodegeneration. In the next section an evaluation is given of how hormonal and metabolic control modulate disease progression, which is followed by a section exploring some preventive methods using natural products and new pharmacological targets. We also explore how medical devices facilitate patient monitoring. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.

Huntington's Disease - Core Concepts and Current Advances

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ISBN: 9789533079530 Year: Pages: 568 DOI: 10.5772/1470 Language: English
Publisher: IntechOpen
Subject: Neurology
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Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, ""Huntington's Disease - Core Concepts and Current Advances"", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area.

Autism Spectrum Disorder - Recent Advances

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Book Series: 2015-04-02 ISBN: 9789535120377 9789535142287 Year: Pages: 378 DOI: 10.5772/58507 Language: English
Publisher: IntechOpen
Subject: Neurology
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This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Update on Amyotrophic Lateral Sclerosis

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ISBN: 9789535126003 9789535126010 9789535141839 Year: Pages: 280 DOI: 10.5772/61682 Language: English
Publisher: IntechOpen
Subject: Neurology
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This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.

A Multidimensional Approach to Post-Traumatic Stress Disorder - from Theory to Practice

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ISBN: 9789535127284 9789535127291 9789535141600 Year: Pages: 254 DOI: 10.5772/61874 Language: English
Publisher: IntechOpen
Subject: Psychology
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Is the heart rate variability biofeedback a promising intervention for PTSD? Is there a link between early traumatic events in life and the presence of psychopathology and interpersonal difficulties in adulthood? Wondering what is the next step for humanistic, psychodynamic, or CBT therapists working with PTSD patients? Look no further. A Multidimensional Approach to Post-Traumatic Stress Disorder - From Theory to Practice explores the PTSD through the lens of the biopsychosocial model. The various topics covered in this book - from the neuro-bio-physiological aspects to the clinical and methodological dimensions involved in investigating the PTSD - address a wide variety of concerns regarding the disorder. The authors of the chapters are internationally renowned leaders in their field of science, sharing both the results of their latest investigations and their thoughtful perspectives on future fundamental and clinical research on PTSD. The knowledge shared by the authors results in an engaging and scientific experience for the initiated reader, yet accessible to the newcomers who are just learning about PTSD.

New Developments in Anxiety Disorders

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ISBN: 9789535127918 9789535127925 Year: Pages: 160 DOI: 10.5772/62656 Language: English
Publisher: IntechOpen
Subject: Neurology
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This book collects the contribution of a selected number of clinical psychiatrists, interested in the clinical application of some aspects of neurobiology of anxiety. The seven chapters of the book address some issues related to the latest acquisitions of neurobiology, in particular those aspects that are related to responses to treatment - both psychological and pharmacological. Some chapters are also dedicated to the comorbidities, a rule rather than an exception when it comes to anxiety. Each author summarized the clinical importance of his work, underlining the clinical pitfalls of this new book on anxiety.

Schizophrenia Treatment - The New Facets

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ISBN: 9789535128250 9789535128267 9789535141341 Year: Pages: 180 DOI: 10.5772/62958 Language: English
Publisher: IntechOpen
Subject: Neurology
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Schizophrenia treatment has many facets. This book begins with the glutamatergic and GABAergic hypofunctioning contribute to the schizophrenic symptoms and their current targeted therapeutics. The genetic, epigenetic, and immune etiologies of schizophrenia and their potential targeted therapeutics as approached in this book are interesting. Understanding cognitive biases and delusional circuits in schizophrenia is important; several behavioral cognitive therapies working on the reduction and avoidance of these cognitive biases are demonstrating their effectiveness. Advances in schizophrenia treatment followed, including transcranial magnetic stimulation and special sport program, are presented at the book's end.

Botulinum Toxin Therapy Manual for Dystonia and Spasticity

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ISBN: 9789535128519 9789535128526 Year: Pages: 182 DOI: 10.5772/61878 Language: English
Publisher: IntechOpen
Subject: Neurology
Added to DOAB on : 2019-10-03 07:51:49

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Taking exception from previous publications and reviews, this handbook boldly knits botulinum toxin therapy indications in both dystonia and spasticity. Botulinum toxin therapy has indeed withstood the test of time in terms of its efficacy and safety, as applied in hyperfunctional states of the muscle and exocrine glands. Topics were chosen spanning from the basic science to the clinical applications and to instrument-guidance injections. The format was envisioned to be timely as one (either a novice or an experienced clinician) applies practical approaches with botulinum toxin therapy ranging from straightforward to challenging clinical scenarios. As well, clinicians and students alike will find the book useful in content and relevance to contemporary times. Please read with no fear and don't doubt because indeed you eventually become the winner as you finish the book.

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