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Clinical Management of Adrenal Tumors

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ISBN: 9789535132653 9789535132660 Year: Pages: 168 DOI: 10.5772/63139 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:50

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This book presents an overview of adrenal tumors written by a multidisciplinary team of world experts who provide comprehensive, evidence-based perspective of their topics in this field and current approaches to the management of adrenal tumors. The areas discussed in this book include an overview of adrenal incidentalomas, unusual presentations of adrenal tumors, genetic basis of pheochromocytomas and paragangliomas, pathophysiology, and medical and surgical treatment and approaches to patients with benign and malignant adrenal tumors. Each chapter written by these experts provides clinical evidence, treatment recommendations, and algorithms. Clinical Management of Adrenal Tumors will serve as a valuable resource of current information regarding adrenal tumors for medical students, residents in training, physicians, and researchers.

Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches

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ISBN: 9781789845044 9781789845051 Year: Pages: 210 DOI: 10.5772/intechopen.74993 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.

Pituitary Diseases

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ISBN: 9781789857474 9781789857481 Year: Pages: 124 DOI: 10.5772/intechopen.72984 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:52

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This book is a very provocative addition to the literature on pituitary diseases, it delivers lots of stimulating work and offers rich scientific material for readers in different disciplines. The book provides a detailed update on current diagnostic and therapeutic techniques useful in the management of pituitary diseases. Microsurgical surgery, medical treatment, and radiotherapy has been used in the last decades; however, the prediction of post-medical, postsurgical treatment, and post-radiotherapy treatment is still controversial. The book contents reflect the multidisciplinary approach needed for patients with pituitary diseases with contribution from neurosurgeons, endocrinologists, neurologists, radiologists, ophthalmologists, pathologists, and radiation oncologists. The book focuses on some pituitary diseases especially the most controversial subjects in the medical and surgical treatment such as dedicated surgical technique by huge pituitary adenoma, the management of celiac patients with growth failure, pituitary apoplexy, neuro ophthalmology findings in pituitary disease, and the immunohistochemical studies in pituitary adenomas, moreover there is a special chapter about transoral robotic surgery (TORS) with the da Vinci system.

Renin-Angiotensin System - Past, Present and Future

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ISBN: 9789535133513 9789535133520 Year: Pages: 268 DOI: 10.5772/63179 Language: English
Publisher: IntechOpen
Subject: Internal medicine
Added to DOAB on : 2019-10-03 07:51:50

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Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.

Trends in Neuroendocrinology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450725 Year: Pages: 138 DOI: 10.3389/978-2-88945-072-5 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General) --- Internal medicine --- Medicine (General)
Added to DOAB on : 2017-07-06 13:27:36
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Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on nerve cells and the production of hormones by the nervous system. The present Research Topic is a compilation of contributions stemming from the 8th International Congress of Neuroendocrinology (ICN2014) held in Sydney, Australia, that illustrates various facets of current neuroendocrine research.

Neuropeptide GPCRs in Neuroendocrinology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192670 Year: Pages: 825 DOI: 10.3389/978-2-88919-267-0 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Medicine (General) --- Neurology --- Science (General)
Added to DOAB on : 2015-12-03 13:02:24
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The human genome encompasses ~ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.

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