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New Research in Obsessive-Compulsive Disorder and Major Depression

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ISBN: 9783039210909 9783039210916 Year: Pages: 102 DOI: 10.3390/books978-3-03921-091-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Psychology
Added to DOAB on : 2019-06-26 08:44:07
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Abstract

Major depression and obsessive–compulsive disorder (OCD) are now recognized among the most frequent psychiatric disorders, affecting 16–17% and 2–3% of the general population, respectively. They are commonly characterized by: i) a high level of psychiatric and somatic comorbidities; ii) a recurrence or chronic profile; and iii) a negative impact on daily functions, thereby leading to a profound impairment of quality of life. Despite significant advances in pharmacological and psychological therapies over the last decades, unsuccessful responses to standard treatment strategies are classically observed in approximately 20–30% of cases. Therefore, there is a significant need for improving the pathophysiological knowledge through a better identification of environmental, clinical, psychological, genetic, anatomical, and biological determinants, specifically implied in the development, the phenotypic expression, and the relapsing course and/or contributing to the therapeutic failure in major depression and OCD. We are convinced that this research approach is particularly relevant providing critical support for the promotion of innovative treatment alternatives potentially useful for the management of resistant forms of major depression and OCD.

Efficiency of Bank Filtration and Post-Treatment

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ISBN: 9783039213054 9783039213061 Year: Pages: 352 DOI: 10.3390/books978-3-03921-306-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Riverbank filtration (RBF) schemes for the production of drinking water are increasingly challenged by new constituents of concern, such as organic micropollutants and pathogens in the source water and hydrological flow variations due to weather extremes. RBF and new technology components are integrated and monitoring and operating regimes are adopted to further optimize water treatment in bank filtration schemes for these new requirements. This Special Issue presents results from the EU project AquaNES “Demonstrating synergies in combined natural and engineered processes for water treatment systems” (www.aquanes.eu). Additionally, papers from other research groups cover the efficiency of bank filtration and post-treatment, advantages and limitations of combining natural and engineered processes, parameter-specific assessment of removal rates during bank filtration, and the design and operation of RBF wells. The feasibility, design, and operation of RBF schemes under specific site conditions are highlighted for sites in the US, India, and South Korea

Keywords

riverbank filtration --- removal efficacy --- dissolved organic carbon (DOC) --- pesticides --- pharmaceutical residues --- riverbank filtration --- organic matter degradation --- manganese --- riverbed --- climate change --- floods --- droughts --- column experiments --- PHREEQC --- decentralized capillary nanofiltration --- anoxic --- suboxic --- organic micropollutants --- bank filtrate --- groundwater --- sulphate --- dissolved organic matter --- high temperature --- sub-oxic conditions --- organic matter composition --- PARAFAC-EEM --- LC-OCD --- redox sensitivity --- micropollutants --- oxypurinol --- gabapentin --- river bank filtration --- hydrological trends --- sustainable water production --- well structure remodeling --- point-bar alluvial setting --- riverbank filtration --- site investigation --- hydrochemistry --- subsurface geology --- riverbank filtration --- organic micropollutants --- water quality --- environmental monitoring --- riverbank filtration --- collector wells --- performance --- entrance velocity --- river bank filtration --- attenuation --- organic micropollutants --- pharmaceuticals --- riverbank filtration --- small communities --- disinfection by-products --- trihalomethanes --- riverbank filtration (RBF) --- Krishna River --- southern India --- water treatment --- water quality --- salinity --- river bank filtration --- ultrafiltration --- surface water treatment --- energy efficiency --- out/in membrane comparison --- inline electrolysis --- bank filtration --- biofilm --- clogging --- filter cake --- pathogen barrier --- pressure loss --- slow sand filtration --- electro-chlorination --- smart villages --- disinfection --- river bank filtration --- rural water supply, online monitoring --- dissolved organic matter --- fluorescence excitation-emission matrix --- LC-OCD --- Nakdong River --- riverbank filtration --- bank filtration --- drinking water treatment --- inorganic chemicals --- organic micropollutants --- Ganga --- Yamuna --- Damodar --- riverbank filtration --- water quality --- organic carbon --- nitrate --- heavy metals --- microorganisms --- riverbank filtration --- riverside water source --- analytical method --- mirror-image method --- optimization --- riverbank filtration --- water quality --- bank filtrate portion --- iron --- manganese --- microorganisms --- system costs --- water supply --- storage tank --- drinking water hydropower --- turbine --- energy generation --- renewable energy

Venom and Toxin as Targeted Therapy

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ISBN: 9783039211890 9783039211906 Year: Pages: 180 DOI: 10.3390/books978-3-03921-190-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology
Added to DOAB on : 2019-12-09 11:49:15
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Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Keywords

disintegrin --- blood vessel formation --- VEGF --- antioxidant enzymes --- oxidative stress biomarkers --- bicarinalin --- antimicrobial peptide --- Helicobacter pylori --- gastric cells --- bacterial adhesion --- SEM --- atopic dermatitis (AD) --- house dust mite extract (DFE) --- 2,4-dinitrochlorobenzene (DNCB) --- bee venom phospholipase A2 (bvPLA2) --- skin inflammation --- CD206 --- mannose receptor --- immunotoxin --- Moxetumomab pasudotox --- targeted therapy --- CD22 --- B cell non-Hodgkin lymphoma --- acute lymphoblastic leukemia --- mantle cell lymphoma --- ribosome-inactivating protein --- BLF1 --- eIF4A --- MYCN --- cancer --- neuroblastoma --- apoptosis --- antimicrobial peptide (AMP) --- dermaseptin --- anuran skin secretion --- drug design --- antimicrobial activity --- anticancer activity --- antiviral activity --- Bougainvillea --- bouganin --- cancer therapy --- immunotherapy --- immunotoxins --- ribosome-inactivating proteins --- rRNA N-glycosylase activity --- VB6-845 --- orellanine --- clearance --- fungal toxin --- half-life --- toad toxins --- Chansu --- Huachansu --- cane toad --- bufadienolides --- indolealkylamines --- inflammation --- cancer --- obsessive–compulsive disorder (OCD) --- snake venom --- cancer --- target therapy --- snake venom --- Malaysian cobras --- N. kaouthia --- N. sumatrana --- O. hannah --- anticancer --- Apis mellifera syriaca --- bee venom --- melittin --- LC-ESI-MS --- solid phase extraction --- in vitro effects --- frog --- mass spectrometry --- molecular cloning --- bombesin-related peptide --- smooth muscle --- Bee venom --- complement system --- decay accelerating factor --- atopic dermatitis --- complement dependent cytotoxicity --- membrane attack complex --- n/a

Extraintestinal Manifestations of Coeliac Disease

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ISBN: 9783038977988 9783038977995 Year: Pages: 270 DOI: 10.3390/books978-3-03897-799-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Nutrition and Food Sciences
Added to DOAB on : 2019-04-25 16:37:17
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Abstract

Coeliac Disease (CD) affects at least 1% of the population. “Classical” CD refers to gastrointestinal presentations with anaemia and gastrointestinal symptoms. CD can, however, present with extraintestinal manifestations, the commonest of which are dermatitis herpetiformis and neurological presentations (e.g., ataxia, neuropathy, encephalopathy). Recognition and research into the pathophysiology of such manifestations is likely to enhance our understanding of this complex autoimmune disorder.

Keywords

dermatitis herpetiformis --- coeliac disease --- fracture --- bone health --- quality of life --- Gilles de la Tourette syndrome (GTS) --- children and adults --- motor and vocal/phonic tics --- obsessive-compulsive disorder (OCD) --- non-coeliac gluten sensitivity (NCGS) --- gluten-free diet --- one-year adherence --- dermatitis herpetiformis --- coeliac disease --- prevalence --- epidermal transglutaminase --- gluten-free diet --- long-term prognosis --- dermatitis herpetiformis --- coeliac disease --- gluten-free diet --- small bowel --- villous atrophy --- prognosis --- gluten neuropathy --- coeliac disease --- gluten free diet --- quality of life --- male --- extra-intestinal --- gastrointestinal --- celiac disease --- celiac disease --- dermatitis herpetiformis --- urticaria --- atopic dermatitis --- psoriasis --- recurrent aphtous ulceration --- rosacea --- alopecia areata --- cutaneous vasculitis --- gluten-free diet --- celiac disease --- glandular autoimmunity --- autoimmune thyroid disease --- type 1 diabetes --- polyglandular autoimmune syndrome --- coeliac disease --- osteoporosis --- fractures --- celiac disease --- non-celiac gluten sensitivity --- psychiatric disorders --- depression --- anxiety disorders --- eating disorders --- ADHD --- autism --- psychosis --- autoimmunity --- celiac hepatitis --- gut–liver axis --- liver immunity --- non-alcoholic fatty liver disease --- tolerance --- intestinal barrier --- celiac disease --- extraintestinal --- recognition --- diagnosis --- clinical presentation --- gluten-free diet --- prognosis --- movement disorders --- coeliac disease --- gluten --- gluten free diet --- celiac disease --- gluten --- gliadin --- autoantibody --- B cell --- T cell --- transglutaminase --- synapsin --- ganglioside --- gluten sensitivity --- gastrointestinal symptoms --- molecular mimicry --- intermolecular help --- biomarker --- autoimmune pancreatitis --- coeliac disease --- pancreatic disorders --- screening --- Gluten ataxia --- antigliadin antibodies --- coeliac disease --- MR spectroscopy --- gluten sensitive enteropathy --- antigliadin antibody titre --- gluten sensitivity --- coeliac disease --- gluten free diet --- migraine --- headache --- fatigue --- energy --- celiac disease --- extra-intestinal manifestations --- gluten --- latent celiac disease --- potential celiac disease --- extra-intestinal manifestations --- mild enteropathy --- early developing celiac disease --- genetic gluten intolerance --- natural history --- celiac trait --- celiac disease --- gluten neuropathy --- gluten ataxia --- prevalence --- incidence --- gluten-free diet

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MDPI - Multidisciplinary Digital Publishing Institute (4)


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english (4)


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2019 (4)