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Diseases of the Abdomen and Pelvis 2018-2021: Diagnostic Imaging - IDKD Book

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Book Series: IDKD Springer Series ISSN: 2523-7829 ISBN: 9783319750187 9783319750194 Year: Pages: 264 DOI: https://doi.org/10.1007/978-3-319-75019-4 Language: English
Publisher: Springer Grant: Foundation for the Advancement of Education in Medical Radiology
Subject: Internal medicine
Added to DOAB on : 2018-06-22 17:34:01
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This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.

Keywords

Gastrointestinal disease --- PET/CT --- Radiology --- X-ray --- IDKD --- Davos

Innovative Radiopharmaceuticals in Oncology and Neurology

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451746 Year: Pages: 114 DOI: 10.3389/978-2-88945-174-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General)
Added to DOAB on : 2017-08-28 14:01:09
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The aim of this Research Topic was to assemble a series of articles describing basic, preclinical and clinical research studies on radiopharmaceuticals and nuclear medicine. The articles were written by attendees of the third Nuclear Technologies for Health Symposium (NTHS, 10th-11th March 2015, Nantes, Frances) under the auspices of the IRON LabEx (Innovative Radiopharmaceuticals for Oncology and Neurology Laboratory of Excellence). This French network, gathering approximately 160 scientists from 12 academic research teams (Funded by “investissements d’Avenir”), fosters transdisciplinary projects between teams with expertise in chemistry, radiochemistry, radiopharmacy, formulation, biology, nuclear medicine and medical physics. The 12 articles within this resulting eBook present a series of comprehensive reviews and original research papers on multimodality imaging and targeted radionuclide therapy; illustrating the different facets of studies currently conducted in these domains.

Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889453948 Year: Pages: 196 DOI: 10.3389/978-2-88945-394-8 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Microbiology
Added to DOAB on : 2018-11-16 17:17:57
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Development and spread of antimicrobial resistance is the result of an evolutionary process by which microorganisms adapt to antibiotics through several mechanisms including alteration of drug target by mutation and horizontal transfer of resistance genes. The concomitant occurrence of independent antimicrobial resistance mechanisms is a serious threat to human health and has appeared in several emerging epidemic clones over the past decade in humans and also in animals. The increasing prevalence of antimicrobial drug resistance among animal and zoonotic foodborne pathogens is of particular concern for public health. In this Ebook, we gathered a collection of articles which deal with the most important aspects of the genetics of acquired antimicrobial resistance extending from medically-important resistance, emerging epidemic resistant clones, main mobile genetic elements spreading resistance, resistomes, dissemination between animals and humans, to the “One Health” concept.

Translocator Protein (TSPO)

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ISBN: 9783038427575 9783038427582 Year: Pages: 176 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2018-03-16 13:21:14
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The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective delivery to mitochondria of drugs and probes. Moreover, the effort in the design and synthesis of new, more specific and effective TSPO ligands proves to be very valuable. All these topics have been addressed in the special issue.

Controversies and Perspectives in the Use of Postoperative Radiotherapy for Prostate Cancer

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889454501 Year: Pages: 74 DOI: 10.3389/978-2-88945-450-1 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Oncology
Added to DOAB on : 2018-11-16 17:17:57
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The use of radical prostatectomy in patients with high risk of recurrence has significantly increased during the past 10 years. Thus, adjuvant radiation as a part of multimodality treatment or salvage radiation at the evidence of prostate-specific antigen (PSA) progression represents mainstay curative-intent options for a great number of prostate cancer patients. Although, few randomized trials and many retrospective studies have been published, many uncertainties still mold the discussions on the best treatment management for men after prostatectomy. This research topic successfully intended to foster discussions on current controversies in the use of postoperative radiotherapy and to present novel perspectives for treatment optimization.

Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889451739 Year: Pages: 183 DOI: 10.3389/978-2-88945-173-9 Language: English
Publisher: Frontiers Media SA
Subject: Neurology --- Science (General)
Added to DOAB on : 2017-08-28 14:01:09
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The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.

In Vivo Imaging in Pharmacological Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452378 Year: Pages: 222 DOI: 10.3389/978-2-88945-237-8 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2017-10-13 14:57:01
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The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.

Targets, Tracers and Translation – Novel Radiopharmaceuticals Boost Nuclear Medicine

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ISBN: 9783039213139 / 9783039213146 Year: Pages: 214 DOI: 10.3390/books978-3-03921-314-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-12-09 11:49:15
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This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.

Keywords

breast cancer --- 68Ga --- GRPR --- NPY(Y1)R --- peptide heterodimers --- PET/CT imaging --- sentinel lymph node --- dextran --- mannose --- 99mTc-radiopharmaceuticals --- glutamate --- metabotropic glutamate receptor subtype 5 --- [18F]PSS232 --- ketamine --- ceftriaxone --- positron emission tomography --- allosteric modulator --- MMPEP --- ABP688 --- pretargeting --- Fusarinine C --- rituximab --- click chemistry --- multimerization --- PET --- gallium-68 --- carbonic anhydrase IX --- girentuximab --- renal cell carcinomas --- 177Lu-radiopharmaceuticals --- radioimmunotherapy --- neuroinflammation --- microglia --- carbon-11 --- radiochemistry --- positron emission tomography --- hypoxia --- radiosensitizer --- benzotriazine-1,4-dioxide (BTDO), benzotriazine-1-monoxide (BTMO), tirapazamine (TPZ), SR 4317 --- radioiodination --- tropomyosin receptor kinase --- positron emission tomography --- neurodegeneration --- oncogenic fusions --- [11C]meta-hydroxyephedrine --- radiosynthesis --- separation --- apparent molar activity --- cholecystokinin-2 receptor --- minigastrin --- molecular imaging --- radiometals --- technetium-99m --- hydrazinonicotinic acid (HYNIC) --- PSMA-617 --- salivary gland uptake --- prostate cancer --- endoradiotherapy --- Chloramine T --- electrophilic radioiodination --- iodine-131 --- Iodo-Gen® --- oxidizing agent --- ?-CIT. --- tumor hypoxia --- PET --- small animal imaging --- azomycin nucleosides --- [18F]FMISO --- bombesin --- gastrin-releasing peptide --- gastrin-releasing peptide receptor --- tumor targeting --- 99mTc-radioligand --- metabolic stability --- neprilysin-inhibition --- phosphoramidon --- n/a --- n/a

Atherosclerosis and Vascular Imaging

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ISBN: 9783038424352 9783038424345 Year: Pages: VIII, 164 DOI: 10.3390/books978-3-03842-435-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-06-27 09:23:42
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Cardiovascular disease is the main cause of death in the West, and vascular disease is the most common cardiovascular clinical problem. The disease results in serious morbidity and mortality, and carries economic cost implications. While conventional risk factors are well established, and their biomarkers regularly monitored, patients may continue to suffer subclinical active disease, even in the absence of risk factors, until they present with sudden cardiac death or stroke. Early disease detection using direct imaging has shown to be more accurate in identifying vulnerable patients and unstable plaques than conventional risk factors. This IJMS issue deals with the current opinion concerning the state-of-the-art imaging technologies available for clinical applications and their unique value over the sole use of conventional risk factor analysis, in identifying vulnerable patients, recommending aggressive treatments, prognosticating, and in assessing related nutritional and environmental issues.

Atherosclerosis and Vascular Imaging 2016

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ISBN: 9783038424321 9783038424338 Year: Pages: VIII, 182 DOI: 10.3390/books978-3-03842-433-8 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biology
Added to DOAB on : 2017-06-27 09:38:14
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Abstract

Cardiovascular disease is the main cause of death in the West, and vascular disease is the most common cardiovascular clinical problem. The disease results in serious morbidity and mortality, and carries economic cost implications. While conventional risk factors are well established, and their biomarkers regularly monitored, patients may continue to suffer subclinical active disease, even in the absence of risk factors, until they present with sudden cardiac death or stroke. Early disease detection using direct imaging has shown to be more accurate in identifying vulnerable patients and unstable plaques than conventional risk factors. This IJMS Special Issue deals with the current opinion concerning the state-of-the-art imaging technologies available for clinical applications, and their unique value over the sole use of conventional risk factor analysis, in identifying vulnerable patients, recommending aggressive treatments, prognosticating, and in assessing related nutritional and environmental issues. This Special Issue is the continuation of our 2015 Special Issue “Atherosclerosis and Vascular Imaging”

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