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Drug Repositioning: Current Advances and Future Perspectives

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889456963 Year: Pages: 153 DOI: 10.3389/978-2-88945-696-3 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Therapeutics
Added to DOAB on : 2019-01-23 14:53:43
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Abstract

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Innovative Places in Europe

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Book Series: Hohenheimer volkswirtschaftliche Schriften ISBN: 9783631633038 Year: Pages: 433 Language: English
Publisher: Peter Lang International Academic Publishing Group
Subject: Economics
Added to DOAB on : 2019-01-15 13:32:59
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Regional disparities and spatial clustering are ubiquitous in today’s world. This study contributes with empirical findings on the distribution of European research and patenting activity since the 1980s at the regional level. Besides a general theoretical part, it offers a quantitative clustering analysis, which makes use of EPO patent applications and a harmonized regional and technological classification. Moreover, the pan-European study incorporates a structural analysis of inter-regional co-patenting networks at the regional and technological level that covers the 1990s and 2000s. Finally, European regional income and growth disparities are addressed by placing emphasis on the spatial distribution of research activity and the regional settlement structure.

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