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The role of arginase in endothelial dysfunction

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889194407 Year: Pages: 115 DOI: 10.3389/978-2-88919-440-7 Language: English
Publisher: Frontiers Media SA
Subject: Allergy and Immunology --- Medicine (General)
Added to DOAB on : 2016-02-05 17:24:33
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In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction.

Ways to improve tumor uptake and penetration of drugs into solid tumors

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193509 Year: Pages: 129 DOI: 10.3389/978-2-88919-350-9 Language: English
Publisher: Frontiers Media SA
Subject: Oncology --- Medicine (General) --- Therapeutics --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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The main scope of this topic is to give an update on pharmacologic and non-pharmacologic approaches to enhance uptake and penetration of cancer drugs into tumors. Inadequate accumulation of drugs in tumors has emerged over the last decade as one of the main problems underlying therapeutic failure and drug resistance in the treatment of cancer. Insufficient drug uptake and penetration is causally related to the abnormal tumor architecture. Thus, poor vascularization, increased resistance to blood flow and impaired blood supply represent a first obstacle to the delivery of antitumor drugs to tumor tissue. Decreased or even inverted transvascular pressure gradients compromise convective delivery of drugs. Eventually, an abnormal extracellular matrix offers increased frictional resistance to tumor drug penetration. Abnormal tumor architecture also changes the biology of tumor cells, which contributes to drug resistance through several different mechanisms. The variability in vessel location and structure can make many areas of the tumor hypoxic, which causes the tumor cells to become quiescent and thereby resistant to many antitumor drugs. In addition, the abnormally long distance of part of the tumor cell population from blood vessels provides a challenge to delivering cancer drugs to these cells. We have recently proposed additional mechanisms of tumor drug resistance, which are also related to abnormal tumor architecture. First, increased interstitial fluid pressure can by itself induce drug resistance through the induction of resistance-promoting paracrine factors. Second, the interaction of drug molecules with vessel- proximal tumor cell layers may also induce the release of these factors, which can spread throughout the cancer, and induce drug resistance in tumor cells distant from blood vessels. As can be seen, abnormal tumor architecture, inadequate drug accumulation and tumor drug resistance are tightly linked phenomena, suggesting the need to normalize the tumor architecture, including blood vessels, and/or increase the accumulation of cancer drugs in tumors in order to increase therapeutic effects. Indeed, several classes of drugs (that we refer to as promoter drugs) have been described, that promote tumor uptake and penetration of antitumor drugs, including those that are vasoactive, modify the barrier function of tumor vessels, debulk tumor cells, and overcome intercellular and stromal barriers. In addition, also non-pharmacologic approaches have been described that enhance tumor accumulation of effector drugs (e.g. convection-enhanced delivery, hyperthermia, etc.). Some drugs that have already received regulatory approval (e.g. the anti-VEGF antibody bevacizumab) exert antitumor effects at least in part through normalization of the tumor vasculature and enhancement of the accumulation of effector drugs. Other drugs, acting through different mechanisms of action, are now in clinical development (e.g. NGR-TNF in phase II/III studies) and others are about to enter clinical investigation (e.g. JO-1).

Flow and Transport Properties of Unconventional Reservoirs 2018

Authors: --- --- ---
ISBN: 9783039211166 / 9783039211173 Year: Pages: 364 DOI: 10.3390/books978-3-03921-117-3 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.

Keywords

fracturing fluid --- rheology --- chelating agent --- viscosity --- polymer --- fluid-solid interaction --- velocity profile --- the average flow velocity --- flow resistance --- pore network model --- shale gas --- volume fracturing --- finite volume method --- production simulation --- multi-scale flow --- multi-scale fracture --- shale gas reservoir --- fractured well transient productivity --- succession pseudo-steady state (SPSS) method --- complex fracture network --- multi-scale flow --- analysis of influencing factors --- tight sandstones --- spontaneous imbibition --- remaining oil distributions --- imbibition front --- imbibition recovery --- NMR --- slip length --- large density ratio --- contact angle --- pseudo-potential model --- lattice Boltzmann method --- micro-fracture --- dissolved gas --- experimental evaluation --- reservoir depletion --- recovery factor --- tight oil --- Lucaogou Formation --- tight oil --- pore structure --- prediction by NMR logs --- tight oil reservoir --- SRV-fractured horizontal well --- multiporosity and multiscale --- flow regimes --- productivity contribution degree of multimedium --- equilibrium permeability --- non-equilibrium permeability --- matrix–fracture interaction --- effective stress --- coal deformation --- porous media --- non-linear flow --- conformable derivative --- fractal --- hydraulic fracturing --- tight reservoirs --- fracture diversion --- extended finite element method --- fracture network --- gas adsorption capacity --- shale reservoirs --- influential factors --- integrated methods --- sulfonate gemini surfactant --- thickener --- temperature-resistance --- clean fracturing fluid --- low-salinity water flooding --- clay mineral composition --- enhanced oil recovery --- wetting angle --- pH of formation water --- fractional diffusion --- fractal geometry --- analytical model --- shale gas reservoir --- carbonate reservoir --- petrophysical characterization --- pore types --- pore structure --- permeability --- fractal dimension --- reservoir classifications --- deep circulation groundwater --- groundwater flow --- geothermal water --- faults --- isotopes --- shale permeability --- local effect --- global effect --- matrix-fracture interactions --- nanopore --- pore structure --- shale --- tight sandstone --- mudstone --- nitrogen adsorption --- fractal --- enhanced geothermal system --- well-placement optimization --- fracture continuum method --- 0-1 programming --- unconventional reservoirs --- petrophysical characterization --- fluid transport physics

Electrospun and Electrosprayed Formulations for Drug Delivery

Authors: ---
ISBN: 9783038979128 / 9783038979135 Year: Pages: 190 DOI: 10.3390/books978-3-03897-913-5 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Therapeutics
Added to DOAB on : 2019-06-26 10:09:00
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This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.

Development and Application of Herbal Medicine from Marine Origin

Authors: --- ---
ISBN: 9783039212217 / 9783039212224 Year: Pages: 140 DOI: 10.3390/books978-3-03921-222-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General)
Added to DOAB on : 2019-08-28 11:21:27
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Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research. Furthermore, worldwide studies have consistently demonstrated that many crude drugs derived from marine plants contain novel ingredients that may benefit health or can be used in the treatment of diseases; some have been developed into health foods, and some even into drugs. It is expected that there are many substances of marine plant origin that will have medical applications in terms of improving human health and are awaiting discovery.In this Special Issue, entitled “Development and Application of Herbal Medicine of Marine Origin”, we will provide a platform for researchers to publish biomedical studies on substances of marine plant origin. We welcome submissions from scientists and academics from across the world.

Micro/Nano Materials for Clean Energy and Environment

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ISBN: 9783039211289 / 9783039211296 Year: Pages: 123 DOI: 10.3390/books978-3-03921-129-6 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:41:30
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The Tsinghua University–University of Waterloo Joint Research Center for Micro/Nano Energy & Environment Technology (JCMEET) is a platform. It was established on Nov.11, 2017. The Chairperson of University Council of Tsinghua University, Dr. Xu Chen, and the President of the University of Waterloo, Dr. Feridun Hamdullahpur, attended the opening ceremony and unveiled the nameplate for the joint research center on 29th of March, 2018. The research center serves as a platform for researchers at both universities to conduct joint research in the targeted areas, and to meet regularly for information exchange, talent exchange, and knowledge mobilization, especially in the fields of micro/nano, energy, and environmental technologies. The center focuses on three main interests: micro/nano energy technology, micro/nano pollution control technology, and relevant fundamental research. In order to celebrate the first anniversary of the Joint Research Center, we were invited to serve as the Guest Editors of this Special Issue of Materials focusing on the topic of micro/nano-materials for clean energy and environment. It collects research papers from a broad range of topics related to micro/nanostructured materials aimed at future energy resources, low emission energy conversion, energy storage, energy efficiency improvement, air emission control, air monitoring, air cleaning, and many other related applications. This Special Issue provides an opportunity and example for the international community to discuss how to actively address the energy and environment issues that we are facing.

Effects of Mycotoxins on the Intestine

Authors: --- ---
ISBN: 9783038977827 9783038977834 Year: Pages: 262 DOI: 10.3390/books978-3-03897-783-4 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Public Health
Added to DOAB on : 2019-05-09 17:16:14
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Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.

Keywords

mice --- aflatoxin B1 --- intestinal bacterial flora --- response --- Clostridium sp. WJ06 --- deoxynivalenol --- pig --- intestinal morphology --- microbial diversity --- aflatoxin M1 --- ochratoxin A --- intestinal epithelial cells --- tight junction --- permeability --- ileum --- jejunum --- deoxynivalenol --- piglet --- contaminated feed --- tight junction --- aflatoxin B1 --- small intestine --- histopathological lesions --- ultrastructural changes --- toll-like receptors --- T-2 toxin --- enteric nervous system --- pig --- vasoactive intestinal polypeptide --- mycotoxins --- zearalenone --- deoxynivalenol --- histology --- ultrastructure --- large intestine --- pig --- Claviceps --- liver --- digestive tract --- mycotoxin --- sclerotia --- ergot alkaloids --- toxicity --- deoxynivalenol --- Saccharomyces cerevisiae boulardii CNCM I-1079 --- intestine --- transcriptome --- inflammation --- oxidative stress --- lipid metabolism --- fumonisin --- microbiota --- pigs --- MiSeq 16S rDNA sequencing --- intestinal microbiota --- hydrogen-rich water --- lactulose --- Fusarium mycotoxins --- piglets --- functional oligosaccharides --- mycotoxins --- swine --- explant technique --- intestinal morphology --- goblet cells --- deoxynivalenol --- zearalenone --- pig --- colon microbiota --- Lactobacillus --- detoxification --- zearalenone --- doses --- caecal water --- genotoxicity --- pre-pubertal gilts --- atlantic salmon --- deoxynivalenol --- feed --- intestine --- PCR --- proliferating cell nuclear antigen --- suppressor of cytokine signaling --- tight junctions --- Zearalenone --- N-acetylcysteine --- SIEC02 cells --- Mitochondrial apoptosis --- n/a

New Trends in Recycled Aggregate Concrete

Authors: --- ---
ISBN: 9783039211401 / 9783039211418 Year: Pages: 280 DOI: 10.3390/books978-3-03921-141-8 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-08-28 11:21:27
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This book is the result of a Special Issue published in Applied Sciences, entitled “New Trends in Recycled Aggregate Concrete"". It identifies emerging research areas within the field of recycled aggregate concrete and contributes to the increased use of this eco-efficient material.Its contents are organised in the following sections: Upscaling the use of recycled aggregate concrete in structural design; Large scale applications of recycled aggregate concrete; Long-term behaviour of recycled aggregate concrete; Performance of recycled aggregate concrete in very aggressive environments; Reliability of recycled aggregate concrete structures; Life cycle assessment of recycled aggregate concrete; New applications of recycled aggregate concrete.

Keywords

reactive power concrete --- shrinkage --- creep --- steel fibre --- model --- compressive strength --- models --- geological nature of aggregates --- quality of aggregates --- concrete --- recycled aggregates --- seismic load --- strain rate --- fiber-reinforced concrete --- dynamic mechanical property --- recycled aggregate quality --- bond strength --- shear behavior --- aggregate interlock mechanism --- size effect --- ready-mixed concrete --- recycled concrete aggregates --- returned concrete --- concrete sludge fines --- soil stabilization --- recycled aggregate --- recycled aggregate concrete --- artificial neural networks --- aggregate characteristic --- input variable --- recycled concrete --- aggregate --- mixture proportioning --- flexural behavior --- recycling --- heavyweight waste glass --- cyclic load --- reinforced concrete member --- recycled aggregate concrete (RAC) --- steel reinforced recycled aggregate concrete (SRRAC) --- elevated temperature --- residual properties --- recycled coarse aggregate concrete --- nylon fiber --- mechanical properties --- permeability --- microstructure --- foam concrete --- cellular concrete --- ceramic foam --- modulus --- crushing --- energy absorbing --- CT --- foam structure --- foam stability --- recycled aggregate --- concrete --- life cycle assessment --- environmental impact --- recycled concrete aggregate --- crumb rubber --- crushed glass --- compressive strength --- tensile splitting strength --- water absorption --- concrete --- aggregates --- fly-ash --- silica fume --- blast-furnace slag --- mechanical properties --- water absorption --- reinforced concrete --- recycled aggregate concrete --- columns --- seismic performance --- numerical analysis --- variable sensitivity --- recycled aggregate --- concrete --- construction waste --- mechanical characteristics --- durable characteristics --- n/a

Gluten-Free Diet

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ISBN: 9783038977360 9783038977377 Year: Pages: 318 DOI: 10.3390/books978-3-03897-737-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-04-25 16:37:17
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Abstract

In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Keywords

Celiac Disease --- depression --- gluten-free diet --- dietary adherence --- gluten --- gastric emptying --- cholecyst --- celiac disease --- non celiac gluten sensitivity --- gluten-free diet --- gastrointestinal symptoms --- quality of life --- Brazilian CD-QoL --- quality of life --- celiac disease --- questionnaire --- coeliac disease --- celiac disease --- gluten --- gluten-free diet --- fortification --- micronutrient --- cost --- celiac disease --- diagnosis --- gliadin --- gluten --- glutenin --- non-celiac gluten sensitivity --- oral food challenge --- pepsin --- wheat allergy --- celiac disease (CD) --- quality of life (QoL) --- gluten-free diet --- disease duration --- place of residence --- educational level --- economic status --- body mass index (BMI) --- celiac disease --- gluten-free diet --- gut microbiota --- gluten-free diet --- celiac disease --- children --- teenagers --- gluten-related disorders --- celiac disease --- gut microbiota --- gluten-free diet --- Pseudomonas --- gluten-free diet --- mineral --- deficiency --- calcium --- iron --- magnesium --- zinc --- celiac disease --- non-celiac gluten sensitivity --- gut motility --- gluten-free diet --- gluten-related disorders --- gluten-free diet --- coeliac disease --- non-coeliac gluten sensitivity --- irritable bowel syndrome --- mood disorders --- affective disorders --- depression --- major depressive disorder --- mental health --- nutrition --- celiac disease --- gluten-free diet --- diary recommended intake --- food habit --- body composition --- non-coeliac gluten sensitivity --- gluten --- wheat --- low FODMAP diet --- irritable bowel syndrome --- beta cell --- beta-cell stress --- celiac disease --- gluten-free diet --- high-fat diet-induced obesity --- intestinal permeability --- islet of Langerhans --- NOD mouse --- type 1 diabetes --- type 2 diabetes --- FODMAP intake --- celiac disease --- irritable bowel syndrome --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- gluten-free diet --- effectiveness --- adherence --- nutritionists --- clinic --- serology --- duodenal biopsies --- structured questionnaires --- peptides derived from gluten in faeces and urine --- gluten --- adherence --- serology --- villous atrophy --- mucosal recovery --- threshold --- celiac disease --- body composition --- gluten free diet --- children --- celiac disease --- gluten --- gluten-free diet --- screening --- outcome --- gluten sensitivity --- osteoporosis --- non-celiac gluten sensitivity --- gluten re-introduction --- gluten-free diet --- gastrointestinal symptoms --- celiac disease --- ?-gliadin --- 33-mer --- DQ2.5-glia-?1 --- DQ2.5-glia-?2 --- DQ2.5-glia-?3 epitopes --- wheat species --- n/a --- gluten --- gluten-free diet --- coeliac disease --- non-celiac gluten sensitivity --- non-coeliac wheat sensitivity --- gliadin --- microbiota

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