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Host-adapted metabolism and its regulation in Bacterial Pathogens

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889195381 Year: Pages: 176 DOI: 10.3389/978-2-88919-538-1 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Science (General)
Added to DOAB on : 2016-01-19 14:05:46
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Pathogens adapt their metabolism rapidly to the host. Our topic covers these phenomenon regarding extracellular and intracellular pathogens as well as general methods to elucidate different metabolic adaptation processes - an essential guide for any scientist wanting to keep abreast of recent developments in infection biology.

Quantifying and Predicting the Influence of Execution Platform on Software Component Performance

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Book Series: The Karlsruhe Series on Software Design and Quality / Ed. by Prof. Dr. Ralf Reussner ISSN: 18670067 ISBN: 9783866447417 Year: Volume: 5 Pages: XVII, 417 p. DOI: 10.5445/KSP/1000024301 Language: ENGLISH
Publisher: KIT Scientific Publishing
Subject: Computer Science
Added to DOAB on : 2019-07-30 20:02:02
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The performance of software components depends on several factors, including the execution platform on which the software components run. To simplify cross-platform performance prediction in relocation and sizing scenarios, a novel approach is introduced in this thesis which separates the application performance profile from the platform performance profile. The approach is evaluated using transparent instrumentation of Java applications and with automated benchmarks for Java Virtual Machines.

Profile: Interdisziplinäre Beiträge

Authors: --- ---
Book Series: Digital Cultures ISBN: 9783957961013 Year: Pages: 150 DOI: 10.14619/021 Language: German
Publisher: meson press
Subject: Media and communication
Added to DOAB on : 2019-11-15 13:41:44
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Profile haben Konjunktur. Seit der Verbreitung von Social Networking Sites sind sie alltäglicher Ort der Selbstdarstellung. Doch die Praktiken und Techniken der Profilierung sind keineswegs neu. Schon lange beschreiben Profile potentielle StraftäterInnen. Nun bestimmen sie auch die potentielle Kreditwürdigkeit. Im Spannungsfeld zwischen Profil und Profilierung nehmen die Beiträge aus Medienwissenschaft, Soziologie, Geschichtswissenschaft und Informatik die vielschichtigen Dimensionen dieses zentralen Phänomens der digitalen Medienkultur in den Blick: Wie verändern sich Bedeutung und Bewertung des Profil-Begriffs? Wie stehen Profile in Zusammenhang mit Subjektivierung und Machtkonstellationen? Welche Wechselwirkungen zwischen Profilen und Privatheit sind gegenwärtig relevant?

Molecular and Metabolic Mechanisms Associated with Fleshy Fruit Quality

Authors: --- --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452729 Year: Pages: 436 DOI: 10.3389/978-2-88945-272-9 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Botany --- Physiology
Added to DOAB on : 2018-02-27 16:16:44
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Fleshy Fruits are a late acquisition of plant evolution. In addition of protecting the seeds, these specialized organs unique to plants were developed to promote seed dispersal via the contribution of frugivorous animals. Fruit development and ripening is a complex process and understanding the underlying genetic and molecular program is a very active field of research. Part of the ripening process is directed to build up quality traits such as color, texture and aroma that make the fruit attractive and palatable. As fruit consumers, humans have developed a time long interaction with fruits which contributed to make the fruit ripening attributes conform our needs and preferences. This issue of Frontiers in Plant Science is intended to cover the most recent advances in our understanding of different aspects of fleshy fruit biology, including the genetic, molecular and metabolic mechanisms associated to each of the fruit quality traits. It is also of prime importance to consider the effects of environmental cues, cultural practices and postharvest methods, and to decipher the mechanism by which they impact fruit quality traits. Most of our knowledge of fleshy fruit development, ripening and quality traits comes from work done in a reduced number of species that are not only of economic importance but can also benefit from a number of genetic and genomic tools available to their specific research communities. For instance, working with tomato and grape offers several advantages since the genome sequences of these two fleshy fruit species have been deciphered and a wide range of biological and genetic resources have been developed. Ripening mutants are available for tomato which constitutes the main model system for fruit functional genomics. In addition, tomato is used as a reference species for climacteric fruit which ripening is controlled by the phytohormone ethylene. Likewise, grape is a reference species for non-climacteric fruit even though no single master switches controlling ripening initiation have been uncovered yet. In the last period, the genome sequence of an increased number of fruit crop species became available which creates a suitable situation for research communities around crops to get organized and information to be shared through public repositories. On the other hand, the availability of genome-wide expression profiling technologies has enabled an easier study of global transcriptional changes in fruit species where the sequenced genome is not yet available. In this issue authors will present recent progress including original data as well as authoritative reviews on our understanding of fleshy fruit biology focusing on tomato and grape as model species.

Building-Blocks of a Data Protection Revolution

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Book Series: Munich Intellectual Property Law Center – MIPLC ISBN: 9783845294025 Year: Volume: 35 Pages: 62 DOI: http://dx.doi.org/10.5771/9783845294025 Language: Deutschland
Publisher: Nomos Verlagsgesellschaft mbH & Co. KG
Subject: Law
Added to DOAB on : 2019-01-09 09:21:26
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The General Data Protection Regulation (GDPR) replaced the old and battered Data Protection Directive on 25 May 2018 after a long-drawn reform. The rapidly evolving technological landscape will test the ability of the GDPR to effectively achieve the goals of protecting personal data and the free movement of data. This book proposes a technological supplement to achieve the goal of data protection as enshrined in the GDPR. The proposal comes in the form of digital identity management platforms built on blockchain technology. However, the very structure of blockchain poses some significant challenges in terms of compatibility with the GDPR. Accordingly, the claim of GDPR being a technologically neutral legislation is examined. The compatibility of a blockchain-based solution is scrutinised on the parameters of data protection principles like accountability, data minimisation, control and data protection by design in conjunction with the right to be forgotten and right to data portability.

DNA, statistics and the law: a cross-disciplinary approach to forensic inference

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889192502 Year: Pages: 39 DOI: 10.3389/978-2-88919-250-2 Language: English
Publisher: Frontiers Media SA
Subject: Science (General) --- Genetics
Added to DOAB on : 2015-11-16 15:44:59
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From ABO typing during the first half of the 20th century, to the use of enzymes and protein contained in blood serums and finally direct DNA typing, biology has been serving forensic purposes for many decades. Statistics, in turn, has been constantly underpinning the discussions of the probative value of results of biological analyses, in particular when defendants could not be considered as excluded as potential sources because of different genetic traits. The marriage between genetics and statistics has never been an easy one, though, as is illustrated by fierce arguments that peaked in the so-called "DNA wars" in some American courtrooms in the mid-1990s. This controversy has contributed to a lively production of research and publications on various interpretative topics, such as the collection of relevant data, foundations in population genetics as well as theoretical and practical considerations in probability and statistics. Both DNA profiling as a technique and the associated statistical considerations are now widely accepted as robust, but this does not yet guarantee or imply a neat transition to their application in court. Indeed, statistical principles applied to results of forensic DNA profiling analyses are a necessary, yet not a sufficient preliminary requirement for the contextually meaningful use of DNA in the law. Ultimately, the appropriate use of DNA in the forensic context relies on inference, i.e. reasoning reasonably in the face of uncertainty. This is all the more challenging that such thought processes need to be adopted by stakeholders from various backgrounds and holding diverse interests. Although several topics of the DNA controversy have been settled over time, some others are still debated (such as the question of how to deal with the probability of error), while yet others - purportedly settled topics - saw some recent revivals (e.g., the question of how to deal with database searches). In addition, new challenging topics have emerged over the last decade, such as the analysis and interpretation of traces containing only low quantities of DNA where artefacts of varying nature may affect results. Both technical and interpretative research involving statistics thus represent areas where ongoing research is necessary, and where scholars from the natural sciences and the law should collaborate. The articles in this Research Topic thus aim to investigate, from an interdisciplinary perspective, the current understanding of the strengths and limitations of DNA profiling results in legal applications. This Research Topic accepts contributions in all frontiers article type categories and places an emphasis on topics with a multidisciplinary perspective that explore (while not being limited to) statistical genetics for forensic scientists, case studies and reports, evaluation and interpretation of forensic findings, communication of expert findings to laypersons, quantitative legal reasoning and fact-finding using probability.

Engineering Synthetic Metabolons: From Metabolic Modelling to Rational Design of Biosynthetic Devices

Authors: ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889199211 Year: Pages: 130 DOI: 10.3389/978-2-88919-921-1 Language: English
Publisher: Frontiers Media SA
Subject: General and Civil Engineering --- Biotechnology
Added to DOAB on : 2016-01-19 14:05:46
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The discipline of Synthetic Biology has recently emerged at the interface of biology and engineering. The definition of Synthetic Biology has been dynamic over time ever since, which exemplifies that the field is rapidly moving and comprises a broad range of research areas. In the frame of this Research Topic, we focus on Synthetic Biology approaches that aim at rearranging biological parts/ entities in order to generate novel biochemical functions with inherent metabolic activity. This Research Topic encompasses Pathway Engineering in living systems as well as the in vitro assembly of biomolecules into nano- and microscale bioreactors. Both, the engineering of metabolic pathways in vivo, as well as the conceptualization of bioreactors in vitro, require rational design of assembled synthetic pathways and depend on careful selection of individual biological functions and their optimization. Mathematical modelling has proven to be a powerful tool in predicting metabolic flux in living and artificial systems, although modelling approaches have to cope with a limitation in experimentally verified, reliable input variables. This Research Topic puts special emphasis on the vital role of modelling approaches for Synthetic Biology, i.e. the predictive power of mathematical simulations for (i) the manipulation of existing pathways and (ii) the establishment of novel pathways in vivo as well as (iii) the translation of model predictions into the design of synthetic assemblies.

Roles of NF-κB in Cancer and Their Therapeutic Approaches

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ISBN: 9783038971177 9783038971184 Year: Pages: X, 330 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Oncology --- Biology
Added to DOAB on : 2018-08-15 10:52:09
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Although mortality rates have declined in recent years, the majority of cancers are still difficult to treat and the medical need for better cancer treatment is evident. The current anticancer armamentarium includes many active agents that are applied across tumor types. However, most of these broadly-active anticancer drugs have a small therapeutic index and barely discriminate between malignant and normal cells. In recent years the focus has shifted to the development of rationally designed, molecularly-targeted therapy for the treatment of a specific cancer, therefore offering the promise of greater specificity coupled with reduced systemic toxicity. NF-kB transcription factor family as emerged as such a promising target for cancer therapy. This Special Issue will explore the routes from NF-kB basic research, cancer research and oncogenomics into the development of NF-kB-based cancer therapeutics and biomarkers.We invite research and review papers in any area of the NF-kB field that are related, but not limited to, fundamental understanding of NF-kB signaling pathways, gene expression profiling, epigenetic regulation, diagnostic, prognostic and pharmacogenomic biomarkers, molecular targets driving the progression of human cancers, cancer drug development on these targets, clinical trial with new agents, and validation in animal models.We hope that this Special Issue reflects the exciting era that we are living in with respect to the field of NF-kB and its applications in cancer research.

Racial Profiling

Authors: --- --- --- --- et al.
Book Series: Postcolonial Studies ISBN: 9783839441459 9783837641455 Year: Pages: 336 DOI: 10.14361/9783839441459 Language: German
Publisher: transcript Verlag
Subject: Sociology
Added to DOAB on : 2019-05-01 11:21:02
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Racist police checks are part of everyday life in Europe. They make it dramatically visible who is not considered a fellow citizen. While much of the dominance society finds this racist practice normal, more and more people are no longer prepared to accept it without resistance. The volume brings together scientific, artistic and activist contributions to the social backgrounds and modes of action of racial profiling and the possibilities of intersectional anti-racist resistance. The focus is on Switzerland, supplemented by perspectives from authors who are familiar with the German context.

Marine Natural Products and Obesity

Authors: ---
ISBN: 9783039211913 9783039211920 Year: Pages: 194 DOI: 10.3390/books978-3-03921-192-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Internal medicine
Added to DOAB on : 2019-08-28 11:21:27
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Obesity and related co-morbidities are increasing worldwide and pose a serious health problem. Changes in lifestyle and diet would be the best remedies to fight obesity; however, many people will still rely on medical aid. Marine organisms have been prolific in the production of bioactive compounds for many diseases, e.g., cancer, and promise to be an excellent source for natural-derived molecules and novel nutraceuticals. Bioactive compounds with beneficial activities towards obesity have been described from diverse marine organism including marine algae, bacteria, sponges, fungi, crustaceans or fish. This Special Issue will highlight the progress in the following topics: Bioactive compounds for the treatment of obesity and obesity-related co-morbidities (diabetes, fatty liver, hyperlipidemia) from marine organisms; the isolation of novel compounds, the bioactivity screening of marine organisms and the elucidation of molecular mode of action of marine bioactive compounds.

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