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Entwicklung und Optimierung eines biotechnologischen Prozesses zur Herstellung mikrobieller Rhamnolipide auf Basis nachwachsender Rohstoffe

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ISBN: 9783866442771 Year: Pages: 156 p. DOI: 10.5445/KSP/1000009236 Language: GERMAN
Publisher: KIT Scientific Publishing
Subject: Chemical Engineering
Added to DOAB on : 2019-07-30 20:02:02
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Im Fokus dieser Arbeit steht die Entwicklung und Optimierung eines biotechnologischen Prozesses zur Herstellung von Rhamnolipiden auf Basis von nachwachsenden Rohstoffen. Ein Schwerpunkt lag hierbei auf der Entwicklung und Evaluierung einer Standardprozessführung, sowie eines auf einem Parallelbioreaktor basierenden, effizienten Screening-Systems. Ein Produk­tions­stammvergleich wurde durchgeführt. Zur Produktanalyse sollte FTIR-Spektroskopie als alternative Analysemethode eingesetzt werden.

Lung Diseases: Chronic Respiratory Infections

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ISBN: 9783038973386 9783038973393 Year: Pages: 216 DOI: 10.3390/books978-3-03897-339-3 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Allergy and Immunology --- Therapeutics
Added to DOAB on : 2018-11-07 11:27:31
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Both chronic and acute infections play a significant role in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD) and both cystic fibrosis (CF) and non-CF bronchiectasis. There is also specific evidence that chronic infection, even in the absence of acute infection, has an influence on the manifestations and disease course. The infections found in COPD, CF, and bronchiectasis share a number of clinical similarities, the most striking of which are bacterial persistence despite the use of antibiotics and antibiotic resistance.In the last two decades, the rate of antibiotic resistance has increased dramatically and poses serious threats for patients and public health. There are different reasons for this increase in resistance, but the overuse of antibiotics in the community is certainly the most prominent. On the other hand, the chronic use of antibiotics in chronic diseases like COPD, CF, and bronchiectasis is also potentially associated with an increase in MDR pathogens. During the last decade, a growing interest has been raised in evaluating nontuberculous mycobacteria’s role in chronic respiratory diseases like bronchiectasis.

Biotechnological Applications of Phage and Phage-Derived Proteins

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ISBN: 9783039214419 9783039214426 Year: Pages: 236 DOI: 10.3390/books978-3-03921-442-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Phages have shown a high biotechnological potential with numerous applications. The advent of high-resolution microscopy techniques aligned with omic and molecular tools have revealed innovative phage features and enabled new processes that can be further exploited for biotechnological applications in a wide variety of fields. The high-quality original articles and reviews presented in this Special Issue demonstrate the incredible potential of phages and their derived proteins in a wide range of biotechnological applications for human benefit. Considering the emergence of amazing new available bioengineering tools and the high abundance of phages and the multitude of phage proteins yet to be discovered and studied, we believe that the upcoming years will present us with many more fascinating and new previously unimagined phage-based biotechnological applications.

Keywords

gene expression regulation --- molecular probe --- macromolecular interactions --- phage-host interaction --- bacteriophage --- endolysin --- Clostridium perfringens --- alpha-sheet --- cancerous tumors --- capsid dynamics --- drug delivery vehicles --- native gel electrophoresis --- neurodegenerative disease --- pathogenic viruses --- phage display --- landscape phage --- major coat protein --- nanomedicine --- diagnostics --- biosensors --- M13 bacteriophage --- biofilm --- porous structure --- filters --- self-assembly --- T7phage library --- sarcoidosis --- tuberculosis --- microarray --- immunoscreening --- R-type pyocin --- bacteriocin --- contractile injection systems --- Pseudomonas aeruginosa --- X-ray crystallography --- receptor-binding protein --- Shigella flexneri --- bacteriophage --- tailspike proteins --- O-antigen --- serotyping --- microtiter plate assay --- fluorescence sensor --- bacteriophages --- encapsulation --- niosomes --- transfersomes --- liposomes --- Staphylococcus aureus --- phage --- Enterococcus faecalis --- Streptococcus agalactiae --- culture enrichment --- bacteriophage --- diagnostics --- Listeria monocytogenes --- endolysin --- magnetic separation --- reporter phage --- endolysin --- Pal --- Cpl-1 --- safety --- toxicity --- immune response --- Streptococcus pneumoniae --- self-assembly --- nanotubular structures --- tail sheath protein --- bacteriophage vB_EcoM_FV3 --- Appelmans --- bacteriophage evolution --- bacteriophage recombination --- phage therapy --- Pseudomonas aeruginosa --- antibiotic resistance --- bacteriophages --- Myoviridae --- bacteriophage-derived lytic enzyme --- enzybiotics --- endolysin --- in vitro activity --- ESKAPE --- n/a

Antimicrobial Resistance in Environmental Waters

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ISBN: 9783038976080 9783038976097 Year: Pages: 188 DOI: 10.3390/books978-3-03897-609-7 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering --- Environmental Engineering
Added to DOAB on : 2019-05-09 17:16:14
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This Special Issue on Antimicrobial Resistance in Environmental Waters features 11 articles on the monitoring and surveillance of antimicrobial resistance (AMR) in natural aquatic systems (i.e., reservoirs, rivers), and effluent discharge from water treatment plants to assess the effectiveness of AMR removal and resulting loads in treated waters. Some of the key elements of AMR studies presented in this Special Issue highlight the underlying drivers of AMR contamination in the environment and the evaluation of the hazard imposed on aquatic organisms in receiving environments through ecological risk assessments. As described in this Issue, screening antimicrobial peptide (AMP) libraries for biofilm disruption and antimicrobial candidates are promising avenues for the development of new treatment options to eradicate resistance.

Microbial Biofilms in Healthcare: Formation, Prevention and Treatment

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ISBN: 9783039284108 9783039284115 Year: Pages: 166 DOI: 10.3390/books978-3-03928-411-5 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2020-04-07 23:07:09
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Biofilms are ubiquitous and their presence in industry can lead to production losses. However, nowhere do biofilms impact human health and welfare as much as those that are found contaminating the healthcare environment, surgical instruments, equipment, and medical implantable devices. Approximately 70% of healthcare-associated infections are due to biofilm formation, resulting in increased patient morbidity and mortality. Biofilms formed on medical implants are recalcitrant to antibiotic treatment, which leaves implant removal as the principal treatment option. In this book, we investigate the role of biofilms in breast and dental implant disease and cancer. We include in vitro models for investigating treatment of chronic wounds and disinfectant action against Candida sp. Also included are papers on the most recent strategies for treating biofilm infection ranging from antibiotics incorporated into bone void fillers to antimicrobial peptides and quorum sensing.

Medicinal Plants and Natural Product Research

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ISBN: 9783039281183 9783039281190 Year: Pages: 231 DOI: 10.3390/books978-3-03928-119-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Plant Sciences
Added to DOAB on : 2020-04-07 23:07:08
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The book entitled Medicinal Plants and Natural Product Research describes various aspects of ethnopharmacological uses of medicinal plants; extraction, isolation, and identification of bioactive compounds from medicinal plants; various aspects of biological activity such as antioxidant, antimicrobial, anticancer, immunomodulatory activity, etc., as well as characterization of plant secondary metabolites as active substances from medicinal plants.

Keywords

Chrysanthemum coronarium L. --- aerial parts --- caffeoylquinic acids --- Malian medicinal plants --- Biophytum umbraculum --- Burkea africana --- Lannea velutina --- Terminalia macroptera --- medicinal plants --- traditional knowledge --- Eastern Himalayas --- mountain plants --- ethnobotany --- ethnopharmacology --- bioprospecting --- antibiotic resistance --- antimicrobial --- mechanism of action --- plant metabolite --- saline habitats --- secondary metabolites --- adaptation --- different solvents --- antibiotic resistance --- antimicrobial activity --- cytotoxicity --- ethnobotany --- Eucalyptus --- natural products --- Pseudomonas aeruginosa --- stingless bees --- Tetragonula --- traditional medicine --- basil varieties --- essential oil --- GC-MS --- harvest --- cluster analysis --- antimicrobial --- antioxidants --- medicinal plants --- BHT --- Ficus hirta --- Moraceae --- carboline alkaloids --- sesquiterpenoids --- flavonoids --- antifungal --- phytochemicals --- Nirgundi --- chaste tree --- antibacterial --- free radical --- scavenger --- oxidative stress --- P. alliaceae --- P. niruri --- S. reticulata --- UPLC --- TQ-ESI-MS --- proanthocyanidins --- mass spectrometry --- antioxidant --- cytotoxicity --- Moringa oleifera --- DPPH --- antioxidant activity --- oxidative stress --- sickle cell anemia --- Ophiopogon --- Liriope --- rbcL --- DNA barcoding --- high-resolution melt curve (HRM) analysis --- allergy --- inflammation --- mast cells --- Immulina® --- immunLoges® --- anthracene derivatives --- antimicrobial --- Asphodelus --- ethnomedicine --- skin diseases --- plant-food --- processing --- nutraceuticals --- inflammation --- health --- Arbutus unedo L. --- ?-glucosidase --- catechin --- HPLC --- NMR --- activity --- bioproduct --- Brunfelsia --- Amazonian --- Ecuador --- ethnobotanic --- ayahuasca --- validation --- drug discovery --- scopoletin

Hurdles for Phage Therapy (PT) to Become a Reality

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ISBN: 9783039213917 9783039213924 Year: Pages: 484 DOI: 10.3390/books978-3-03921-392-4 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Biology --- Microbiology
Added to DOAB on : 2019-12-09 11:49:15
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Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.

Keywords

Staphylococcus aureus --- bacteriophage --- phage therapy --- vB_SauM-fRuSau02 --- Twortlikevirus --- antibiotic --- antimicrobial resistance --- magistral preparation --- compounding pharmacy --- phage therapy --- regulatory framework --- personalized medicine --- bacteriophage --- phage --- horizontal gene transfer --- co-evolution --- phage therapy --- industrial phage application --- antimicrobial resistance (AMR) --- Germany --- pH stability --- phage-host interactions --- genomics --- antibiotic-resistance --- phage preparation --- lysins --- biofilms --- typhoid fever --- Salmonella Typhi --- extended-spectrum beta lactamases (ESBL) --- Democratic Republic of the Congo --- bacteriophages --- MALDI-MS --- Staphylococcus --- bacteriophages --- phage therapy --- Kayvirus --- Viral proteins --- bacteriophage --- therapy --- phage therapy --- bacterial disease --- infection --- target selection --- Bacteriophage --- phage therapy --- resistance --- adaptation --- prophage --- production --- regulation --- phage therapy --- viral genomes --- best practices --- IND --- high-throughput sequencing --- bacteriophages --- phages --- food safety --- foodborne illness --- phage therapy --- history of science --- science communication --- bacteriophage --- phage therapy --- sustainable agriculture --- zoonosis --- antibiotic resistance --- phage therapy --- experimental therapy --- phage cocktails --- anti-phage antibodies --- prophage --- immunomodulation --- phage therapy --- evolution --- bacterial resistance --- virulence --- Listeria ivanovii --- bacteriophages --- alginate --- production --- disinfection --- phagodisinfection --- virus–host interactions --- bacteriophage efficacy --- gastrointestinal tract --- phage therapy --- bacteriophage --- phage therapy --- antimicrobial resistance --- antibiotic --- global health --- developing countries --- infectious disease --- bacteriophage --- phage --- phage therapy --- phage-resistance --- phage therapy --- bacterial infection --- capsule depolymerase --- antibiotic --- animal model --- bacterial resistance --- bacteriophage --- immunology --- innate immunity --- adaptive immunity --- human host --- phage-human host interaction --- bacterial infection --- antibiotic resistance --- bacteriophage --- antibiotic therapy --- phage therapy --- cases report --- abortive infection --- prophage --- adsorption --- Enterococcus --- rhamnopolysaccharide --- bacteriophage --- phage therapy --- Staphylococcus aureus --- biofilm --- antimicrobial --- frequency of resistance --- phage sensitivity --- resistance management --- nontraditional antibacterial --- bacteriophages --- phage therapy --- antibiotic resistance --- Pseudomonas aeruginosa --- Escherichia coli --- Staphylococcus aureus --- Brussels --- Belgium --- phage biocontrol --- patent landscape --- crop production --- bacteriophage --- phage therapy --- multidrug-resistant bacteria --- antimicrobial resistance --- bacteriophage therapy --- compassionate use --- antibiotic resistance --- phage therapy --- PTMP --- ATMP --- regulatory framework --- pharmaceutical paradigm shift --- clinical trial --- magistral formula --- personalized medicine --- phage therapy --- E. faecalis --- OrthoMCL --- antimicrobial resistance --- capsule --- Galleria mellonella --- Klebsiella pneumoniae --- phage therapy --- n/a --- antimicrobial resistance --- bacteriophage --- personalised medicines --- phage therapy --- pharmaceutical legislation --- regulatory framework

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