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In Vivo Imaging in Pharmacological Research

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452378 Year: Pages: 222 DOI: 10.3389/978-2-88945-237-8 Language: English
Publisher: Frontiers Media SA
Subject: Therapeutics --- Science (General)
Added to DOAB on : 2017-10-13 14:57:01
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The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early stages and marked, in the end, by high rates of failure. As a consequence, the overall process leading to the production of a successful drug is very costly. The improvement of the net outcome in drug discovery and development would require, amongst other important factors, a good understanding of the molecular events that characterize the disease or pathology in order to better identify likely targets of interest, to optimize the interaction of an active agent (small molecule or macromolecule of natural or synthetic origin) with those targets, and to facilitate the study of the pharmacokinetics, pharmacodynamics and toxicity of an active agent in suitable models and in human subjects. The objective of this Research Topic is to highlight new developments and applications of imaging techniques with the objective of performing pharmacological studies in vivo, in animal models and in humans. In the domain of drug discovery, the pharmacological and biomedical questions constitute the center of attention. In this sense, it is fundamental to keep in mind the strengths and limitations of each analytical or imaging technique. At the end, the judicious application of the technique with the aim of supporting the search for answers to manifold questions arising during a long and painstaking path provides a continuous role for imaging within the complex area of drug discovery and development.

The Molecular and Cellular Basis for Parkinson's Disease

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ISBN: 9783039215485 9783039215492 Year: Pages: 230 DOI: 10.3390/books978-3-03921-549-2 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Neurology
Added to DOAB on : 2019-12-09 11:49:15
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The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.

Keywords

epigenetics --- Parkinson’s disease --- brain --- DNA methylation --- Parkinson’s disease --- fatty acid ?-oxidation --- long-chain acylcarnitine --- Parkinson’s disease --- fatty acyls --- glycerolipids --- glycerophospholipids --- sphingolipids --- sterol lipids --- lipoproteins --- ?-synuclein-mediated pathology --- disease-modifying effects --- neuroprotection --- autophagy --- cysteinyl-dopamine --- hypochlorite --- oxidative stress --- Parkinson’s disease --- redox cycling --- Parkinson’s disease --- brain iron --- motor dysfunction --- neurometabolites --- magnetic resonance imaging --- magnetic resonance spectroscopy --- GABA --- spectroscopy --- Parkinson’s disease --- neuroinflammation --- alpha-Synuclein --- immunotherapy --- mesenchymal stem cells --- secretome --- exosomes --- Parkinson’s disease --- microRNAs --- Parkinson disease --- multiprofessional therapy --- inpatient treatment --- multimodal complex treatment --- caffeic acid --- chlorogenic acid --- rotenone --- Parkinson’s disease --- neuroprotection --- dopaminergic neuron --- myenteric plexus --- enteric glial cell --- metallothionein --- Parkinson’s disease --- microbiota --- molecular mimicry --- microbiome --- alpha-synuclein --- curli --- gut-brain axis --- neurodegeneration --- glucocerebrosidase --- Parkinson’s disease --- Gaucher’s disease --- Lewy Body Dementia --- REM sleep behavior disorders --- [123I]FP-CIT-SPECT --- DAT --- nigral cells --- Parkinson’s disease --- parkinsonisms --- cell line --- differentiation --- HOG --- immature oligodendrocyte --- Krabbe’s disease --- oligodendrocyte --- mature oligodendrocyte --- MO3.13 --- myelin --- multiple sclerosis --- schizophrenia --- SH-SY5Y

MaxEnt 2019—Proceedings, 2019, MaxEnt 2019The 39th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering

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ISBN: 9783039284764 9783039284771 Year: Pages: 312 DOI: 10.3390/books978-3-03928-477-1 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Science (General) --- Mathematics
Added to DOAB on : 2020-04-07 23:07:09
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This Proceedings book presents papers from the 39th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering, MaxEnt 2019. The workshop took place at the Max Planck Institute for Plasma Physics in Garching near Munich, Germany, from 30 June to 5 July 2019, and invited contributions on all aspects of probabilistic inference, including novel techniques, applications, and work that sheds new light on the foundations of inference. Addressed are inverse and uncertainty quantification (UQ) and problems arising from a large variety of applications, such as earth science, astrophysics, material and plasma science, imaging in geophysics and medicine, nondestructive testing, density estimation, remote sensing, Gaussian process (GP) regression, optimal experimental design, data assimilation, and data mining.

Instruments and Methods for Cyclotron Produced Radioisotopes

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ISBN: 9783039282029 9783039282036 Year: Pages: 230 DOI: 10.3390/books978-3-03928-203-6 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: General and Civil Engineering --- Technology (General)
Added to DOAB on : 2020-01-30 16:39:46
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The focus of this Special Issue is aimed at enhancing the discussion of Engineering Education, particularly related to technological and professional learning. In the 21st century, students face a challenging demand: they are expected to have the best scientific expertise, but also highly developed social skills and qualities like teamwork, creativity, communication, or leadership. Even though students and teachers are becoming more aware of this necessity, there is still a gap between academic life and the professional world. In this Special Edition Book, the reader can find works tackling interesting topics such as educational resources addressing students’ development of competencies, the importance of final year projects linked to professional environments, and multicultural or interdisciplinary challenges.

Keywords

cyclotron --- PET --- titanium-45 --- unconventional radionuclides --- cyclotron --- targetry --- thermal study --- recycling of [18O]-water --- enrichment grade --- fractional distillation --- azeotropic mixtures --- molecular sieve desiccant --- 165Er --- 52Mn --- irradiation --- separation --- resin --- radiometals --- heavy Rare Earth Elements (hREE) --- liquid targets --- medical cyclotron --- radiometals --- gallium-68 --- copper-64 --- copper-61 --- purification --- disposable kit --- radiopharmaceuticals --- radionuclide production --- target stations --- targetry --- 70 MeV cyclotron --- beam energy --- ion accelerator --- medical cyclotron --- ion source --- filament --- cyclotron --- medical isotopes --- SPECT --- cyclotron --- medical radioisotope production --- radioactive impurities --- cross-section --- stacked-foils --- gamma spectroscopy --- thick target yield --- Radionuclide Yield Calculator --- cyclotron target --- carbon-11 --- recoil escape --- boron nitride nanotubes --- BNNTs --- cyclotrons --- radionuclide production --- solid, liquid and gas targets --- PET --- medical isotopes --- Ga-68 --- solid target --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- cyclotron --- targetry --- solid target --- metal 3D-printing --- target temperature --- radiometals --- radionuclides --- radioisotopes --- medical radioisotopes --- radioisotope targetry --- solid radioisotope targets --- radioisotope target processing --- medical cyclotrons --- PET --- medical isotopes --- solid target system --- radioisotope production --- Molybdenum-100 --- cyclotron --- molybdenum material recovery --- actinium-225 --- thorium --- spallation --- proton target --- ANSYS --- targeted alpha therapy --- cyclotron --- stack-foil --- monitor reaction --- cyclotron solid target --- radioisotope production --- magnetron sputtering --- thick film deposition --- cyclotron --- powder target --- thermal study --- vortex target --- Gallium-68 --- Technetium-99m --- medical Sc radioisotopes --- radioisotope production --- thick target yield measurements --- cross-section reconstruction --- numerical analysis --- cyclotrons --- targets --- target chemistry --- radioisotopes --- theranostics

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