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Impact of Lipid Peroxidation on the Physiology and Pathophysiology of Cell Membranes

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889450824 Year: Pages: 88 DOI: 10.3389/978-2-88945-082-4 Language: English
Publisher: Frontiers Media SA
Subject: Physiology --- Science (General)
Added to DOAB on : 2017-07-06 13:27:36
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Abstract

The general process of lipid peroxidation consists of three stages: initiation, propagation, and termination. The initiation phase of lipid peroxidation includes hydrogen atom abstraction. Several species can abstract the first hydrogen atom and include the radicals: hydroxyl, alkoxyl, peroxyl, and possibly HO* 2. The membrane lipids, mainly phospholipids, containing polyunsaturated fatty acids are predominantly susceptible to peroxidation because abstraction from a methylene group of a hydrogen atom, which contains only one electron, leaves at the back an unpaired electron on the carbon. The initial reaction of *OH with polyunsaturated fatty acids produces a lipid radical (L*), which in turn reacts with molecular oxygen to form a lipid hydroperoxide (LOOH). Further, the LOOH formed can suffer reductive cleavage by reduced metals, such as Fe++, producing lipid alkoxyl radical (LO*). Peroxidation of lipids can disturb the assembly of the membrane, causing changes in fluidity and permeability, alterations of ion transport and inhibition of metabolic processes. In addition, LOOH can break down, frequently in the presence of reduced metals or ascorbate, to reactive aldehyde products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), 4-hydroxy-2-hexenal (4-HHE) and acrolein. Lipid peroxidation is one of the major outcomes of free radical-mediated injury to tissue mainly because it can greatly alter the physicochemical properties of membrane lipid bilayers, resulting in severe cellular dysfunction. In addition, a variety of lipid by-products are produced as a consequence of lipid peroxidation, some of which can exert beneficial biological effects under normal physiological conditions. Intensive research performed over the last decades have also revealed that by-products of lipid peroxidation are also involved in cellular signalling and transduction pathways under physiological conditions, and regulate a variety of cellular functions, including normal aging. In the present collection of articles, both aspects (adverse and benefitial) of lipid peroxidation are illustrated in different biological paradigms. We expect this eBook may encourage readers to expand the current knowledge on the complexity of physiological and pathophysiological roles of lipid peroxidation.

Fluid Flow in Fractured Porous Media

Authors: ---
ISBN: 9783039214235 / 9783039214242 Year: Volume: 1 Pages: 578 DOI: 10.3390/books978-3-03921-424-2 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
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Abstract

The fluid flow in fracture porous media plays a significant role in the assessment of deep underground reservoirs, such as through CO2 sequestration, enhanced oil recovery, and geothermal energy development. Many methods have been employed—from laboratory experimentation to theoretical analysis and numerical simulations—and allowed for many useful conclusions. This Special Issue aims to report on the current advances related to this topic. This collection of 58 papers represents a wide variety of topics, including on granite permeability investigation, grouting, coal mining, roadway, and concrete, to name but a few. We sincerely hope that the papers published in this Special Issue will be an invaluable resource for our readers.

Keywords

scanning electron microscope (SEM) images --- permeability --- high temperature --- Darcy’s law --- confining pressures --- chemical grouts --- grain size of sand --- initial water contained in sand --- grouted sand --- macroscopic mechanical behaviors --- microstructure characteristics --- ductile failure --- gas concentration --- gob-side entry retaining (GER) --- limestone roof --- roof-cutting resistance --- roadside backfill body (RBB) --- solid backfill coal mining --- goaf --- water soaked height --- loose gangue backfill material --- deformation --- crushing ratio --- fracture grouting --- cement–silicate grout --- geophysical prospecting --- seepage --- Yellow River Embankment --- contiguous seams --- water-dripping roadway --- roadway deformation --- bolt support --- pervious concrete --- permeability coefficient --- porosity --- pore distribution characteristics --- strength --- soil–structure interface --- internal erosion --- critical hydraulic gradient --- orthogonal tests --- Pseudo Steady-State (PPS) constant --- finite-conductivity fracture --- conductivity-influence function --- normalized conductivity-influence function --- circular closed reservoir --- glutenite --- gravel --- hydraulic fracture --- numerical simulation --- propagation --- glauberite cavern for storing oil &amp --- gas --- thermal-hydrological-chemical interactions --- temperature --- brine concentration --- microstructure --- micro-CT --- damage --- cyclic heating and cooling --- physical and mechanical parameters --- failure mode --- acoustic emission --- anisotropy --- bedding plane orientation --- coal --- gas --- adsorption–desorption --- laboratory experiment --- pore pressure --- hydro-mechanical coupling --- fracture closure --- constitutive model --- effective stress --- debris flow --- dynamic characteristics --- numerical analysis --- debris-resisting barriers --- coal measures sandstone --- creep characteristics --- seepage pressure --- seepage-creep --- microscopic morphology --- Darcy flow --- heterogeneity --- numerical manifold method --- high-order --- refraction law --- hydraulic fracture network --- cohesive element method --- coal seams --- fracture propagation --- discontinuous natural fracture --- secondary fracture --- fault water inrush --- coupled THM model --- nonlinear flow in fractured porous media --- numerical model --- warning levels of fault water inrush --- bentonite-sand mixtures --- differential settlement --- deformation --- hydraulic conductivity --- crack --- geogrid --- enhanced permeability --- deviatoric stress --- mechanical behavior transition --- CH4 seepage --- volumetric strain --- strain-based percolation model --- rock-soil mechanics --- soft filling medium --- segmented grouting --- split grouting --- model experiment --- reinforcement mechanism --- longwall mining --- gob behaviors --- stress relief --- permeability --- gas drainage --- hard and thick magmatic rocks --- orthogonal ratio test --- similar simulation --- fracture --- bed separation --- disaster-causing mechanism --- artificial joint rock --- shear-flow coupled test --- hydraulic aperture --- roughness --- seepage pressure --- mixing --- conservative solute --- fractal --- roughness --- fracture --- transversely isotropic rocks --- failure mechanism --- particle flow modeling --- interface --- n/a --- fractured porous rock mass --- grouting experiment --- visualization system --- flow law --- layered progressive grouting --- sandstone and mudstone particles --- rheological deformation --- segmented rheological model --- rheological limit strain --- rheological test --- water-rock interaction --- dry-wet cycles --- slope stability --- laboratory experiment --- mechanical properties --- Xinjiang --- land reclamation --- management period --- soil particle size --- fluid flow in reclaimed soil --- effluents --- soil properties --- cohesive soils --- contamination --- time variation --- stabilization --- mixer --- viscoelastic fluid --- pore structure --- orthogonal test --- fluid–solid coupling theory --- similar-material --- regression equation --- optimum proportioning --- hydraulic fracturing --- gas fracturing --- oriented perforation --- fracture propagation --- damage mechanics --- fluid viscosity --- CO2 flooding --- supercritical CO2 --- CO2 geological storage --- tight sandstone gas reservoirs --- enhanced gas recovery --- flotation --- coal particle --- collision angle --- initial settlement position --- particle velocity --- adhesion efficiency --- green mining --- paste-like slurry --- XRD --- intelligent torque rheometer --- on-site monitoring --- cyclic wetting-drying --- deterioration --- sandstone --- mudstone --- elastic modulus --- uniaxial compressive strength --- permeability characteristics --- grading broken gangue --- compressive stress --- compression deformation --- mine shaft --- alternate strata --- surrounding rock --- shaft lining --- relief excavation --- consolidation process --- unsaturated soil --- semi-analytical solution --- impeded drainage boundary --- excess pore-pressures --- coalbed methane (CBM) --- soft coal masses --- pore structure --- fractal pore characteristics --- hydraulic fractures --- PPCZ --- multitude parameters --- propagation pattern --- stress interference --- naturally fracture --- filtration effects --- grout penetration --- unified pipe-network method --- two-phase flow --- fractured porous medium --- new cementitious material --- cement-based paste discharge --- XRD --- TG/DTG --- SEM --- MIP --- mechanical behaviors --- rock fracture --- shear-flow coupled test --- constant normal stiffness conditions --- transmissivity --- hydraulic aperture --- water inrush prevention --- backfill mining --- strata movement --- ground pressure --- floor failure depth --- water–rock interaction --- degradation mechanism --- mixed mode fracture resistance --- fracture criteria --- T-stress --- hydro-power --- high-steep slope --- fractured rock --- permeability --- seepage control --- gas-bearing coal --- electrical potential --- charge separation --- gas adsorption --- damage evolution --- Unsaturation --- chloride --- concrete --- coupling model --- numerical calculation --- debris flow --- forecasting --- rainfall-unstable soil coupling mechanism(R-USCM) --- scoops3D --- Jiaohe --- non-aqueous phase liquid --- finite element method --- two-phase flow --- mixed-form formulation --- FLAC --- pore structure --- movable fluid --- tight sandstones --- Ordos Basin --- tectonically deformed coal --- coal and gas outburst --- coal-like material --- mechanical properties --- deformation feature --- adsorption/desorption properties --- minerals --- mechanical properties --- uniaxial compressive strength --- crack distribution characteristics --- discrete element method --- lignite --- nitric acid modification --- pore structure --- surface characteristics --- adsorption performance --- n/a

Fluid Flow in Fractured Porous Media

Authors: ---
ISBN: 9783039214730 / 9783039214747 Year: Volume: 2 Pages: 492 DOI: 10.3390/books978-3-03921-474-7 Language: eng
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Technology (General) --- General and Civil Engineering
Added to DOAB on : 2019-12-09 11:49:15
License:

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Abstract

The fluid flow in fracture porous media plays a significant role in the assessment of deep underground reservoirs, such as through CO2 sequestration, enhanced oil recovery, and geothermal energy development. Many methods have been employed—from laboratory experimentation to theoretical analysis and numerical simulations—and allowed for many useful conclusions. This Special Issue aims to report on the current advances related to this topic. This collection of 58 papers represents a wide variety of topics, including on granite permeability investigation, grouting, coal mining, roadway, and concrete, to name but a few. We sincerely hope that the papers published in this Special Issue will be an invaluable resource for our readers.

Keywords

scanning electron microscope (SEM) images --- permeability --- high temperature --- Darcy’s law --- confining pressures --- chemical grouts --- grain size of sand --- initial water contained in sand --- grouted sand --- macroscopic mechanical behaviors --- microstructure characteristics --- ductile failure --- gas concentration --- gob-side entry retaining (GER) --- limestone roof --- roof-cutting resistance --- roadside backfill body (RBB) --- solid backfill coal mining --- goaf --- water soaked height --- loose gangue backfill material --- deformation --- crushing ratio --- fracture grouting --- cement–silicate grout --- geophysical prospecting --- seepage --- Yellow River Embankment --- contiguous seams --- water-dripping roadway --- roadway deformation --- bolt support --- pervious concrete --- permeability coefficient --- porosity --- pore distribution characteristics --- strength --- soil–structure interface --- internal erosion --- critical hydraulic gradient --- orthogonal tests --- Pseudo Steady-State (PPS) constant --- finite-conductivity fracture --- conductivity-influence function --- normalized conductivity-influence function --- circular closed reservoir --- glutenite --- gravel --- hydraulic fracture --- numerical simulation --- propagation --- glauberite cavern for storing oil &amp --- gas --- thermal-hydrological-chemical interactions --- temperature --- brine concentration --- microstructure --- micro-CT --- damage --- cyclic heating and cooling --- physical and mechanical parameters --- failure mode --- acoustic emission --- anisotropy --- bedding plane orientation --- coal --- gas --- adsorption–desorption --- laboratory experiment --- pore pressure --- hydro-mechanical coupling --- fracture closure --- constitutive model --- effective stress --- debris flow --- dynamic characteristics --- numerical analysis --- debris-resisting barriers --- coal measures sandstone --- creep characteristics --- seepage pressure --- seepage-creep --- microscopic morphology --- Darcy flow --- heterogeneity --- numerical manifold method --- high-order --- refraction law --- hydraulic fracture network --- cohesive element method --- coal seams --- fracture propagation --- discontinuous natural fracture --- secondary fracture --- fault water inrush --- coupled THM model --- nonlinear flow in fractured porous media --- numerical model --- warning levels of fault water inrush --- bentonite-sand mixtures --- differential settlement --- deformation --- hydraulic conductivity --- crack --- geogrid --- enhanced permeability --- deviatoric stress --- mechanical behavior transition --- CH4 seepage --- volumetric strain --- strain-based percolation model --- rock-soil mechanics --- soft filling medium --- segmented grouting --- split grouting --- model experiment --- reinforcement mechanism --- longwall mining --- gob behaviors --- stress relief --- permeability --- gas drainage --- hard and thick magmatic rocks --- orthogonal ratio test --- similar simulation --- fracture --- bed separation --- disaster-causing mechanism --- artificial joint rock --- shear-flow coupled test --- hydraulic aperture --- roughness --- seepage pressure --- mixing --- conservative solute --- fractal --- roughness --- fracture --- transversely isotropic rocks --- failure mechanism --- particle flow modeling --- interface --- n/a --- fractured porous rock mass --- grouting experiment --- visualization system --- flow law --- layered progressive grouting --- sandstone and mudstone particles --- rheological deformation --- segmented rheological model --- rheological limit strain --- rheological test --- water-rock interaction --- dry-wet cycles --- slope stability --- laboratory experiment --- mechanical properties --- Xinjiang --- land reclamation --- management period --- soil particle size --- fluid flow in reclaimed soil --- effluents --- soil properties --- cohesive soils --- contamination --- time variation --- stabilization --- mixer --- viscoelastic fluid --- pore structure --- orthogonal test --- fluid–solid coupling theory --- similar-material --- regression equation --- optimum proportioning --- hydraulic fracturing --- gas fracturing --- oriented perforation --- fracture propagation --- damage mechanics --- fluid viscosity --- CO2 flooding --- supercritical CO2 --- CO2 geological storage --- tight sandstone gas reservoirs --- enhanced gas recovery --- flotation --- coal particle --- collision angle --- initial settlement position --- particle velocity --- adhesion efficiency --- green mining --- paste-like slurry --- XRD --- intelligent torque rheometer --- on-site monitoring --- cyclic wetting-drying --- deterioration --- sandstone --- mudstone --- elastic modulus --- uniaxial compressive strength --- permeability characteristics --- grading broken gangue --- compressive stress --- compression deformation --- mine shaft --- alternate strata --- surrounding rock --- shaft lining --- relief excavation --- consolidation process --- unsaturated soil --- semi-analytical solution --- impeded drainage boundary --- excess pore-pressures --- coalbed methane (CBM) --- soft coal masses --- pore structure --- fractal pore characteristics --- hydraulic fractures --- PPCZ --- multitude parameters --- propagation pattern --- stress interference --- naturally fracture --- filtration effects --- grout penetration --- unified pipe-network method --- two-phase flow --- fractured porous medium --- new cementitious material --- cement-based paste discharge --- XRD --- TG/DTG --- SEM --- MIP --- mechanical behaviors --- rock fracture --- shear-flow coupled test --- constant normal stiffness conditions --- transmissivity --- hydraulic aperture --- water inrush prevention --- backfill mining --- strata movement --- ground pressure --- floor failure depth --- water–rock interaction --- degradation mechanism --- mixed mode fracture resistance --- fracture criteria --- T-stress --- hydro-power --- high-steep slope --- fractured rock --- permeability --- seepage control --- gas-bearing coal --- electrical potential --- charge separation --- gas adsorption --- damage evolution --- Unsaturation --- chloride --- concrete --- coupling model --- numerical calculation --- debris flow --- forecasting --- rainfall-unstable soil coupling mechanism(R-USCM) --- scoops3D --- Jiaohe --- non-aqueous phase liquid --- finite element method --- two-phase flow --- mixed-form formulation --- FLAC --- pore structure --- movable fluid --- tight sandstones --- Ordos Basin --- tectonically deformed coal --- coal and gas outburst --- coal-like material --- mechanical properties --- deformation feature --- adsorption/desorption properties --- minerals --- mechanical properties --- uniaxial compressive strength --- crack distribution characteristics --- discrete element method --- lignite --- nitric acid modification --- pore structure --- surface characteristics --- adsorption performance --- n/a

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