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New anti-infective strategies for treatment of tularemia

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Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889193394 Year: Pages: 78 DOI: 10.3389/978-2-88919-339-4 Language: English
Publisher: Frontiers Media SA
Subject: Internal medicine --- Science (General)
Added to DOAB on : 2016-03-10 08:14:32
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Francisella tularensis, the causative agent of tularemia, is a paradigm among human pathogens. This Gram-negative bacterium has an intracellular lifestyle, which probably reflects an adaptation to its natural animal and protozoa reservoirs. This is one of the most infectious agents in humans and animals; only a few bacteria are needed to induce a severe infection in both types of hosts. The clinical presentation and severity of human tularemia varies according to the portal of entry of bacteria, the bacterial inoculum, the virulence of the infecting strain, and the immune response of the host. Although most infections occur after direct inoculation of bacteria through the skin (through skin wounds or bites of arthropods), pneumonia due to inhalation of infected aerosols is the most feared of the clinical forms of the disease, particularly in the context of biological threat. Two subspecies are responsible for tularemia (subsp. tularensis and subsp. holarctica), and several clades have been described for each, which might be associated with changes in disease severity in humans. Tularemia is also more severe in people with an impaired immune response. No safe vaccine is currently available for prophylaxis of tularemia in humans. On the other hand, control of proliferation of F. tularensis in wildlife is not feasible. Thus, only the anti-infective agents are used for treatment and prophylaxis of human tularemia. The standard options include aminoglycosides (gentamicin), tetracyclines (eg, doxycycline) and fluoroquinolones (eg, ciprofloxacin). The selection of acquired resistance to these antibiotics in F. tularensis, especially in the context of a biological threat, may quickly limit the therapeutic options. New prophylactic and therapeutic alternatives must be developed rapidly. The present Research Topic focuses on potential new strategies for treatment of tularemia, including the development and evaluation of new compounds having proper antibacterial activity, reducing the virulence of F. tularensis or enhancing the immune host response.

Abrasiva, Schleif- und Poliermittel der Metallverarbeitung in Geschichte, Archäologie und Experiment

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Book Series: Beiträge zur Technikgeschichte/Studies in the History of Technology ISBN: 9783906897370 Year: Volume: 1 Pages: 120 DOI: 10.19218/3906897370 Language: German
Publisher: LIBRUM Publishers & Editors LLC
Subject: Archaeology
Added to DOAB on : 2020-10-12 14:45:25
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Metalle schleifen und polieren in der Antike – Alte Quellen und neue Experimente.Seit der Mensch seine Werkzeuge und Jagdwaffen herstellen kann, hat er sie auch geschliffen. Nach den ersten Werkstoffen Knochen, Geweih und Holz stellten später die Metalle besondere Anforderungen. Rohgüsse von Schmuck und Geräten sowie geschmiedete Werkzeuge und Waffen mussten überschliffen, Schneiden und Klingen geschärft und Oberflächen aus ästhetischen Gründen auch poliert werden.Welche Schleif- und Poliermittel die Handwerker der Antike hierfür verwendeten, ist kaum bekannt; die schriftlichen Quellen sind rar, und archäologische Befunde schwer zu erkennen und zu dokumentieren. Dieses Buch stellt zusammen, welche Abrasivmaterialien dem frühen Handwerk zur Verfügung standen, wo die Rohstoffe zu finden und wie die Materialien aufzubereiten sind. Die antiken Autoren, die diese Materialien erwähnten, werden zitiert, und mit Experimenteller Archäologie hat der Autor die Tauglichkeit und Effizienz aller Schleifgeräte, Schleifmittel und Polierstoffe getestet.

Biological Engagement Programs: Reducing Threats and Strengthening Global Health Security Through Scientific Collaboration

Authors: --- ---
Book Series: Frontiers Research Topics ISSN: 16648714 ISBN: 9782889452736 Year: Pages: 199 DOI: 10.3389/978-2-88945-273-6 Language: English
Publisher: Frontiers Media SA
Subject: Medicine (General) --- Public Health --- Science (General) --- Microbiology
Added to DOAB on : 2018-02-27 16:16:44
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Biological engagement programs are a set of projects or activities between partner countries that strengthen global health security to achieve mutually beneficial outcomes. Engagement programs are an effective way to work collaboratively towards a common threat reduction goal, usually with a strong focus on strengthening health systems and making the world a safer place. Cooperative programs are built upon trust and sharing of information and resources to increase the capacity and capabilities of partner countries. Biological engagement programs reduce the threat of infectious disease with a focus on pathogens of security concern, such as those pathogens identified by the U.S. Government as Biological Select Agent and Toxins. These programs seek to develop technical or scientific relationships between countries to combat infectious diseases both in humans and animals. Through laboratory biorisk management, diagnostics, pathogen detection, biosurveillance and countermeasure development for infectious diseases, deep relationships are fostered between countries. Biological engagement programs are designed to address dual-use issues in pathogen research by promoting responsible science methodologies and cultures. Scientific collaboration is a core mechanism for engagement programs are designed to strengthen global health security, including prevention of avoidable epidemics; detection of threats as early as possible; and rapid and effective outbreak response. This Research Topic discusses Biological Engagement Programs, highlighting the successes and challenges of these cooperative programs. Articles in this topic outlined established engagement programs as well as described what has been learned from historical cooperative engagement programs not focused on infectious diseases. Articles in this topic highlighted selected research, trainings, and programs in Biological Engagement Programs from around the world. This Topic eBook first delves into Policies and Lessons Learned; then describes Initiatives in Biosafety & Biosecurity; the core of this work documents Cooperative Research Results from the field; then lastly the Topic lays out potential Future Directions to the continued success of the World’s cooperative science in reducing the threat of infectious diseases.

Natural Products for Cancer Prevention and Therapy

Authors: ---
ISBN: 9783038973102 9783038973119 Year: Pages: 260 DOI: 10.3390/books978-3-03897-311-9 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Medicine (General) --- Oncology --- Therapeutics
Added to DOAB on : 2018-11-07 10:17:54
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ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[This Special Issue book, “Natural Products for Cancer Prevention and Therapy”, is based on recent advances in natural products for cancer prevention and therapy. For this purpose, the authors of this book have been organizing a biennial international conference series. The first meeting (First International Conference on Natural Products for Cancer Prevention and Therapy) was held in Istanbul between 31 August and 2 September 2015, with the support and contribution of many valuable researchers in this field. The abstracts of the first conference were published in the Anticancer Drugs journal as a supplement. The second meeting, namely The Second International Conference on Natural Products for Cancer Prevention and Therapy, was held at Erciyes University, Kayseri, Turkey, between 8 and 11 November 2017. The abstracts of all of the presentations from the second meeting were published in the Special Issue of Proceedings by the MDPI publishing group. Furthermore, the conference report and the selected full-length papers based on the presentations at the meeting, as well as other papers based on natural products for cancer prevention and therapy, were published as a Special Issue of the Nutrients journal from MDPI. This Special Issue has contributions from various participants of the aforementioned conference, as well as other cancer and natural product researchers. These contributions include original research papers, authoritative and up-to-date reviews, and commentaries on the following topics and areas:•Natural products for the prevention and therapy of oncologic diseases•Mechanism of natural agents for anticancer and cancer preventive effects•In vitro, in vivo, and clinical studies related to natural agents and cancer•Combinatorial effects of phytochemicals and cancer chemotherapeutic drugs•Challenges and innovative approaches for anticancer drug development based on natural products•Emerging studies on anticancer phytochemicals]

Working in China

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Book Series: Asia's Transformations ISBN: 9780203966983 9780415769990 9780415770002 9781135988913 9781135988906 9781135988869 Year: DOI: 10.4324/9780203966983 Language: English
Publisher: Taylor & Francis
Subject: Economics --- Sociology --- Science (General)
Added to DOAB on : 2019-11-08 11:21:03
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After a quarter of a century of market reform, China has become the workshop of the world and the leading growth engine of the global economy. Its immense labour force accounts for some twenty-nine per cent of the world's total labour pool but all too little is known about Chinese labour beyond the image of workers toiling under appalling sweatshop conditions for extremely low wages. Working in China introduces the lived experiences of labour in a wide range of occupations and work settings. The chapters of this book cover professional employees such as engineers and lawyers, service workers such as bar hostesses, domestic maids and hotel workers, and industrial workers in a variety of factories. The mosaic of human faces, organizational dynamics and workers' voices presented in the book reflect the complexity of changes and challenges taking place in the Chinese workplace today. Based on extraordinary and thorough field research, this book will have a wide readership at undergraduate level and beyond, appealing to students and scholars from a myriad of disciplines including Chinese studies, labour studies, sociology and political economy.

Keywords

unit --- chinese --- engineer --- karaoke --- bars --- insurance --- sales --- agents --- sex --- workers

Developments in the Call Centre Industry

Authors: ---
Book Series: Routledge Studies in Business Organizations and Networks ISBN: 9780203003008 9780415357029 9780415511483 9781134248827 9781134248810 9781134248773 Year: DOI: 10.4324/9780203003008 Language: English
Publisher: Taylor & Francis
Subject: Business and Management --- Economics
Added to DOAB on : 2019-11-08 11:21:27
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Over the past ten years there has been a massive growth in call centres worldwide. These centres are said to represent the most dynamic growth area in white-collar employment internationally since the mid 1990s. Yet the footloose and global nature of the industry means that jobs will always be susceptible to outsourced operations, ICT developments, public sector subsidization of business restructuring and re-location, and cheaper operations elsewhere. This book conducts a thorough analysis of this modern phenomenon.

Keywords

work --- employees --- managers --- agents --- operation --- sector --- offshoring --- research --- business --- process

A Commemorative Issue in Honor of Professor Nick Hadjiliadis: Metal Complex Interactions with Nucleic Acids and/or DNA

Authors: ---
ISBN: 9783038975113 9783038975120 Year: Pages: 256 DOI: 10.3390/books978-3-03897-512-0 Language: English
Publisher: MDPI - Multidisciplinary Digital Publishing Institute
Subject: Biochemistry --- Biology --- Medicine (General) --- Therapeutics
Added to DOAB on : 2019-02-05 12:36:28
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This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on “Metal Complex Interactions with Nucleic Acids and/or DNA”. This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover, this Special Issue on "Metal Complexes Interactions with Nucleic Acids and/or DNA" provides an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.

Designing Adaptive Virtual Worlds

Authors: ---
ISBN: 9783110367669 9783110399219 Year: Pages: 144 DOI: 10.2478/9783110367669 Language: English
Publisher: De Gruyter
Subject: Computer Science
Added to DOAB on : 2014-11-17 10:10:40
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Designing adaptive virtual worlds takes the design of places for education, entertainment, online communities, business, and cultural activities in 3D virtual worlds to a new level. The place metaphor provides a rich source of styles and examples for designing in 3D virtual worlds. This book is one of the first design books in the field showing how those styles can be captured in a design grammar so that unique places can be created through computational agents responding to the changing needs of the people in the virtual world. Applying the techniques introduced in this book has immediate implications on the design of games and functional places in existing virtual world platforms such as Second Life, OpenSim and Active Worlds as well as future virtual worlds in which the boundaries between digital and physical environments blur.

How Change Happens

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Book Series: OXFAM ISBN: 9780198785392 Year: Pages: 288 DOI: 10.1093/acprof:oso/9780198785392.001.0001 Language: English
Publisher: Oxford University Press Grant: Oxfam America
Subject: Business and Management --- Economics --- Political Science
Added to DOAB on : 2016-10-26 11:01:03
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Human society is full of would-be ‘change agents’, a restless mix of campaigners, lobbyists, and officials, both individuals and organizations, set on transforming the world. They want to improve public services, reform laws and regulations, guarantee human rights, get a fairer deal for those on the sharp end, achieve greater recognition for any number of issues, or simply be treated with respect. Striking then, that not many universities have a Department of Change Studies, to which social activists can turn for advice and inspiration. Instead, scholarly discussions of change are fragmented with few conversations crossing disciplinary boundaries, rarely making it onto the radars of those actively seeking change. This book aims to bridge the gap between academia and practice, bringing together the best research from a range of academic disciplines and the evolving practical understanding of activists to explore the topic of social and political change. Drawing on many first-hand examples from the global experience of Oxfam, one of the world’s largest social justice NGOs, as well as insights gleaned from studying and working on international development, it tests ideas and offers the latest thinking on what works to achieve progressive change.

The Economy as a Complex Spatial System: Macro, Meso and Micro Perspectives

Authors: --- --- --- --- et al.
Book Series: Springer Proceedings in Complexity ISSN: 2213-8684 / 2213-8692 ISBN: 9783319656267 9783319656274 Year: Pages: 220 DOI: https://doi.org/10.1007/978-3-319-65627-4 Language: English
Publisher: Springer Nature
Subject: Economics
Added to DOAB on : 2017-11-24 16:21:26
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This collected volume represents the final outcome of the COST Action IS1104 “The EU in the new complex geography of economic systems: models, tools and policy evaluation”.Visualizing the EU as a complex and multi-layered network, the book is organized in three parts, each of them dealing with a different level of analysis: At the macro-level, Part I considers the interactions within large economic systems (regions or countries) involving trade, workers migration, and other factor movements. At the meso-level, Part II discusses interactions within specific but wide-ranging markets, with a focus on financial markets and banking systems. Lastly, at the micro-level, Part III explores the decision-making of single firms, especially in the context of location decisions.

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